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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8affects localizationISOCASP8 (Homo sapiens)6480464CTDsorafenib affects the localization of CASP8 protein modified formPMID:17909059
Casp8increases cleavageISOCASP8 (Homo sapiens)6480464CTDsorafenib results in increased cleavage of CASP8 proteinPMID:18200035
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[sorafenib co-treated with TNFSF10 protein] promotes the reaction [CASP8 protein modified form results in increased cleavage of BID protein]; [sorafenib co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [sorafenib co-treated with TNFSF10 protein] results in increased cleavage of CASP8 protein; [sorafenib co-treated with Vitamin K 1] results in increased cleavage of CASP8 protein; [sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to FAS protein binds to FADD protein]; [sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to CASP8 protein binds to ATG5 protein binds to HSPA5 protein]; [sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein; ATG5 protein inhibits the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]; Boc-D-FMK inhibits the reaction [sorafenib results in increased cleavage of and results in increased activity of CASP8 protein]; EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]; EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [FAS protein binds to FADD protein binds to CASP8 protein]]; EIF2AK3 protein promotes the reaction [[sorafenib co-treated with vorinostat] results in increased cleavage of CASP8 protein]; FADD protein promotes the reaction [[sorafenib co-treated with vorinostat] promotes the reaction [CASP8 protein binds to ATG5 protein binds to HSPA5 protein binds to FAS protein]]; sorafenib results in increased cleavage of and results in increased activity of CASP8 proteinPMID:16007148 PMID:16109713 PMID:17909059 PMID:18787411 PMID:20071162 PMID:20301194
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