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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:65408
Term: andrographolide
Definition: A labdane diterpenoid isolated from the leaves and roots of Andrographis paniculata that exhibits anti-HIV, anti-inflammatory and antineoplastic properties.
Chemical ID: MESH:C030419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8multiple interactionsEXP 6480464CTDandrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP8 protein]PMID:20946909
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDandrographolide results in increased activity of CASP8 proteinPMID:19097688
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDandrographolide results in increased expression of CASP8 mRNAPMID:24563380
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[andrographolide co-treated with Cisplatin] results in increased expression of CASP8 mRNA; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP3 protein]]; CASP8 affects the reaction [Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP9 protein]]; CASP8 results in increased susceptibility to [andrographolide co-treated with Fluorouracil]; Fluorouracil promotes the reaction [andrographolide results in increased activity of CASP8 protein]PMID:19097688 PMID:24563380
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