GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | increases expression | EXP | | 6480464 | CTD | Copper deficiency results in increased expression of CASP8 mRNA; Copper results in increased expression of CASP8 protein | PMID:17418555 PMID:30556269 | Casp8 | multiple interactions | EXP | | 6480464 | CTD | [Copper deficiency co-treated with tetrathiomolybdate] results in increased cleavage of CASP8 protein; [Copper deficiency co-treated with tetrathiomolybdate] results in increased expression of CASP8 protein | PMID:22276220 | Casp8 | increases expression | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Copper analog results in increased expression of CASP8 protein | PMID:22000994 | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | [Ditiocarb binds to Copper] which results in increased activity of CASP8 protein; [Thiosemicarbazones binds to Copper] which results in decreased activity of CASP8 protein | PMID:20931265 PMID:22951949 | Casp8 | multiple interactions | ISO | Casp8 (Mus musculus) | 6480464 | CTD | [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP8 mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of CASP8 protein | PMID:31491480 | | ||||||||||||||||||||||
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