RGD Reference Report - The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. - Rat Genome Database

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The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.

Authors: Arriza, JL  Dawson, TM  Simerly, RB  Martin, LJ  Caron, MG  Snyder, SH  Lefkowitz, RJ 
Citation: Arriza JL, etal., J Neurosci 1992 Oct;12(10):4045-55.
RGD ID: 632163
Pubmed: PMID:1403099   (View Abstract at PubMed)
PMCID: PMC6575981   (View Article at PubMed Central)

The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated receptor desensitization may reflect a general molecular mechanism operative on many G-protein-coupled receptor systems and, particularly, synaptic neurotransmitter receptors. Two distinct cDNAs encoding beta ARK isozymes were isolated from rat brain and sequenced. The regional and cellular distributions of these two gene products, termed beta ARK1 and beta ARK2, were determined in brain by in situ hybridization and by immunohistochemistry at the light and electron microscopic levels. The beta ARK isozymes were found to be expressed primarily in neurons distributed throughout the CNS. Ultrastructurally, beta ARK1 and beta ARK2 immunoreactivities were present both in association with postsynaptic densities and, presynaptically, with axon terminals. The beta ARK isozymes have a regional and subcellular distribution consistent with a general role in the desensitization of synaptic receptors.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Grk2Ratprotein modification process  IDA phosphorylationRGD 
Grk3Ratprotein modification process  IDA phosphorylationRGD 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Grk2Rataxon terminus  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk3Rataxon terminus  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk2Ratdendritic shaft  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk3Ratdendritic shaft  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk2Ratdendritic spine  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk3Ratdendritic spine  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk2Ratglutamatergic synapse is_active_inIDA PMID:1403099SynGO 
Grk3Ratglutamatergic synapse is_active_inIDA PMID:1403099SynGO 
Grk2Ratneuronal cell body  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk3Ratneuronal cell body  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk2Ratpostsynaptic density is_active_inIDA PMID:1403099SynGO 
Grk2Ratpostsynaptic density  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk3Ratpostsynaptic density is_active_inIDA PMID:1403099SynGO 
Grk3Ratpostsynaptic density  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk2Ratpresynapse is_active_inIDA PMID:1403099SynGO 
Grk2Ratpresynapse  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 
Grk3Ratpresynapse is_active_inIDA PMID:1403099SynGO 
Grk3Ratpresynapse  IDA MMO:0000538 ex vivo light microscopy with immunohistochemistryRGD 

Molecular Function

  

Objects Annotated

Genes (Rattus norvegicus)
Grk2  (G protein-coupled receptor kinase 2)
Grk3  (G protein-coupled receptor kinase 3)

Objects referenced in this article
Gene GRK2 G protein-coupled receptor kinase 2 Homo sapiens
Gene GRK3 G protein-coupled receptor kinase 3 Homo sapiens
Gene Grk2 G protein-coupled receptor kinase 2 Mus musculus
Gene Grk3 G protein-coupled receptor kinase 3 Mus musculus

Additional Information