Mir296 (microRNA 296) - Rat Genome Database

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Gene: Mir296 (microRNA 296) Rattus norvegicus
Analyze
Symbol: Mir296
Name: microRNA 296
RGD ID: 2325345
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in negative regulation of thyroid gland epithelial cell proliferation. Orthologous to human MIR296 (microRNA 296); INTERACTS WITH atrazine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-296; rno-mir-296
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,470,069 - 183,470,146 (-)NCBIGRCr8
mRatBN7.23163,051,838 - 163,051,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,051,838 - 163,051,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3166,850,873 - 166,850,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,348,455 - 175,348,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,091,717 - 173,091,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,357,490 - 172,357,567 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,357,490 - 172,357,567 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,408,788 - 178,408,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,226,950 - 162,227,027 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A TSH-CREB1-microRNA loop is required for thyroid cell growth. Leone V, etal., Mol Endocrinol. 2011 Oct;25(10):1819-30. doi: 10.1210/me.2011-0014. Epub 2011 Aug 4.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:18806776   PMID:19091803   PMID:20403161   PMID:20439489   PMID:23646144   PMID:25751060   PMID:26500043   PMID:30467970  


Genomics

Comparative Map Data
Mir296
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83183,470,069 - 183,470,146 (-)NCBIGRCr8
mRatBN7.23163,051,838 - 163,051,915 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3163,051,838 - 163,051,915 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3166,850,873 - 166,850,950 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03175,348,455 - 175,348,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03173,091,717 - 173,091,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03172,357,490 - 172,357,567 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3172,357,490 - 172,357,567 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03178,408,788 - 178,408,865 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3162,226,950 - 162,227,027 (-)NCBICelera
Cytogenetic Map3q43NCBI
MIR296
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382058,817,615 - 58,817,694 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2058,817,615 - 58,817,694 (-)EnsemblGRCh38hg38GRCh38
GRCh372057,392,670 - 57,392,749 (-)NCBIGRCh37GRCh37hg19GRCh37
Celera2054,133,130 - 54,133,209 (-)NCBICelera
Cytogenetic Map20q13.32NCBI
HuRef2054,179,091 - 54,179,170 (-)NCBIHuRef
CHM1_12057,294,310 - 57,294,389 (-)NCBICHM1_1
T2T-CHM13v2.02060,600,214 - 60,600,293 (-)NCBIT2T-CHM13v2.0
Mir296
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392174,108,840 - 174,108,918 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2174,108,840 - 174,108,918 (-)EnsemblGRCm39 Ensembl
GRCm382174,267,047 - 174,267,125 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2174,267,047 - 174,267,125 (-)EnsemblGRCm38mm10GRCm38
MGSCv372174,092,548 - 174,092,626 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera2180,232,045 - 180,232,123 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map297.88NCBI

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:30260
Count of gene targets:12610
Count of transcripts:13877
Interacting mature miRNAs:rno-miR-296-3p, rno-miR-296-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3145925360166177555Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3145925360166177555Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3145925360166177555Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3120538241165538241Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3145925360166177555Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3145925360166177555Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3145925360166177555Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3118839124163839124Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3145925360166177555Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 31 6 3 3 5 5 31 29 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000053742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3163,051,838 - 163,051,915 (-)Ensembl
Rnor_6.0 Ensembl3172,357,490 - 172,357,567 (-)Ensembl
RefSeq Acc Id: NR_031940
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83183,470,069 - 183,470,146 (-)NCBI
mRatBN7.23163,051,838 - 163,051,915 (-)NCBI
Rnor_6.03172,357,490 - 172,357,567 (-)NCBI
Rnor_5.03178,408,788 - 178,408,865 (-)NCBI
Celera3162,226,950 - 162,227,027 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325345 AgrOrtholog
BioCyc Gene G2FUF-46476 BioCyc
Ensembl Genes ENSRNOG00000035619 Ensembl
miRBase MI0000967 ENTREZGENE
NCBI Gene 100314282 ENTREZGENE
PhenoGen Mir296 PhenoGen
RatGTEx ENSRNOG00000035619 RatGTEx
RNAcentral URS00001C3AC1 RNACentral
  URS00001F4670 RNACentral
  URS000075CE8E RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir296  microRNA 296  Mir296  microRNA mir-296  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED