Mmp20 (matrix metallopeptidase 20 (enamelysin)) - Rat Genome Database

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Gene: Mmp20 (matrix metallopeptidase 20 (enamelysin)) Mus musculus
Analyze
Symbol: Mmp20
Name: matrix metallopeptidase 20 (enamelysin)
RGD ID: 1318676
MGI Page MGI
Description: Predicted to enable metalloendopeptidase activity. Acts upstream of or within amelogenesis; extracellular matrix disassembly; and protein catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in enamel organ; incisor; lower jaw molar; and upper jaw incisor. Used to study amelogenesis imperfecta hypomaturation type 2A2. Human ortholog(s) of this gene implicated in amelogenesis imperfecta hypomaturation type 2A2. Orthologous to human MMP20 (matrix metallopeptidase 20).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: enamel metalloproteinase; enamelysin; matrix metalloproteinase 20 (enamelysin); matrix metalloproteinase-20; MMP-20
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,628,232 - 7,674,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,628,232 - 7,674,980 (+)EnsemblGRCm39 Ensembl
GRCm3897,628,231 - 7,674,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,628,231 - 7,674,979 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,628,231 - 7,674,968 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,628,240 - 7,674,979 (+)NCBIMGSCv36mm8
Celera95,018,752 - 5,065,648 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. Mouse MP Annotation Import Pipeline RGD automated import pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10610728   PMID:10932192   PMID:10949577   PMID:11023266   PMID:12206593   PMID:12393861   PMID:12477932   PMID:15063736   PMID:15296943   PMID:15525533   PMID:15557396   PMID:15734845  
PMID:15748894   PMID:16113801   PMID:16674657   PMID:16674658   PMID:16998127   PMID:17364666   PMID:18714142   PMID:20147630   PMID:20487000   PMID:20665536   PMID:20929715   PMID:21144496  
PMID:21267068   PMID:21285247   PMID:21386097   PMID:21454549   PMID:21525715   PMID:21873635   PMID:22243238   PMID:22243247   PMID:22243248   PMID:22351765   PMID:22866057   PMID:23421805  
PMID:24067343   PMID:24072097   PMID:24466234   PMID:26513418   PMID:27066511   PMID:27403713   PMID:28174279   PMID:29535349   PMID:29684584   PMID:30149392   PMID:30929801   PMID:32674056  
PMID:33659251   PMID:34012043   PMID:34034544   PMID:37914726  


Genomics

Comparative Map Data
Mmp20
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,628,232 - 7,674,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,628,232 - 7,674,980 (+)EnsemblGRCm39 Ensembl
GRCm3897,628,231 - 7,674,968 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,628,231 - 7,674,979 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,628,231 - 7,674,968 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,628,240 - 7,674,979 (+)NCBIMGSCv36mm8
Celera95,018,752 - 5,065,648 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
MMP20
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,576,832 - 102,625,332 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,576,832 - 102,625,332 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,447,563 - 102,496,063 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611101,952,776 - 102,001,273 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411101,952,775 - 102,001,273NCBI
Celera1199,609,116 - 99,657,267 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,374,581 - 98,423,040 (-)NCBIHuRef
CHM1_111102,330,639 - 102,378,769 (-)NCBICHM1_1
T2T-CHM13v2.011102,579,028 - 102,627,492 (-)NCBIT2T-CHM13v2.0
Mmp20
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,074,279 - 13,114,894 (+)NCBIGRCr8
mRatBN7.284,789,415 - 4,830,035 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,789,415 - 4,830,035 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,748,991 - 8,789,552 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.087,046,772 - 7,087,333 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.085,049,092 - 5,089,708 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,823,147 - 5,875,555 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,833,359 - 5,875,232 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,826,487 - 5,877,399 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,467,263 - 4,507,865 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,467,232 - 4,507,654 (+)NCBI
Celera86,348,869 - 6,389,463 (+)NCBICelera
Cytogenetic Map8q11NCBI
Mmp20
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,815,450 - 5,869,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,815,450 - 5,869,016 (-)NCBIChiLan1.0ChiLan1.0
MMP20
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,369,818 - 103,419,591 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,459,433 - 104,507,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,518,573 - 97,566,881 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,011,084 - 101,059,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,011,084 - 101,059,322 (-)Ensemblpanpan1.1panPan2
MMP20
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,106,717 - 29,154,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,106,717 - 29,155,071 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha529,054,854 - 29,102,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,158,125 - 29,205,612 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,158,125 - 29,205,612 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,193,037 - 29,240,434 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,072,357 - 29,119,832 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,247,616 - 29,295,291 (+)NCBIUU_Cfam_GSD_1.0
Mmp20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,183,414 - 86,226,115 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,310,426 - 5,352,883 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,310,426 - 5,352,883 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP20
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,261,443 - 33,308,047 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,261,448 - 33,308,047 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,208,054 - 37,254,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP20
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1193,946,136 - 93,997,656 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl193,947,582 - 93,996,815 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,863,724 - 31,912,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp20
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878277,558 - 320,093 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878277,569 - 320,093 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp20
1743 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:443
Count of miRNA genes:327
Interacting mature miRNAs:364
Transcripts:ENSMUST00000034487
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902913Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130341840Mouse

Markers in Region
Mmp20  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,673,081 - 7,673,682UniSTSGRCm38
MGSCv3797,673,081 - 7,673,682UniSTSGRCm37
Celera95,063,761 - 5,064,362UniSTS
Cytogenetic Map9A1UniSTS
cM Map9 UniSTS
AV064505  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3897,669,529 - 7,669,618UniSTSGRCm38
MGSCv3797,669,529 - 7,669,618UniSTSGRCm37
Celera95,060,209 - 5,060,298UniSTS
Cytogenetic Map9A1UniSTS
Whitehead/MRC_RH991.94UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034487   ⟹   ENSMUSP00000034487
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl97,628,232 - 7,674,980 (+)Ensembl
GRCm38.p6 Ensembl97,628,231 - 7,674,979 (+)Ensembl
RefSeq Acc Id: NM_013903   ⟹   NP_038931
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3997,628,232 - 7,674,969 (+)NCBI
GRCm3897,628,231 - 7,674,968 (+)ENTREZGENE
MGSCv3797,628,231 - 7,674,968 (+)RGD
Celera95,018,752 - 5,065,648 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_038931   ⟸   NM_013903
- Peptide Label: preproprotein
- UniProtKB: A7MCV5 (UniProtKB/Swiss-Prot),   P57748 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034487   ⟸   ENSMUST00000034487

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P57748-F1-model_v2 AlphaFold P57748 1-482 view protein structure

Promoters
RGD ID:8668758
Promoter ID:EPDNEW_M12410
Type:single initiation site
Name:Mmp20_1
Description:Mus musculus matrix metallopeptidase 20 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3897,628,202 - 7,628,262EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1353466 AgrOrtholog
Ensembl Genes ENSMUSG00000018620 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034487 ENTREZGENE
  ENSMUST00000034487.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot
  3.40.390.10 UniProtKB/Swiss-Prot
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot
  Hemopexin-like_repeat UniProtKB/Swiss-Prot
  M10A_MMP UniProtKB/Swiss-Prot
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot
  Pept_M10A UniProtKB/Swiss-Prot
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot
  Peptidase_Metallo UniProtKB/Swiss-Prot
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot
  PGBD-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:30800 UniProtKB/Swiss-Prot
MGD MGI:1353466 ENTREZGENE
NCBI Gene 30800 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot
  PTHR10201:SF125 UniProtKB/Swiss-Prot
Pfam Hemopexin UniProtKB/Swiss-Prot
  Peptidase_M10 UniProtKB/Swiss-Prot
  PG_binding_1 UniProtKB/Swiss-Prot
PhenoGen Mmp20 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot
PRINTS MATRIXIN UniProtKB/Swiss-Prot
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot
  HEMOPEXIN_2 UniProtKB/Swiss-Prot
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot
  ZnMc UniProtKB/Swiss-Prot
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF47090 UniProtKB/Swiss-Prot
  SSF50923 UniProtKB/Swiss-Prot
UniProt A7MCV5 ENTREZGENE
  MMP20_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A7MCV5 UniProtKB/Swiss-Prot