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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620945
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp8
Name: caspase 8
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp8decreases cleavageEXP 6480464CTDCadmium Chloride results in decreased cleavage of CASP8 proteinPMID:22457795
Casp8decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of CASP8 proteinPMID:22457795
Casp8increases methylationEXP 6480464CTDCadmium Chloride results in increased methylation of CASP8 promoterPMID:22457795
Casp8multiple interactionsEXP 6480464CTDagomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CASP8 protein]; Cadmium Chloride inhibits the reaction [TNF protein results in increased cleavage of and results in increased activity of CASP8 protein]; Decitabine inhibits the reaction [Cadmium Chloride results in decreased cleavage of CASP8 protein]; Decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 protein]; Decitabine inhibits the reaction [Cadmium Chloride results in increased methylation of CASP8 promoter]PMID:16263807 PMID:22457795 PMID:36356678
Casp8decreases expressionISOCASP8 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of CASP8 mRNAPMID:19426795 PMID:23941782 PMID:25448810
Casp8decreases expressionISOCasp8 (Mus musculus)6480464CTDCadmium Chloride results in decreased expression of CASP8 proteinPMID:35844137
Casp8decreases response to substanceISOCASP8 (Homo sapiens)6480464CTDCASP8 results in decreased susceptibility to Cadmium ChloridePMID:25448810
Casp8increases activityISOCASP8 (Homo sapiens)6480464CTDCadmium Chloride results in increased activity of CASP8 proteinPMID:21697648 PMID:23485651
Casp8increases activityISOCasp8 (Mus musculus)6480464CTDCadmium Chloride results in increased activity of CASP8 proteinPMID:16421179 PMID:21252392
Casp8increases expressionISOCASP8 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of CASP8 mRNA; Cadmium Chloride results in increased expression of CASP8 proteinPMID:12160620 PMID:21796402 PMID:24291162 PMID:28342888
Casp8increases expressionISOCasp8 (Mus musculus)6480464CTDCadmium Chloride results in increased expression of CASP8 proteinPMID:21420465 PMID:28342888
Casp8increases methylationISOCASP8 (Homo sapiens)6480464CTDCadmium Chloride results in increased methylation of CASP8 promoterPMID:25448810
Casp8multiple interactionsISOCASP8 (Homo sapiens)6480464CTD[Cadmium Chloride co-treated with Fluorouracil] affects the expression of CASP8 protein; Cadmium Chloride affects the reaction [Fluorouracil results in decreased expression of CASP8 mRNA]; decitabine inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 mRNA]; Fluorouracil affects the reaction [Cadmium Chloride results in decreased expression of CASP8 mRNA]; TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]PMID:23941782 PMID:25448810 PMID:28342888
Casp8multiple interactionsISOCasp8 (Mus musculus)6480464CTD[Mercuric Chloride co-treated with sodium arsenite co-treated with Cadmium Chloride] results in increased activity of CASP8 protein; arjunolic acid inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]; Melatonin inhibits the reaction [Cadmium Chloride results in decreased expression of CASP8 protein]; Sirolimus inhibits the reaction [TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]]; TGFB1 protein inhibits the reaction [Cadmium Chloride results in increased expression of CASP8 protein]PMID:16421179 PMID:21420465 PMID:28342888 PMID:35844137
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