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Gene: MC1R (melanocortin 1 receptor) Homo sapiens
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Symbol: MC1R
Name: melanocortin 1 receptor
Description: Exhibits melanocyte-stimulating hormone receptor activity and ubiquitin protein ligase binding activity. Involved in UV-damage excision repair; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and negative regulation of tumor necrosis factor production. Localizes to the plasma membrane. Implicated in familial melanoma; major depressive disorder; melanoma; and oculocutaneous albinism type II.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha melanocyte stimulating hormone receptor; CMM5; hair color 2 (red); HCL2; MC1-R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocortin receptor 1; melanocyte-stimulating hormone receptor; melanotropin receptor; MGC14337; MSH-R; SHEP2
Orthologs:
Mus musculus (house mouse) : Mc1r (melanocortin 1 receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mc1r (melanocortin 1 receptor)  Alliance
Canis lupus familiaris (dog) : MC1R (melanocortin 1 receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mc1r (melanocortin 1 receptor)
Sus scrofa (pig) : MC1R (melanocortin 1 receptor)
Heterocephalus glaber (naked mole-rat) : Mc1r (melanocortin 1 receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1689,912,119 - 89,920,977 (+)Ensembl
GRCh381689,917,879 - 89,920,977 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371689,984,287 - 89,987,385 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,512,527 - 88,514,886 (+)NCBINCBI36hg18NCBI36
Build 341688,512,526 - 88,514,885NCBI
Celera1675,049,377 - 75,052,475 (+)NCBI
Cytogenetic Map16q24.3NCBI
HuRef1675,677,396 - 75,680,494 (+)NCBIHuRef
CHM1_11691,396,407 - 91,399,505 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences