GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | increases activity | EXP | | 6480464 | CTD | Streptozocin results in increased activity of CASP8 protein | PMID:29606028 | Casp8 | increases cleavage | EXP | | 6480464 | CTD | Streptozocin results in increased cleavage of CASP8 protein | PMID:25541178 | Casp8 | increases expression | EXP | | 6480464 | CTD | Streptozocin results in increased expression of CASP8 mRNA; Streptozocin results in increased expression of CASP8 protein | PMID:23267840 PMID:28856781 | Casp8 | multiple interactions | EXP | | 6480464 | CTD | Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]; nifuroxazide inhibits the reaction [Streptozocin results in increased activity of CASP8 protein] | PMID:23267840 PMID:25541178 PMID:28856781 PMID:29606028 | |
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