Amtn (amelotin) - Rat Genome Database

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Pathways
Gene: Amtn (amelotin) Rattus norvegicus
Analyze
Symbol: Amtn
Name: amelotin
RGD ID: 1592356
Description: Involved in odontogenesis of dentin-containing tooth. Located in basement membrane and cell-cell junction. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 3B. Orthologous to human AMTN (amelotin); INTERACTS WITH 17beta-estradiol; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC689404
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,932,664 - 19,945,223 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1419,932,665 - 19,945,223 (-)EnsemblGRCr8
mRatBN7.21419,648,624 - 19,661,181 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,648,625 - 19,661,181 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1419,637,910 - 19,650,433 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,956,785 - 20,969,312 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,659,453 - 19,672,010 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,282,488 - 21,301,966 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,286,510 - 21,299,068 (-)Ensemblrn6Rnor6.0
Rnor_5.01421,199,165 - 21,211,724 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41421,231,281 - 21,243,840 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1418,985,029 - 18,997,588 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
basement membrane  (IBA,IDA,IEA,ISO)
cell-cell junction  (IBA,IDA,IEA,ISO)
extracellular matrix  (IDA,IEA,ISO)
extracellular region  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning of rat amelotin and localization of the protein to the basal lamina of maturation stage ameloblasts and junctional epithelium. Moffatt P, etal., Biochem J. 2006 Oct 1;399(1):37-46.
3. Identification of secreted and membrane proteins in the rat incisor enamel organ using a signal-trap screening approach. Moffatt P, etal., Eur J Oral Sci. 2006 May;114 Suppl 1:139-46; discussion 164-5, 380-1.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16304441   PMID:17143547   PMID:21154245   PMID:25407797  


Genomics

Comparative Map Data
Amtn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81419,932,664 - 19,945,223 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1419,932,665 - 19,945,223 (-)EnsemblGRCr8
mRatBN7.21419,648,624 - 19,661,181 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1419,648,625 - 19,661,181 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1419,637,910 - 19,650,433 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01420,956,785 - 20,969,312 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01419,659,453 - 19,672,010 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01421,282,488 - 21,301,966 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1421,286,510 - 21,299,068 (-)Ensemblrn6Rnor6.0
Rnor_5.01421,199,165 - 21,211,724 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41421,231,281 - 21,243,840 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1418,985,029 - 18,997,588 (-)NCBICelera
Cytogenetic Map14p22NCBI
AMTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38470,518,569 - 70,532,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl470,518,569 - 70,532,743 (+)Ensemblhg38GRCh38
GRCh37471,384,286 - 71,398,460 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36471,418,887 - 71,433,048 (+)NCBIBuild 36Build 36hg18NCBI36
Celera468,742,456 - 68,756,611 (+)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef467,186,745 - 67,200,947 (+)NCBIHuRef
CHM1_1471,420,321 - 71,434,469 (+)NCBICHM1_1
T2T-CHM13v2.0473,859,546 - 73,873,706 (+)NCBIT2T-CHM13v2.0
Amtn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39588,523,967 - 88,533,775 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl588,523,967 - 88,533,775 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38588,376,108 - 88,385,916 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl588,376,108 - 88,385,916 (+)Ensemblmm10GRCm38
MGSCv37588,805,133 - 88,814,941 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36589,450,669 - 89,460,477 (+)NCBIMGSCv36mm8
Celera586,527,988 - 86,537,811 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map543.56NCBI
Amtn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554472,423,136 - 2,433,150 (-)Ensembl
ChiLan1.0NW_0049554472,422,189 - 2,433,633 (-)NCBIChiLan1.0ChiLan1.0
AMTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2359,552,262 - 59,566,420 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1459,747,310 - 59,761,467 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0453,691,674 - 53,705,831 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1460,036,818 - 60,050,965 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl460,036,818 - 60,050,965 (-)EnsemblpanPan2panpan1.1
AMTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11359,855,278 - 59,867,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1359,852,490 - 59,867,516 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1359,589,466 - 59,601,272 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01360,661,869 - 60,673,675 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1360,659,061 - 60,673,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11360,276,328 - 60,288,126 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01359,767,889 - 59,779,694 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01360,914,773 - 60,926,557 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Amtn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528515,752,086 - 15,763,534 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365984,203,255 - 4,215,567 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365984,204,094 - 4,210,492 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AMTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl867,312,972 - 67,326,730 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1867,312,108 - 67,327,775 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2871,220,759 - 71,234,938 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AMTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1718,982,101 - 19,041,207 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660843,844,544 - 3,856,990 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Amtn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248901,875,456 - 1,936,427 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Amtn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1111,898,640 - 1,911,219 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Amtn
121 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:153
Interacting mature miRNAs:174
Transcripts:ENSRNOT00000065315, ENSRNOT00000065778
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat

Markers in Region
D14Got30  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81419,933,042 - 19,933,322 (+)Marker Load Pipeline
mRatBN7.21419,649,002 - 19,649,280 (+)MAPPERmRatBN7.2
Rnor_6.01421,286,888 - 21,287,167NCBIRnor6.0
Rnor_5.01421,199,544 - 21,199,823UniSTSRnor5.0
RGSC_v3.41421,231,660 - 21,231,939UniSTSRGSC3.4
RGSC_v3.41421,231,659 - 21,231,939RGDRGSC3.4
Celera1418,985,408 - 18,985,687UniSTS
RGSC_v3.11421,231,660 - 21,231,939RGD
RH 3.4 Map14296.2RGD
RH 3.4 Map14296.2UniSTS
Cytogenetic Map14p21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 6 10 37 42 42 11 32 11 3 94 60 4 22 11 44 31 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000065778   ⟹   ENSRNOP00000058805
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1419,932,665 - 19,945,223 (-)Ensembl
mRatBN7.2 Ensembl1419,648,625 - 19,661,181 (-)Ensembl
Rnor_6.0 Ensembl1421,286,510 - 21,299,068 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118895   ⟹   ENSRNOP00000094485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1419,933,386 - 19,943,966 (-)Ensembl
mRatBN7.2 Ensembl1419,649,344 - 19,659,924 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000135096   ⟹   ENSRNOP00000102595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1419,932,665 - 19,945,223 (-)Ensembl
RefSeq Acc Id: NM_001044296   ⟹   NP_001037761
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81419,932,664 - 19,945,223 (-)NCBI
mRatBN7.21419,648,624 - 19,661,181 (-)NCBI
Rnor_6.01421,286,509 - 21,299,068 (-)NCBI
Rnor_5.01421,199,165 - 21,211,724 (-)NCBI
RGSC_v3.41421,231,281 - 21,243,840 (-)RGD
Celera1418,985,029 - 18,997,588 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599383   ⟹   XP_017454872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81419,932,664 - 19,945,114 (-)NCBI
mRatBN7.21419,648,624 - 19,661,062 (-)NCBI
Rnor_6.01421,282,488 - 21,301,966 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001037761 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454872 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABA54405 (Get FASTA)   NCBI Sequence Viewer  
  CAJ77764 (Get FASTA)   NCBI Sequence Viewer  
  EDL88510 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058805
  ENSRNOP00000058805.2
GenBank Protein Q3HS82 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001037761   ⟸   NM_001044296
- Peptide Label: precursor
- UniProtKB: Q3HS82 (UniProtKB/Swiss-Prot),   A6KKK0 (UniProtKB/TrEMBL),   A0A8I6AL31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454872   ⟸   XM_017599383
- Peptide Label: isoform X1
- UniProtKB: Q3HS82 (UniProtKB/Swiss-Prot),   A6KKK0 (UniProtKB/TrEMBL),   A0A8I6AL31 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058805   ⟸   ENSRNOT00000065778
Ensembl Acc Id: ENSRNOP00000094485   ⟸   ENSRNOT00000118895
Ensembl Acc Id: ENSRNOP00000102595   ⟸   ENSRNOT00000135096

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3HS82-F1-model_v2 AlphaFold Q3HS82 1-212 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592356 AgrOrtholog
BioCyc Gene G2FUF-16154 BioCyc
Ensembl Genes ENSRNOG00000003776 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065778 ENTREZGENE
  ENSRNOT00000065778.4 UniProtKB/Swiss-Prot
InterPro Amelotin UniProtKB/Swiss-Prot
KEGG Report rno:689404 UniProtKB/Swiss-Prot
NCBI Gene 689404 ENTREZGENE
PANTHER AMELOTIN UniProtKB/Swiss-Prot
  PTHR36858 UniProtKB/Swiss-Prot
Pfam Amelotin UniProtKB/Swiss-Prot
PhenoGen Amtn PhenoGen
RatGTEx ENSRNOG00000003776 RatGTEx
UniProt A0A8I6AL31 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L1Z8_RAT UniProtKB/TrEMBL
  A6KKK0 ENTREZGENE, UniProtKB/TrEMBL
  AMTN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Amtn  amelotin  LOC689404  amelotin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689404  amelotin  LOC686338  similar to Protein UNQ689/PRO1329 homolog precursor  Data merged from RGD:1583165 1643240 APPROVED
2006-11-20 LOC689404  amelotin      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC686338  similar to Protein UNQ689/PRO1329 homolog precursor      Symbol and Name status set to provisional 70820 PROVISIONAL