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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:G protein mediated signaling pathway via Galphas family
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Accession:PW:0000227 term browser browse the term
Definition:Based on sequence similarity, the Galpha genes have been grouped into four classes. Exchange of GDP to GTP promoted through binding to receptors dissociates the heterotrimeric Galpa/beta/gamma complex. GTP-bound Galpha can then interact with downstream effectors. Lipid modification of Galpha regulates membrane localization and interactions with specific effectors.


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G protein mediated signaling pathway via Galphas family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 ISO RGD PMID:18948702 RGD:2312469 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Adcy2 adenylate cyclase 2 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236 		JBrowse link
G Adcy3 adenylate cyclase 3 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686 		JBrowse link
G Adcy4 adenylate cyclase 4 ISO RGD PMID:18948702 RGD:2312469 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108 		JBrowse link
G Adcy5 adenylate cyclase 5 ISO
IDA		 RGD PMID:18948702 PMID:17010343 PMID:26468202 RGD:2312469, RGD:2315004, RGD:11041137 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adcy6 adenylate cyclase 6 ISO
IDA		 RGD PMID:18948702 PMID:15579502 PMID:17010343 RGD:2312469, RGD:2313211, RGD:2315004 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Adcy7 adenylate cyclase 7 ISO RGD PMID:18948702 RGD:2312469 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311 		JBrowse link
G Adcy8 adenylate cyclase 8 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Adcy9 adenylate cyclase 9 ISO RGD PMID:18948702 RGD:2312469 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
G Adrb1 adrenoceptor beta 1 TAS RGD PMID:10577992 RGD:1559319 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 TAS RGD PMID:10577992 RGD:1559319 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 ISO RGD PMID:8011597 RGD:1559323 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B IDA RGD PMID:19047484 RGD:2312649 NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Avpr2 arginine vasopressin receptor 2 ISO RGD PMID:14624682 RGD:1579891 NCBI chr  X:151,633,501...151,636,155
Ensembl chr  X:151,633,522...151,635,989 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:16484629 RGD:5147387 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:16484629 RGD:5147387 NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904 		JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:21303898 RGD:11041134 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:21303898 RGD:11041134 NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774 		JBrowse link
G Gcgr glucagon receptor IDA RGD PMID:17010343 RGD:2315004 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640 		JBrowse link
G Gnal G protein subunit alpha L ISO RGD PMID:24144882 RGD:11041135 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599 		JBrowse link
G Gnas GNAS complex locus IDA
ISO
IMP		 RGD PMID:15297467 PMID:18948702 PMID:14624682 PMID:15579502 PMID:15687107 More... RGD:1580407, RGD:2312469, RGD:1579891, RGD:2313211, RGD:1625210, RGD:2315004 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO RGD PMID:19767412 RGD:5128698 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 TAS RGD PMID:1403099 RGD:632163 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 TAS RGD PMID:1403099 RGD:632163 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor IDA RGD PMID:8440169 RGD:2292602 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Mc1r melanocortin 1 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr19:51,452,448...51,455,375
Ensembl chr19:51,453,239...51,454,192 		JBrowse link
G Mc2r melanocortin 2 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488 		JBrowse link
G Mc3r melanocortin 3 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr 3:161,016,347...161,017,444
Ensembl chr 3:161,016,347...161,017,444 		JBrowse link
G Mc4r melanocortin 4 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719 		JBrowse link
G Mc5r melanocortin 5 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:61,915,188...61,920,229
Ensembl chr18:61,915,188...61,920,229 		JBrowse link
G Pth1r parathyroid hormone 1 receptor ISO RGD PMID:21777186 PMID:19395963 RGD:7207465, RGD:7207470 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs7 regulator of G-protein signaling 7 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:86,979,269...87,408,834
Ensembl chr13:86,979,279...87,408,888 		JBrowse link
G Rgs7bp regulator of G-protein signaling 7 binding protein ISO RGD PMID:21303898 RGD:11041134 NCBI chr 2:36,133,944...36,231,505
Ensembl chr 2:36,139,201...36,231,505 		JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO RGD PMID:21303898 RGD:11041134 NCBI chr10:94,195,265...94,270,892
Ensembl chr10:94,197,054...94,270,892 		JBrowse link
G Snx13 sorting nexin 13 ISO RGD PMID:17173929 RGD:4140388 NCBI chr 6:51,758,258...51,862,260
Ensembl chr 6:51,753,036...51,860,224 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2634
      G protein mediated signaling pathway 160
        heterotrimeric G protein mediated signaling pathway 78
          G protein mediated signaling pathway via Galphas family 37
paths to the root