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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:27656
Term: camptothecin
Definition: A pyranoindolizinoquinoline that is pyrano[3',4':6,7]indolizino[1,2-b]quinoline which is substituted by oxo groups at positions 3 and 14, and by an ethyl group and a hydroxy group at position 4 (the S enantiomer).
Chemical ID: MESH:D002166
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8multiple interactionsEXP 6480464CTDNaphthoquinones analog inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]PMID:19497415
Casp8affects cleavageISOCASP8 (Homo sapiens)6480464CTDCamptothecin affects the cleavage of CASP8 proteinPMID:10896673
Casp8decreases expressionISOCASP8 (Homo sapiens)6480464CTDCamptothecin results in decreased expression of CASP8 mRNAPMID:30581319
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDCamptothecin results in increased activity of CASP8 proteinPMID:15475000 PMID:34635930
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDCamptothecin results in increased expression of CASP8 proteinPMID:30885713
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; [Camptothecin co-treated with FAS protein] results in increased activity of CASP8 protein; [Camptothecin co-treated with FAS protein] results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Camptothecin results in increased activity of CASP8 protein]; MAD2L1 protein affects the reaction [Camptothecin results in increased expression of CASP8 protein]PMID:15475000 PMID:15958570 PMID:19633536 PMID:30885713
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