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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945 Species: Rattus norvegicus RGD Object: Gene Symbol: Casp8 Name: caspase 8

Acc ID: CHEBI:7596 Term: nitroprusside Definition: An iron coordination entity that has formula C5FeN6O. CasRN: 15078-28-1 Chemical ID: MESH:D009599

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	EXP		6480464	CTD	Nitroprusside results in increased activity of CASP8 protein	PMID:18311796
multiple interactions	EXP		6480464	CTD	cilostazol inhibits the reaction [Nitroprusside results in increased activity of CASP8 protein]	PMID:18311796
multiple interactions	ISO	RGD:730846	6480464	CTD	Nitroprusside inhibits the reaction [Deferoxamine results in increased activity of CASP8 protein]	PMID:16374551