Enam Gene Search Result

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1306796	Enam	enamelin	ENCODES a protein that exhibits structural constituent of tooth enamel (ortholog); INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog) ... (more) ; amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix (ortholog); INTERACTS WITH 17beta-estradiol; bisphenol A; cadmium dichloride	14	19840773	19865476	Rat	46	symbol , PhenoGen , name , description	gene, protein-coding, PROVISIONAL [RefSeq]
1315614	ENAM	enamelin	Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene encodes the largest protein in the enamel matrix of developing teeth. The protein is involved in the mineralization and ... (more) structural organization of enamel. Defects in this gene result in amelogenesis imperfect type 1C.[provided by RefSeq, Oct 2009]	4	70628744	70646824	Human	165	symbol , COSMIC , name , description , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1315615	Enam	enamelin	A structural constituent of tooth enamel. Acts upstream of or within several processes, including ameloblast differentiation; amelogenesis; and positive regulation of enamel mineralization. Located in extracellular matrix. I ... (more) s expressed in jaw. Used to study amelogenesis imperfecta type 1B. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1B and amelogenesis imperfecta type 1C. Orthologous to human ENAM (enamelin). [provided by Alliance of Genome Resources, Jul 2025]	5	88635834	88653908	Mouse	107	symbol , PhenoGen , name , description	gene, protein-coding, VALIDATED [RefSeq]
9044833	Enam	enamelin	ENCODES a protein that exhibits structural constituent of tooth enamel (ortholog); INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog) ... (more) ; amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix (ortholog)	NW_004955447	2331251	2345459	Chinchilla	16	symbol , name , description	gene, protein-coding, MODEL [RefSeq]
11755446	ENAM	enamelin	ENCODES a protein that exhibits structural constituent of tooth enamel (inferred); INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog) ... (more) ; amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix (inferred)	4	53574316	53592465	Bonobo	19	symbol , name , description	gene, protein-coding, MODEL [RefSeq]
12050329	ENAM	enamelin	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta; amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix (ortholog)	13	59934299	59948279	Dog	21	symbol , name	gene, protein-coding, MODEL [RefSeq]
12699831	Enam	enamelin	ENCODES a protein that exhibits structural constituent of tooth enamel (inferred); INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog) ... (more) ; amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix (inferred)	NW_004936598	4118031	4132342	Squirrel	19	symbol , name , description	gene, protein-coding, MODEL [RefSeq]
14160706	ENAM	enamelin	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix ( ... (more) ortholog)				Pig	21	symbol , name	gene, protein-coding, PROVISIONAL [RefSeq]
18611928	ENAM	enamelin	ENCODES a protein that exhibits structural constituent of tooth enamel (inferred); INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog) ... (more) ; amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix (inferred)				Green Monkey	19	symbol , name , description	gene, protein-coding, MODEL [RefSeq]
18924223	Enam	enamelin	ENCODES a protein that exhibits structural constituent of tooth enamel (inferred); INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog) ... (more) ; amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix (inferred)				Naked Mole-Rat	19	symbol , name , description	gene, protein-coding, MODEL [RefSeq]
155240956	enam						Tropical Clawed Frog		symbol	gene, null
626081798	Enam	enamelin	ENCODES a protein that exhibits structural constituent of tooth enamel (ortholog); INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog) ... (more) ; amelogenesis imperfecta type 1B (ortholog); amelogenesis imperfecta type 1C (ortholog); FOUND IN extracellular matrix (ortholog)				Black Rat	16	symbol , name , description	gene, protein-coding, MODEL [RefSeq]
407987294	enam.L						African Clawed Frog		symbol	gene, null
407987344	enam.L						African Clawed Frog		symbol	gene, null
407987351	enam.L						African Clawed Frog		symbol	gene, null
407987377	enam.L						African Clawed Frog		symbol	gene, null
626468253	enam.L						African Clawed Frog		symbol	gene, null
16571948	ENAM-AS1	ENAM and JCHAIN antisense RNA 1					Human		symbol , COSMIC , name , Human Proteome Map	gene, lncrna
629021600	ENAM-AS1	ENAM and JCHAIN antisense RNA 1					Human		symbol , GTEx , COSMIC , name , Human Proteome Map	gene, ncrna
10149	Ambn	ameloblastin	This gene encodes an extracellular matrix glycoprotein that is involved in the formation of dental enamel. Mice lacking the encoded protein fail to undergo normal ameloblast differentiation and develop enamel. Mice overprodu ... (more) cing the product of this gene develop thinner and more porous enamel, with disrupted rod patterns and abnormal crystallites. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]	5	88603850	88616390	Mouse	54	description	gene, protein-coding, REVIEWED [RefSeq]
1604908	AMTN	amelotin	The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enam ... (more) amel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]	4	70518569	70532743	Human	50	description	gene, protein-coding, VALIDATED [RefSeq]
1318676	Mmp20	matrix metallopeptidase 20 (enamelysin)	This gene encodes a member of the matrix metalloproteinase family of zinc-dependent endopeptidases capable of degrading extracellular matrix proteins. This gene is expressed specifically in the ameloblasts and odontoblasts, and the encoded protein is an inactive zymogen that requires proteolytic rem ... (more) oval of a N-terminal propeptide to become enzymatically active. Mice lacking the encoded protein display an amelogenesis imperfecta phenotype. [provided by RefSeq, Oct 2015]	9	7628232	7674969	Mouse	65	old_gene_name , name	gene, protein-coding, REVIEWED [RefSeq]
14241858	MMP20	matrix metallopeptidase 20	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypom ... (more) aturation type 2A2 (ortholog); amelogenesis imperfecta type 1C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred)				Pig	25	old_gene_name	gene, protein-coding, PROVISIONAL [RefSeq]
736409	AMBN	ameloblastin	This gene encodes the nonamelogenin enamel matrix protein ameloblastin. The encoded protein may be important in enamel matrix formation and mineralization. This gene is located in the calcium-binding phosphoprotein gene clus ... (more) ter on chromosome 4. Mutations in this gene may be associated with dentinogenesis imperfect and autosomal dominant amylogenesis imperfect. [provided by RefSeq, Aug 2011]	4	70592256	70607288	Human	89	old_gene_name , description	gene, protein-coding, REVIEWED [RefSeq]
126925993	Cftr^em1Ang	cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 1, Ang	ASSOCIATED WITH abnormal enamel development; abnormal olfactory epithelium physiology; decreased body weight; ASSOCIATED WITH cystic fibrosis; dental enamel hypoplasia				Rat	11	description	gene, allele
126925995	Cftr^em2Ang	cystic fibrosis transmembrane conductance regulator; CRISPR/Cas9 induced mutant 2, Ang	ASSOCIATED WITH abnormal enamel development; abnormal olfactory epithelium physiology; absent vas deferens; ASSOCIATED WITH cystic fibrosis; dental enamel hypoplasia				Rat	12	description	gene, allele
1318675	MMP20	matrix metallopeptidase 20	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secrete ... (more) d as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]	11	102576832	102625332	Human	71	old_gene_name , description	gene, protein-coding, REVIEWED [RefSeq]
1604986	ODAPH	odontogenesis associated phosphoprotein	Dental enamel forms the outer cap of teeth and is the hardest substance found in vertebrates. This gene is thought to encode an extracellular matrix acidic phosphoprotein that has a function in enamel mineralization during a ... (more) melogenesis. Mutations in this gene are associated with recessive hypomineralized amelogenesis imperfecta. [provided by RefSeq, Oct 2012]	4	75556066	75565893	Human	28	description	gene, protein-coding, REVIEWED [RefSeq]
1551322	Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	Predicted to enable serine-type endopeptidase activity. Acts upstream of or within amelogenesis; extracellular matrix disassembly; and protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space and secretory granule. Is expressed in alim ... (more) entary system; male reproductive gland or organ; and skin. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to human KLK4 (kallikrein related peptidase 4). [provided by Alliance of Genome Resources, Jul 2025]	7	43530584	43535228	Mouse	68	old_gene_name , name	gene, protein-coding, VALIDATED [RefSeq]
735380	Amelx	amelogenin, X-linked	Enables several functions, including growth factor activity; hydroxyapatite binding activity; and metal ion binding activity. Involved in cell adhesion; enamel mineralization; and regulation of cell population proliferation. Located in basement membrane; cell su ... (more) rface; and supramolecular complex. Part of protein-containing complex. Is expressed in several structures, including connective tissue; eye; jaw; nervous system; and skeleton. Used to study amelogenesis imperfecta type 1E. Human ortholog(s) of this gene implicated in amelogenesis imperfecta and amelogenesis imperfecta type 1E. Orthologous to several human genes including AMELX (amelogenin X-linked). [provided by Alliance of Genome Resources, Apr 2025]	X	167959110	167970205	Mouse	133	old_gene_name , description	gene, protein-coding, VALIDATED [RefSeq]
1353266	KLK4	kallikrein related peptidase 4	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members l ... (more) ocated in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]	19	50906351	50911395	Human	82	old_gene_name , description	gene, protein-coding, REVIEWED [RefSeq]
1303228	Klk4	kallikrein-related peptidase 4	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); peptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); extracellular matrix disassembly (ortholog); ASSOCIATED WITH amelog ... (more) enesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog); FOUND IN extracellular region (inferred); INTERACTS WITH bisphenol A; Cuprizon; genistein	1	103480731	103485963	Rat	61	old_gene_name , description	gene, protein-coding, VALIDATED [RefSeq]
13845608	KLK4	kallikrein related peptidase 4	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); peptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); extracellular matrix disassembly (ortholog); ASSOCIATED WITH amelog ... (more) enesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog); FOUND IN extracellular region (inferred)				Pig	33	old_gene_name , description	gene, protein-coding, VALIDATED [RefSeq]
8974484	Ambn	ameloblastin	ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN cell adhesion (ortholog); regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 1F (ortholog); BCARD syndrome (ortholog); osteoporosis-pseudoglioma syndrome (ortholog)	NW_004955447	2363240	2374827	Chinchilla	10	old_gene_name	gene, protein-coding, MODEL [RefSeq]
1308730	Mmp20	matrix metallopeptidase 20	ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A2 (ortholog); amelogenesis imperfecta type 1 ... (more) C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; acetamide	8	13074279	13114894	Rat	46	old_gene_name	gene, protein-coding, PROVISIONAL [RefSeq]
12292767	MMP20	matrix metallopeptidase 20	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); metalloendopeptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); extracellular matrix disassembly (ortholog); protein catabolic process (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypom ... (more) aturation type 2A2 (ortholog); amelogenesis imperfecta type 1C (ortholog); autosomal dominant intellectual developmental disorder 56 (ortholog); FOUND IN extracellular matrix (inferred)	5	29106717	29154628	Dog	25	old_gene_name	gene, protein-coding, MODEL [RefSeq]
1306718	Adgrf2	adhesion G protein-coupled receptor F2	ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic diso ... (more) rder (ortholog); FOUND IN membrane (inferred); INTERACTS WITH bisphenol A; lead diacetate; trichloroethene	9	25735607	25745962	Rat	33	description	gene, protein-coding, MODEL [RefSeq]
9061525	Adgrf2	adhesion G protein-coupled receptor F2	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic disorder (ortholog)	NW_004955437	12104938	12126649	Chinchilla	6	description	gene, protein-coding, MODEL [RefSeq]
12233051	ADGRF2	adhesion G protein-coupled receptor F2	ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic diso ... (more) rder (ortholog); FOUND IN membrane (inferred)	12	15716866	15739690	Dog	14	description	gene, protein-coding, MODEL [RefSeq]
12647246	Adgrf2	adhesion G protein-coupled receptor F2	ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic diso ... (more) rder (ortholog); FOUND IN membrane (inferred)	NW_004936476	12836901	12857743	Squirrel	14	description	gene, protein-coding, MODEL [RefSeq]
14148268	ADGRF2	adhesion G protein-coupled receptor F2	ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic diso ... (more) rder (ortholog); FOUND IN membrane (inferred)				Pig	14	description	gene, protein-coding, MODEL [RefSeq]
18919414	Adgrf2	adhesion G protein-coupled receptor F2	ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic diso ... (more) rder (ortholog); FOUND IN membrane (inferred)				Naked Mole-Rat	14	description	gene, protein-coding, MODEL [RefSeq]
625965654	Adgrf2	adhesion G protein-coupled receptor F2	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic disorder (ortholog)				Black Rat	6	description	gene, protein-coding, MODEL [RefSeq]
11784439	AMBN	ameloblastin	ENCODES a protein that exhibits growth factor activity (inferred); structural constituent of tooth enamel (inferred); INVOLVED IN regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 1F (ortholog); BCARD syndrome ( ... (more) ortholog); osteoporosis-pseudoglioma syndrome (ortholog)	4	53616553	53631566	Bonobo	14	description	gene, protein-coding, MODEL [RefSeq]
12264726	AMBN	ameloblastin	ENCODES a protein that exhibits structural constituent of tooth enamel (inferred); INVOLVED IN regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 1F (ortholog); BCARD syndrome (ortholog); osteoporosis-pseudogliom ... (more) a syndrome (ortholog)	13	59899968	59912699	Dog	14	description	gene, protein-coding, MODEL [RefSeq]
12541806	Ambn	ameloblastin	ENCODES a protein that exhibits growth factor activity (inferred); structural constituent of tooth enamel (inferred); INVOLVED IN regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 1F (ortholog); BCARD syndrome ( ... (more) ortholog); osteoporosis-pseudoglioma syndrome (ortholog)	NW_004936598	4154801	4166565	Squirrel	14	description	gene, protein-coding, MODEL [RefSeq]
14255442	AMBN	ameloblastin	ENCODES a protein that exhibits structural constituent of tooth enamel (inferred); INVOLVED IN regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 1F (ortholog); BCARD syndrome (ortholog); osteoporosis-pseudogliom ... (more) a syndrome (ortholog)				Pig	14	description	gene, protein-coding, PROVISIONAL [RefSeq]
18505382	AMBN	ameloblastin	ENCODES a protein that exhibits growth factor activity (inferred); structural constituent of tooth enamel (inferred); INVOLVED IN regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 1F (ortholog); BCARD syndrome ( ... (more) ortholog); osteoporosis-pseudoglioma syndrome (ortholog)				Green Monkey	14	description	gene, protein-coding, MODEL [RefSeq]
18930589	Ambn	ameloblastin	ENCODES a protein that exhibits growth factor activity (inferred); structural constituent of tooth enamel (inferred); INVOLVED IN regulation of cell population proliferation (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 1F (ortholog); BCARD syndrome ( ... (more) ortholog); osteoporosis-pseudoglioma syndrome (ortholog)				Naked Mole-Rat	14	description	gene, protein-coding, MODEL [RefSeq]
2107	Amelx	amelogenin, X-linked	ENCODES a protein that exhibits identical protein binding; structural constituent of tooth enamel; calcium ion binding (ortholog); INVOLVED IN response to calcium ion; response to nutrient; response to xenobiotic stimulus; ASSOCIATED WITH autosomal dominant hypo ... (more) calcemia; amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1E (ortholog); FOUND IN endocytic vesicle; basement membrane (ortholog); cell surface (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 6-propyl-2-thiouracil	X	28648803	28660099	Rat	85	description	gene, protein-coding, VALIDATED [RefSeq]
735379	AMELX	amelogenin X-linked	This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in mu ... (more) ltiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]	X	11293413	11309588	Human	89	description	gene, protein-coding, REVIEWED [RefSeq]
8927324	Amelx	amelogenin X-linked	ENCODES a protein that exhibits calcium ion binding (ortholog); growth factor activity (ortholog); hydroxyapatite binding (ortholog); INVOLVED IN amelogenesis (ortholog); cell adhesion (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis im ... (more) perfecta (ortholog); amelogenesis imperfecta type 1E (ortholog); autosomal dominant hypocalcemia (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); endocytic vesicle (ortholog)	NW_004955544	1974889	1979063	Chinchilla	37	description	gene, protein-coding, MODEL [RefSeq]
12591208	Amelx	amelogenin X-linked	ENCODES a protein that exhibits identical protein binding (ortholog); structural constituent of tooth enamel (ortholog); INVOLVED IN response to calcium ion (ortholog); response to nutrient (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH ... (more) amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1E (ortholog); autosomal dominant hypocalcemia (ortholog); FOUND IN endocytic vesicle (ortholog)	NW_004936470	1169906	1174166	Squirrel	35	description	gene, protein-coding, MODEL [RefSeq]
14274300	AMELX	amelogenin X-linked	ENCODES a protein that exhibits calcium ion binding; identical protein binding; growth factor activity (ortholog); INVOLVED IN enamel mineralization; amelogenesis (ortholog); cell adhesion (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogene ... (more) sis imperfecta type 1E (ortholog); autosomal dominant hypocalcemia (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); endocytic vesicle (ortholog)				Pig	35	description	gene, protein-coding, PROVISIONAL [RefSeq]
18502563	AMELX	amelogenin X-linked	ENCODES a protein that exhibits identical protein binding (ortholog); structural constituent of tooth enamel (ortholog); INVOLVED IN response to calcium ion (ortholog); response to nutrient (ortholog); response to xenobiotic stimulus (ortholog); ASSOCIATED WITH ... (more) amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 1E (ortholog); autosomal dominant hypocalcemia (ortholog); FOUND IN endocytic vesicle (ortholog)				Green Monkey	35	description	gene, protein-coding, MODEL [RefSeq]
626066053	Amelx	amelogenin X-linked	ENCODES a protein that exhibits calcium ion binding (ortholog); growth factor activity (ortholog); hydroxyapatite binding (ortholog); INVOLVED IN amelogenesis (ortholog); cell adhesion (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis im ... (more) perfecta (ortholog); amelogenesis imperfecta type 1E (ortholog); autosomal dominant hypocalcemia (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); endocytic vesicle (ortholog)				Black Rat	37	description	gene, protein-coding, MODEL [RefSeq]
1343944	AMELY	amelogenin Y-linked	This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in a related gene on chromosome X cause X-linked amelogenesis imperfecta. [provided by ... (more) RefSeq, Jul 2008]	Y	6865918	6911752	Human	16	description	gene, protein-coding, REVIEWED [RefSeq]
11840196	AMELY	amelogenin Y-linked	ENCODES a protein that exhibits calcium ion binding (ortholog); growth factor activity (ortholog); hydroxyapatite binding (ortholog); INVOLVED IN amelogenesis (ortholog); cell adhesion (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis im ... (more) perfecta type 1E (ortholog); autosomal dominant hypocalcemia (ortholog); male infertility (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); endocytic vesicle (ortholog)	X	3898819	3930686	Bonobo	34	description	gene, protein-coding, MODEL [RefSeq]
1592356	Amtn	amelotin	INVOLVED IN odontogenesis of dentin-containing tooth; amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); amelogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane; cell-cell junctio ... (more) n; extracellular matrix; INTERACTS WITH 17beta-estradiol; bisphenol A; cadmium dichloride	14	19932664	19945223	Rat	49	description	gene, protein-coding, PROVISIONAL [RefSeq]
1614326	Amtn	amelotin	Involved in odontogenesis of dentin-containing tooth and positive regulation of enamel mineralization. Located in basement membrane and cell-cell junction. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3B. Orthologous to human AMTN (a ... (more) melotin). [provided by Alliance of Genome Resources, Jul 2025]	5	88523967	88533775	Mouse	57	description	gene, protein-coding, VALIDATED [RefSeq]
8843566	Amtn	amelotin	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); amelogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane (orthol ... (more) og); cell-cell junction (ortholog); extracellular matrix (ortholog)	NW_004955447	2422189	2433633	Chinchilla	20	description	gene, protein-coding, MODEL [RefSeq]
11684551	AMTN	amelotin	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); amelogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane (inferred); cell-cell junction (inferred); extracellular mat ... (more) rix (inferred)	4	53691674	53705831	Bonobo	21	description	gene, protein-coding, MODEL [RefSeq]
12072321	AMTN	amelotin	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); amelogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane (inferred); cell-cell junction (inferred); extracellular mat ... (more) rix (inferred)	13	59855278	59867133	Dog	21	description	gene, protein-coding, MODEL [RefSeq]
12603978	Amtn	amelotin	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); amelogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane (inferred); cell-cell junction (inferred); extracellular mat ... (more) rix (inferred)	NW_004936598	4204094	4210492	Squirrel	21	description	gene, protein-coding, MODEL [RefSeq]
13861230	AMTN	amelotin	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); amelogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane (inferred); cell-cell junction (inferred); extracellular mat ... (more) rix (inferred)				Pig	21	description	gene, protein-coding, MODEL [RefSeq]
18757873	AMTN	amelotin	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); amelogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane (orthol ... (more) og); cell-cell junction (ortholog); extracellular matrix (ortholog)				Green Monkey	20	description	gene, protein-coding, MODEL [RefSeq]
18932393	Amtn	amelotin	ENCODES a protein that exhibits nucleic acid binding (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); positive regulation of biomineral tissue development (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); a ... (more) melogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane (ortholog); cell-cell junction (ortholog); extracellular matrix (ortholog)				Naked Mole-Rat	19	description	gene, protein-coding, MODEL [RefSeq]
625835821	Amtn	amelotin	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); odontogenesis of dentin-containing tooth (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 3A (ortholog); amelogenesis imperfecta type 3B (ortholog); FOUND IN basement membrane (orthol ... (more) og); cell-cell junction (ortholog); extracellular matrix (ortholog)				Black Rat	20	description	gene, protein-coding, MODEL [RefSeq]
2332	Cftr	CF transmembrane conductance regulator	ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ATP hydrolysis activity (ortholog); bicarbonate transmembrane transporter activity (ortholog); INVOLVED IN bicarbonate transport; cellular response to anoxia; cellular response to heat; PARTICIPATES IN bile acid transport pathway; AS ... (more) SOCIATED WITH abnormal chloride level; abnormal circulating protein level; abnormal enamel development; ASSOCIATED WITH autosomal recessive polycystic kidney disease; cholestasis; congenital bilateral absence of vas deferens; FOUND IN apical plasma membrane; basolateral plasma membrane; dendrite; INTERACTS WITH 17beta-estradiol; 3',5'-cyclic AMP; 3-isobutyl-1-methyl-7H-xanthine	4	47422084	47694646	Rat	773	description	gene, protein-coding, PROVISIONAL [RefSeq]
1305571	Cnnm4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (ortholog); sodium ion transmembrane transporter activity (ortholog); INVOLVED IN enamel mineralization (ortholog); intracellular monoatomic cation homeostasis (ortholog); magnesium ... (more) ion homeostasis (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN dendrite; neuronal cell body; basolateral plasma membrane (ortholog); INTERACTS WITH 3-chloropropane-1,2-diol; acrylamide; bisphenol A	9	46207602	46246817	Rat	108	description	gene, protein-coding, PROVISIONAL [RefSeq]
1313680	Cnnm4	cyclin M4	Enables magnesium ion transmembrane transporter activity and sodium ion transmembrane transporter activity. Acts upstream of or within enamel mineralization; magnesium ion homeostasis; and magnesium ion transport. Located in basolateral plasma membrane. Is expre ... (more) ssed in colon and metanephros. Human ortholog(s) of this gene implicated in Jalili syndrome. Orthologous to human CNNM4 (cyclin and CBS domain divalent metal cation transport mediator 4). [provided by Alliance of Genome Resources, Jul 2025]	1	36510678	36547857	Mouse	111	description	gene, protein-coding, VALIDATED [RefSeq]
8995988	Cnnm4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (ortholog); sodium ion transmembrane transporter activity (ortholog); INVOLVED IN enamel mineralization (ortholog); intracellular monoatomic cation homeostasis (ortholog); magnesium ... (more) ion homeostasis (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN basolateral plasma membrane (ortholog); dendrite (ortholog); neuronal cell body (ortholog)	NW_004955470	4131348	4177172	Chinchilla	19	description	gene, protein-coding, MODEL [RefSeq]
11922291	CNNM4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (inferred); sodium ion transmembrane transporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN enamel mineralization (ortholog); magnesium ion home ... (more) ostasis (ortholog); magnesium ion transport (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog)	2A	102503084	102553029	Bonobo	33	description	gene, protein-coding, MODEL [RefSeq]
12318329	CNNM4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (inferred); sodium ion transmembrane transporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN enamel mineralization (ortholog); magnesium ion home ... (more) ostasis (ortholog); magnesium ion transport (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog)	10	45157418	45197323	Dog	32	description	gene, protein-coding, MODEL [RefSeq]
12521674	Cnnm4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (inferred); sodium ion transmembrane transporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN enamel mineralization (ortholog); magnesium ion home ... (more) ostasis (ortholog); magnesium ion transport (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog)	NW_004936744	715523	754148	Squirrel	33	description	gene, protein-coding, MODEL [RefSeq]
14099121	CNNM4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (inferred); sodium ion transmembrane transporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN enamel mineralization (ortholog); magnesium ion home ... (more) ostasis (ortholog); magnesium ion transport (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog)				Pig	32	description	gene, protein-coding, MODEL [RefSeq]
18519975	CNNM4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (inferred); sodium ion transmembrane transporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN enamel mineralization (ortholog); magnesium ion home ... (more) ostasis (ortholog); magnesium ion transport (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN dendrite (ortholog); neuronal cell body (ortholog)				Green Monkey	33	description	gene, protein-coding, MODEL [RefSeq]
18914814	Cnnm4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (inferred); sodium ion transmembrane transporter activity (inferred); transmembrane transporter activity (inferred); INVOLVED IN enamel mineralization (ortholog); intracellular mono ... (more) atomic cation homeostasis (ortholog); magnesium ion homeostasis (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN basolateral plasma membrane (ortholog); dendrite (ortholog); neuronal cell body (ortholog)				Naked Mole-Rat	30	description	gene, protein-coding, MODEL [RefSeq]
625985783	Cnnm4	cyclin and CBS domain divalent metal cation transport mediator 4	ENCODES a protein that exhibits magnesium ion transmembrane transporter activity (ortholog); sodium ion transmembrane transporter activity (ortholog); INVOLVED IN enamel mineralization (ortholog); intracellular monoatomic cation homeostasis (ortholog); magnesium ... (more) ion homeostasis (ortholog); ASSOCIATED WITH Amaurosis Hypertrichosis (ortholog); fundus dystrophy (ortholog); genetic disease (ortholog); FOUND IN basolateral plasma membrane (ortholog); dendrite (ortholog); neuronal cell body (ortholog)				Black Rat	19	description	gene, protein-coding, MODEL [RefSeq]
2441	Ctbp1	C-terminal binding protein 1	ENCODES a protein that exhibits NAD binding; PDZ domain binding; protein homodimerization activity; INVOLVED IN presynapse to nucleus signaling pathway; negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES I ... (more) N Notch signaling pathway; chronic myeloid leukemia pathway; Notch signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm; extrinsic component of presynaptic endocytic zone membrane; glutamatergic synapse; INTERACTS WITH 2,6-dinitrotoluene; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil	14	81679956	81707331	Rat	199	description	gene, protein-coding, PROVISIONAL [RefSeq]
8775760	Ctbp1	C-terminal binding protein 1	ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); No ... (more) tch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog); GABA-ergic synapse (ortholog)	NW_004955514	630168	652817	Chinchilla	92	description	gene, protein-coding, MODEL [RefSeq]
11791927	CTBP1	C-terminal binding protein 1	ENCODES a protein that exhibits chromatin binding (ortholog); lncRNA binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); presynapse to nucleus signaling pathway (ortholog); PARTICIPAT ... (more) ES IN Notch signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog); GABA-ergic synapse (ortholog)	4	1354806	1393244	Bonobo	97	description	gene, protein-coding, MODEL [RefSeq]
12420669	CTBP1	C-terminal binding protein 1	ENCODES a protein that exhibits chromatin binding (ortholog); identical protein binding (ortholog); lncRNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); presynapse to nucleus signaling pathway (ortholog); PAR ... (more) TICIPATES IN Notch signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog); GABA-ergic synapse (ortholog)	3	91385733	91400252	Dog	96	description	gene, protein-coding, MODEL [RefSeq]
12605158	Ctbp1	C-terminal binding protein 1	ENCODES a protein that exhibits PDZ domain binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); presynapse to nucleus signaling pathway (ortholog); PARTICIPATES IN Notch ... (more) signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog)	NW_004936477	22032712	22055160	Squirrel	96	description	gene, protein-coding, MODEL [RefSeq]
14252430	CTBP1	C-terminal binding protein 1	ENCODES a protein that exhibits chromatin binding (ortholog); lncRNA binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); presynapse to nucleus signaling pathway (ortholog); PARTICIPAT ... (more) ES IN Notch signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog); GABA-ergic synapse (ortholog)				Pig	97	description	gene, protein-coding, MODEL [RefSeq]
18386608	CTBP1	C-terminal binding protein 1	ENCODES a protein that exhibits PDZ domain binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); presynapse to nucleus signaling pathway (ortholog); PARTICIPATES IN Notch ... (more) signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog)				Green Monkey	95	description	gene, protein-coding, MODEL [RefSeq]
18912536	Ctbp1	C-terminal binding protein 1	ENCODES a protein that exhibits chromatin binding (ortholog); identical protein binding (ortholog); lncRNA binding (ortholog); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); Notch signaling pathway (ortholog); presynapse to nucleus signaling pathway (ortholog); PAR ... (more) TICIPATES IN Notch signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog); GABA-ergic synapse (ortholog)				Naked Mole-Rat	96	description	gene, protein-coding, MODEL [RefSeq]
625854094	Ctbp1	C-terminal binding protein 1	ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of DNA-templated transcription (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); No ... (more) tch signaling pathway (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); genetic disease (ortholog); HYPOTONIA, ATAXIA, DEVELOPMENTAL DELAY, AND TOOTH ENAMEL DEFECT SYNDROME (ortholog); FOUND IN cytoplasm (ortholog); extrinsic component of presynaptic endocytic zone membrane (ortholog); GABA-ergic synapse (ortholog)				Black Rat	92	description	gene, protein-coding, MODEL [RefSeq]
2508	Dmp1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits Hsp70 protein binding; calcium ion binding (ortholog); extracellular matrix binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enam ... (more) >el mineralization (ortholog); ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); nucleus (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; bisphenol A	14	5833111	5867154	Rat	83	description	gene, protein-coding, VALIDATED [RefSeq]
736577	Dmp1	dentin matrix protein 1	Enables extracellular matrix binding activity. Acts upstream of or within extracellular matrix organization; positive regulation of cell-substrate adhesion; and regulation of enamel mineralization. Located in cytoplasm; extracellular matrix; and nucleus. Is expr ... (more) essed in several structures, including alimentary system; bone; genitourinary system; limb; and nervous system. Used to study autosomal recessive hypophosphatemic rickets. Orthologous to human DMP1 (dentin matrix acidic phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]	5	104345441	104361968	Mouse	158	description	gene, protein-coding, VALIDATED [RefSeq]
8843157	Dmp1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits calcium ion binding (ortholog); extracellular matrix binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enam ... (more) >enamel mineralization (ortholog); ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); nucleus (ortholog)	NW_004955474	2188090	2200284	Chinchilla	15	description	gene, protein-coding, MODEL [RefSeq]
11974153	DMP1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits calcium ion binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enamel mineralization (ortholog); ... (more) ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); nucleus (inferred)	4	79943709	79957430	Bonobo	20	description	gene, protein-coding, MODEL [RefSeq]
12382461	DMP1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits calcium ion binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enamel mineralization (ortholog); ... (more) ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); nucleus (inferred)	32	11022900	11053900	Dog	20	description	gene, protein-coding, MODEL [RefSeq]
12692910	Dmp1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits calcium ion binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enamel mineralization (ortholog); ... (more) ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); nucleus (inferred)	NW_004936905	419478	427335	Squirrel	21	description	gene, protein-coding, MODEL [RefSeq]
14103887	DMP1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits calcium ion binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enamel mineralization (ortholog); ... (more) ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); nucleus (inferred)				Pig	20	description	gene, protein-coding, PROVISIONAL [RefSeq]
18562134	DMP1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits calcium ion binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enamel mineralization (ortholog); ... (more) ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); extracellular matrix (inferred); nucleus (inferred)				Green Monkey	20	description	gene, protein-coding, MODEL [RefSeq]
18913322	Dmp1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits calcium ion binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enamel mineralization (ortholog); ... (more) ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)				Naked Mole-Rat	18	description	gene, protein-coding, MODEL [RefSeq]
626003476	Dmp1	dentin matrix acidic phosphoprotein 1	ENCODES a protein that exhibits calcium ion binding (ortholog); extracellular matrix binding (ortholog); Hsp70 protein binding (ortholog); INVOLVED IN extracellular matrix organization (ortholog); positive regulation of cell-substrate adhesion (ortholog); regulation of enam ... (more) >enamel mineralization (ortholog); ASSOCIATED WITH autosomal recessive hypophosphatemic rickets (ortholog); Desbuquois dysplasia (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (ortholog); extracellular matrix (ortholog); nucleus (ortholog)				Black Rat	15	description	gene, protein-coding, MODEL [RefSeq]
1306364	Fam20a	FAM20A, golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activator activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN biomineral tissue development (ortholog); calcium ion homeostasis (ortholog); enamel mineralization (o ... (more) rtholog); ASSOCIATED WITH amelogenesis imperfecta type 1G (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aflatoxin B1	10	95136799	95197176	Rat	133	description	gene, protein-coding, VALIDATED [RefSeq]
1314940	Fam20a	FAM20A, golgi associated secretory pathway pseudokinase	Predicted to enable protein serine/threonine kinase activator activity. Involved in positive regulation of protein phosphorylation. Acts upstream of or within enamel mineralization and response to bacterium. Located in Golgi apparatus and endoplasmic reticulum. ... (more) Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; genitourinary system; and respiratory system. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1G. Orthologous to human FAM20A (FAM20A golgi associated secretory pathway pseudokinase). [provided by Alliance of Genome Resources, Jul 2025]	11	109563752	109613989	Mouse	155	description	gene, protein-coding, VALIDATED [RefSeq]
9019659	Fam20a	FAM20A golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activator activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN biomineral tissue development (ortholog); calcium ion homeostasis (ortholog); enamel mineralization (o ... (more) rtholog); ASSOCIATED WITH amelogenesis imperfecta type 1G (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog)	NW_004955478	4182568	4236819	Chinchilla	21	description	gene, protein-coding, MODEL [RefSeq]
11865837	FAM20A	FAM20A golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN enamel mineralization (ortholog); positive regulation of protein phosphorylation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH amelogenesis imperfect ... (more) a type 1G (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); extracellular space (inferred)	17	62474317	62537800	Bonobo	27	description	gene, protein-coding, MODEL [RefSeq]
12427477	FAM20A	FAM20A golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN enamel mineralization (ortholog); positive regulation of protein phosphorylation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH amelogenesis imperfect ... (more) a type 1G (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); extracellular space (inferred)	9	15205887	15218873	Dog	29	description	gene, protein-coding, MODEL [RefSeq]
12454120	Fam20a	FAM20A golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN enamel mineralization (ortholog); positive regulation of protein phosphorylation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH amelogenesis imperfect ... (more) a type 1G (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); extracellular space (inferred)	NW_004936541	7867856	7916145	Squirrel	27	description	gene, protein-coding, MODEL [RefSeq]
14017018	FAM20A	FAM20A golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN enamel mineralization (ortholog); positive regulation of protein phosphorylation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH amelogenesis imperfect ... (more) a type 1G (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); extracellular space (inferred); INTERACTS WITH deoxynivalenol				Pig	31	description	gene, protein-coding, MODEL [RefSeq]
18413262	FAM20A	FAM20A golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN enamel mineralization (ortholog); positive regulation of protein phosphorylation (ortholog); response to bacterium (ortholog); ASSOCIATED WITH amelogenesis imperfect ... (more) a type 1G (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum (inferred); extracellular space (inferred)				Green Monkey	27	description	gene, protein-coding, MODEL [RefSeq]
18926146	Fam20a	FAM20A golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN biomineral tissue development (ortholog); calcium ion homeostasis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta type 1G (orth ... (more) olog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog)				Naked Mole-Rat	24	description	gene, protein-coding, MODEL [RefSeq]
626129377	Fam20a	FAM20A golgi associated secretory pathway pseudokinase	ENCODES a protein that exhibits protein serine/threonine kinase activator activity (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN biomineral tissue development (ortholog); calcium ion homeostasis (ortholog); enamel mineralization (o ... (more) rtholog); ASSOCIATED WITH amelogenesis imperfecta type 1G (ortholog); genetic disease (ortholog); Hereditary Neoplastic Syndromes (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum (ortholog); extracellular space (ortholog)				Black Rat	21	description	gene, protein-coding, MODEL [RefSeq]
9034808	Fam20c	FAM20C golgi associated secretory pathway kinase	ENCODES a protein that exhibits calcium ion binding (ortholog); manganese ion binding (ortholog); protease binding (ortholog); INVOLVED IN biomineral tissue development (ortholog); dentinogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amel ... (more) ogenesis imperfecta (ortholog); COVID-19 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)	NW_004955460	8142325	8192044	Chinchilla	46	description	gene, protein-coding, MODEL [RefSeq]
11955703	FAM20C	FAM20C golgi associated secretory pathway kinase	ENCODES a protein that exhibits calcium ion binding (ortholog); manganese ion binding (ortholog); protease binding (ortholog); INVOLVED IN biomineral tissue development (ortholog); dentinogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amel ... (more) ogenesis imperfecta (ortholog); COVID-19 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); Golgi membrane (ortholog)	7	311468	394623	Bonobo	50	description	gene, protein-coding, MODEL [RefSeq]
12432310	FAM20C	FAM20C golgi associated secretory pathway kinase	ENCODES a protein that exhibits calcium ion binding (ortholog); manganese ion binding (ortholog); protease binding (ortholog); INVOLVED IN biomineral tissue development (ortholog); dentinogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amel ... (more) ogenesis imperfecta; COVID-19 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); Golgi membrane (ortholog)	6	16448603	16497064	Dog	48	description	gene, protein-coding, MODEL [RefSeq]
12655207	Fam20c	FAM20C golgi associated secretory pathway kinase	ENCODES a protein that exhibits protein serine/threonine kinase activity (ortholog); INVOLVED IN dentinogenesis (ortholog); enamel mineralization (ortholog); odontoblast differentiation (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); COVID-19 (or ... (more) tholog); Desbuquois dysplasia (ortholog); FOUND IN cytoplasm (inferred); extracellular space (inferred); Golgi apparatus (inferred)	NW_004936754	596878	649585	Squirrel	51	description	gene, protein-coding, MODEL [RefSeq]
14262154	FAM20C	FAM20C golgi associated secretory pathway kinase	ENCODES a protein that exhibits calcium ion binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN dentinogenesis (ortholog); enamel mineralization (ortholog); odontoblast differentiation (ortholog); ASSOCIATED WITH amelogenesis imp ... (more) erfecta (ortholog); COVID-19 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cytoplasm (ortholog); INTERACTS WITH deoxynivalenol				Pig	54	description	gene, protein-coding, MODEL [RefSeq]
18649872	FAM20C	FAM20C golgi associated secretory pathway kinase	ENCODES a protein that exhibits calcium ion binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN dentinogenesis (ortholog); enamel mineralization (ortholog); odontoblast differentiation (ortholog); ASSOCIATED WITH amelogenesis imp ... (more) erfecta (ortholog); COVID-19 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cytoplasm (ortholog)				Green Monkey	51	description	gene, protein-coding, MODEL [RefSeq]
18919093	Fam20c	FAM20C golgi associated secretory pathway kinase	ENCODES a protein that exhibits manganese ion binding (ortholog); protease binding (ortholog); protein kinase activity (ortholog); INVOLVED IN biomineral tissue development (ortholog); dentinogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH ... (more) amelogenesis imperfecta (ortholog); COVID-19 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN Golgi membrane (ortholog)				Naked Mole-Rat	53	description	gene, protein-coding, MODEL [RefSeq]
625932519	Fam20c	FAM20C golgi associated secretory pathway kinase	ENCODES a protein that exhibits calcium ion binding (ortholog); manganese ion binding (ortholog); protease binding (ortholog); INVOLVED IN biomineral tissue development (ortholog); dentinogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amel ... (more) ogenesis imperfecta (ortholog); COVID-19 (ortholog); Desbuquois dysplasia (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); Golgi apparatus (ortholog)				Black Rat	46	description	gene, protein-coding, MODEL [RefSeq]
1603342	FAM83H	family with sequence similarity 83 member H	The protein encoded by this gene plays an important role in the structural development and calcification of tooth enamel. Defects in this gene are a cause of amelogenesis imperfecta type 3 (AI3). [provided by RefSeq, Mar 2010]	8	143723933	143733779	Human	126	description	gene, protein-coding, REVIEWED [RefSeq]
2628	Fosl2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits DNA binding; DNA-binding transcription factor activity; double-stranded DNA binding; INVOLVED IN circadian rhythm; conditioned taste aversion; female pregnancy; ASSOCIATED WITH renal carcinoma; Reperfusion Injury; APLASIA CUTIS-ENAM ... (more) n>EL DYSPLASIA SYNDROME (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription factor AP-1 complex (ortholog); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate	6	30017952	30039269	Rat	348	description	gene, protein-coding, VALIDATED [RefSeq]
8748904	Fosl2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ... (more) ASSOCIATED WITH APLASIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription factor AP-1 complex (ortholog)	NW_004955469	10297179	10319180	Chinchilla	133	description	gene, protein-coding, MODEL [RefSeq]
11691152	FOSL2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH APLA ... (more) SIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription factor AP-1 complex (inferred)	2A	28392328	28416838	Bonobo	140	description	gene, protein-coding, MODEL [RefSeq]
12212417	FOSL2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH APLA ... (more) SIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription factor AP-1 complex (inferred)	17	22340469	22364994	Dog	141	description	gene, protein-coding, MODEL [RefSeq]
12559718	Fosl2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH APLA ... (more) SIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription factor AP-1 complex (inferred)	NW_004936493	4308683	4327102	Squirrel	141	description	gene, protein-coding, MODEL [RefSeq]
14035129	FOSL2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH APLA ... (more) SIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription factor AP-1 complex (inferred); INTERACTS WITH deoxynivalenol				Pig	142	description	gene, protein-coding, PROVISIONAL [RefSeq]
18591518	FOSL2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ASSOCIATED WITH APLA ... (more) SIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); transcription factor AP-1 complex (inferred)				Green Monkey	143	description	gene, protein-coding, MODEL [RefSeq]
18916966	Fosl2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ... (more) ASSOCIATED WITH APLASIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (ortholog); transcription factor AP-1 complex (ortholog)				Naked Mole-Rat	140	description	gene, protein-coding, MODEL [RefSeq]
626107379	Fosl2	FOS like 2, AP-1 transcription factor subunit	ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN alveolar secondary septum development (ortholog); B cell differentiation (ortholog); B cell proliferation (ortholog); ... (more) ASSOCIATED WITH APLASIA CUTIS-ENAMEL DYSPLASIA SYNDROME (ortholog); colon adenocarcinoma (ortholog); colorectal cancer (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); transcription factor AP-1 complex (ortholog)				Black Rat	133	description	gene, protein-coding, MODEL [RefSeq]
620283	Foxo1	forkhead box O1	ENCODES a protein that exhibits DNA-binding transcription factor activity; sequence-specific DNA binding; transcription coactivator binding; INVOLVED IN cellular response to dexamethasone stimulus; cellular response to hydrogen peroxide; enamel mineralization; P ... (more) ARTICIPATES IN interleukin-6 signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; ASSOCIATED WITH Experimental Liver Cirrhosis; Insulin Resistance; metabolic dysfunction-associated steatotic liver disease; FOUND IN cytoplasm; nucleus; cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran	2	138462974	138541420	Rat	669	description	gene, protein-coding, PROVISIONAL [RefSeq]
1622400	Gdf5	growth differentiation factor 5	This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is ... (more) proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation. [provided by RefSeq, Aug 2016]	2	155782943	155787204	Mouse	253	description	gene, protein-coding, VALIDATED [RefSeq]
1552765	Itgb6	integrin beta 6	Enables integrin binding activity. Involved in cell adhesion mediated by integrin and transforming growth factor beta production. Acts upstream of or within several processes, including enamel mineralization; lung development; and mononuclear cell differentiatio ... (more) n. Located in external side of plasma membrane. Part of integrin alphav-beta6 complex. Is expressed in several structures, including alimentary system; diaphragm; limb; metanephros; and vertebral axis musculature. Used to study asthma and pulmonary emphysema. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (integrin subunit beta 6). [provided by Alliance of Genome Resources, Jul 2025]	2	60428636	60553005	Mouse	276	description	gene, protein-coding, VALIDATED [RefSeq]
1313338	Klk1	kallikrein 1	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein are unable to generate significant levels of kinins in most tissues, develop cardiovascular abnormalities and exhibit hypercalciuria of renal origin. This gene is located in a cluster of several related kallikrein genes on chromosome 7. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, Feb 2016]	7	43874784	43879046	Mouse	144	description	gene, protein-coding, REVIEWED [RefSeq]
1553029	Klk11	kallikrein related-peptidase 11	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]	7	43424041	43428687	Mouse	41	description	gene, protein-coding, REVIEWED [RefSeq]
1615982	Klk1b1	kallikrein 1-related peptidase b1	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43616175	43620742	Mouse	27	description	gene, protein-coding, REVIEWED [RefSeq]
1615989	Klk1b11	kallikrein 1-related peptidase b11	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43645301	43649299	Mouse	25	description	gene, protein-coding, REVIEWED [RefSeq]
1615987	Klk1b16	kallikrein 1-related peptidase b16	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43771678	43791034	Mouse	23	description	gene, protein-coding, REVIEWED [RefSeq]
1615986	Klk1b21	kallikrein 1-related peptidase b21	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43654040	43756007	Mouse	38	description	gene, protein-coding, VALIDATED [RefSeq]
1615985	Klk1b24	kallikrein 1-related peptidase b24	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43837658	43841879	Mouse	37	description	gene, protein-coding, REVIEWED [RefSeq]
1615984	Klk1b27	kallikrein 1-related peptidase b27	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43701714	43706136	Mouse	44	description	gene, protein-coding, REVIEWED [RefSeq]
1615983	Klk1b5	kallikrein 1-related peptidase b5	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43865898	43870127	Mouse	42	description	gene, protein-coding, REVIEWED [RefSeq]
1615981	Klk1b8	kallikrein 1-related peptidase b8	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43600090	43604368	Mouse	29	description	gene, protein-coding, REVIEWED [RefSeq]
1619278	Klk1b9	kallikrein 1-related peptidase b9	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]	7	43625485	43629800	Mouse	22	description	gene, protein-coding, REVIEWED [RefSeq]
11955895	KLK4	kallikrein related peptidase 4	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); peptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); extracellular matrix disassembly (ortholog); ASSOCIATED WITH amelog ... (more) enesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog); FOUND IN extracellular region (inferred); secretory granule (inferred)	19	47849158	47876522	Bonobo	30	description	gene, protein-coding, MODEL [RefSeq]
12117701	KLK4	kallikrein related peptidase 4	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); peptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); extracellular matrix disassembly (ortholog); ASSOCIATED WITH amelog ... (more) enesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog); FOUND IN extracellular region (inferred)	1	105950948	105955464	Dog	27	description	gene, protein-coding, VALIDATED [RefSeq]
12451457	Klk4	kallikrein related peptidase 4	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); peptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); extracellular matrix disassembly (ortholog); ASSOCIATED WITH amelog ... (more) enesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog); FOUND IN extracellular region (inferred); secretory granule (inferred)	NW_004936889	583259	586412	Squirrel	30	description	gene, protein-coding, MODEL [RefSeq]
18367744	KLK4	kallikrein related peptidase 4	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); peptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); extracellular matrix disassembly (ortholog); ASSOCIATED WITH amelog ... (more) enesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog); FOUND IN extracellular region (inferred); secretory granule (inferred)				Green Monkey	30	description	gene, protein-coding, MODEL [RefSeq]
18927080	Klk4	kallikrein related peptidase 4	ENCODES a protein that exhibits hydrolase activity (inferred); metal ion binding (inferred); peptidase activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); extracellular matrix disassembly (ortholog); ASSOCIATED WITH amelog ... (more) enesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog); FOUND IN extracellular region (inferred); secretory granule (inferred)				Naked Mole-Rat	30	description	gene, protein-coding, MODEL [RefSeq]
625946633	Klk4	kallikrein related peptidase 4	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); extracellular matrix disassembly (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta type 2A1 (ortholog); breast cancer (ortholog)				Black Rat	18	description	gene, protein-coding, MODEL [RefSeq]
1315025	Klk7	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]	7	43460718	43465811	Mouse	60	description	gene, protein-coding, REVIEWED [RefSeq]
1314361	Klk8	kallikrein related-peptidase 8	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. Mice lacking the encoded protein exhibit impaired long-term potentiation and increased anxiety, as well as a hyperkeratosis phenotype. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]	7	43447001	43453250	Mouse	132	description	gene, protein-coding, REVIEWED [RefSeq]
10843	Klkb1	kallikrein B, plasma 1	This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded pr ... (more) eproprotein undergoes proteolytic processing to generate a disulfide-linked heterodimeric enzyme comprised of heavy and light chains. A complete deletion of the encoded protein prevents occlusive thrombus formation in mice with a minimal role in provoked bleeding. [provided by RefSeq, May 2016]	8	45719725	45747872	Mouse	197	description	gene, protein-coding, REVIEWED [RefSeq]
11764646	LOC100991737	putative adhesion G protein-coupled receptor F2P	ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic diso ... (more) rder (ortholog); FOUND IN membrane (inferred)	6	47239514	47279734	Bonobo	17	description	gene, protein-coding, MODEL [RefSeq]
18465674	LOC103221399	putative adhesion G protein-coupled receptor F2P	INVOLVED IN amelogenesis (ortholog); enamel mineralization (ortholog); gene expression (ortholog); ASSOCIATED WITH autistic disorder (ortholog)				Green Monkey	6	description	gene, protein-coding, MODEL [RefSeq]
1556913	Nectin1	nectin cell adhesion molecule 1	Enables several functions, including cell adhesion mediator activity; protein homodimerization activity; and virus receptor activity. Involved in cochlea morphogenesis; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and homophilic cell adhesion via plasma membrane adhes ... (more) ion molecules. Acts upstream of or within several processes, including camera-type eye development; desmosome organization; and enamel mineralization. Located in adherens junction; apical junction complex; and cell-cell contact zone. Is active in hippocampal mossy fiber to CA3 synapse and presynaptic active zone membrane. Is expressed in brain; jaw; renal vesicle; sensory organ; and skin. Human ortholog(s) of this gene implicated in cleft lip; cleft lip-palate-ectodermal dysplasia syndrome; cleft palate; and ectodermal dysplasia. Orthologous to human NECTIN1 (nectin cell adhesion molecule 1). [provided by Alliance of Genome Resources, Jul 2025]	9	43655251	43718758	Mouse	257	description	gene, protein-coding, VALIDATED [RefSeq]
1553240	Nectin2	nectin cell adhesion molecule 2	Enables cell adhesion molecule binding activity and protein homodimerization activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules and spermatid development. Acts upstream of or within several processes, including establishment of mitochondrion localization; sperm mit ... (more) ochondrion organization; and spermatid development. Located in cell-cell contact zone; plasma membrane; and zonula adherens. Is expressed in brain; cochlea; enamel organ; male reproductive system; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2). [provided by Alliance of Genome Resources, Jul 2025]	7	19450569	19483498	Mouse	235	description	gene, protein-coding, VALIDATED [RefSeq]
1617954	Odaph	odontogenesis associated phosphoprotein	Predicted to be involved in positive regulation of enamel mineralization. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A4. Orthologous to human ODAPH (odontogenesis associated phosphoprotein). [provided by Alliance of ... (more) Genome Resources, Jul 2025]	5	92135332	92143176	Mouse	38	description	gene, protein-coding, VALIDATED [RefSeq]
6489816	Odaph	odontogenesis associated phosphoprotein	INVOLVED IN positive regulation of biomineral tissue development (ortholog); positive regulation of enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A4 (ortholog); FOUND IN extracellular region (inferred); INTERACTS ... (more) WITH 17beta-estradiol (ortholog); 2-palmitoylglycerol (ortholog); acrylamide (ortholog)	14	16356104	16364420	Rat	24	description	gene, protein-coding, VALIDATED [RefSeq]
8751030	Odaph	odontogenesis associated phosphoprotein	INVOLVED IN positive regulation of biomineral tissue development (ortholog); positive regulation of enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A4 (ortholog)	NW_004955474	1502798	1509307	Chinchilla	6	description	gene, protein-coding, MODEL [RefSeq]
11671420	ODAPH	odontogenesis associated phosphoprotein	INVOLVED IN positive regulation of biomineral tissue development (inferred); positive regulation of enamel mineralization (inferred); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A4 (ortholog)	4	48640355	48649546	Bonobo	7	description	gene, protein-coding, MODEL [RefSeq]
12442868	Odaph	odontogenesis associated phosphoprotein	INVOLVED IN positive regulation of biomineral tissue development (ortholog); positive regulation of enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A4 (ortholog)	NW_004936598	400214	407597	Squirrel	6	description	gene, protein-coding, MODEL [RefSeq]
13877290	ODAPH	odontogenesis associated phosphoprotein	INVOLVED IN positive regulation of biomineral tissue development (inferred); positive regulation of enamel mineralization (inferred); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A4 (ortholog); INTERACTS WITH deoxynivalenol; graphene oxide				Pig	9	description	gene, protein-coding, MODEL [RefSeq]
18634416	ODAPH	odontogenesis associated phosphoprotein	INVOLVED IN positive regulation of biomineral tissue development (inferred); positive regulation of enamel mineralization (inferred); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A4 (ortholog)				Green Monkey	7	description	gene, protein-coding, MODEL [RefSeq]
625913586	Odaph	odontogenesis associated phosphoprotein	INVOLVED IN positive regulation of biomineral tissue development (ortholog); positive regulation of enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta hypomaturation type 2A4 (ortholog)				Black Rat	6	description	gene, protein-coding, MODEL [RefSeq]
732638	Ppara	peroxisome proliferator activated receptor alpha	Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; lipid binding activity; and nuclear receptor activity. Involved in several processes, including negative regulation of appetite; peroxisome proliferator activated receptor signaling pathway; and regulation of gen ... (more) e expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of biosynthetic process; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; early conceptus; gut; hemolymphoid system gland; and skeletal muscle. Used to study diabetes mellitus and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2025]	15	85619112	85691052	Mouse	1616	description	gene, protein-coding, VALIDATED [RefSeq]
11757610	PPARA	peroxisome proliferator activated receptor alpha	ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholo ... (more) g); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN nucleus (ortholog)				Bonobo	224	description	gene, protein-coding, MODEL [RefSeq]
12618260	Ppara	peroxisome proliferator activated receptor alpha	ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholo ... (more) g); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN nucleus (ortholog)	NW_004936629	3672445	3725645	Squirrel	226	description	gene, protein-coding, MODEL [RefSeq]
14213069	PPARA	peroxisome proliferator activated receptor alpha	ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholo ... (more) g); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN fibrillar center (inferred); nuclear body (inferred); nucleus (inferred); INTERACTS WITH bezafibrate; cadmium atom; cadmium dichloride				Pig	244	description	gene, protein-coding, PROVISIONAL [RefSeq]
18369218	PPARA	peroxisome proliferator activated receptor alpha	ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholo ... (more) g); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN nucleus (ortholog)				Green Monkey	224	description	gene, protein-coding, MODEL [RefSeq]
18905207	Ppara	peroxisome proliferator activated receptor alpha	ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); MDM2/MDM4 family protein binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); INVOLVED IN behavioral response to nicotine (ortholog); cellular response to fructose stimulus (ortholo ... (more) g); enamel mineralization (ortholog); ASSOCIATED WITH abdominal obesity-metabolic syndrome (ortholog); acute kidney tubular necrosis (ortholog); alcohol use disorder (ortholog); FOUND IN nucleus (ortholog)				Naked Mole-Rat	229	description	gene, protein-coding, MODEL [RefSeq]
1313210	Rell2	RELT-like 2	Enables collagen binding activity. Acts upstream of or within positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in lip; lower jaw molar dental lamina; lower jaw molar enamel organ; and oral epithelium. Orthologous to huma ... (more) n RELL2 (RELT like 2). [provided by Alliance of Genome Resources, Jul 2025]	18	38088107	38092232	Mouse	73	description	gene, protein-coding, VALIDATED [RefSeq]
1615906	Rogdi	rogdi homolog	Acts upstream of or within several processes, including enamel mineralization; locomotor rhythm; and pH reduction. Predicted to be located in nuclear envelope. Predicted to be part of RAVE complex. Predicted to be active in hippocampal mossy fiber to CA3 synapse ... (more) and presynapse. Is expressed in several structures, including central nervous system; genitourinary system; nose; spinal ganglion; and tooth. Used to study Kohlschutter-Tonz syndrome. Human ortholog(s) of this gene implicated in Kohlschutter-Tonz syndrome. Orthologous to human ROGDI (rogdi atypical leucine zipper). [provided by Alliance of Genome Resources, Jul 2025]	16	4826593	4831438	Mouse	153	description	gene, protein-coding, VALIDATED [RefSeq]
1314247	SLC24A4	solute carrier family 24 member 4	This gene encodes a sodium/potassium/calcium exchange protein. The encoded antiporter transports one calcium and one potassium ion in exchange for four sodium ions and has been implicated in amelogenesis and enamel maturation. Certain variants in this gene have ... (more) been associated with skin, hair, and eye pigmentation, while other variants have been identified in people with hypomaturation-type amelogenesis imperfecta. [provided by RefSeq, Nov 2023]	14	92322581	92501481	Human	148	description	gene, protein-coding, REVIEWED [RefSeq]
11311	Slc4a2	solute carrier family 4 (anion exchanger), member 2	Enables chloride:bicarbonate antiporter activity. Involved in several processes, including amelogenesis; negative regulation of CD8-positive, alpha-beta T cell activation; and positive regulation of enamel mineralization. Located in basolateral plasma membrane. ... (more) Is expressed in brain; cornea; and testis. Human ortholog(s) of this gene implicated in osteopetrosis. Orthologous to human SLC4A2 (solute carrier family 4 member 2). [provided by Alliance of Genome Resources, Jul 2025]	5	24628834	24645945	Mouse	202	description	gene, protein-coding, VALIDATED [RefSeq]
1352585	STATH	statherin	Predicted to enable extracellular matrix constituent, lubricant activity and hydroxyapatite binding activity. Predicted to be a structural constituent of tooth enamel. Predicted to be involved in negative regulation of bone mineralization; ossification; and sali ... (more) va secretion. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]	4	69995966	70002570	Human	34	description	gene, protein-coding, VALIDATED [RefSeq]
8904614	Stim1	stromal interaction molecule 1	ENCODES a protein that exhibits calcium channel regulator activity (ortholog); calcium ion binding (ortholog); channel activator activity (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); detection of calcium ion (ortholog); enam ... (more) el mineralization (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); common variable immunodeficiency 10 (ortholog); congenital structural myopathy (ortholog); FOUND IN cortical endoplasmic reticulum (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)	NW_004955414	19652990	19849353	Chinchilla	101	description	gene, protein-coding, MODEL [RefSeq]
11829292	STIM1	stromal interaction molecule 1	ENCODES a protein that exhibits calcium channel regulator activity (ortholog); channel activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); detection of calcium ion (ortholog); enam ... (more) '>enamel mineralization (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); common variable immunodeficiency 10 (ortholog); congenital structural myopathy (ortholog); FOUND IN cortical endoplasmic reticulum (ortholog); growth cone (ortholog); plasma membrane (ortholog)	11	3726501	3954951	Bonobo	109	description	gene, protein-coding, MODEL [RefSeq]
12394910	STIM1	stromal interaction molecule 1	ENCODES a protein that exhibits calcium channel regulator activity (ortholog); channel activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); detection of calcium ion (ortholog); enam ... (more) '>enamel mineralization (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); common variable immunodeficiency 10 (ortholog); congenital structural myopathy (ortholog); FOUND IN cortical endoplasmic reticulum (ortholog); growth cone (ortholog); plasma membrane (ortholog)	21	26394592	26594764	Dog	109	description	gene, protein-coding, MODEL [RefSeq]
12560613	Stim1	stromal interaction molecule 1	ENCODES a protein that exhibits calcium channel regulator activity (ortholog); channel activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); detection of calcium ion (ortholog); enam ... (more) '>enamel mineralization (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); common variable immunodeficiency 10 (ortholog); congenital structural myopathy (ortholog); FOUND IN cortical endoplasmic reticulum (ortholog); growth cone (ortholog); plasma membrane (ortholog)	NW_004936498	849775	1063552	Squirrel	108	description	gene, protein-coding, MODEL [RefSeq]
14020716	STIM1	stromal interaction molecule 1	ENCODES a protein that exhibits calcium channel regulator activity (ortholog); channel activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); detection of calcium ion (ortholog); enam ... (more) '>enamel mineralization (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); common variable immunodeficiency 10 (ortholog); congenital structural myopathy (ortholog); FOUND IN cortical endoplasmic reticulum (ortholog); growth cone (ortholog); plasma membrane (ortholog)				Pig	110	description	gene, protein-coding, PROVISIONAL [RefSeq]
18407648	STIM1	stromal interaction molecule 1	ENCODES a protein that exhibits calcium channel regulator activity (ortholog); channel activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); detection of calcium ion (ortholog); enam ... (more) '>enamel mineralization (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); common variable immunodeficiency 10 (ortholog); congenital structural myopathy (ortholog); FOUND IN cortical endoplasmic reticulum (ortholog); growth cone (ortholog); plasma membrane (ortholog)				Green Monkey	107	description	gene, protein-coding, MODEL [RefSeq]
18933789	Stim1	stromal interaction molecule 1	ENCODES a protein that exhibits calcium channel regulator activity (ortholog); channel activator activity (ortholog); identical protein binding (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); detection of calcium ion (ortholog); enam ... (more) '>enamel mineralization (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); common variable immunodeficiency 10 (ortholog); congenital structural myopathy (ortholog); FOUND IN cortical endoplasmic reticulum (ortholog); growth cone (ortholog); plasma membrane (ortholog)				Naked Mole-Rat	107	description	gene, protein-coding, MODEL [RefSeq]
625848283	Stim1	stromal interaction molecule 1	ENCODES a protein that exhibits calcium channel regulator activity (ortholog); calcium ion binding (ortholog); channel activator activity (ortholog); INVOLVED IN activation of store-operated calcium channel activity (ortholog); detection of calcium ion (ortholog); enam ... (more) el mineralization (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); common variable immunodeficiency 10 (ortholog); congenital structural myopathy (ortholog); FOUND IN cortical endoplasmic reticulum (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)				Black Rat	101	description	gene, protein-coding, MODEL [RefSeq]
1321243	TUFT1	tuftelin 1	Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth f ... (more) actor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]	1	151540309	151583583	Human	138	description	gene, protein-coding, VALIDATED [RefSeq]
1321244	Tuft1	tuftelin 1	Tuftelin is an acidic protein that is thought to play a role in dental enamel mineralization and is implicated in caries susceptibility. It is also thought to be involved with adaptation to hypoxia, mesenchymal stem cell function, and neurotrophin nerve growth f ... (more) actor mediated neuronal differentiation. [provided by RefSeq, Aug 2014]	3	94520060	94566179	Mouse	144	description	gene, protein-coding, VALIDATED [RefSeq]
1563550	Wdr72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN cytoplasm (ortholog); endosome (ortholog); extracellular region (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A	8	83718897	83902128	Rat	109	description	gene, protein-coding, PROVISIONAL [RefSeq]
1622619	Wdr72	WD repeat domain 72	Acts upstream of or within several processes, including ameloblast differentiation; enamel mineralization; and protein-containing complex assembly. Located in endosome and nucleus. Used to study amelogenesis imperfecta hypomaturation type 2A3. Human ortholog(s) ... (more) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A3. Orthologous to human WDR72 (WD repeat domain 72). [provided by Alliance of Genome Resources, Jul 2025]	9	74017608	74190485	Mouse	118	description	gene, protein-coding, VALIDATED [RefSeq]
9059391	Wdr72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN cytoplasm (ortholog); endosome (ortholog); extracellular region (ortholog)	NW_004955409	1451506	1631976	Chinchilla	35	description	gene, protein-coding, MODEL [RefSeq]
11970046	WDR72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN endosome (ortholog); extracellular region (ortholog); nucleus (ortholog)	15	32449840	32695815	Bonobo	40	description	gene, protein-coding, MODEL [RefSeq]
12168669	WDR72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN endosome (ortholog); extracellular region (ortholog); nucleus (ortholog)	30	19120021	19340781	Dog	37	description	gene, protein-coding, MODEL [RefSeq]
12584195	Wdr72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN endosome (ortholog); extracellular region (ortholog); nucleus (ortholog)	NW_004936471	15233828	15416415	Squirrel	40	description	gene, protein-coding, MODEL [RefSeq]
14082501	WDR72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN endosome (ortholog); extracellular region (ortholog); nucleus (ortholog)				Pig	37	description	gene, protein-coding, MODEL [RefSeq]
18511318	WDR72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN endosome (ortholog); extracellular region (ortholog); nucleus (ortholog)				Green Monkey	40	description	gene, protein-coding, MODEL [RefSeq]
18911394	Wdr72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN cytoplasm (ortholog); endosome (ortholog); extracellular region (ortholog)				Naked Mole-Rat	37	description	gene, protein-coding, MODEL [RefSeq]
626163920	Wdr72	WD repeat domain 72	INVOLVED IN ameloblast differentiation (ortholog); amelogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); amelogenesis imperfecta hypomaturation type 2A3 (ortholog); amelogenesis imperfecta type 1C (ortholo ... (more) g); FOUND IN cytoplasm (ortholog); endosome (ortholog); extracellular region (ortholog)				Black Rat	35	description	gene, protein-coding, MODEL [RefSeq]

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