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Gene: FAM20C (FAM20C golgi associated secretory pathway kinase) Pan paniscus

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Symbol:

FAM20C

Name:

FAM20C golgi associated secretory pathway kinase

RGD ID:

11955703

Description:

ENCODES a protein that exhibits calcium ion binding (ortholog); manganese ion binding (ortholog); protease binding (ortholog); INVOLVED IN biomineral tissue development (ortholog); dentinogenesis (ortholog); enamel mineralization (ortholog); ASSOCIATED WITH amelogenesis imperfecta (ortholog); COVID-19 (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); Golgi membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

extracellular serine/threonine protein kinase FAM20C; FAM20C, golgi associated secretory pathway kinase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	5,096,988 - 5,181,447 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	53,421,707 - 53,506,134 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	311,468 - 394,623 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	575,633 - 635,643 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amelogenesis imperfecta (ISO)

COVID-19 (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

genetic disease (ISO)

Hypophosphatemic Rickets (ISO)

Perinatal Death (ISO)

Raine Syndrome (ISO)

rickets (ISO)

Tooth Demineralization (ISO)

X-linked dominant hypophosphatemic rickets (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biomineral tissue development (ISO)

dentinogenesis (ISO)

enamel mineralization (IEA,ISO)

odontoblast differentiation (ISO)

osteoclast maturation (ISO)

positive regulation of bone mineralization (ISO)

positive regulation of osteoblast differentiation (ISO)

protein phosphorylation (ISO)

regulation of fibroblast growth factor receptor signaling pathway (ISO)

regulation of phosphorus metabolic process (ISO)

skeletal system development (ISO)

Cellular Component

cytoplasm (ISO)

extracellular space (ISO)

Golgi apparatus (IEA)

Golgi membrane (ISO)

nucleoplasm (ISO)

Molecular Function

ATP binding (IEA)

calcium ion binding (ISO)

manganese ion binding (ISO)

metal ion binding (IEA)

protease binding (ISO)

protein binding (ISO)

protein kinase activity (ISO)

protein serine/threonine kinase activity (IEA,ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

FAM20C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	5,096,988 - 5,181,447 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	53,421,707 - 53,506,134 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	311,468 - 394,623 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	575,633 - 635,643 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

FAM20C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	192,571 - 260,772 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	192,571 - 260,772 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	192,571 - 300,738 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	288,052 - 304,059 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	288,195 - 304,059	NCBI
Celera	7	211,215 - 273,622 (+)	NCBI		Celera
Cytogenetic Map	7	p22.3	NCBI
HuRef	7	203,619 - 219,084 (+)	NCBI		HuRef
HuRef	7	155,848 - 180,386 (+)	NCBI		HuRef
CHM1_1	7	192,335 - 299,664 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	293,238 - 360,993 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	303,573 - 364,808 (+)	NCBI

Fam20c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	138,740,836 - 138,795,818 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	138,740,269 - 138,795,832 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	138,755,081 - 138,810,063 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	138,754,514 - 138,810,077 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	139,231,035 - 139,286,017 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	139,008,742 - 139,063,705 (+)	NCBI		MGSCv36	mm8
Celera	5	135,807,755 - 135,865,362 (+)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	77.19	NCBI

Fam20c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	20,940,654 - 20,999,072 (-)	NCBI		GRCr8
mRatBN7.2	12	15,826,864 - 15,885,423 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	15,826,871 - 15,884,543 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	16,638,165 - 16,695,811 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	17,261,890 - 17,319,536 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	16,284,652 - 16,341,671 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	17,913,771 - 17,972,733 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	17,913,767 - 17,972,737 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	19,906,233 - 19,965,797 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	16,340,407 - 16,399,325 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	16,371,029 - 16,473,541 (-)	NCBI
Celera	12	17,578,522 - 17,635,987 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

Fam20c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955460	8,143,824 - 8,193,825 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955460	8,142,325 - 8,192,044 (+)	NCBI	ChiLan1.0	ChiLan1.0

FAM20C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	16,448,603 - 16,497,064 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	16,448,588 - 16,497,752 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	17,920,483 - 17,969,286 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	16,577,996 - 16,626,815 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	16,578,012 - 16,628,609 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	16,380,418 - 16,429,206 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	16,306,905 - 16,355,670 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	16,596,937 - 16,645,742 (-)	NCBI		UU_Cfam_GSD_1.0

Fam20c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	144,360,748 - 144,413,468 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936754	596,872 - 653,098 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936754	596,878 - 649,585 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FAM20C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	163,421 - 200,459 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	159,107 - 200,462 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	89,974 - 94,208 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103246914
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	21,299,235 - 21,371,603 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	21,299,213 - 21,371,577 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666090	190,813 - 259,923 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fam20c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	25,984,091 - 26,032,649 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	25,984,642 - 26,032,089 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008973180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063606161	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008973180 ⟹ XP_008971428

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	5,096,988 - 5,163,390 (+)	NCBI
NHGRI_mPanPan1	7	53,421,720 - 53,488,082 (+)	NCBI
Mhudiblu_PPA_v0	7	311,480 - 381,574 (+)	NCBI
PanPan1.1	7	575,633 - 635,643 (+)	NCBI

Sequence:

show sequence

CTGCCGCCGGCGGCCGAGCCGGCCGAGCGCGCCTTGCGGGGGCGGGATCCCGGCGCCCTAAGAC
CCCACGACCCCGCGCACCGGCCGCTGCTGCGAGACCCCGGCCCGCGTCGGTCCGAGTCGCCCCC
CGGCCCCGGCGGAGACGCCTCCCTCCTGGCCAGGCTGTTCGAGCACCCGCTGTACCGGGTGGCG
GTTCCGCCGCTCACGGAGGAGGACGGCCTGTTCACTGTGAACAGCGACACCAGGCTCAGCCCCA
AAGCGGCGGAGAACCCGGGCTGGCCGCATGCGGGTGCTGAAGGTGCAGAATTCCCCTCCCCCGG
GGAGGCGGCCGTGGACTCCTATCCCAACTGGCTCAAGTTCCACATTGGTATCAACCGGTACGAG
CTGTACTCCAGACACAACCCGGCCATCGAGGCCCTGCTGCACGACCTCAGCTCCCAGAGGATCA
CCAGCGTGGCCATGAAGTCGGGGGGCACGCAGCTGAAGCTCATCATGACCTTCCAGAATTACGG
GCAAGCGCTGTTCAAACCCATGAAACAAACGAGGGAGCAGGAGACGCCCCCTGACTTTTTTTAT
TTCTCTGACTACGAGAGGCACAATGCGGAGATTGCTGCCTTCCACCTGGACAGGATCCTGGACT
TCCGCCGGGTCCCTCCCGTGGCCGGCAGGATGGTCAACATGACCAAGGAGATCCGGGACGTCAC
ACGGGACAAGAAGCTCTGGAGGACCTTCTTCATCTCTCCAGCCAACAACATCTGCTTCTACGGC
GAGTGCTCCTACTACTGCTCCACGGAGCATGCCCTGTGCGGGAAGCCAGACCAGATCGAGGGCT
CGCTGGCGGCCTTCCTGCCCGACCTGTCCCTGGCCAAGAGGAAGACCTGGCGGAACCCTTGGCG
GCGTTCCTACCACAAGCGCAAGAAGGCCGAGTGGGAGGTGGACCCTGACTACTGCGAGGAGGTG
AAGCAGACACCGCCCTACGACAGCAGCCACCGCATCCTGGACGTCATGGACATGACGATCTTCG
ACTTCCTCATGGGAAACATGGACCGTCACCACTACGAGACTTTTGAGAAGTTTGGGAATGAAAC
GTTCATCATCCACTTAGACAATGGAAGAGGGTTTGGGAAGTATTCGCACGACGAGCTCTCCATC
CTGGTGCCGCTACAGCAGTGCTGCAGGATCCGGAAGTCCACCTACCTGCGTCTGCAGCTCCTGG
CCAAGGAGGAGTACAAACTGAGCCTGCTGATGGCCGAGTCTCTGCGGGGGGACCAGGTGGCACC
CGTGCTGTACCAGCCGCACCTGGAGGCCCTGGACCGGCGGCTCCGCGTCGTGCTAAAGGCCGTC
CGGGACTGCGTGGAGAGGGACGGGCTCCACAGCGTGGTGGAGGAGGACCTGGACACTGGGCACA
GAGCCGCCTCGGCGAGGTAGTGTCCGCCGGCCGCTGCGCTGCCCGGGATGGAGACAGAGGGGCC
GGACCTCCCAGCAAGCGCTGCCCGGGACGGAGACAGAGGGGCCGGACCTCCCAGCAAGCGCTGC
CCGGGATGGAGACAGGGGCCGGACCTCCCAGCAAGCGCATGCGCCCGTCGTGAATTCAGTGAAT
TCAGAGGCAGGACGGGATCATCCGGAGTCGGGAGCTGCTGCCACAGGAGGCGAGGCTCCCCAGG
TCTCACAGGACACATTTTGTCAGTGTTTGACCAGAAAAGCTTGGGAAGGAAGCGCTGTCTGTGC
TCACGGACAGAGGTGGCCGGCGCCGGAGGCATTCCATCCTTTCT

hide sequence

RefSeq Acc Id:

XM_034963407 ⟹ XP_034819298

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	5,096,988 - 5,181,447 (+)	NCBI
NHGRI_mPanPan1	7	53,421,707 - 53,506,134 (+)	NCBI
Mhudiblu_PPA_v0	7	311,468 - 394,623 (+)	NCBI

RefSeq Acc Id:

XM_063606161 ⟹ XP_063462231

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	5,096,988 - 5,163,390 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008971428	(Get FASTA)	NCBI Sequence Viewer
	XP_034819298	(Get FASTA)	NCBI Sequence Viewer
	XP_063462231	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000034744.1

RefSeq Acc Id:	XP_008971428 ⟸ XM_008973180
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9C8J1 (UniProtKB/TrEMBL)
- Sequence:	show sequence LPPAAEPAERALRGRDPGALRPHDPAHRPLLRDPGPRRSESPPGPGGDASLLARLFEHPLYRVA VPPLTEEDGLFTVNSDTRLSPKAAENPGWPHAGAEGAEFPSPGEAAVDSYPNWLKFHIGINRYE LYSRHNPAIEALLHDLSSQRITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFY FSDYERHNAEIAAFHLDRILDFRRVPPVAGRMVNMTKEIRDVTRDKKLWRTFFISPANNICFYG ECSYYCSTEHALCGKPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEV KQTPPYDSSHRILDVMDMTIFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSI LVPLQQCCRIRKSTYLRLQLLAKEEYKLSLLMAESLRGDQVAPVLYQPHLEALDRRLRVVLKAV RDCVERDGLHSVVEEDLDTGHRAASAR hide sequence

RefSeq Acc Id:	XP_034819298 ⟸ XM_034963407
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063462231 ⟸ XM_063606161
- Peptide Label:	isoform X1

Protein Domains

FAM20 C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000040208	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000057628.1	UniProtKB/TrEMBL
InterPro	FAM20	UniProtKB/TrEMBL
	FAM20_C	UniProtKB/TrEMBL
KEGG Report	pps:100990393	UniProtKB/TrEMBL
NCBI Gene	FAM20C	ENTREZGENE
PANTHER	EXTRACELLULAR SERINE/THREONINE PROTEIN KINASE FAM20C	UniProtKB/TrEMBL
	PTHR12450	UniProtKB/TrEMBL
Pfam	Fam20C	UniProtKB/TrEMBL
UniProt	A0A2R9C8J1	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	FAM20C	FAM20C golgi associated secretory pathway kinase		FAM20C, golgi associated secretory pathway kinase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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