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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:18088
Term: formononetin
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone substituted by a methoxy group at position 4'.
Chemical ID: MESH:C007768
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDformononetin results in increased activity of CASP8 proteinPMID:23867903
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDformononetin results in increased expression of CASP8 mRNAPMID:23867903
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [formononetin results in increased expression of CASP8 mRNA]; Epirubicin promotes the reaction [formononetin results in increased activity of CASP8 protein]; Epirubicin promotes the reaction [formononetin results in increased expression of CASP8 mRNA]PMID:23867903
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