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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:insulin-like growth factor signaling pathway
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Accession:PW:0000238 term browser browse the term
Definition:Insulin-like growth factor signaling plays important roles in cell growth and proliferation. Produced primarily by the liver in response to stimulation by growth hormone (GH), the proteins activate cognate receptors to prompt intracellular signaling pathways and cell growth in a variety of tissues. Deregulation of the pathway has been associated with various conditions, including cancer.
Synonyms:related_synonym: insulin-like growth factor receptor signaling pathway


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insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200100 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO PID PID:200100 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member ISO PID PID:200100 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO PID PID:200100 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein ISO PID PID:200100 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238 		JBrowse link
G Esr1 estrogen receptor 1 IDA RGD PMID:20042609 RGD:7242068 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Grb10 growth factor receptor bound protein 10 ISO PID PID:200100 NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IMP
ISO		 PID
RGD		 PMID:15272025 PID:200100, RGD:1581313 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200100 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Igf1 insulin-like growth factor 1 IDA
ISO		 PID
RGD		 PMID:16083987 PMID:7526037 PMID:15862547 PID:200100, RGD:1580473, RGD:12904768, RGD:1626333 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor IMP
IDA
ISO		 PID
RGD		 PMID:15272025 PMID:20042609 PMID:15862547 PID:200100, RGD:1581313, RGD:7242068, RGD:1626333 NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO RGD PMID:15862547 RGD:1626333 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit ISO RGD PMID:15862547 RGD:1626333 NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 ISO RGD PMID:15862547 RGD:1626333 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 ISO RGD PMID:15862547 RGD:1626333 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO RGD PMID:15862547 RGD:1626333 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083 		JBrowse link
G Igfbp4 insulin-like growth factor binding protein 4 ISO RGD PMID:15862547 RGD:1626333 NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225 		JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 ISO RGD PMID:15862547 RGD:1626333 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156 		JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 ISO RGD PMID:15862547 RGD:1626333 NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966 		JBrowse link
G Irs1 insulin receptor substrate 1 IMP
ISO		 PID
RGD		 PMID:15272025 PID:200100, RGD:1581313 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO PID PID:200100 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Irs4 insulin receptor substrate 4 NAS RGD PMID:17720279 RGD:2301084 NCBI chr  X:105,344,020...105,360,004 JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200100 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200100 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200100 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200100 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Prkcd protein kinase C, delta ISO PID PID:200100 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkcz protein kinase C, zeta ISO PID PID:200100 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Prkd1 protein kinase D1 ISO PID PID:200100 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO PID PID:200100 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200100 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Pxn paxillin ISO PID PID:200100 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO PID PID:200100 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200100 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO PID PID:200100 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200100 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200100 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Wdr6 WD repeat domain 6 NAS RGD PMID:17720279 RGD:2301084 NCBI chr 8:109,268,079...109,274,504
Ensembl chr 8:109,268,079...109,274,499 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO PID PID:200100 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta ISO PID PID:200100 NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668 		JBrowse link
altered insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin-like growth factor 1 IEP RGD PMID:15996002 RGD:1580474 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      growth factor signaling pathway 523
        insulin-like growth factor signaling pathway 40
          altered insulin-like growth factor signaling pathway 1
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          insulin-like growth factor signaling pathway 40
            altered insulin-like growth factor signaling pathway 1
paths to the root