Fam20c (FAM20C, golgi associated secretory pathway kinase) - Rat Genome Database

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Gene: Fam20c (FAM20C, golgi associated secretory pathway kinase) Mus musculus
Analyze
Symbol: Fam20c
Name: FAM20C, golgi associated secretory pathway kinase
RGD ID: 1323720
MGI Page MGI
Description: Enables calcium ion binding activity and protein serine/threonine kinase activity. Acts upstream of or within several processes, including odontoblast differentiation; odontogenesis of dentin-containing tooth; and osteoclast maturation. Located in Golgi apparatus and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; genitourinary system; and musculoskeletal system. Used to study rickets. Human ortholog(s) of this gene implicated in amelogenesis imperfecta. Orthologous to human FAM20C (FAM20C golgi associated secretory pathway kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C76981; dentin matrix protein 4; DMP; DMP-4; DMP4; extracellular serine/threonine protein kinase Fam20C; family with sequence similarity 20, member C; GEF-CK; golgi-enriched fraction casein kinase; KIAA4081; MGC7673; mKIAA4081
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,740,836 - 138,795,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,740,269 - 138,795,832 (+)EnsemblGRCm39 Ensembl
GRCm385138,755,081 - 138,810,063 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,754,514 - 138,810,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,231,035 - 139,286,017 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,008,742 - 139,063,705 (+)NCBIMGSCv36mm8
Celera5135,807,755 - 135,865,362 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3',5'-cyclic AMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-fluorouracil  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
calcitriol  (ISO)
carbon nanotube  (EXP)
cisplatin  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fipronil  (ISO)
flutamide  (ISO)
genistein  (EXP)
indometacin  (ISO)
inulin  (EXP)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
ketoconazole  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
nickel atom  (ISO)
oxaliplatin  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bone structure  (IAGP)
abnormal cementum morphology  (IAGP)
abnormal chondrocyte differentiation  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal cued conditioning behavior  (IAGP)
abnormal dental pulp cavity morphology  (IAGP)
abnormal dentin development  (IAGP)
abnormal dentin morphology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal femur morphology  (IAGP)
abnormal glomerular capsule parietal layer morphology  (IAGP)
abnormal jaw morphology  (IAGP)
abnormal lacrimal gland physiology  (IAGP)
abnormal limb long bone morphology  (IAGP)
abnormal long bone diaphysis morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal osteocyte canaliculus morphology  (IAGP)
abnormal osteocyte dendritic process morphology  (IAGP)
abnormal osteocyte lacuna morphology  (IAGP)
abnormal osteocyte lacunocanalicular system morphology  (IAGP)
abnormal osteocyte morphology  (IAGP)
abnormal periodontal ligament morphology  (IAGP)
abnormal postnatal growth/weight/body size  (IAGP)
abnormal prepulse inhibition  (IAGP)
abnormal salivary gland morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal tooth hard tissue morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal tooth root morphology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral column morphology  (IAGP)
abnormal vitamin D level  (IAGP)
absent bone trabeculae  (IAGP)
absent enamel  (IAGP)
alveolar process atrophy  (IAGP)
apical tooth abscess  (IAGP)
conical molar  (IAGP)
decreased body height  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IAGP)
decreased bone mineral density  (IAGP)
decreased bone mineralization  (IAGP)
decreased bone volume  (IAGP)
decreased chondrocyte apoptosis  (IAGP)
decreased chondrocyte proliferation  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating phosphate level  (IAGP)
decreased collagen level  (IAGP)
decreased compact bone thickness  (IAGP)
decreased Leydig cell number  (IAGP)
decreased locomotor activity  (IAGP)
decreased trabecular bone thickness  (IAGP)
decreased trabecular bone volume  (IAGP)
delayed bone ossification  (IAGP)
delayed cranial suture closure  (IAGP)
delayed endochondral bone ossification  (IAGP)
dental pulp inflammation  (IAGP)
dental pulp necrosis  (IAGP)
detached junctional epithelium  (IAGP)
distended abdomen  (IAGP)
extramedullary hematopoiesis  (IAGP)
female infertility  (IAGP)
flat face  (IAGP)
fragile skeleton  (IAGP)
impaired balance  (IAGP)
impaired hearing  (IAGP)
impaired osteoblast differentiation  (IAGP)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating parathyroid hormone level  (IAGP)
increased width of hypertrophic chondrocyte zone  (IAGP)
male infertility  (IAGP)
mandibular hyperostosis  (IAGP)
osteomalacia  (IAGP)
osteosclerosis  (IAGP)
periodontal ligament necrosis  (IAGP)
periodontal pocket  (IAGP)
periodontium inflammation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
rickets  (IAGP)
short snout  (IAGP)
small cranium  (IAGP)
small molars  (IAGP)
tooth abscess  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Variability of systemic and oro-dental phenotype in two families with non-lethal Raine syndrome with FAM20C mutations. Acevedo AC, etal., BMC Med Genet. 2015 Feb 21;16:8. doi: 10.1186/s12881-015-0154-5.
2. Dysregulated gene expression in the primary osteoblasts and osteocytes isolated from hypophosphatemic Hyp mice. Miyagawa K, etal., PLoS One. 2014 Apr 7;9(4):e93840. doi: 10.1371/journal.pone.0093840. eCollection 2014.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Exome sequencing reveals FAM20c mutations associated with fibroblast growth factor 23-related hypophosphatemia, dental anomalies, and ectopic calcification. Rafaelsen SH, etal., J Bone Miner Res. 2013 Jun;28(6):1378-85. doi: 10.1002/jbmr.1850.
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development. Simpson MA, etal., Am J Hum Genet. 2007 Nov;81(5):906-12. Epub 2007 Sep 14.
9. Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice. Vogel P, etal., Vet Pathol. 2012 Nov;49(6):998-1017. doi: 10.1177/0300985812453177. Epub 2012 Jun 25.
10. Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice. Wang X, etal., PLoS Genet. 2012;8(5):e1002708. doi: 10.1371/journal.pgen.1002708. Epub 2012 May 17.
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:15676076   PMID:15782199   PMID:16141072   PMID:16141073  
PMID:17369251   PMID:20644212   PMID:21267068   PMID:21549343   PMID:21677750   PMID:21873635   PMID:22008794   PMID:22900076   PMID:22936805   PMID:23703840   PMID:24006456   PMID:24026952  
PMID:24194600   PMID:24874551   PMID:25479552   PMID:25515778   PMID:25537657   PMID:25789606   PMID:25833681   PMID:26273529   PMID:26324849   PMID:27626380   PMID:28620244   PMID:29337188  
PMID:30520731   PMID:30864688   PMID:31317746   PMID:31914633   PMID:32416287   PMID:33028367   PMID:33905141   PMID:34343663   PMID:34433585   PMID:36572689   PMID:36914045   PMID:37357253  
PMID:37698039  


Genomics

Comparative Map Data
Fam20c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395138,740,836 - 138,795,818 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5138,740,269 - 138,795,832 (+)EnsemblGRCm39 Ensembl
GRCm385138,755,081 - 138,810,063 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5138,754,514 - 138,810,077 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,231,035 - 139,286,017 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,008,742 - 139,063,705 (+)NCBIMGSCv36mm8
Celera5135,807,755 - 135,865,362 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.19NCBI
FAM20C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387192,571 - 260,772 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7192,571 - 260,772 (+)EnsemblGRCh38hg38GRCh38
GRCh377192,571 - 300,738 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367288,052 - 304,059 (+)NCBINCBI36Build 36hg18NCBI36
Build 347288,195 - 304,059NCBI
Celera7211,215 - 273,622 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7203,619 - 219,084 (+)NCBIHuRef
HuRef7155,848 - 180,386 (+)NCBIHuRef
CHM1_17192,335 - 299,664 (+)NCBICHM1_1
T2T-CHM13v2.07293,238 - 360,993 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27303,573 - 364,808 (+)NCBI
Fam20c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81220,940,654 - 20,999,072 (-)NCBIGRCr8
mRatBN7.21215,826,864 - 15,885,423 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,826,871 - 15,884,543 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1216,638,165 - 16,695,811 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,261,890 - 17,319,536 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01216,284,652 - 16,341,671 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,913,771 - 17,972,733 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,913,767 - 17,972,737 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,906,233 - 19,965,797 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41216,340,407 - 16,399,325 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11216,371,029 - 16,473,541 (-)NCBI
Celera1217,578,522 - 17,635,987 (-)NCBICelera
Cytogenetic Map12q11NCBI
Fam20c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,143,824 - 8,193,825 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,142,325 - 8,192,044 (+)NCBIChiLan1.0ChiLan1.0
FAM20C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v265,096,988 - 5,181,447 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1753,421,707 - 53,506,134 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07311,468 - 394,623 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17575,633 - 635,643 (+)NCBIpanpan1.1PanPan1.1panPan2
FAM20C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,448,603 - 16,497,064 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,448,588 - 16,497,752 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,920,483 - 17,969,286 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,577,996 - 16,626,815 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,578,012 - 16,628,609 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,380,418 - 16,429,206 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,306,905 - 16,355,670 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,596,937 - 16,645,742 (-)NCBIUU_Cfam_GSD_1.0
Fam20c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344144,360,748 - 144,413,468 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936754596,872 - 653,098 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936754596,878 - 649,585 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAM20C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3163,421 - 200,459 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13159,107 - 200,462 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2389,974 - 94,208 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103246914
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12821,299,235 - 21,371,603 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2821,299,213 - 21,371,577 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666090190,813 - 259,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam20c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474025,984,091 - 26,032,649 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474025,984,642 - 26,032,089 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fam20c
1956 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1359
Count of miRNA genes:643
Interacting mature miRNAs:801
Transcripts:ENSMUST00000026972, ENSMUST00000159176, ENSMUST00000160645, ENSMUST00000160988, ENSMUST00000161641
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13464243Ahl20_mage related hearing loss, early onset 20 (mouse)5107906299141906412Mouse
1300913Bwefm_mbody weight females and males day 10 (mouse)Not determined5109439348143439459Mouse
11528552Scram1_mspinal cord resistance to astrocytoma modifier 1 (mouse)5121455402151758149Mouse
1301363Pbwg13_mpostnatal body weight growth 13 (mouse)Not determined5125133457151758149Mouse
1300827Cora1_mcorrelation in cytokine production 1 (mouse)Not determined5115156883149157015Mouse
13464251Ahl21_mage related hearing loss, early onset 21 (mouse)5109167240143167381Mouse
1301226Bbaa2_mB.burgdorferi-associated arthritis 2 (mouse)Not determined5115156883149157015Mouse
12880406Jcdq2_mjoint cartilage degeneration QTL 2 (mouse)5129787831151758149Mouse
13464143Bbaa2b_mB.burgdorferi-associated arthritis 2b (mouse)5133052969140709801Mouse
11049557Lmr26_mleishmaniasis resistance 26 (mouse)5133925558151758149Mouse
10412191Bbaa24_mB.burgdorferi-associated arthritis 24 (mouse)Not determined5119945037141700466Mouse
1301362Prnr1_mprion resistance 1 (mouse)Not determined589418876146787935Mouse
10043890Trigq4_mtriglyceride QTL 4 (mouse)Not determined5107906299141906412Mouse
27226719Tibw6_mtibia width 6, proximal, 16 week (mouse)572857343139985755Mouse
1301543Hypch_mhypercholesterolemia (mouse)Not determined5109238624139118905Mouse
4141081Nidd7k_mNidd7 on KK-A (mouse)Not determined119945037149347326Mouse
1301986Bpq4_mblood pressure QTL 4 (mouse)Not determined5121555236151758149Mouse
4142473Chlq11_mcirculating hormone level QTL 11 (mouse)Not determined5107906299141906412Mouse
4141218Ath24_matherosclerosis 24 (mouse)Not determined129520084151758149Mouse
1301857Bglq14_mbody growth late QTL 14 (mouse)Not determined5118948964151758149Mouse
10412197Bbaa25_mB.burgdorferi-associated arthritis 25 (mouse)Not determined5109167240143167381Mouse
1302079Lbw3_mlupus NZB x NZW 3 (mouse)Not determined5124700335151758149Mouse
1301715Elmaz2_melevated maze behavior 2 (mouse)Not determined5125178229141700466Mouse

Markers in Region
D5Mit121  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385138,790,582 - 138,790,731UniSTSGRCm38
MGSCv375139,266,536 - 139,266,685UniSTSGRCm37
Celera5135,843,368 - 135,843,517UniSTS
Cytogenetic Map5G2UniSTS
cM Map578.0UniSTS
Whitehead Genetic566.7UniSTS
RH126073  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm385138,809,849 - 138,810,054UniSTSGRCm38
MGSCv375139,285,803 - 139,286,008UniSTSGRCm37
Celera5135,865,148 - 135,865,353UniSTS
Cytogenetic Map5G2UniSTS
Whitehead/MRC_RH51674.13UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001359593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC165444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK196973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK220286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY778962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000026972   ⟹   ENSMUSP00000026972
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,740,269 - 138,795,832 (+)Ensembl
GRCm38.p6 Ensembl5138,754,514 - 138,810,077 (+)Ensembl
RefSeq Acc Id: ENSMUST00000159176
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,772,255 - 138,794,914 (+)Ensembl
GRCm38.p6 Ensembl5138,786,500 - 138,809,159 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160645   ⟹   ENSMUSP00000124584
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,740,838 - 138,795,136 (+)Ensembl
GRCm38.p6 Ensembl5138,755,083 - 138,809,381 (+)Ensembl
RefSeq Acc Id: ENSMUST00000160988
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,774,529 - 138,793,094 (+)Ensembl
GRCm38.p6 Ensembl5138,788,774 - 138,807,339 (+)Ensembl
RefSeq Acc Id: ENSMUST00000161641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,792,945 - 138,795,160 (+)Ensembl
GRCm38.p6 Ensembl5138,807,190 - 138,809,405 (+)Ensembl
RefSeq Acc Id: ENSMUST00000197027
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl5138,740,842 - 138,744,604 (+)Ensembl
GRCm38.p6 Ensembl5138,755,087 - 138,758,849 (+)Ensembl
RefSeq Acc Id: NM_001359593   ⟹   NP_001346522
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395138,740,836 - 138,795,818 (+)NCBI
GRCm385138,755,081 - 138,810,063 (+)NCBI
Sequence:
RefSeq Acc Id: NM_030565   ⟹   NP_085042
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm395138,740,836 - 138,795,818 (+)NCBI
GRCm385138,755,081 - 138,810,063 (+)NCBI
MGSCv375139,231,035 - 139,286,017 (+)RGD
Celera5135,807,755 - 135,865,362 (+)RGD
cM Map5 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_085042   ⟸   NM_030565
- Peptide Label: isoform 1
- UniProtKB: Q6PKA8 (UniProtKB/Swiss-Prot),   Q571A3 (UniProtKB/Swiss-Prot),   Q4FJP0 (UniProtKB/Swiss-Prot),   Q8JZP7 (UniProtKB/Swiss-Prot),   Q5MJS3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001346522   ⟸   NM_001359593
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000026972   ⟸   ENSMUST00000026972
RefSeq Acc Id: ENSMUSP00000124584   ⟸   ENSMUST00000160645

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5MJS3-F1-model_v2 AlphaFold Q5MJS3 1-579 view protein structure

Promoters
RGD ID:6888530
Promoter ID:EPDNEW_M7716
Type:multiple initiation site
Name:Fam20c_1
Description:Mus musculus family with sequence similarity 20, member C , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7717  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385138,755,082 - 138,755,142EPDNEW
RGD ID:6888532
Promoter ID:EPDNEW_M7717
Type:single initiation site
Name:Fam20c_2
Description:Mus musculus family with sequence similarity 20, member C , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M7716  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm385138,758,558 - 138,758,618EPDNEW
RGD ID:6836890
Promoter ID:MM_KWN:44572
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000094170,   OTTMUST00000075201,   OTTMUST00000075202
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv365139,229,881 - 139,232,142 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2136853 AgrOrtholog
Ensembl Genes ENSMUSG00000025854 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026972 ENTREZGENE
  ENSMUST00000026972.8 UniProtKB/Swiss-Prot
  ENSMUST00000160645.8 UniProtKB/TrEMBL
InterPro FAM20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAM20_C UniProtKB/Swiss-Prot
KEGG Report mmu:80752 UniProtKB/Swiss-Prot
MGD MGI:2136853 ENTREZGENE
NCBI Gene 80752 ENTREZGENE
PANTHER EXTRACELLULAR SERINE/THREONINE PROTEIN KINASE FAM20C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Fam20C UniProtKB/Swiss-Prot
PhenoGen Fam20c PhenoGen
PROSITE PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
UniProt E0CY01_MOUSE UniProtKB/TrEMBL
  FA20C_MOUSE UniProtKB/Swiss-Prot
  Q4FJP0 ENTREZGENE
  Q571A3 ENTREZGENE
  Q5MJS3 ENTREZGENE
  Q6PKA8 ENTREZGENE
  Q8JZP7 ENTREZGENE
UniProt Secondary Q4FJP0 UniProtKB/Swiss-Prot
  Q571A3 UniProtKB/Swiss-Prot
  Q6PKA8 UniProtKB/Swiss-Prot
  Q8JZP7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-11-03 Fam20c  FAM20C, golgi associated secretory pathway kinase  Fam20c  family with sequence similarity 20, member C  Symbol and/or name change 5135510 APPROVED