GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | increases expression | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in increased expression of CASP8 protein | PMID:17767197 | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | [[methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP9 protein] which results in increased cleavage of CASP8 protein; [[parthenolide results in decreased activity of RELA protein] which results in increased activity of CASP8 protein] which results in increased susceptibility to Tamoxifen; [methylselenic acid co-treated with Tamoxifen] results in increased cleavage of CASP8 protein; [Tamoxifen co-treated with TNFSF10 protein] results in decreased expression of CASP8 protein modified form | PMID:17767197 PMID:18790785 PMID:20154269 | | ||||||||||||||||||||||
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