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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:47322
Term: N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Definition: A member of the class of isoquinolines that is isoquinoline-8-sulfonamide which is substituted by chlorine at position 5 and in which the sulfonamide nitrogen is substituted by a 2-aminoethyl group. It is an inhibitor of casein kinase I.
Chemical ID: MESH:C058815
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTDN-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide affects the localization of and results in increased cleavage of and results in increased activity of CASP8 proteinPMID:15520213
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