Mir296 (microRNA 296) - Rat Genome Database

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Gene: Mir296 (microRNA 296) Rattus norvegicus
Analyze
Symbol: Mir296
Name: microRNA 296
RGD ID: 2325345
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in negative regulation of thyroid gland epithelial cell proliferation. Orthologous to human MIR296 (microRNA 296); INTERACTS WITH atrazine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-296; rno-mir-296
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,470,069 - 183,470,146 (-)NCBIGRCr8
mRatBN7.23163,051,838 - 163,051,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,051,838 - 163,051,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3166,850,873 - 166,850,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,348,455 - 175,348,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,091,717 - 173,091,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,357,490 - 172,357,567 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,357,490 - 172,357,567 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,408,788 - 178,408,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,226,950 - 162,227,027 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir296Ratpre-eclampsia  ISOMIR296 (Homo sapiens)9068941miRNA:increased expression:blood serum (human) RGDPMID:25017274 and REF_RGD_ID:155882496
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir296Ratamyotrophic lateral sclerosis type 8  ISOMIR296 (Homo sapiens)8554872ClinVar Annotator: match by term: Amyotrophic lateral sclerosis type 8ClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir296RatAlzheimer's disease  ISOMIR296 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25992776
Mir296RatMyocardial Reperfusion Injury  ISOMIR296 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22050707

1 to 20 of 31 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir296Ratacrolein decreases expressionISOMIR296 (Homo sapiens)6480464Acrolein results in decreased expression of MIR296CTDPMID:24812010
Mir296Rataflatoxin B1 multiple interactionsISOMIR296 (Homo sapiens)6480464[CYP2A13 protein co-treated with Aflatoxin B1] results in decreased expression of MIR296 mRNA alternative formCTDPMID:26084420
Mir296Ratatrazine increases expressionEXP 6480464Atrazine results in increased expression of MIR296 mRNACTDPMID:36841081
Mir296Ratbenzo[a]pyrene affects methylationISOMIR296 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of MIR296 promoterCTDPMID:30157460
Mir296Ratbis(2-ethylhexyl) phthalate decreases expressionEXP 6480464Diethylhexyl Phthalate results in decreased expression of MIR296 mRNACTDPMID:28192093
Mir296Ratbis(2-ethylhexyl) phthalate multiple interactionsISOMir296 (Mus musculus)6480464[ovalbumin-alum co-treated with Diethylhexyl Phthalate] results in decreased expression of MIR296CTDPMID:36508822
Mir296Ratbisphenol A increases methylationEXP 6480464bisphenol A results in increased methylation of MIR296 geneCTDPMID:28505145
Mir296Ratbleomycin A2 affects expressionEXP 6480464Bleomycin affects the expression of MIR296 mRNACTDPMID:25933445
Mir296Ratethanol decreases expressionISOMir296 (Mus musculus)6480464Ethanol results in decreased expression of MIR296 mRNACTDPMID:19091803
Mir296Ratfuran decreases expressionEXP 6480464furan results in decreased expression of MIR296 mRNACTDPMID:20562052
Mir296Rathydrogen peroxide increases expressionISOMIR296 (Homo sapiens)6480464Hydrogen Peroxide results in increased expression of MIR296 mRNACTDPMID:26339600
Mir296RatLicochalcone B decreases expressionISOMIR296 (Homo sapiens)6480464licochalcone B results in decreased expression of MIR296 mRNACTDPMID:33647349
Mir296Ratnitrofen increases expressionEXP 6480464nitrofen results in increased expression of MIR296 mRNACTDPMID:26720608
Mir296Ratparacetamol increases expressionEXP 6480464Acetaminophen results in increased expression of MIR296 mRNACTDPMID:22112502
Mir296Ratparacetamol decreases expressionEXP 6480464Acetaminophen results in decreased expression of MIR296 mRNACTDPMID:22112502
Mir296Ratperfluorooctane-1-sulfonic acid increases expressionEXP 6480464perfluorooctane sulfonic acid results in increased expression of MIR296 mRNACTDPMID:24420840
Mir296Ratphenoxymethylpenicillin decreases expressionEXP 6480464Penicillin V results in decreased expression of MIR296 mRNACTDPMID:22112502
Mir296RatPirarubicin multiple interactionsEXP 6480464Rutin inhibits the reaction [pirarubicin results in increased expression of MIR296 mRNA]CTDPMID:32864822
Mir296RatPirarubicin increases expressionEXP 6480464pirarubicin results in increased expression of MIR296 mRNACTDPMID:32864822
Mir296Ratprogesterone increases expressionISOMIR296 (Homo sapiens)6480464Progesterone results in increased expression of MIR296 mRNACTDPMID:22950660

1 to 20 of 31 rows

Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir296Ratcellular response to ethanol acts_upstream_of_or_withinISOMir296 (Mus musculus)1624291 PMID:19091803RGDPMID:19091803
Mir296Ratcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOMir296 (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
Mir296RatmiRNA-mediated post-transcriptional gene silencing involved_inISOMIR296 (Homo sapiens)1624291 PMID:18977327 more ...RGDPMID:18977327 more ...
Mir296Ratnegative regulation of gene expression acts_upstream_of_or_withinISOMir296 (Mus musculus)1624291 PMID:18806776RGDPMID:18806776
Mir296Ratnegative regulation of thyroid gland epithelial cell proliferation  IDA 10059418 RGD 
Mir296Ratossification acts_upstream_of_or_withinISOMir296 (Mus musculus)1624291 PMID:25751060RGDPMID:25751060
Mir296Ratpositive regulation of cell migration involved_inISOMIR296 (Homo sapiens)1624291 PMID:27927008RGDPMID:27927008
Mir296Ratpositive regulation of cell migration involved in sprouting angiogenesis involved_inISOMIR296 (Homo sapiens)1624291 PMID:18977327RGDPMID:18977327
Mir296Ratpositive regulation of platelet-derived growth factor receptor signaling pathway involved_inISOMIR296 (Homo sapiens)1624291 PMID:18977327RGDPMID:18977327
Mir296Ratpositive regulation of vascular endothelial growth factor receptor signaling pathway involved_inISOMIR296 (Homo sapiens)1624291 PMID:18977327RGDPMID:18977327
Mir296Ratsensory perception of sound acts_upstream_of_or_withinISOMir296 (Mus musculus)1624291 PMID:23646144RGDPMID:23646144
1 to 11 of 11 rows

Molecular Function

  


#
Reference Title
Reference Citation
1. A TSH-CREB1-microRNA loop is required for thyroid cell growth. Leone V, etal., Mol Endocrinol. 2011 Oct;25(10):1819-30. doi: 10.1210/me.2011-0014. Epub 2011 Aug 4.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:16381832   PMID:17604727   PMID:18806776   PMID:19091803   PMID:20403161   PMID:20439489   PMID:23646144   PMID:25751060   PMID:26500043   PMID:30467970  



Mir296
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,470,069 - 183,470,146 (-)NCBIGRCr8
mRatBN7.23163,051,838 - 163,051,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,051,838 - 163,051,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3166,850,873 - 166,850,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,348,455 - 175,348,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,091,717 - 173,091,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,357,490 - 172,357,567 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,357,490 - 172,357,567 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,408,788 - 178,408,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,226,950 - 162,227,027 (-)NCBICelera
Cytogenetic Map3q43NCBI
MIR296
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,817,615 - 58,817,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,817,615 - 58,817,694 (-)EnsemblGRCh38hg38GRCh38
GRCh372057,392,670 - 57,392,749 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera2054,133,130 - 54,133,209 (-)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,179,091 - 54,179,170 (-)NCBIHuRef
CHM1_12057,294,310 - 57,294,389 (-)NCBICHM1_1
T2T-CHM13v2.02060,600,214 - 60,600,293 (-)NCBIT2T-CHM13v2.0
Mir296
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,108,840 - 174,108,918 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,108,840 - 174,108,918 (-)EnsemblGRCm39 Ensembl
GRCm382174,267,047 - 174,267,125 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,267,047 - 174,267,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv372174,092,548 - 174,092,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera2180,232,045 - 180,232,123 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.88NCBI

.

Predicted Targets
Summary Value
Count of predictions:30260
Count of gene targets:12610
Count of transcripts:13877
Interacting mature miRNAs:rno-miR-296-3p, rno-miR-296-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 27 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat

1 to 10 of 27 rows



circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 31 6 3 3 5 5 31 29 3


RefSeq Transcripts NR_031940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,051,838 - 163,051,915 (-)Ensembl
Rnor_6.0 Ensembl3172,357,490 - 172,357,567 (-)Ensembl
RefSeq Acc Id: NR_031940
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,470,069 - 183,470,146 (-)NCBI
mRatBN7.23163,051,838 - 163,051,915 (-)NCBI
Rnor_6.03172,357,490 - 172,357,567 (-)NCBI
Rnor_5.03178,408,788 - 178,408,865 (-)NCBI
Celera3162,226,950 - 162,227,027 (-)NCBI
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 9 of 9 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-46476 BioCyc
Ensembl Genes ENSRNOG00000035619 Ensembl
miRBase MI0000967 ENTREZGENE
NCBI Gene 100314282 ENTREZGENE
PhenoGen Mir296 PhenoGen
RatGTEx ENSRNOG00000035619 RatGTEx
RNAcentral URS00001C3AC1 RNACentral
  URS00001F4670 RNACentral
  URS000075CE8E RNACentral
1 to 9 of 9 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir296  microRNA 296  Mir296  microRNA mir-296  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED