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Gene: MC1R (melanocortin 1 receptor) Pan paniscus

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Symbol:

MC1R

Name:

melanocortin 1 receptor

RGD ID:

11927033

Description:

ENCODES a protein that exhibits hormone binding (ortholog); melanocortin receptor activity (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN intracellular signal transduction (ortholog); melanin biosynthetic process (ortholog); negative regulation of tumor necrosis factor production (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphas family; melanocortin system pathway; ASSOCIATED WITH Acute-Phase Reaction (ortholog); age related macular degeneration 7 (ortholog); allergic contact dermatitis (ortholog); FOUND IN cytoplasm (inferred); cytoskeleton (inferred); intercellular bridge (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC100980448; melanocyte-stimulating hormone receptor; TUBB3; tubulin beta-3 chain; tubulin, beta 3 class III

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MC1R (melanocortin 1 receptor)	NCBI	Ortholog
Mus musculus (house mouse):	Mc1r (melanocortin 1 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mc1r (melanocortin 1 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MC1R (melanocortin 1 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mc1r (melanocortin 1 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MC1R (melanocortin 1 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mc1r (melanocortin 1 receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	99,765,927 - 99,787,492 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	105,653,522 - 105,674,638 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	70,676,447 - 70,697,636 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	90,340,876 - 90,362,291 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Experimental Data Annotations Click to see Annotation Detail View

Vertebrate Trait

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
MC1R	Bonobo	coat/hair pigmentation trait		ISO	MC1R (Canis lupus familiaris)	9068941	Coat colour and melanistic mask	OMIA	PMID:12692165 more ...

Disease Annotations Click to see Annotation Detail View

Acute-Phase Reaction (ISO)

allergic contact dermatitis (ISO)

atopic dermatitis (ISO)

autosomal recessive chronic granulomatous disease 4 (ISO)

bacterial pneumonia (ISO)

basal cell carcinoma (ISO)

bilateral breast cancer (ISO)

breast cancer (ISO)

colitis (ISO)

Experimental Melanoma (ISO)

familial melanoma (ISO)

Fanconi anemia (ISO)

Hyperalgesia (ISO)

Hyperoxia (ISO)

Hypopigmentation (ISO)

KBG syndrome (ISO)

Kidney Reperfusion Injury (ISO)

major depressive disorder (ISO)

melanoma (ISO)

oculocutaneous albinism type II (ISO)

primary ciliary dyskinesia 33 (ISO)

Reperfusion Injury (ISO)

Seasonal Allergic Rhinitis (ISO)

skin melanoma (ISO)

SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 2 (ISO)

UV-Induced Skin Damage (ISO)

vitiligo (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IEA)

cytoskeleton organization (IEA)

G protein-coupled receptor signaling pathway (IEA)

intracellular signal transduction (ISO)

melanin biosynthetic process (ISO)

microtubule-based process (IEA)

negative regulation of tumor necrosis factor production (ISO)

phospholipase C-activating G protein-coupled receptor signaling pathway (ISO)

pigmentation (ISO)

positive regulation of cAMP/PKA signal transduction (ISO)

positive regulation of feeding behavior (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of feeding behavior (ISO)

sensory perception of pain (ISO)

signal transduction (IEA)

UV-damage excision repair (ISO)

Cellular Component

cytoplasm (IEA)

cytoskeleton (IEA)

intercellular bridge (IEA)

membrane (IEA)

microtubule (IEA)

mitotic spindle (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

GTP binding (IEA)

GTPase activity (IEA)

hormone binding (ISO)

melanocortin receptor activity (ISO)

melanocyte-stimulating hormone receptor activity (IEA)

protein binding (ISO)

structural constituent of cytoskeleton (IEA)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

G protein mediated signaling pathway via Galphas family (ISO)

melanocortin system pathway (ISO)

Experimental Data Annotations Click to see Annotation Detail View

Vertebrate Trait

coat/hair pigmentation trait (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MC1R
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	99,765,927 - 99,787,492 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	105,653,522 - 105,674,638 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	70,676,447 - 70,697,636 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	90,340,876 - 90,362,291 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

MC1R
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	89,918,862 - 89,920,972 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	89,912,119 - 89,920,973 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	89,985,270 - 89,987,380 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	88,512,527 - 88,514,886 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	88,512,526 - 88,514,885	NCBI
Celera	16	75,049,377 - 75,052,475 (+)	NCBI		Celera
Cytogenetic Map	16	q24.3	NCBI
HuRef	16	75,677,396 - 75,680,494 (+)	NCBI		HuRef
CHM1_1	16	91,396,407 - 91,399,505 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	96,005,107 - 96,007,217 (+)	NCBI		T2T-CHM13v2.0

Mc1r
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	124,133,839 - 124,137,483 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	124,133,846 - 124,137,483 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	123,407,082 - 123,410,744 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	123,407,107 - 123,410,744 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	125,930,982 - 125,934,644 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	126,293,586 - 126,294,847 (+)	NCBI		MGSCv36	mm8
Celera	8	127,649,606 - 127,653,268 (+)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	72.1	NCBI

Mc1r
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	68,360,950 - 68,363,877 (+)	NCBI		GRCr8
mRatBN7.2	19	51,452,448 - 51,455,375 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	51,453,239 - 51,454,192 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	58,246,649 - 58,249,576 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	58,924,137 - 58,927,064 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	61,145,249 - 61,148,176 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	56,215,420 - 56,219,987 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	56,216,812 - 56,217,766 (+)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	66,926,656 - 66,929,094 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.1	19	53,743,365 - 53,744,540 (+)	NCBI
Celera	19	50,684,385 - 50,688,952 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

MC1R
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	63,694,296 - 63,695,249 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	63,707,491 - 63,708,444 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	63,922,271 - 63,923,224 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	5	63,942,798 - 63,943,751 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	63,780,332 - 63,781,285 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	64,186,690 - 64,187,643 (-)	NCBI		UU_Cfam_GSD_1.0

Mc1r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	24,441,187 - 24,444,410 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936641	193,885 - 198,730 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MC1R
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	181,225 - 182,187 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	181,225 - 182,187 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	255,611 - 256,573 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	6	p	NCBI

Mc1r
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	132,904 - 133,860 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624746	131,356 - 137,745 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003804980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008965976	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008965980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008965983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008965994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034941140	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034941141	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034941142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034941143	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034941144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063597849	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063597850	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063597851	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063597852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063597853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB296237	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB598373	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB598374	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB598375	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JARIFH020000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003804980 ⟹ XP_003805028

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	99,765,927 - 99,787,492 (+)	NCBI
NHGRI_mPanPan1	16	105,653,522 - 105,674,638 (+)	NCBI
Mhudiblu_PPA_v0	16	70,682,259 - 70,697,636 (+)	NCBI
PanPan1.1	16	90,345,893 - 90,362,291 (+)	NCBI

Sequence:

show sequence

GGACGAGTAATTCCATCCTCCTCCCGCTTCCACCCTTCAGCACAGACGCAGTCTTCAGCAAGAA
AGTGCTGGGAACGCCCTGGAGTGAACCCAGGAAGATGCCTGCAGTGGGTGCCAGGACCCCTCCC
CACCGTCCCTGCTGGGCTTCGGGGCCACGCCCGACTGCTGTGAACGGCCTGCAGAGCACCACGT
GCGACGGCTGGAGGCGAGAGGTCTGCCTTTGATGTGGCTGTTGGTGCAGGGCCTGTGGTGCCTT
CCGCAGCGGAAATGGCGCGCCGCCCGGGGAGGGCGGGAGCAGCGTCCCGGGTGCCCCTGTGAGG
ATGAGCAACGAGATGACTGGAGGGTCCCCGAAGACCTCACCAGGGTGGCCCCAGCCGGTCCGCT
CCCAGGAAGCAACACCCCCACAGCCCCAGGGCCGCAGCTGAGGGGGTCGCCACTCTGGCTGGGC
GAGGCTGGGCCCTTGGGGGCAGGCGCCAGAGTGGCCTCAGGCTCTACCAGATGCCTGAAAGCAC
CAACCCCTCCAGGGCTCACTAGCATTGGACGCTTTCACGCTCTGCCCTGGCCGGAAGCCCCCTC
ACCCCCCGCGATGTGCAACTCCTGCAGGGCTCACTCAGTTTCCAGAACTTTAATTATTGGAAAG
TTCTCCCTGGTCCAGCCCCCAAATCTGCCGTGAACGTTGACAGCTGAGTTGCTGCTCCATGCAT
GCTTTGGCTGAGAGCAGAGGGGGCCCCTGTCCTCCCTGAGCTGCTGACGTGGGGAGGGGTGAAG
GGTGGGGCCTCTGGAGAGGGCAGGTCCCGGGGAAGCTCCGGACTCCTAGAGGGGCGGCCAGGTG
GGGGCCCTGGTGACCAGGACAGACTGTGGTGTTTTTTAACGTAAAGGAGATCTGCGGTGTGAGG
GACCCCCTGGGTGCTGCACGCCGCCTGGTGGCGTGCCGGGCCATGGTGGGTGCTCACGCCCCTG
GCATGTGCCCGGCATGTGCCCGGCATGTGGCCGCCCTCAGTGGGAGGGGCTCCGAGGACGACTT
TTAAAAACGCAGAGAAAAGCTCCATTCTTCCCAGGACCTCAGCGCAGCCCTGGCCCAGGAAGGC
AGGAGACAGAGGCCAAGACGGTCCAGAGGTGTCGAAATGTCCTGGGGACCTGAGCAGCAGCCAC
CAGGGAAGAGGCAGGGAGGGAGCTGAGGACCAGGCTTGGTTGTGAGAATCCCTGAGCCCAGGGG
GTTGATGCCAGGAGGTGTCTGGACTGGCTGGGCCATGCCTGGGCTGACCTGTCCAGCCACGGAG
AGGGTGTGAGGGCAGATCTGGGGGTGCCCAGATGGAAGGAGGCAGGCATGGGGGACACCCAAGG
CCCCCTGGCAGCACCATGAACTAAGCAGGACACCTGGAGGGGGAGAACTGTGGGGACCTGGAGG
CCTCCAACGACCCCTTCCTGCTTCCTGGTCAGGACTATGGCTGTGCAGGGATCCCAGAGAAGAC
TCCTGGGCTCCCTCAACTCCACCCCCACAGCCATCCCCCAGCTGGGGCTGGCTGCCAACCAGAC
AGGAGCCGGGTGCCTGGAGGTGTCCATCCCTGACTGGCTCTTCCTCAGCCTGGGGCTGGTGAGC
TTGGTGGAGAACATGCTGGTGGTGGCCACCATCGCCAAGAACCGGAACCTGCACTCACCCATGT
ACTGCTTCATCTGCTGCCTGGCCCTGTCGGACCTGCTGGTGAGTGGGAGCAACGTGCTGGAGAT
GGCCGTCATCCTCCTGCTGGAGGCCGGTGCACTGGTGGCCCGGGCTGCGGTGCTGCAGCAGGTG
GACAATGTCATTGACGTGATCACCTGCAGCTCCATGCTGTCCAGCCTCTGCTTCCTGGGCGCCA
TCGCCGTGGACCGCTACATCTCCATCTTCTACGCACTGCGCTACCACAGCATCGTGACCCTGCC
GCGGGCGCGGCGAGCCATCGCGGCCATCTGGGTGGCCAGTGTCCTCTTCAGCACGCTCTTCATC
GCCTACTGCGACCACACGGCCGTCCTGCTGTGCCTCGTGGTCTTCTTCCTGGCTGTGCTGGTGC
TCATGGCCGTGCTGTACGTCCACATGCTGGCCCGGGCCTGCCAGCACGCCCAGGGCATCGCCCG
CCTCCACAAGAGGCAGCGCCCGGTCCACCAGGGCTTTGGCCTTAAAGGCGCTGTCACCCTCACC
ATCCTGCTGGGCATTTTCTTCCTCTGCTGGGGCCCCTTCTTCCTGCATCTCACACTCATCGTCC
TCTGCCCCGAGCACCCCACGTGCGGCTGCATCTTCAAGAACTTCAACCTCTTTCTCGCCCTCAT
CATCTGCAATGCCATCATCGACCCCCTCATCTACGCCTTCCACAGCCAGGAGCTCCGCAGGACG
CTCAAGGAGGTGCTGACGTGCTCCTGCTCTCAGGACCGTGCCCTCGTCAGCTGGGATGTGAAGT
CTCTGGGTGGAAGTGTGTGCCAAGAGCTACTCCCACAGCAGCCCCAGAAGGGGCTTTGTGACCA
GAAAGCTTCTTCCACAGCCCTGCAGCGGCTCTTGCAAAAGGAGTTCTGGGAAGTCATCAGTGAT
GAGCATGGCATCGACCCCAGCGGCAACTACGTGGGCGACTCGGACTTGCAGCTGGAGCGGATCA
GCGTCTACTACAACGAGGCCTCTTCTCACAAGTACGTGCCTCGAGCCATTCTGGTGGACCTGGA
ACCCGGAACCATGGACAGTGTCCGCTCAGGGGCCTTTGGACATCTCTTCAGGCCTGACAATTTC
ATCTTTGGTCAGAGTGGGGCCGGCAACAACTGGGCCAAGGGTCACTACACGGAGGGGGCGGAGC
TGGTGGATTCGGTCCTGGATGTCGTGCGGAAGGAGTGTGAAAACTGCGACTGCCTGCAGGGCTT
CCAGCTGACCCACTCGCTGGGGGGCGGCACGGGCTCCGGCATGGGCACGCTGCTCATCAGCAAG
GTGCGTGAGGAGTATCCCGACCGCATCATGAACACCTTCAGCGTCGTGCCCTCGCCCAAGGTGT
CAGACACGGTGGTGGAGCCCTACAACGCCACGCTGTCCATCCACCAGCTGGTGGAGAACACGGA
TGAGACCTACTGCATCGACAACGAGGCGCTCTACGACATCTGCTTCCGCACCCTCAAGCTGGCC
ACGCCCACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGAGTCACCACCTCCT
TGCGCTTCCCGGGCCAGCTCAACGCTGACCTGCGCAAGCTGGCCGTCAACATGGTGCCCTTCCC
GCGCCTGCACTTCTTCATGCCCGGCTTCGCCCCCCTCACAGCCCGGGGCAGCCAGCAGTACCGG
GCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATGGCTGCCTGCG
ACCCACGCCACGGCCGCTACCTGACGGTGGCCACCGTGTTCCGGGGCCGCATGTCCATGAAGGA
GGTGGACGAGCAGATGCTGGCCATCCAGAGCAAGAACAGCAGCTACTTCGTGGAGTGGATCCCC
AACAACGTGAAGGTGGCCGTGTGTGACATCCCGCCCCGCGGCCTCAAGATGTCCTCCACCTTCA
TCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGCATCTCCGAGCAGTTCACGGCCATGTT
CCGGCGCAAGGCCTTCCTGCACTGGTACACGGGCGAGGGCATGGACGAGATGGAGTTCACCGAG
GCCGAGAGCAACATGAACGACCTGGTGTCCGAGTACCAGCAGTACCAGGACGCCACGGCCGAGG
AGGAGGGTGAGATGTACGAAGACGACGAGGAGGAGTCGGAGGCCCAGGGCCCCAAGTGAAGCTG
CTCGCAGCTGGAGTGAGAGGCAGGTGGCGGCCGGGGCCGAGGCCAGCAGTGTCTAAACCCCCGG
AGCCATCTCGCTGCCGACACCCTGCTTTCCCCTCGCCCTAGGGCTCCCTTGCCGCCCTCCTGCA
GTATTTACGGCCTCATCCTCCCCACCTAGGCCACGTGTGAGCTGCTCCCGTCTCTGTCTTATTG
CAGCTCCAGGCCTGACGTTTTACGGTTTTGTTTTTTACTGGTTTGTGTTTATATTTTCGGGGAT
ACTTAATAAATCTATTGCTGTCAGATACCCTT

hide sequence

RefSeq Acc Id:

XM_063597849 ⟹ XP_063453919

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	99,775,729 - 99,787,492 (+)	NCBI

RefSeq Acc Id:

XM_063597850 ⟹ XP_063453920

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	99,765,927 - 99,774,517 (+)	NCBI

RefSeq Acc Id:

XM_063597851 ⟹ XP_063453921

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	99,765,927 - 99,774,517 (+)	NCBI

RefSeq Acc Id:

XM_063597852 ⟹ XP_063453922

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	99,770,595 - 99,774,517 (+)	NCBI

RefSeq Acc Id:

XM_063597853 ⟹ XP_063453923

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	99,765,927 - 99,774,517 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003805028	(Get FASTA)	NCBI Sequence Viewer
	XP_063453919	(Get FASTA)	NCBI Sequence Viewer
	XP_063453920	(Get FASTA)	NCBI Sequence Viewer
	XP_063453921	(Get FASTA)	NCBI Sequence Viewer
	XP_063453922	(Get FASTA)	NCBI Sequence Viewer
	XP_063453923	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAF48469	(Get FASTA)	NCBI Sequence Viewer
	BAK20445	(Get FASTA)	NCBI Sequence Viewer
	BAK20446	(Get FASTA)	NCBI Sequence Viewer
	BAK20447	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000003521.1
	ENSPPAP00000012154.1

RefSeq Acc Id:	XP_003805028 ⟸ XM_003804980
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9A5J7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGAGCLEVSIPDWLFLSLGLVSLVENMLVVATIA KNRNLHSPMYCFICCLALSDLLVSGSNVLEMAVILLLEAGALVARAAVLQQVDNVIDVITCSSM LSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAIAAIWVASVLFSTLFIAYCDHTAVLLCL VVFFLAVLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGP FFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSCSQD RALVSWDVKSLGGSVCQELLPQQPQKGLCDQKASSTALQRLLQKEFWEVISDEHGIDPSGNYVG DSDLQLERISVYYNEASSHKYVPRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWA KGHYTEGAELVDSVLDVVRKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNT FSVVPSPKVSDTVVEPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVS ATMSGVTTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMF DAKNMMAACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPP RGLKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEY QQYQDATAEEEGEMYEDDEEESEAQGPK hide sequence

RefSeq Acc Id:	XP_063453920 ⟸ XM_063597850
- Peptide Label:	isoform X2
- UniProtKB:	A3KFA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063453921 ⟸ XM_063597851
- Peptide Label:	isoform X2
- UniProtKB:	A3KFA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063453923 ⟸ XM_063597853
- Peptide Label:	isoform X2
- UniProtKB:	A3KFA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063453922 ⟸ XM_063597852
- Peptide Label:	isoform X2
- UniProtKB:	A3KFA6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063453919 ⟸ XM_063597849
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R8ZLA1 (UniProtKB/TrEMBL)

Protein Domains

G-protein coupled receptors family 1 profile Tubulin/FtsZ 2-layer sandwich Tubulin/FtsZ GTPase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000014788	UniProtKB/TrEMBL
	ENSPPAG00000029262	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000016224.1	UniProtKB/TrEMBL
	ENSPPAT00000034816.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.287.600	UniProtKB/TrEMBL
	3.30.1330.20	UniProtKB/TrEMBL
	3.40.50.1440	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Beta_tubulin	UniProtKB/TrEMBL
	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Melcrt_ACTH_rcpt	UniProtKB/TrEMBL
	MSH_rcpt	UniProtKB/TrEMBL
	Tub_FtsZ_C	UniProtKB/TrEMBL
	Tubulin	UniProtKB/TrEMBL
	Tubulin/FtsZ-like_C	UniProtKB/TrEMBL
	Tubulin/FtsZ_2-layer-sand-dom	UniProtKB/TrEMBL
	Tubulin/FtsZ_GTPase_sf	UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/TrEMBL
	Tubulin_CS	UniProtKB/TrEMBL
	Tubulin_FtsZ_GTPase	UniProtKB/TrEMBL
KEGG Report	pps:100980448	UniProtKB/TrEMBL
NCBI Gene	LOC100980448	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	PTHR11588	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
	Tubulin	UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/TrEMBL
PRINTS	BETATUBULIN	UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/TrEMBL
	MCRFAMILY	UniProtKB/TrEMBL
	MELNOCYTESHR	UniProtKB/TrEMBL
	TUBULIN	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
	TUBULIN	UniProtKB/TrEMBL
SMART	7TM_GPCR_Srsx	UniProtKB/TrEMBL
	Tubulin	UniProtKB/TrEMBL
	Tubulin_C	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
	SSF52490	UniProtKB/TrEMBL
	SSF55307	UniProtKB/TrEMBL
UniProt	A0A2R8ZLA1	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9A5J7	ENTREZGENE, UniProtKB/TrEMBL
	A3KFA6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-13	MC1R	melanocortin 1 receptor	LOC100980448	tubulin beta-3 chain	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

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