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Gene: Mc1r (melanocortin 1 receptor) Rattus norvegicus

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Symbol:

Mc1r

Name:

melanocortin 1 receptor

RGD ID:

1312046

Description:

Enables hormone binding activity and melanocortin receptor activity. Involved in positive regulation of feeding behavior. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; INTERACTS WITH acrolein; thioacetamide; (-)-epigallocatechin 3-gallate (ortholog).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AC132057.1; alpha melanocyte stimulating hormone receptor; LOC292083; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocyte-stimulating hormone receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	68,360,950 - 68,363,877 (+)	NCBI		GRCr8
mRatBN7.2	19	51,452,448 - 51,455,375 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	51,453,239 - 51,454,192 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	58,246,649 - 58,249,576 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,924,137 - 58,927,064 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	61,145,249 - 61,148,176 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	56,215,420 - 56,219,987 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	56,216,812 - 56,217,766 (+)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	66,926,656 - 66,929,094 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.1	19	53,743,365 - 53,744,540 (+)	NCBI
Celera	19	50,684,385 - 50,688,952 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	Acute-Phase Reaction		IEP		6484138	mRNA:increased expression:liver (rat)	RGD
Mc1r	Rat	allergic contact dermatitis		ISO	RGD:1323827	5687319		RGD
Mc1r	Rat	atopic dermatitis		ISO	RGD:1323827	5687321	protein: increased expression: skin	RGD
Mc1r	Rat	bacterial pneumonia		ISO	RGD:1323827	5687324		RGD
Mc1r	Rat	colitis		ISO	RGD:1323827	5687320		RGD
Mc1r	Rat	Experimental Melanoma		ISO	RGD:1323827	5687319		RGD
Mc1r	Rat	Hyperoxia		ISO	RGD:1323827	6484136	mRNA:increased expression:lung (mouse)	RGD
Mc1r	Rat	Hypopigmentation		ISO	RGD:1323826	1600618	DNA:missense mutations,insertions:cds:multiple	RGD
Mc1r	Rat	Kidney Reperfusion Injury		IEP		5687322	protein:decreased expression:kidney outer medulla	RGD
Mc1r	Rat	major depressive disorder		ISO	RGD:1323826	5687198	DNA:SNP:cds: rs885479,R163Q	RGD
Mc1r	Rat	melanoma		ISO	RGD:1323826	6484659	DNA:missense mutations:cds:multiple (human)	RGD
Mc1r	Rat	melanoma		ISO	RGD:1323826	1600619	DNA:missense mutations:cds:multiple (human)	RGD
Mc1r	Rat	Reperfusion Injury	no_association	ISO	RGD:1323827	5687323		RGD
Mc1r	Rat	Seasonal Allergic Rhinitis	no_association	ISO	RGD:1323827	5687317		RGD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	age related macular degeneration 7		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Macular degeneration, age-related, neovascular type	ClinVar
Mc1r	Rat	autosomal recessive chronic granulomatous disease 4		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative	ClinVar	PMID:28492532
Mc1r	Rat	bilateral breast cancer		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: bilateral breast cancer	ClinVar	PMID:16809487\|PMID:16982779\|PMID:24335900\|PMID:24982914\|PMID:25741868\|PMID:28492532
Mc1r	Rat	breast cancer		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Malignant breast neoplasm	ClinVar	PMID:10631149\|PMID:12876664\|PMID:15994880\|PMID:16601669\|PMID:17616515\|PMID:17952075\|PMID:18366057\|PMID:19320745\|PMID:19585506\|PMID:19710684\|PMID:21128237\|PMID:24439955\|PMID:25631192\|PMID:25741868\|PMID:26389780\|PMID:26389967\|PMID:28492532\|PMID:9302268\|PMID:9665397
Mc1r	Rat	familial melanoma		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Cutaneous malignant melanoma 5 \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:10403794\|PMID:10631149\|PMID:10733465\|PMID:10816645\|PMID:11030758\|PMID:11254446\|PMID:11487574\|PMID:11511307\|PMID:11707265\|PMID:11933208\|PMID:12687585\|PMID:12839583\|PMID:12851329\|PMID:12876664\|PMID:14757863\|PMID:14961558\|PMID:14975928\|PMID:15221796\|PMID:15957185\|PMID:15979202\|PMID:15994880\|PMID:15998953\|PMID:16172233\|PMID:16280005\|PMID:16309897\|PMID:16463023\|PMID:16567973\|PMID:16595073\|PMID:16601669\|PMID:16645598\|PMID:16809487\|PMID:16982779\|PMID:16988943\|PMID:17072629\|PMID:17279550\|PMID:17316231\|PMID:17434924\|PMID:17496785\|PMID:17616515\|PMID:17952075\|PMID:18067130\|PMID:18366057\|PMID:18402696\|PMID:18795926\|PMID:18803811\|PMID:18839200\|PMID:18983535\|PMID:19194882\|PMID:19269164\|PMID:19320745\|PMID:19338054\|PMID:19493000\|PMID:19585506\|PMID:19656326\|PMID:19710684\|PMID:19799798\|PMID:19924138\|PMID:20043015\|PMID:20158590\|PMID:20457063\|PMID:20629734\|PMID:20876876\|PMID:21128237\|PMID:21430882\|PMID:21672182\|PMID:21749400\|PMID:22079958\|PMID:22095472\|PMID:22095742\|PMID:22493355\|PMID:22547573\|PMID:22854540\|PMID:22978401\|PMID:23312576\|PMID:23360207\|PMID:23384855\|PMID:23522749\|PMID:23647022\|PMID:23711066\|PMID:24033266\|PMID:24045876\|PMID:24238329\|PMID:24335900\|PMID:24439955\|PMID:24617981\|PMID:24660985\|PMID:24982914\|PMID:25268584\|PMID:25284244\|PMID:25631192\|PMID:25736238\|PMID:25741868\|PMID:25794181\|PMID:26103569\|PMID:26197705\|PMID:26389780\|PMID:26389967\|PMID:26800492\|PMID:27084066\|PMID:27229376\|PMID:27473757\|PMID:28242083\|PMID:28492532\|PMID:28869973\|PMID:29340229\|PMID:31382929\|PMID:7581459\|PMID:8605020\|PMID:8894704\|PMID:8944016\|PMID:8990005\|PMID:9032047\|PMID:9302268\|PMID:9571181\|PMID:9665397
Mc1r	Rat	familial melanoma		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Cutaneous malignant melanoma 5 \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:10403794\|PMID:10631149\|PMID:10733465\|PMID:10816645\|PMID:11030758\|PMID:11254446\|PMID:11487574\|PMID:11511307\|PMID:11707265\|PMID:11933208\|PMID:12687585\|PMID:12839583\|PMID:12851329\|PMID:12876664\|PMID:14757863\|PMID:14961558\|PMID:14975928\|PMID:15221796\|PMID:15957185\|PMID:15979202\|PMID:15994880\|PMID:15998953\|PMID:16172233\|PMID:16280005\|PMID:16309897\|PMID:16463023\|PMID:16567973\|PMID:16595073\|PMID:16601669\|PMID:16645598\|PMID:16809487\|PMID:16982779\|PMID:16988943\|PMID:17072629\|PMID:17279550\|PMID:17316231\|PMID:17434924\|PMID:17496785\|PMID:17616515\|PMID:17952075\|PMID:18067130\|PMID:18366057\|PMID:18402696\|PMID:18795926\|PMID:18803811\|PMID:18839200\|PMID:18983535\|PMID:19194882\|PMID:19269164\|PMID:19320745\|PMID:19338054\|PMID:19493000\|PMID:19585506\|PMID:19656326\|PMID:19710684\|PMID:19799798\|PMID:19924138\|PMID:20043015\|PMID:20158590\|PMID:20457063\|PMID:20629734\|PMID:20876876\|PMID:21128237\|PMID:21672182\|PMID:21749400\|PMID:22079958\|PMID:22095472\|PMID:22095742\|PMID:22493355\|PMID:22547573\|PMID:22854540\|PMID:22978401\|PMID:23312576\|PMID:23360207\|PMID:23384855\|PMID:23522749\|PMID:23647022\|PMID:23711066\|PMID:24033266\|PMID:24045876\|PMID:24238329\|PMID:24335900\|PMID:24439955\|PMID:24617981\|PMID:24982914\|PMID:25268584\|PMID:25284244\|PMID:25631192\|PMID:25736238\|PMID:25741868\|PMID:25794181\|PMID:26103569\|PMID:26197705\|PMID:26389967\|PMID:26546047\|PMID:26800492\|PMID:27084066\|PMID:27229376\|PMID:27473757\|PMID:28166811\|PMID:28242083\|PMID:28492532\|PMID:28869973\|PMID:29340229\|PMID:31382929\|PMID:7581459\|PMID:8894704\|PMID:8944016\|PMID:8990005\|PMID:9032047\|PMID:9302268\|PMID:9571181\|PMID:9665397
Mc1r	Rat	familial melanoma		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Cutaneous malignant melanoma 5 \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:10403794\|PMID:10631149\|PMID:10733465\|PMID:10816645\|PMID:11030758\|PMID:11254446\|PMID:11487574\|PMID:11511307\|PMID:11707265\|PMID:11933208\|PMID:12687585\|PMID:12839583\|PMID:12851329\|PMID:12876664\|PMID:14757863\|PMID:14961558\|PMID:14975928\|PMID:15221796\|PMID:15957185\|PMID:15979202\|PMID:15994880\|PMID:15998953\|PMID:16172233\|PMID:16280005\|PMID:16309897\|PMID:16463023\|PMID:16567973\|PMID:16595073\|PMID:16601669\|PMID:16645598\|PMID:16809487\|PMID:16982779\|PMID:16988943\|PMID:17072629\|PMID:17279550\|PMID:17316231\|PMID:17434924\|PMID:17496785\|PMID:17616515\|PMID:17952075\|PMID:18067130\|PMID:18366057\|PMID:18402696\|PMID:18795926\|PMID:18803811\|PMID:18839200\|PMID:18983535\|PMID:19194882\|PMID:19269164\|PMID:19320745\|PMID:19338054\|PMID:19493000\|PMID:19585506\|PMID:19656326\|PMID:19710684\|PMID:19799798\|PMID:19924138\|PMID:20043015\|PMID:20158590\|PMID:20457063\|PMID:20629734\|PMID:20876876\|PMID:21128237\|PMID:21430882\|PMID:21672182\|PMID:21749400\|PMID:22079958\|PMID:22095472\|PMID:22095742\|PMID:22493355\|PMID:22547573\|PMID:22854540\|PMID:22978401\|PMID:23312576\|PMID:23360207\|PMID:23522749\|PMID:23647022\|PMID:24033266\|PMID:24045876\|PMID:24238329\|PMID:24335900\|PMID:24439955\|PMID:24617981\|PMID:24982914\|PMID:25268584\|PMID:25284244\|PMID:25631192\|PMID:25736238\|PMID:25741868\|PMID:25794181\|PMID:26103569\|PMID:26197705\|PMID:26389967\|PMID:26800492\|PMID:27084066\|PMID:27473757\|PMID:28166811\|PMID:28242083\|PMID:28492532\|PMID:28869973\|PMID:29340229\|PMID:31382929\|PMID:7581459\|PMID:8894704\|PMID:8944016\|PMID:8990005\|PMID:9032047\|PMID:9302268\|PMID:9571181\|PMID:9665397
Mc1r	Rat	familial melanoma		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Cutaneous malignant melanoma 5 \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:10403794\|PMID:10631149\|PMID:10733465\|PMID:10816645\|PMID:11030758\|PMID:11254446\|PMID:11487574\|PMID:11511307\|PMID:11707265\|PMID:11933208\|PMID:12687585\|PMID:12839583\|PMID:12851329\|PMID:12876664\|PMID:14757863\|PMID:14961558\|PMID:14975928\|PMID:15221796\|PMID:15957185\|PMID:15979202\|PMID:15994880\|PMID:15998953\|PMID:16172233\|PMID:16280005\|PMID:16309897\|PMID:16463023\|PMID:16567973\|PMID:16595073\|PMID:16601669\|PMID:16645598\|PMID:16809487\|PMID:16982779\|PMID:16988943\|PMID:17072629\|PMID:17279550\|PMID:17316231\|PMID:17434924\|PMID:17496785\|PMID:17616515\|PMID:17952075\|PMID:18067130\|PMID:18366057\|PMID:18402696\|PMID:18795926\|PMID:18803811\|PMID:18839200\|PMID:18983535\|PMID:19194882\|PMID:19269164\|PMID:19320745\|PMID:19338054\|PMID:19493000\|PMID:19585506\|PMID:19656326\|PMID:19710684\|PMID:19799798\|PMID:19924138\|PMID:20043015\|PMID:20158590\|PMID:20457063\|PMID:20629734\|PMID:20876876\|PMID:21128237\|PMID:21430882\|PMID:21672182\|PMID:21749400\|PMID:22079958\|PMID:22095472\|PMID:22095742\|PMID:22464597\|PMID:22493355\|PMID:22547573\|PMID:22854540\|PMID:22978401\|PMID:23312576\|PMID:23360207\|PMID:23384855\|PMID:23522749\|PMID:23647022\|PMID:23711066\|PMID:24033266\|PMID:24045876\|PMID:24238329\|PMID:24335900\|PMID:24439955\|PMID:24617981\|PMID:24660985\|PMID:24982914\|PMID:25268584\|PMID:25284244\|PMID:25631192\|PMID:25736238\|PMID:25741868\|PMID:25794181\|PMID:26103569\|PMID:26197705\|PMID:26389780\|PMID:26389967\|PMID:26800492\|PMID:27084066\|PMID:27229376\|PMID:27473757\|PMID:28242083\|PMID:28360400\|PMID:28492532\|PMID:28869973\|PMID:29340229\|PMID:31382929\|PMID:34326492\|PMID:7581459\|PMID:8605020\|PMID:8894704\|PMID:8944016\|PMID:8990005\|PMID:9032047\|PMID:9302268\|PMID:9571181\|PMID:9665397
Mc1r	Rat	Fanconi anemia		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Fanconi anemia	ClinVar	PMID:19367192\|PMID:28492532\|PMID:29098742\|PMID:9721219
Mc1r	Rat	KBG syndrome		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: KBG syndrome	ClinVar	PMID:28492532\|PMID:31602316
Mc1r	Rat	melanoma		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Malignant Melanoma Susceptibility \| ClinVar Annotator: match by term: Melanoma	ClinVar	PMID:16809487\|PMID:16982779\|PMID:17616515\|PMID:18366057\|PMID:19799798\|PMID:21128237\|PMID:23647022\|PMID:24033266\|PMID:25741868\|PMID:26103569\|PMID:26197705\|PMID:28492532\|PMID:7581459
Mc1r	Rat	oculocutaneous albinism type II		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: ALBINISM, OCULOCUTANEOUS, TYPE II, MODIFIER OF \| ClinVar Annotator: match more ...	ClinVar	PMID:10631149\|PMID:11030758\|PMID:11487574\|PMID:11511307\|PMID:11933208\|PMID:12839583\|PMID:12851329\|PMID:12876664\|PMID:14961558\|PMID:14975928\|PMID:15221796\|PMID:15979202\|PMID:15994880\|PMID:15998953\|PMID:16280005\|PMID:16463023\|PMID:16567973\|PMID:16595073\|PMID:16601669\|PMID:16645598\|PMID:16809487\|PMID:16982779\|PMID:16988943\|PMID:17072629\|PMID:17316231\|PMID:17434924\|PMID:17496785\|PMID:17616515\|PMID:17952075\|PMID:18067130\|PMID:18366057\|PMID:18402696\|PMID:18795926\|PMID:18983535\|PMID:19194882\|PMID:19269164\|PMID:19320745\|PMID:19338054\|PMID:19493000\|PMID:19585506\|PMID:19710684\|PMID:19799798\|PMID:20629734\|PMID:20876876\|PMID:21128237\|PMID:21749400\|PMID:22095472\|PMID:22464597\|PMID:22547573\|PMID:22978401\|PMID:23312576\|PMID:23360207\|PMID:23522749\|PMID:23647022\|PMID:24033266\|PMID:24335900\|PMID:24439955\|PMID:24617981\|PMID:24982914\|PMID:25284244\|PMID:25631192\|PMID:25741868\|PMID:26103569\|PMID:26197705\|PMID:26389780\|PMID:26389967\|PMID:28242083\|PMID:28492532\|PMID:31382929\|PMID:34326492\|PMID:7581459\|PMID:9032047\|PMID:9302268\|PMID:9571181\|PMID:9665397
Mc1r	Rat	primary ciliary dyskinesia 33		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: Primary ciliary dyskinesia 33	ClinVar	PMID:28492532
Mc1r	Rat	SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: RED HAIR COLOR \| ClinVar Annotator: match by term: Skin/hair/eye more ...	ClinVar	PMID:10631149\|PMID:11933208\|PMID:12839583\|PMID:12851329\|PMID:14961558\|PMID:15979202\|PMID:16280005\|PMID:16595073\|PMID:16601669\|PMID:16809487\|PMID:16988943\|PMID:17072629\|PMID:17434924\|PMID:17616515\|PMID:18067130\|PMID:18402696\|PMID:19320745\|PMID:19493000\|PMID:19585506\|PMID:19710684\|PMID:20876876\|PMID:21128237\|PMID:22547573\|PMID:23522749\|PMID:23647022\|PMID:24335900\|PMID:24617981\|PMID:24982914\|PMID:25741868\|PMID:26197705\|PMID:28242083\|PMID:28492532\|PMID:9302268
Mc1r	Rat	UV-Induced Skin Damage		ISO	RGD:1323826	8554872	ClinVar Annotator: match by term: UV-induced skin damage, susceptibility to	ClinVar	PMID:16463023\|PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	basal cell carcinoma		ISO	RGD:1323826	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:18539553
Mc1r	Rat	Hyperalgesia		ISO	RGD:1323826	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19996949
Mc1r	Rat	melanoma		ISO	RGD:1323826	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:19578364\|PMID:21559390\|PMID:21983785
Mc1r	Rat	oculocutaneous albinism type II		ISO	RGD:1323826	11554173	CTD Direct Evidence: marker/mechanism	CTD
Mc1r	Rat	skin melanoma		ISO	RGD:1323826	11554173	CTD Direct Evidence: marker/mechanism	CTD
Mc1r	Rat	vitiligo		ISO	RGD:1323826	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:22561518

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	familial melanoma		ISO	RGD:1323826	7240710		OMIM
Mc1r	Rat	oculocutaneous albinism type II		ISO	RGD:1323826	7240710		OMIM
Mc1r	Rat	SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2		ISO	RGD:1323826	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	(-)-epigallocatechin 3-gallate	decreases expression	ISO	RGD:1323826	6480464	epigallocatechin gallate results in decreased expression of MC1R mRNA	CTD	PMID:20706672
Mc1r	Rat	1H-indole	affects binding	ISO	RGD:1323826	6480464	indole analog binds to MC1R protein	CTD	PMID:11909711
Mc1r	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1323827	6480464	Tetrachlorodibenzodioxin affects the expression of MC1R mRNA	CTD	PMID:21570461
Mc1r	Rat	acrolein	increases expression	EXP		6480464	Acrolein results in increased expression of MC1R mRNA	CTD	PMID:38090360
Mc1r	Rat	acrylamide	increases expression	ISO	RGD:1323826	6480464	Acrylamide results in increased expression of MC1R mRNA	CTD	PMID:32763439
Mc1r	Rat	aflatoxin B1	increases expression	ISO	RGD:1323826	6480464	Aflatoxin B1 results in increased expression of MC1R mRNA	CTD	PMID:21641981
Mc1r	Rat	aristolochic acid A	increases expression	ISO	RGD:1323826	6480464	aristolochic acid I results in increased expression of MC1R mRNA	CTD	PMID:33212167
Mc1r	Rat	arsenous acid	increases expression	ISO	RGD:1323826	6480464	Arsenic Trioxide results in increased expression of MC1R mRNA	CTD	PMID:20458559
Mc1r	Rat	atrazine	decreases expression	ISO	RGD:1323826	6480464	Atrazine results in decreased expression of MC1R mRNA	CTD	PMID:22378314
Mc1r	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1323826	6480464	Benzo(a)pyrene results in increased expression of MC1R mRNA	CTD	PMID:22316170
Mc1r	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1323826	6480464	Benzo(a)pyrene results in increased methylation of MC1R promoter	CTD	PMID:27901495
Mc1r	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1323826	6480464	Benzo(a)pyrene affects the methylation of MC1R 5' UTR	CTD	PMID:27901495
Mc1r	Rat	benzo[a]pyrene	multiple interactions	ISO	RGD:1323827	6480464	Benzo(a)pyrene promotes the reaction [AHR protein binds to MC1R promoter]	CTD	PMID:19654925
Mc1r	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1323826	6480464	Benzo(a)pyrene results in decreased expression of MC1R mRNA	CTD	PMID:20106945
Mc1r	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1323826	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MC1R mRNA	CTD	PMID:20382639
Mc1r	Rat	bisphenol A	decreases methylation	ISO	RGD:1323827	6480464	bisphenol A results in decreased methylation of MC1R promoter	CTD	PMID:27312807
Mc1r	Rat	bisphenol A	decreases expression	ISO	RGD:1323826	6480464	bisphenol A results in decreased expression of MC1R mRNA	CTD	PMID:29275510
Mc1r	Rat	chlorogenic acid	increases expression	ISO	RGD:1323826	6480464	Chlorogenic Acid results in increased expression of MC1R mRNA	CTD	PMID:20706672
Mc1r	Rat	clofibrate	multiple interactions	ISO	RGD:1323827	6480464	[Clofibrate co-treated with Acetaminophen] affects the expression of MC1R mRNA; PPARA affects the reaction [[Clofibrate more ...	CTD	PMID:17585979
Mc1r	Rat	clozapine	increases expression	ISO	RGD:1323826	6480464	Clozapine results in increased expression of MC1R mRNA	CTD	PMID:17346280
Mc1r	Rat	cobalt dichloride	decreases expression	ISO	RGD:1323826	6480464	cobaltous chloride results in decreased expression of MC1R mRNA	CTD	PMID:19376846
Mc1r	Rat	diarsenic trioxide	increases expression	ISO	RGD:1323826	6480464	Arsenic Trioxide results in increased expression of MC1R mRNA	CTD	PMID:20458559
Mc1r	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1323826	6480464	di-n-butylphosphoric acid affects the expression of MC1R mRNA	CTD	PMID:37042841
Mc1r	Rat	dimethyl sulfoxide	affects expression	ISO	RGD:1323826	6480464	Dimethyl Sulfoxide affects the expression of MC1R mRNA	CTD	PMID:24834073
Mc1r	Rat	eumelanin	increases chemical synthesis	ISO	RGD:1323827	6480464	MC1R protein results in increased chemical synthesis of eumelanin	CTD	PMID:24975581
Mc1r	Rat	fenofibrate	multiple interactions	ISO	RGD:1323827	6480464	[Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of more ...	CTD	PMID:23872139
Mc1r	Rat	fenofibrate	decreases expression	ISO	RGD:1323827	6480464	Fenofibrate results in decreased expression of MC1R mRNA	CTD	PMID:23872139
Mc1r	Rat	genistein	decreases expression	ISO	RGD:1323826	6480464	Genistein results in decreased expression of MC1R mRNA	CTD	PMID:20706672
Mc1r	Rat	hydroquinone	decreases expression	ISO	RGD:1323826	6480464	hydroquinone results in decreased expression of MC1R mRNA	CTD	PMID:23738040
Mc1r	Rat	kojic acid	decreases expression	ISO	RGD:1323827	6480464	kojic acid results in decreased expression of MC1R protein	CTD	PMID:27586645
Mc1r	Rat	kojic acid	increases expression	ISO	RGD:1323826	6480464	kojic acid results in increased expression of MC1R protein	CTD	PMID:23738040
Mc1r	Rat	melanins	multiple interactions	ISO	RGD:1323827	6480464	[Fenofibrate results in decreased expression of MC1R mRNA] which results in decreased chemical synthesis of more ...	CTD	PMID:23872139
Mc1r	Rat	menadione	affects expression	ISO	RGD:1323826	6480464	Vitamin K 3 affects the expression of MC1R mRNA	CTD	PMID:20044591
Mc1r	Rat	N-ethyl-N-nitrosourea	increases mutagenesis	ISO	RGD:1323827	6480464	Ethylnitrosourea results in increased mutagenesis of MC1R exon; Ethylnitrosourea results in increased mutagenesis of MC1R more ...	CTD	PMID:16300676
Mc1r	Rat	naphthalene	affects binding	ISO	RGD:1323826	6480464	naphthalene analog binds to MC1R protein	CTD	PMID:11909711
Mc1r	Rat	Osajin	decreases expression	ISO	RGD:1323826	6480464	osajin results in decreased expression of MC1R mRNA	CTD	PMID:20706672
Mc1r	Rat	paracetamol	affects expression	ISO	RGD:1323827	6480464	Acetaminophen affects the expression of MC1R mRNA	CTD	PMID:17562736
Mc1r	Rat	paracetamol	multiple interactions	ISO	RGD:1323827	6480464	[Clofibrate co-treated with Acetaminophen] affects the expression of MC1R mRNA; PPARA affects the reaction [[Clofibrate more ...	CTD	PMID:17585979
Mc1r	Rat	Phaeomelanin	increases chemical synthesis	ISO	RGD:1323827	6480464	MC1R gene mutant form results in increased chemical synthesis of phaeomelanin	CTD	PMID:24975581
Mc1r	Rat	phenobarbital	affects expression	ISO	RGD:1323827	6480464	Phenobarbital affects the expression of MC1R mRNA	CTD	PMID:19136022
Mc1r	Rat	pifithrin-alpha hydrobromide	decreases expression	ISO	RGD:1323826	6480464	pifithrin results in decreased expression of MC1R mRNA	CTD	PMID:19098008
Mc1r	Rat	pirinixic acid	decreases expression	ISO	RGD:1323827	6480464	pirinixic acid results in decreased expression of MC1R mRNA	CTD	PMID:17950772
Mc1r	Rat	pirinixic acid	affects expression	ISO	RGD:1323827	6480464	pirinixic acid affects the expression of MC1R mRNA	CTD	PMID:19136022
Mc1r	Rat	pirinixic acid	multiple interactions	ISO	RGD:1323827	6480464	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of MC1R mRNA]	CTD	PMID:17950772
Mc1r	Rat	Pomiferin	decreases expression	ISO	RGD:1323826	6480464	pomiferin results in decreased expression of MC1R mRNA	CTD	PMID:20706672
Mc1r	Rat	puerarin	decreases expression	ISO	RGD:1323826	6480464	puerarin results in decreased expression of MC1R mRNA	CTD	PMID:20706672
Mc1r	Rat	quercitrin	increases expression	ISO	RGD:1323826	6480464	quercitrin results in increased expression of MC1R mRNA	CTD	PMID:25193878
Mc1r	Rat	resveratrol	decreases expression	ISO	RGD:1323826	6480464	resveratrol results in decreased expression of MC1R mRNA	CTD	PMID:20706672
Mc1r	Rat	Rosavin	decreases expression	ISO	RGD:1323826	6480464	rosavin results in decreased expression of MC1R mRNA	CTD	PMID:20706672
Mc1r	Rat	rotenone	decreases expression	ISO	RGD:1323826	6480464	Rotenone results in decreased expression of MC1R mRNA	CTD	PMID:29955902
Mc1r	Rat	sunitinib	decreases expression	ISO	RGD:1323826	6480464	Sunitinib results in decreased expression of MC1R mRNA	CTD	PMID:31533062
Mc1r	Rat	temozolomide	increases expression	ISO	RGD:1323826	6480464	Temozolomide results in increased expression of MC1R mRNA	CTD	PMID:31758290
Mc1r	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of MC1R mRNA	CTD	PMID:34492290
Mc1r	Rat	triptonide	increases expression	ISO	RGD:1323827	6480464	triptonide results in increased expression of MC1R mRNA	CTD	PMID:33045310
Mc1r	Rat	urethane	decreases expression	ISO	RGD:1323826	6480464	Urethane results in decreased expression of MC1R mRNA	CTD	PMID:28818685

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	adenylate cyclase-activating G protein-coupled receptor signaling pathway	involved_in	ISO	RGD:1323826	1624291	PMID:19329486, PMID:19743876	RGD	PMID:19329486\|PMID:19743876
Mc1r	Rat	adenylate cyclase-activating G protein-coupled receptor signaling pathway	involved_in	IBA	MGI:1333809\|PANTHER:PTN002733616\|UniProtKB:F1STP7\|UniProtKB:P32245\|UniProtKB:P33032\|UniProtKB:P41968\|UniProtKB:Q01718\|UniProtKB:Q01726\|ZFIN:ZDB-GENE-021223-2\|ZFIN:ZDB-GENE-030502-2	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Mc1r	Rat	adenylate cyclase-activating G protein-coupled receptor signaling pathway	involved_in	IEA	UniProtKB:Q01726\|ensembl:ENSP00000451605	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	G protein-coupled receptor signaling pathway	involved_in	IEA	InterPro:IPR000276\|InterPro:IPR000761\|InterPro:IPR001671	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Mc1r	Rat	G protein-coupled receptor signaling pathway	involved_in	IEA	UniProtKB-KW:KW-0297	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Mc1r	Rat	intracellular signal transduction	involved_in	ISO	RGD:1323827	1624291	PMID:18292087	RGD	PMID:18292087
Mc1r	Rat	intracellular signal transduction	involved_in	IEA	UniProtKB:Q01727\|ensembl:ENSMUSP00000095929	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	melanin biosynthetic process	acts_upstream_of_or_within	ISO	RGD:1323827	1624291	MGI:1856028 PMID:7665913	RGD	PMID:7665913
Mc1r	Rat	melanin biosynthetic process	acts_upstream_of_or_within	IEA	UniProtKB:Q01727\|ensembl:ENSMUSP00000095929	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	negative regulation of tumor necrosis factor production	involved_in	ISO	RGD:1323826	1624291	PMID:10233018	RGD	PMID:10233018
Mc1r	Rat	negative regulation of tumor necrosis factor production	involved_in	IEA	UniProtKB:Q01726\|ensembl:ENSP00000451605	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	phospholipase C-activating G protein-coupled receptor signaling pathway	involved_in	ISO	RGD:1323827	1624291	PMID:18292087	RGD	PMID:18292087
Mc1r	Rat	phospholipase C-activating G protein-coupled receptor signaling pathway	involved_in	IEA	UniProtKB:Q01727\|ensembl:ENSMUSP00000095929	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	pigmentation	acts_upstream_of_or_within	ISO	RGD:1323827	1624291	MGI:1856029	RGD	MGI:87265
Mc1r	Rat	positive regulation of cAMP/PKA signal transduction	involved_in	ISO	RGD:1323827	1624291	PMID:18292087	RGD	PMID:18292087
Mc1r	Rat	positive regulation of cAMP/PKA signal transduction	involved_in	IEA	UniProtKB:Q01727\|ensembl:ENSMUSP00000095929	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	positive regulation of feeding behavior		IMP		5508708		RGD
Mc1r	Rat	positive regulation of transcription by RNA polymerase II	involved_in	ISO	RGD:1323827	1624291	PMID:18292087	RGD	PMID:18292087
Mc1r	Rat	positive regulation of transcription by RNA polymerase II	involved_in	IEA	UniProtKB:Q01727\|ensembl:ENSMUSP00000095929	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	regulation of feeding behavior		IMP		5508707		RGD
Mc1r	Rat	sensory perception of pain	acts_upstream_of_or_within	ISO	RGD:1323827	1624291	MGI:1856028 PMID:12663858	RGD	PMID:12663858
Mc1r	Rat	sensory perception of pain	acts_upstream_of_or_within	IEA	UniProtKB:Q01727\|ensembl:ENSMUSP00000095929	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	signal transduction	involved_in	IEA	UniProtKB-KW:KW-0807	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Mc1r	Rat	UV-damage excision repair	involved_in	ISO	RGD:1323826	1624291	PMID:18292087	RGD	PMID:18292087
Mc1r	Rat	UV-damage excision repair	involved_in	IEA	UniProtKB:Q01726\|ensembl:ENSP00000451605	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	cytoplasm	is_active_in	IBA	MGI:104615\|PANTHER:PTN002733616\|UniProtKB:F1STP7\|UniProtKB:O95977\|UniProtKB:P34972\|UniProtKB:Q92633\|UniProtKB:Q9HBW0\|ZFIN:ZDB-GENE-030502-2	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Mc1r	Rat	membrane	located_in	IEA	InterPro:IPR000276\|InterPro:IPR000761\|InterPro:IPR001671\|InterPro:IPR017452	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Mc1r	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Mc1r	Rat	membrane	located_in	IEA	UniRule:UR000084119	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Mc1r	Rat	plasma membrane	located_in	ISO	RGD:1323826	1624291	PMID:19452503, PMID:31097585	RGD	PMID:19452503\|PMID:31097585
Mc1r	Rat	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Mc1r	Rat	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Mc1r	Rat	plasma membrane	located_in	IEA	UniRule:UR000084119	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Mc1r	Rat	plasma membrane	located_in	IEA	UniProtKB:Q01726\|ensembl:ENSP00000451605	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	plasma membrane	is_active_in	IBA	MGI:104615\|MGI:108429\|MGI:1096355\|MGI:1858422\|PANTHER:PTN002733616\|RGD:2369\|RGD:619713\|RGD:620563\|UniProtKB:F1STP7\|UniProtKB:O95136\|UniProtKB:P21453\|UniProtKB:P21554\|UniProtKB:P33032\|UniProtKB:Q01726\|UniProtKB:Q92633\|UniProtKB:Q99500\|UniProtKB:Q9UBY5\|ZFIN:ZDB-GENE-030502-1\|ZFIN:ZDB-GENE-030502-2	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	G protein-coupled receptor activity	enables	IEA	InterPro:IPR000276	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Mc1r	Rat	G protein-coupled receptor activity	enables	IEA	UniProtKB-KW:KW-0297	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Mc1r	Rat	hormone binding		IMP		1626221		RGD
Mc1r	Rat	melanocortin receptor activity		IMP		1626221		RGD
Mc1r	Rat	melanocortin receptor activity	enables	IEA	InterPro:IPR001671	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Mc1r	Rat	melanocortin receptor activity	enables	IEA	UniProtKB:Q01727\|ensembl:ENSMUSP00000095929	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	melanocortin receptor activity	enables	IEA	ARBA:ARBA00029254	1600115	GO_REF:0000117	UniProt	GO_REF:0000117
Mc1r	Rat	melanocortin receptor activity	enables	ISO	RGD:1323827	1624291	PMID:18292087	RGD	PMID:18292087
Mc1r	Rat	melanocyte-stimulating hormone receptor activity	enables	ISO	RGD:1323826	1624291	UniProtKB:P01189 PMID:19743876	RGD	PMID:19743876
Mc1r	Rat	melanocyte-stimulating hormone receptor activity	enables	ISO	RGD:1323827	1624291	PMID:9454589	RGD	PMID:9454589
Mc1r	Rat	melanocyte-stimulating hormone receptor activity	enables	IEA	UniProtKB:Q01727\|ensembl:ENSMUSP00000095929	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	melanocyte-stimulating hormone receptor activity	enables	IEA	UniRule:UR000084119	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Mc1r	Rat	melanocyte-stimulating hormone receptor activity	enables	IBA	MGI:99456\|PANTHER:PTN002733711\|UniProtKB:Q01726	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Mc1r	Rat	melanocyte-stimulating hormone receptor activity	enables	IEA	UniProtKB:Q01726\|ensembl:ENSP00000451605	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Mc1r	Rat	melanocyte-stimulating hormone receptor activity	enables	IEA	InterPro:IPR000761	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Mc1r	Rat	protein binding	enables	ISO	RGD:1323826	1624291	UniProtKB:P01189\|UniProtKB:Q8TCY5\|UniProtKB:Q96G30\|UniProtKB:Q9H1Y3 PMID:19329486, PMID:19743876, PMID:31097585	RGD	PMID:19329486\|PMID:19743876\|PMID:31097585
Mc1r	Rat	protein binding	enables	ISO	RGD:1323827	1624291	PR:Q03288 PMID:9454589	RGD	PMID:9454589
Mc1r	Rat	ubiquitin protein ligase binding	enables	ISO	RGD:1323826	1624291	UniProtKB:O60291 PMID:19737927	RGD	PMID:19737927
Mc1r	Rat	ubiquitin protein ligase binding	enables	IEA	UniProtKB:Q01726\|ensembl:ENSP00000451605	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	G protein mediated signaling pathway via Galphas family		ISO	RGD:1323826	5144213		RGD
Mc1r	Rat	melanocortin system pathway		ISO	RGD:1323826	5144213		RGD

Vertebrate Trait

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Mc1r	Rat	coat/hair pigmentation trait		ISO	RGD:12175281	9068941	Coat colour, melanistic mask	OMIA	PMID:12692165\|PMID:21353269\|PMID:29932470\|PMID:33672409\|PMID:34751460\|PMID:35510419\|PMID:35595349\|PMID:36427679\|PMID:37582787

#	Reference Title	Reference Citation
1.	The melanocortin system in control of inflammation.	Catania A, etal., ScientificWorldJournal. 2010 Sep 14;10:1840-53.
2.	MC1R: three novel variants identified in a malignant melanoma association study in the Spanish population.	Fernandez L, etal., Carcinogenesis. 2007 Aug;28(8):1659-64. Epub 2007 Apr 13.
3.	Pleiotropic effects of the melanocortin 1 receptor (MC1R) gene on human pigmentation.	Flanagan N, etal., Hum Mol Genet. 2000 Oct 12;9(17):2531-7.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Increased alpha-melanocyte-stimulating hormone (alpha-MSH) levels and melanocortin receptors expression associated with pigmentation in an NC/Nga mouse model of atopic dermatitis.	Hiramoto K, etal., Exp Dermatol. 2010 Feb;19(2):132-6. Epub 2009 Nov 2.
6.	Alpha-melanocyte-stimulating hormone plays an important role in the onset of pollinosis in a pollen allergy mouse model.	Hiramoto K, etal., Int Arch Allergy Immunol. 2010;153(1):13-8. Epub 2010 Mar 30.
7.	Change of melanocortin receptor expression in rat kidney ischemia-reperfusion injury.	Lee YS, etal., Transplant Proc. 2008 Sep;40(7):2142-4.
8.	Inflamed phenotype of the mesenteric microcirculation of melanocortin type 3 receptor-null mice after ischemia-reperfusion.	Leoni G, etal., FASEB J. 2008 Dec;22(12):4228-38. Epub 2008 Aug 29.
9.	The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans.	Loser K, etal., PLoS One. 2010 Feb 1;5(2):e8958.
10.	Crucial role of the melanocortin receptor MC1R in experimental colitis.	Maaser C, etal., Gut. 2006 Oct;55(10):1415-22. Epub 2006 Mar 16.
11.	Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response.	Malik IA, etal., Histochem Cell Biol. 2012 Mar;137(3):279-91. Epub 2011 Dec 20.
12.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
13.	Effects of MCH and a MCH1-receptor antagonist on (palatable) food and water intake.	Morens C, etal., Brain Res. 2005 Nov 16;1062(1-2):32-8. Epub 2005 Oct 28.
14.	Evidence for a stimulatory action of melanin-concentrating hormone on luteinising hormone release involving MCH1 and melanocortin-5 receptors.	Murray JF, etal., J Neuroendocrinol. 2006 Mar;18(3):157-67.
15.	Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats.	Nair SG, etal., Psychopharmacology (Berl). 2009 Jul;205(1):129-40. Epub 2009 Apr 2.
16.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
17.	Increased expression of tissue inhibitor of metalloproteinases (TIMP-I) and metallothionein in murine lungs after hyperoxic exposure.	Piedboeuf B, etal., Am J Respir Cell Mol Biol. 1994 Feb;10(2):123-32.
18.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
20.	Comprehensive gene review and curation	RGD comprehensive gene curation
21.	Alpha-MSH promotes spontaneous post-ischemic pneumonia in mice via melanocortin-receptor-1.	Schulte-Herbruggen O, etal., Exp Neurol. 2008 Apr;210(2):731-9. Epub 2008 Jan 19.
22.	The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.	Valverde P, etal., Hum Mol Genet. 1996 Oct;5(10):1663-6.
23.	Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response.	Wu GS, etal., Psychiatr Genet. 2011 Feb;21(1):14-8.

PMID:7665913	PMID:9183385	PMID:9454589	PMID:10233018	PMID:12663858	PMID:18292087	PMID:19329486	PMID:19452503	PMID:19737927	PMID:19743876	PMID:19745571	PMID:21800996
PMID:30356069	PMID:31486022	PMID:36446431	PMID:37490042	PMID:38185389

Mc1r
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	68,360,950 - 68,363,877 (+)	NCBI		GRCr8
mRatBN7.2	19	51,452,448 - 51,455,375 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	51,453,239 - 51,454,192 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	58,246,649 - 58,249,576 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,924,137 - 58,927,064 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	61,145,249 - 61,148,176 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	56,215,420 - 56,219,987 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	56,216,812 - 56,217,766 (+)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	66,926,656 - 66,929,094 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.1	19	53,743,365 - 53,744,540 (+)	NCBI
Celera	19	50,684,385 - 50,688,952 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

MC1R
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	89,918,862 - 89,920,972 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	89,912,119 - 89,920,973 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	89,985,270 - 89,987,380 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	88,512,527 - 88,514,886 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	88,512,526 - 88,514,885	NCBI
Celera	16	75,049,377 - 75,052,475 (+)	NCBI		Celera
Cytogenetic Map	16	q24.3	NCBI
HuRef	16	75,677,396 - 75,680,494 (+)	NCBI		HuRef
CHM1_1	16	91,396,407 - 91,399,505 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	96,005,107 - 96,007,217 (+)	NCBI		T2T-CHM13v2.0

Mc1r
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	124,133,839 - 124,137,483 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	124,133,846 - 124,137,483 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	123,407,082 - 123,410,744 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	123,407,107 - 123,410,744 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	125,930,982 - 125,934,644 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	126,293,586 - 126,294,847 (+)	NCBI		MGSCv36	mm8
Celera	8	127,649,606 - 127,653,268 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	72.1	NCBI

MC1R
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	99,765,927 - 99,787,492 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	105,653,522 - 105,674,638 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	70,676,447 - 70,697,636 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	90,340,876 - 90,362,291 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

MC1R
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	63,694,296 - 63,695,249 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	63,707,491 - 63,708,444 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	63,922,271 - 63,923,224 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	5	63,942,798 - 63,943,751 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	63,780,332 - 63,781,285 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	64,186,690 - 64,187,643 (-)	NCBI		UU_Cfam_GSD_1.0

Mc1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	24,441,187 - 24,444,410 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936641	193,885 - 198,730 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MC1R
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	181,225 - 182,187 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	181,225 - 182,187 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	255,611 - 256,573 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	6	p	NCBI

Mc1r
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	132,904 - 133,860 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	131,356 - 137,745 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants in Mc1r
7 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	133
Count of miRNA genes:	106
Interacting mature miRNAs:	117
Transcripts:	ENSRNOT00000058145
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	49976481	53225766	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	44340214	55283277	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	NM_001401091	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006222790	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB306978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB973121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC132057	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LC579562	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000058145 ⟹ ENSRNOP00000088368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	51,453,239 - 51,454,192 (+)	Ensembl

RefSeq Acc Id:

NM_001401091 ⟹ NP_001388020

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	68,360,950 - 68,363,877 (+)	NCBI
mRatBN7.2	19	51,452,448 - 51,455,375 (+)	NCBI


Protein RefSeqs	NP_001388020	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAG85194	(Get FASTA)	NCBI Sequence Viewer
	BAU20222	(Get FASTA)	NCBI Sequence Viewer
	EDL92809	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000088368.1
	ENSRNOP00000100524

Ensembl Acc Id:

ENSRNOP00000088368 ⟸ ENSRNOT00000058145

RefSeq Acc Id:	NP_001388020 ⟸ NM_001401091
- UniProtKB:	A0A0U5AX81 (UniProtKB/TrEMBL), A6IZY1 (UniProtKB/TrEMBL), B6ZGR5 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 1 profile

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-5326	BioCyc
Ensembl Genes	ENSRNOG00000038193	Ensembl, UniProtKB/TrEMBL
	ENSRNOG00000074229	ENTREZGENE
Ensembl Transcript	ENSRNOT00000058145.4	UniProtKB/TrEMBL
	ENSRNOT00000158200	ENTREZGENE
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Melcrt_ACTH_rcpt	UniProtKB/TrEMBL
	MSH_rcpt	UniProtKB/TrEMBL
NCBI Gene	Mc1r	ENTREZGENE
OMIM	155555
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PhenoGen	Mc1r	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	MCRFAMILY	UniProtKB/TrEMBL
	MELNOCYTESHR	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000038193	RatGTEx
	ENSRNOG00000074229	RatGTEx
SMART	7TM_GPCR_Srsx	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A0U5AX81	ENTREZGENE, UniProtKB/TrEMBL
	A6IZY1	ENTREZGENE
	B6ZGR5	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A6IZY1	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Mc1r	melanocortin 1 receptor	AC132057.1		Data merged from RGD:15004283	737654	PROVISIONAL
2021-09-02	AC132057.1		Mc1r	melanocortin 1 receptor	Symbol and/or name change	19259462	PROVISIONAL
2021-08-09	Mc1r	melanocortin 1 receptor	AC132057.1		Symbol and/or name change	19259462	PROVISIONAL
2019-11-08	AC132057.1				Symbol and Name status set to provisional	45752	PROVISIONAL
2008-04-30	Mc1r	melanocortin 1 receptor	Mc1r_predicted	melanocortin 1 receptor (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mc1r_predicted	melanocortin 1 receptor (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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