GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | decreases response to substance | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | CASP8 protein mutant form results in decreased susceptibility to Etoposide | PMID:21801448 | Casp8 | increases activity | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Etoposide results in increased activity of CASP8 protein | PMID:15475000 | Casp8 | increases cleavage | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Etoposide results in increased cleavage of CASP8 protein | PMID:21801448 | Casp8 | increases response to substance | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | CASP8 protein results in increased susceptibility to Etoposide | PMID:22010212 | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] inhibits the reaction [CASP8 protein mutant form results in decreased susceptibility to Etoposide]; acetyl-leucyl-glutamyl-histidyl-aspartal inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP8 protein; Etoposide results in increased expression of and results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP8 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein] | PMID:15475000 PMID:21745461 PMID:21801448 PMID:22010212 | | ||||||||||||||||||||||
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