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Pathways

ONTOLOGY REPORT - ANNOTATIONS


Term:vascular endothelial growth factor receptor signaling pathway
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Accession:GO:0048010 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Comment:In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
Synonyms:exact_synonym: VEGF receptor signaling pathway;   VEGF receptor signalling pathway;   VEGFR signaling pathway
 xref: Reactome:R-HSA-194138 "Signaling by VEGF"
 never_in_taxon: NCBITaxon:2 ! Bacteria;   NCBITaxon:2157 ! Archaea;   NCBITaxon:4751 ! Fungi
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa



show annotations for term's descendants           Sort by:
vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO
IEA
(PMID:21245381)
GO_REF:0000107
RGD
Ensembl
PMID:21245381 GO_REF:0000107 NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IMP RGD PMID:14693680 RGD:1580560 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 involved_in
acts_upstream_of_or_within
ISO
IBA
IEA
(PMID:11312102), (PMID:1312256), (PMID:9299537)
GO_REF:0000033
GO_REF:0000002
GO_REF:0000107
MGI:1934260 (PMID:9689083)
RGD
GO_Central
InterPro
Ensembl
PMID:1312256 PMID:9299537 PMID:9689083 PMID:11312102 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in
acts_upstream_of_or_within
IMP
ISO
IBA
(PMID:11532940), (PMID:19779139)
(PMID:9012504)
GO_REF:0000033
RGD
GO_Central
PMID:9012504 PMID:11532940 PMID:19779139 PMID:11683876 GO_REF:0000033, RGD:727326 NCBI chr10:34,414,834...34,455,878
Ensembl chr10:34,414,733...34,456,645
JBrowse link
G Foxc1 forkhead box C1 acts_upstream_of_or_within ISO MGI:1347481 (PMID:16678147) RGD PMID:16678147 NCBI chr17:32,840,119...32,844,100
Ensembl chr17:32,805,858...32,844,347
JBrowse link
G Foxc2 forkhead box C2 acts_upstream_of_or_within ISO MGI:1347466 (PMID:16678147) RGD PMID:16678147 NCBI chr19:66,094,718...66,097,420
Ensembl chr19:66,094,700...66,153,977
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 involved_in ISO
IEA
(PMID:18440775)
GO_REF:0000107
RGD
Ensembl
PMID:18440775 GO_REF:0000107 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301
JBrowse link
G Kdr kinase insert domain receptor involved_in
acts_upstream_of_or_within
IMP
ISS
ISO
IEA
GO_REF:0000024
(PMID:10102632), (PMID:11387210), (PMID:21885851), (PMID:23529610)
GO_REF:0000117
GO_REF:0000002
GO_REF:0000107
(PMID:8356051)
UniProt
RGD
InterPro
Ensembl
PMID:8356051 PMID:10102632 PMID:11387210 PMID:21885851 PMID:23529610 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 GO_REF:0000117, RGD:729081, RGD:2292019, RGD:2301848 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in ISO
IEA
(PMID:18440775)
GO_REF:0000107
RGD
Ensembl
PMID:18440775 GO_REF:0000107 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 involved_in ISO
IBA
IEA
(PMID:18440775)
GO_REF:0000033
GO_REF:0000107
RGD
GO_Central
Ensembl
PMID:18440775 GO_REF:0000033 GO_REF:0000107 NCBI chr13:45,066,027...45,112,326
Ensembl chr13:45,066,031...45,112,326
JBrowse link
G Nrp1 neuropilin 1 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:21245381)
GO_REF:0000033
MGI:2450311|MGI:3512101 (PMID:12852851)
(PMID:23639442)
RGD
GO_Central
PMID:12852851 PMID:21245381 PMID:23639442 GO_REF:0000033 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702
JBrowse link
G Pgf placental growth factor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 6:110,547,165...110,557,747
Ensembl chr 6:110,547,153...110,557,747
JBrowse link
G Prkd1 protein kinase D1 involved_in ISO
IEA
UniProtKB:Q9BZL6 (PMID:18059339), (PMID:18440775), (PMID:20497126)
GO_REF:0000107
RGD
Ensembl
PMID:18059339 PMID:18440775 PMID:20497126 GO_REF:0000107 NCBI chr 6:73,460,640...73,774,433
Ensembl chr 6:73,460,640...73,836,509
JBrowse link
G Prkd2 protein kinase D2 involved_in ISO
IEA
UniProtKB:Q15139 (PMID:18059339), (PMID:18440775), (PMID:20497126)
GO_REF:0000107
RGD
Ensembl
PMID:18059339 PMID:18440775 PMID:20497126 GO_REF:0000107 NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:86,642,629...86,670,675
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISO (PMID:21245381)
(PMID:17698736)
RGD PMID:17698736 PMID:21245381 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806
JBrowse link
G Sulf1 sulfatase 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:16778174)
UniProt
RGD
PMID:16778174 GO_REF:0000024 NCBI chr 5:11,145,950...11,308,622
Ensembl chr 5:11,145,950...11,308,643
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in
acts_upstream_of_or_within
IMP
ISO
IEA
IBA
(PMID:23639442), (PMID:31915155)
(PMID:1312256), (PMID:18059339), (PMID:18440775), (PMID:20497126), (PMID:21245381), (PMID:7929439)
GO_REF:0000107
GO_REF:0000117
(PMID:1592003)
GO_REF:0000033
RGD
Ensembl
UniProt
GO_Central
PMID:1312256 PMID:1592003 PMID:7929439 PMID:18059339 PMID:18440775 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000117, RGD:2301848 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vegfb vascular endothelial growth factor B involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152
JBrowse link
G Vegfc vascular endothelial growth factor C involved_in
acts_upstream_of_or_within
ISO
ISS
IEA
IBA
(PMID:23878260)
GO_REF:0000024
GO_REF:0000107
MGI:95561 (PMID:9012504), (PMID:9247316)
(PMID:24552833)
GO_REF:0000033
RGD
UniProt
Ensembl
GO_Central
PMID:9012504 PMID:9247316 PMID:23878260 PMID:24552833 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887
JBrowse link
G Vegfd vascular endothelial growth factor D involved_in
acts_upstream_of_or_within
IMP
IEA
ISO
IBA
GO_REF:0000117
UniProtKB:P35916 (PMID:11574540)
GO_REF:0000033
UniProt
RGD
GO_Central
PMID:11574540 PMID:11683876 GO_REF:0000033 GO_REF:0000117, RGD:727326 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:33,706,055...33,740,167
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (PMID:23529610) RGD PMID:23529610 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706
JBrowse link
negative regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cadm4 cell adhesion molecule 4 involved_in ISS
ISO
GO_REF:0000024
(PMID:25893857)
UniProt
RGD
PMID:25893857 GO_REF:0000024 NCBI chr 1:89,203,089...89,225,345
Ensembl chr 1:89,202,554...89,225,345
JBrowse link
G Cnmd chondromodulin acts_upstream_of_or_within ISO MGI:2448465 (PMID:16980969) RGD PMID:16980969 NCBI chr15:61,450,617...61,475,382
Ensembl chr15:61,450,450...61,475,350
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:19033661)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19033661 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:39,312,745...39,483,730
JBrowse link
G Emilin1 elastin microfibril interfacer 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:25056700)
Ensembl
RGD
PMID:25056700 GO_REF:0000107 NCBI chr 6:31,175,919...31,183,657
Ensembl chr 6:31,175,919...31,183,657
JBrowse link
G Epn2 epsin 2 involved_in ISO
IEA
(PMID:28717225)
GO_REF:0000107
RGD
Ensembl
PMID:28717225 GO_REF:0000107 NCBI chr10:46,697,238...46,759,128
Ensembl chr10:46,697,238...46,759,092
JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate involved_in ISO
IEA
(PMID:18977327)
GO_REF:0000107
RGD
Ensembl
PMID:18977327 GO_REF:0000107 NCBI chr10:106,237,988...106,256,174
Ensembl chr10:106,237,824...106,256,174
JBrowse link
G Hhex hematopoietically expressed homeobox involved_in IDA
ISO
IEA
PMID:15016828
(PMID:12588764)
GO_REF:0000107
RGD
Ensembl
PMID:12588764 PMID:15016828 GO_REF:0000107, RGD:8554322 NCBI chr 1:244,602,945...244,608,532
Ensembl chr 1:244,602,825...244,608,604
JBrowse link
G Mir200c microRNA 200c acts_upstream_of ISO (PMID:24205206) RGD PMID:24205206 NCBI chr 4:159,209,965...159,210,033 JBrowse link
G Mmrn1 multimerin 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:91,205,462...91,280,862
Ensembl chr 4:91,233,240...91,280,861
JBrowse link
G Mmrn2 multimerin 2 involved_in ISO
IEA
IBA
(PMID:22020326)
GO_REF:0000107
GO_REF:0000033
RGD
Ensembl
GO_Central
PMID:22020326 GO_REF:0000033 GO_REF:0000107 NCBI chr16:9,712,181...9,733,653
Ensembl chr16:9,711,953...9,733,653
JBrowse link
G Nedd4 NEDD4 E3 ubiquitin protein ligase involved_in ISS
ISO
GO_REF:0000024
(PMID:15060076)
UniProt
RGD
PMID:15060076 GO_REF:0000024 NCBI chr 8:82,264,751...82,349,642
Ensembl chr 8:82,264,649...82,349,633
JBrowse link
G Pdcd6 programmed cell death 6 involved_in ISO
IEA
(PMID:21893193)
GO_REF:0000107
RGD
Ensembl
PMID:21893193 GO_REF:0000107 NCBI chr 1:30,795,105...30,810,771
Ensembl chr 1:30,795,040...30,810,773
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P97333 (PMID:23639442)
Ensembl
RGD
PMID:23639442 GO_REF:0000107 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416
JBrowse link
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vegfa vascular endothelial growth factor A involved_in IEA
ISO
GO_REF:0000107
(PMID:31915155)
Ensembl
RGD
PMID:31915155 GO_REF:0000107 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
positive regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:3629660 (PMID:17560563) RGD PMID:17560563 NCBI chr 2:52,533,939...52,610,980
Ensembl chr 2:52,533,939...52,610,980
JBrowse link
G Fgf18 fibroblast growth factor 18 acts_upstream_of_or_within ISO MGI:2178751 (PMID:17014841) RGD PMID:17014841 NCBI chr10:18,210,240...18,241,929
Ensembl chr10:18,210,512...18,240,933
JBrowse link
G Fgf9 fibroblast growth factor 9 acts_upstream_of_or_within ISO MGI:2135961 (PMID:17544391) RGD PMID:17544391 NCBI chr15:36,325,552...36,369,995
Ensembl chr15:36,325,599...36,367,926
JBrowse link
G Grb10 growth factor receptor bound protein 10 involved_in ISS
ISO
GO_REF:0000024
(PMID:15060076)
UniProt
RGD
PMID:15060076 GO_REF:0000024 NCBI chr14:90,708,653...90,816,399
Ensembl chr14:90,708,653...90,816,387
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha acts_upstream_of_or_within ISO MGI:2386649|MGI:2386679 (PMID:11691837) RGD PMID:11691837 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
JBrowse link
G Mir10a microRNA 10a involved_in ISO RNAcentral:URS000058760A_9606 (PMID:22955733) RGD PMID:22955733 NCBI chr10:81,779,709...81,779,818
Ensembl chr10:81,779,709...81,779,818
JBrowse link
G Mir10b microRNA 10b involved_in ISO RNAcentral:URS000016D2D4_9606 (PMID:22955733) RGD PMID:22955733 NCBI chr 3:80,035,859...80,035,967
Ensembl chr 3:80,035,859...80,035,967
JBrowse link
G Mir1224 microRNA 1224 involved_in ISO (PMID:28717225) RGD PMID:28717225 NCBI chr11:93,811,291...93,811,375 JBrowse link
G Mir296 microRNA 296 involved_in ISO (PMID:18977327) RGD PMID:18977327 NCBI chr 3:183,470,069...183,470,146 JBrowse link
G Mt3 metallothionein 3 involved_in ISO
IEA
ISS
(PMID:18295594)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:18295594 GO_REF:0000024 GO_REF:0000107 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080
JBrowse link
G Prkcb protein kinase C, beta involved_in ISS
ISO
GO_REF:0000024
(PMID:11805327)
UniProt
RGD
PMID:11805327 GO_REF:0000024 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740
JBrowse link
G Prkd2 protein kinase D2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:19001381)
UniProt
Ensembl
RGD
PMID:19001381 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:86,642,629...86,670,675
JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO
IEA
(PMID:21385766)
GO_REF:0000107
RGD
Ensembl
PMID:21385766 GO_REF:0000107 NCBI chr11:24,067,869...25,108,694
Ensembl chr11:24,067,878...25,108,694
JBrowse link
G Vegfb vascular endothelial growth factor B involved_in ISO (PMID:18259607) RGD PMID:18259607 NCBI chr 1:213,601,570...213,607,254
Ensembl chr 1:213,600,966...213,607,152
JBrowse link
regulation of vascular endothelial growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 involved_in ISO (PMID:19144989) RGD PMID:19144989 NCBI chr 1:64,985,161...64,993,274
Ensembl chr 1:64,985,161...64,993,276
JBrowse link
G Fzd4 frizzled class receptor 4 acts_upstream_of_or_within ISO MGI:2387667 (PMID:16093361) RGD PMID:16093361 NCBI chr 1:152,692,507...152,701,372
Ensembl chr 1:152,692,507...152,701,372
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:253,368,400...253,385,495
Ensembl chr 1:253,367,683...253,385,491
JBrowse link
G Myof myoferlin involved_in ISO (PMID:17702744) RGD PMID:17702744 NCBI chr 1:245,086,109...245,234,768
Ensembl chr 1:245,086,109...245,234,768
JBrowse link
G Nrp1 neuropilin 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702
JBrowse link
G Tmem204 transmembrane protein 204 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
MGI:95561|MGI:96683 (PMID:20439428)
GO_Central
RGD
PMID:20439428 GO_REF:0000033 NCBI chr10:14,581,025...14,608,878
Ensembl chr10:14,581,026...14,606,427
JBrowse link
G Vegfc vascular endothelial growth factor C IMP RGD PMID:11683876 RGD:727326 NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887
JBrowse link
G Vegfd vascular endothelial growth factor D IMP RGD PMID:11683876 RGD:727326 NCBI chr  X:33,704,582...33,740,305
Ensembl chr  X:33,706,055...33,740,167
JBrowse link
vascular endothelial growth factor receptor-1 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt1 Fms related receptor tyrosine kinase 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:15952180)
Ensembl
RGD
PMID:15952180 GO_REF:0000107 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:12,333,430...12,504,750
JBrowse link
vascular endothelial growth factor receptor-2 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec14a C-type lectin domain containing 14A involved_in
acts_upstream_of_or_within_negative_effect
ISO
IEA
(PMID:27991863)
MGI:6404416 (PMID:27991863)
GO_REF:0000117
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:27991863 GO_REF:0000107 GO_REF:0000117 NCBI chr 6:81,616,414...81,619,556
Ensembl chr 6:81,612,953...81,619,614
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:19033661)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19033661 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:39,312,745...39,483,730
Ensembl chr 3:39,312,745...39,483,730
JBrowse link
G Kdr kinase insert domain receptor involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:15215251), (PMID:24205206)
Ensembl
UniProt
RGD
PMID:15215251 PMID:24205206 GO_REF:0000024 GO_REF:0000107 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192
JBrowse link
G Pdcd6 programmed cell death 6 involved_in ISO
IEA
(PMID:21893193)
GO_REF:0000107
RGD
Ensembl
PMID:21893193 GO_REF:0000107 NCBI chr 1:30,795,105...30,810,771
Ensembl chr 1:30,795,040...30,810,773
JBrowse link
G Slc31a1 solute carrier family 31 member 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:35027734)
UniProt
Ensembl
RGD
PMID:35027734 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO
IEA
(PMID:23688497)
GO_REF:0000107
RGD
Ensembl
PMID:23688497 GO_REF:0000107 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
vascular endothelial growth factor receptor-3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec14a C-type lectin domain containing 14A involved_in
acts_upstream_of_or_within_positive_effect
ISO
IEA
(PMID:27991863)
MGI:6404416 (PMID:27991863)
GO_REF:0000117
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:27991863 GO_REF:0000107 GO_REF:0000117 NCBI chr 6:81,616,414...81,619,556
Ensembl chr 6:81,612,953...81,619,614
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19665
    cellular process 18832
      signal transduction 7243
        cell surface receptor signaling pathway 2949
          enzyme-linked receptor protein signaling pathway 1106
            cell surface receptor protein tyrosine kinase signaling pathway 693
              vascular endothelial growth factor receptor signaling pathway 53
                negative regulation of vascular endothelial growth factor receptor signaling pathway 13
                positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 1
                positive regulation of vascular endothelial growth factor receptor signaling pathway 14
                regulation of vascular endothelial growth factor receptor signaling pathway + 35
                vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment 0
                vascular endothelial growth factor receptor-1 signaling pathway 1
                vascular endothelial growth factor receptor-2 signaling pathway 6
                vascular endothelial growth factor receptor-3 signaling pathway 1
Path 2
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  biological_process 19665
    biological regulation 13556
      regulation of biological process 13124
        signaling 7822
          signal transduction 7243
            cell surface receptor signaling pathway 2949
              enzyme-linked receptor protein signaling pathway 1106
                cell surface receptor protein tyrosine kinase signaling pathway 693
                  vascular endothelial growth factor receptor signaling pathway 53
                    negative regulation of vascular endothelial growth factor receptor signaling pathway 13
                    positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway 1
                    positive regulation of vascular endothelial growth factor receptor signaling pathway 14
                    regulation of vascular endothelial growth factor receptor signaling pathway + 35
                    vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment 0
                    vascular endothelial growth factor receptor-1 signaling pathway 1
                    vascular endothelial growth factor receptor-2 signaling pathway 6
                    vascular endothelial growth factor receptor-3 signaling pathway 1
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