Fzd4 (frizzled class receptor 4) - Rat Genome Database

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Gene: Fzd4 (frizzled class receptor 4) Rattus norvegicus
Analyze
Symbol: Fzd4
Name: frizzled class receptor 4
RGD ID: 71017
Description: Enables Wnt-protein binding activity and signaling receptor activity. Involved in Wnt signaling pathway; positive regulation of dendrite morphogenesis; and positive regulation of neuron projection arborization. Predicted to be located in cell surface; cell-cell junction; and dendrite. Predicted to be active in glutamatergic synapse and plasma membrane. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4); PARTICIPATES IN Wnt signaling pathway; basal cell carcinoma pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: frizzled family receptor 4; frizzled homolog 4; frizzled homolog 4 (Drosophila); frizzled receptor 4; frizzled receptor 4 (Drosophila); frizzled-4; fz-4; rFz4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21143,280,065 - 143,288,799 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,280,065 - 143,285,724 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,227,346 - 151,236,226 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01158,403,735 - 158,412,613 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01151,277,642 - 151,286,520 (+)NCBIRnor_WKY
Rnor_6.01153,589,471 - 153,598,376 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,589,471 - 153,598,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01159,893,040 - 159,901,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,953,743 - 145,957,666 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,032,165 - 146,036,072 (+)NCBI
Celera1141,540,910 - 141,549,599 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
8-Br-cAMP  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diazinon  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
menadione  (ISO)
methotrexate  (ISO)
mifepristone  (ISO)
nickel atom  (EXP,ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
potassium cyanide  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
blood vessel development  (ISO)
canonical Wnt signaling pathway  (IBA,ISO)
cell population proliferation  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cerebellum vasculature morphogenesis  (ISO)
cytokine-mediated signaling pathway  (IEA)
endothelial cell differentiation  (ISO)
establishment of blood-brain barrier  (ISO)
extracellular matrix-cell signaling  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
locomotion involved in locomotory behavior  (ISO)
luteinization  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
Norrin signaling pathway  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of dendrite morphogenesis  (IMP)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of neuron projection arborization  (IGI,ISO)
positive regulation of Wnt signaling pathway  (ISO)
progesterone secretion  (ISO)
regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
response to hypoxia  (ISO)
retina vasculature development in camera-type eye  (ISO)
retina vasculature morphogenesis in camera-type eye  (IBA,ISO)
retinal blood vessel morphogenesis  (ISO)
sensory perception of sound  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
vasculogenesis  (ISO)
Wnt signaling pathway  (IGI,ISO)
Wnt signaling pathway, calcium modulating pathway  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition. Acevedo VD, etal., Cancer Cell. 2007 Dec;12(6):559-71.
2. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Klein D, etal., Hepatology. 2008 Mar;47(3):1018-31.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Wnt signaling in the ovary: identification and compartmentalized expression of wnt-2, wnt-2b, and frizzled-4 mRNAs. Ricken A, etal., Endocrinology 2002 Jul;143(7):2741-9.
15. Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Robitaille J, etal., Nat Genet. 2002 Oct;32(2):326-30. Epub 2002 Aug 12.
16. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
Additional References at PubMed
PMID:11425903   PMID:12490564   PMID:14688793   PMID:15024691   PMID:15035989   PMID:15195140   PMID:15370539   PMID:16093361   PMID:16115200   PMID:16163358   PMID:16501258   PMID:17955262  
PMID:18156211   PMID:18234671   PMID:19001373   PMID:19388021   PMID:19643732   PMID:19837032   PMID:20439489   PMID:20802536   PMID:22575959   PMID:23376485   PMID:25550365   PMID:28733458  
PMID:30135577   PMID:34119828  


Genomics

Comparative Map Data
Fzd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21143,280,065 - 143,288,799 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,280,065 - 143,285,724 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1151,227,346 - 151,236,226 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01158,403,735 - 158,412,613 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01151,277,642 - 151,286,520 (+)NCBIRnor_WKY
Rnor_6.01153,589,471 - 153,598,376 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1153,589,471 - 153,598,375 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01159,893,040 - 159,901,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41145,953,743 - 145,957,666 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11146,032,165 - 146,036,072 (+)NCBI
Celera1141,540,910 - 141,549,599 (+)NCBICelera
Cytogenetic Map1q32NCBI
FZD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,945,679 - 86,955,395 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1186,945,679 - 86,955,395 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,656,721 - 86,666,437 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361186,334,369 - 86,344,081 (-)NCBINCBI36Build 36hg18NCBI36
Build 341186,334,369 - 86,344,081NCBI
Celera1183,968,074 - 83,977,786 (-)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1182,945,786 - 82,952,580 (-)NCBIHuRef
CHM1_11186,542,809 - 86,552,528 (-)NCBICHM1_1
T2T-CHM13v2.01186,886,525 - 86,896,237 (-)NCBIT2T-CHM13v2.0
Fzd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39789,053,574 - 89,062,341 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl789,053,563 - 89,062,342 (+)EnsemblGRCm39 Ensembl
GRCm38789,404,366 - 89,410,110 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl789,404,355 - 89,413,134 (+)EnsemblGRCm38mm10GRCm38
MGSCv37796,552,876 - 96,558,620 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36789,279,586 - 89,285,277 (+)NCBIMGSCv36mm8
Celera786,759,990 - 86,765,732 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.32NCBI
Fzd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554146,094,585 - 6,098,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554146,094,585 - 6,103,910 (+)NCBIChiLan1.0ChiLan1.0
FZD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11185,606,572 - 85,616,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,611,989 - 85,616,065 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01181,973,680 - 82,007,733 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FZD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12112,699,886 - 12,709,132 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2112,699,774 - 12,724,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2112,566,451 - 12,575,366 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02112,882,804 - 12,891,736 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2112,882,819 - 12,891,405 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12112,669,287 - 12,678,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02112,740,838 - 12,749,754 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02112,797,007 - 12,805,927 (+)NCBIUU_Cfam_GSD_1.0
Fzd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494773,060,370 - 73,067,275 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649814,662,659 - 14,666,883 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493649814,657,641 - 14,666,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FZD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl920,717,344 - 20,721,460 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1920,714,995 - 20,721,460 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2923,000,092 - 23,006,583 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FZD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1178,164,243 - 78,199,296 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl178,188,630 - 78,198,187 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604347,525,967 - 47,562,995 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fzd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248453,046,063 - 3,050,560 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248452,972,308 - 3,055,596 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fzd4
33 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:42
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000023205
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat

Markers in Region
RH130494  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,288,449 - 143,288,645 (+)MAPPERmRatBN7.2
Rnor_6.01153,598,027 - 153,598,222NCBIRnor6.0
Rnor_5.01159,901,596 - 159,901,791UniSTSRnor5.0
RGSC_v3.41145,962,688 - 145,962,883UniSTSRGSC3.4
Celera1141,549,250 - 141,549,445UniSTS
RH 3.4 Map11115.3UniSTS
Cytogenetic Map1q32UniSTS
Fzd4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,283,789 - 143,284,621 (+)MAPPERmRatBN7.2
Rnor_6.01153,593,196 - 153,594,027NCBIRnor6.0
Rnor_5.01159,896,765 - 159,897,596UniSTSRnor5.0
RGSC_v3.41145,957,468 - 145,958,299UniSTSRGSC3.4
Celera1141,544,635 - 141,545,465UniSTS
Cytogenetic Map1q32UniSTS
Fzd4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21143,284,678 - 143,284,862 (+)MAPPERmRatBN7.2
Rnor_6.01153,594,085 - 153,594,268NCBIRnor6.0
Rnor_5.01159,897,654 - 159,897,837UniSTSRnor5.0
RGSC_v3.41145,958,357 - 145,958,540UniSTSRGSC3.4
Celera1141,545,523 - 141,545,706UniSTS
Cytogenetic Map1q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 33 23 15 2 15 3 6 4 35 27 11 3
Low 3 10 34 26 17 26 5 5 70 14 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023205   ⟹   ENSRNOP00000023205
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1153,589,471 - 153,598,375 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106139   ⟹   ENSRNOP00000088712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,280,065 - 143,285,724 (+)Ensembl
RefSeq Acc Id: NM_022623   ⟹   NP_072145
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21143,280,065 - 143,288,799 (+)NCBI
Rnor_6.01153,589,471 - 153,598,376 (+)NCBI
Rnor_5.01159,893,040 - 159,901,945 (+)NCBI
RGSC_v3.41145,953,743 - 145,957,666 (+)RGD
Celera1141,540,910 - 141,549,599 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_072145 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF01036 (Get FASTA)   NCBI Sequence Viewer  
  EDM18582 (Get FASTA)   NCBI Sequence Viewer  
  Q9QZH0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_072145   ⟸   NM_022623
- Peptide Label: precursor
- UniProtKB: Q9QZH0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023205   ⟸   ENSRNOT00000023205
RefSeq Acc Id: ENSRNOP00000088712   ⟸   ENSRNOT00000106139
Protein Domains
FZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZH0-F1-model_v2 AlphaFold Q9QZH0 1-538 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71017 AgrOrtholog
BioCyc Gene G2FUF-58568 BioCyc
Ensembl Genes ENSRNOG00000016848 Ensembl
  ENSRNOG00000063590 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000088712 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000106139 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.2000.10 UniProtKB/Swiss-Prot
InterPro Frizzled/SFRP UniProtKB/Swiss-Prot
  Frizzled/Smoothened_TM UniProtKB/Swiss-Prot
  Frizzled_dom UniProtKB/Swiss-Prot
  Frizzled_dom_sf UniProtKB/Swiss-Prot
  FZ4_CRD UniProtKB/Swiss-Prot
  FZD4 UniProtKB/Swiss-Prot
  GPCR_2-like UniProtKB/Swiss-Prot
KEGG Report rno:64558 UniProtKB/Swiss-Prot
NCBI Gene 64558 ENTREZGENE
PANTHER PTHR11309 UniProtKB/Swiss-Prot
  PTHR11309:SF23 UniProtKB/Swiss-Prot
Pfam Frizzled UniProtKB/Swiss-Prot
  PF01392 UniProtKB/Swiss-Prot
PhenoGen Fzd4 PhenoGen
PRINTS FRIZZLED UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot
  PS50038 UniProtKB/Swiss-Prot
SMART FRI UniProtKB/Swiss-Prot
  Frizzled UniProtKB/Swiss-Prot
Superfamily-SCOP SSF63501 UniProtKB/Swiss-Prot
UniProt FZD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-06 Fzd4  frizzled class receptor 4  Fzd4  frizzled family receptor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Fzd4  frizzled family receptor 4  Fzd4  frizzled homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Fzd4  frizzled homolog 4 (Drosophila)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expresssed in ovarian granulosa cells 634517