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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]PMID:23267840 PMID:25541178
Casp8decreases expressionISOCASP8 (Homo sapiens)6480464CTDCurcumin results in decreased expression of CASP8 mRNA; Curcumin results in decreased expression of CASP8 proteinPMID:17148446 PMID:33582110
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDCurcumin results in increased activity of CASP8 proteinPMID:17096185
Casp8increases cleavageISOCASP8 (Homo sapiens)6480464CTDCurcumin results in increased cleavage of CASP8 proteinPMID:14555224 PMID:22523229
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CASP8 protein; Curcumin inhibits the reaction [Oxygen deficiency results in increased expression of CASP8 mRNA]; Curcumin results in increased cleavage of and results in increased activity of CASP8 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Curcumin results in increased cleavage of CASP8 protein]PMID:16173963 PMID:22523229 PMID:23452621 PMID:27430728
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