Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8increases activityEXP 6480464CTDHydrogen Peroxide results in increased activity of CASP8 proteinPMID:15799720 PMID:16157298 PMID:16647178
Casp8increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of CASP8 proteinPMID:20946910 PMID:27525270
Casp8multiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]; [mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]; Cholesterol promotes the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]; Hydrogen Peroxide promotes the reaction [Cholesterol results in increased expression of CASP8 protein]; Luteolin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP8 protein]PMID:15799720 PMID:16647178 PMID:20946910 PMID:27525270
Casp8affects expressionISOCASP8 (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of CASP8 proteinPMID:21179406
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased activity of CASP8 proteinPMID:21431366
Casp8increases expressionISOCasp8 (Mus musculus)6480464CTDHydrogen Peroxide results in increased expression of CASP8 mRNAPMID:31696622
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTDMelatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP8 protein]PMID:21431366
Go Back to source page   Continue to Ontology report