GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp8 | affects expression | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Valproic Acid affects the expression of CASP8 mRNA | PMID:25979313 | Casp8 | affects expression | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Valproic Acid affects the expression of CASP8 mRNA | PMID:17292431 | Casp8 | increases cleavage | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Valproic Acid results in increased cleavage of CASP8 protein | PMID:19006566 | Casp8 | increases expression | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | Valproic Acid results in increased expression of CASP8 mRNA; Valproic Acid results in increased expression of CASP8 protein | PMID:21771726 PMID:23179753 PMID:24383497 PMID:24935251 PMID:26272509 PMID:28001369 | Casp8 | increases expression | ISO | Casp8 (Mus musculus) | 6480464 | CTD | Valproic Acid results in increased expression of CASP8 mRNA | PMID:24896083 | Casp8 | multiple interactions | ISO | CASP8 (Homo sapiens) | 6480464 | CTD | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CASP8 mRNA; [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of CASP8 mRNA; [Valproic Acid co-treated with Arsenic Trioxide] results in increased expression of CASP8 protein; [Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein; [Valproic Acid co-treated with fludarabine] results in increased cleavage of CASP8 protein; CASP8 mRNA affects the reaction [[Valproic Acid co-treated with Decitabine] results in increased susceptibility to TNFSF10 protein]; Valproic Acid promotes the reaction [Decitabine results in increased expression of CASP8 mRNA]; Valproic Acid promotes the reaction [Decitabine results in increased expression of CASP8 protein]; Valproic Acid results in increased cleavage of and results in increased activity of CASP8 protein | PMID:19006566 PMID:21771726 PMID:22814014 PMID:25815518 PMID:27188386 | | ||||||||||||||||||||||
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