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Gene: Fzd4 (frizzled class receptor 4) Mus musculus
Symbol: Fzd4
Name: frizzled class receptor 4
Description: Exhibits Wnt-activated receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; regulation of transcription, DNA-templated; and vasculature development. Localizes to several cellular components, including cell-cell junction; dendrite; and glutamatergic synapse. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4); PARTICIPATES IN Wnt signaling pathway; basal cell carcinoma pathway; Wnt signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: frizzled homolog 4; frizzled-4; fz-4; Fz4; mFz4
Homo sapiens (human) : FZD4 (frizzled class receptor 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fzd4 (frizzled class receptor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fzd4 (frizzled class receptor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FZD4 (frizzled class receptor 4)
Canis lupus familiaris (dog) : FZD4 (frizzled class receptor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fzd4 (frizzled class receptor 4)
Sus scrofa (pig) : FZD4 (frizzled class receptor 4)
Chlorocebus sabaeus (African green monkey) : FZD4 (frizzled class receptor 4)
Heterocephalus glaber (naked mole-rat) : Fzd4 (frizzled class receptor 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl789,404,355 - 89,413,134 (+)EnsemblGRCm38mm10GRCm38
GRCm38789,404,366 - 89,410,110 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37796,552,876 - 96,558,620 (+)NCBIGRCm37mm9NCBIm37
MGSCv36789,279,586 - 89,285,277 (+)NCBImm8
Celera786,759,990 - 86,765,732 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Fzd4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733796
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.