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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of apoptotic signaling pathway
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Accession:GO:2001235 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of apoptotic signaling pathway.
Synonyms:exact_synonym: positive regulation of apoptotic signalling pathway
 never_in_taxon: NCBITaxon:4896 ! Schizosaccharomyces pombe

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positive regulation of apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within ISO (PMID:10845921) MGI PMID:10845921 NCBI chrNW_004955455:7,886,720...7,906,214
Ensembl chrNW_004955455:7,895,974...7,906,505 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 acts_upstream_of_or_within ISO (PMID:16183742) MGI PMID:16183742 NCBI chrNW_004955405:34,619,780...34,693,616
Ensembl chrNW_004955405:34,623,267...34,693,677 		JBrowse link
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within ISO (PMID:8918887) MGI PMID:8918887 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118 		JBrowse link
G Bmf Bcl2 modifying factor acts_upstream_of_or_within ISO (PMID:11546872) MGI PMID:11546872 NCBI chrNW_004955416:7,048,654...7,068,917
Ensembl chrNW_004955416:7,052,290...7,068,910 		JBrowse link
G Camk2b calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (PMID:17367784) MGI PMID:17367784 NCBI chrNW_004955456:7,711,583...7,760,506
Ensembl chrNW_004955456:7,713,552...7,760,207 		JBrowse link
G Casp2 caspase 2 acts_upstream_of_or_within ISO (PMID:16183742) MGI PMID:16183742 NCBI chrNW_004955494:353,572...369,207
Ensembl chrNW_004955494:353,310...368,873 		JBrowse link
G Ctsc cathepsin C acts_upstream_of_or_within ISO (PMID:20435891) MGI PMID:20435891 NCBI chrNW_004955414:5,062,355...5,092,631
Ensembl chrNW_004955414:5,062,355...5,092,154 		JBrowse link
G Ctsh cathepsin H acts_upstream_of_or_within ISO (PMID:20435891) MGI PMID:20435891 NCBI chrNW_004955533:39,237...54,881
Ensembl chrNW_004955533:39,284...54,837 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO (PMID:19903888) UniProt PMID:19903888 NCBI chrNW_004955419:6,229,437...6,416,619
Ensembl chrNW_004955419:6,228,591...6,416,402 		JBrowse link
G Daxx death domain associated protein acts_upstream_of_or_within ISO (PMID:10684855) MGI PMID:10684855 NCBI chrNW_004955437:1,869,692...1,874,041
Ensembl chrNW_004955437:1,869,572...1,873,050 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 acts_upstream_of_or_within ISO (PMID:15680327) MGI PMID:15680327 NCBI chrNW_004955465:5,878,055...5,895,232
Ensembl chrNW_004955465:5,878,058...5,895,223 		JBrowse link
G Fas Fas cell surface death receptor involved_in ISO (PMID:11096076) CAFA PMID:11096076 NCBI chrNW_004955425:3,961,671...3,987,513
Ensembl chrNW_004955425:3,961,013...3,987,455 		JBrowse link
G Ifnb1 interferon beta 1 involved_in ISO (PMID:10918594), (PMID:11337497) UniProt PMID:10918594 PMID:11337497 NCBI chrNW_004955434:23,301,623...23,302,304 JBrowse link
G Il19 interleukin 19 acts_upstream_of_or_within ISO (PMID:12370360) MGI PMID:12370360 NCBI chrNW_004955406:42,376,102...42,384,902
Ensembl chrNW_004955406:42,376,104...42,384,902 		JBrowse link
G Inca1 inhibitor of CDK, cyclin A1 interacting protein 1 acts_upstream_of_or_within ISO (PMID:21750715) MGI PMID:21750715 NCBI chrNW_004955467:10,391,957...10,397,212
Ensembl chrNW_004955467:10,392,219...10,397,168 		JBrowse link
G Ing5 inhibitor of growth family member 5 acts_upstream_of_or_within ISO (PMID:21750715) MGI PMID:21750715 NCBI chrNW_004955542:135,634...160,991
Ensembl chrNW_004955542:132,560...148,138 		JBrowse link
G Inhbb inhibin subunit beta B acts_upstream_of_or_within ISO (PMID:20454446) MGI PMID:20454446 NCBI chrNW_004955459:9,482,998...9,488,489
Ensembl chrNW_004955459:9,482,873...9,488,489 		JBrowse link
G Jak2 Janus kinase 2 acts_upstream_of_or_within ISO (PMID:15012602) MGI PMID:15012602 NCBI chrNW_004955434:9,227,897...9,341,208
Ensembl chrNW_004955434:9,227,595...9,341,208 		JBrowse link
G Maged1 MAGE family member D1 acts_upstream_of_or_within ISO (PMID:17488777)
(PMID:19268530)		 MGI PMID:17488777 PMID:19268530 NCBI chrNW_004955543:2,939,960...3,052,442
Ensembl chrNW_004955543:2,975,259...3,052,504 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 acts_upstream_of_or_within ISO (PMID:16458303) MGI PMID:16458303 NCBI chrNW_004955556:1,593,552...1,705,543
Ensembl chrNW_004955556:1,593,494...1,665,784 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 acts_upstream_of_or_within ISO (PMID:16458303) MGI PMID:16458303 NCBI chrNW_004955408:391,094...430,638
Ensembl chrNW_004955408:391,094...430,981 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor acts_upstream_of_or_within ISO (PMID:14517295) MGI PMID:14517295 NCBI chrNW_004955461:2,714,022...2,718,872
Ensembl chrNW_004955461:2,714,022...2,718,982 		JBrowse link
G Nfatc4 nuclear factor of activated T cells 4 acts_upstream_of_or_within ISO (PMID:20530871) MGI PMID:20530871 NCBI chrNW_004955409:35,931,208...35,941,555
Ensembl chrNW_004955409:35,931,173...35,940,696 		JBrowse link
G Ngfr nerve growth factor receptor acts_upstream_of_or_within ISO (PMID:10764727) MGI PMID:10764727 NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305 		JBrowse link
G Nkx3-1 NK3 homeobox 1 involved_in ISO (PMID:20599703) UniProt PMID:20599703 NCBI chrNW_004955403:46,807,846...46,809,924
Ensembl chrNW_004955403:46,806,178...46,836,310 		JBrowse link
G Osm oncostatin M acts_upstream_of_or_within ISO (PMID:15012602) MGI PMID:15012602 NCBI chrNW_004955455:4,510,711...4,515,282
Ensembl chrNW_004955455:4,511,769...4,514,633 		JBrowse link
G Pdcd7 programmed cell death 7 acts_upstream_of_or_within ISO (PMID:10037816) MGI PMID:10037816 NCBI chrNW_004955450:10,294,184...10,307,234
Ensembl chrNW_004955450:10,294,276...10,306,367 		JBrowse link
G Pml PML nuclear body scaffold acts_upstream_of_or_within ISO (PMID:10684855) MGI PMID:10684855 NCBI chrNW_004955450:3,654,854...3,692,057
Ensembl chrNW_004955450:3,656,498...3,692,406 		JBrowse link
G Prkcd protein kinase C delta acts_upstream_of_or_within ISO (PMID:15731106) MGI PMID:15731106 NCBI chrNW_004955430:3,125,066...3,151,857
Ensembl chrNW_004955430:3,124,738...3,153,274 		JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:9778245) MGI PMID:9778245 NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:14988002) UniProt PMID:14988002 NCBI chrNW_004955414:16,436,899...16,442,325
Ensembl chrNW_004955414:16,436,899...16,443,073 		JBrowse link
G Tgfbr1 transforming growth factor beta receptor 1 involved_in ISO (PMID:18758450) UniProt PMID:18758450 NCBI chrNW_004955419:26,490,899...26,546,349
Ensembl chrNW_004955419:26,490,899...26,547,017 		JBrowse link
G Tp63 tumor protein p63 acts_upstream_of_or_within ISO (PMID:9774969) MGI PMID:9774969 NCBI chrNW_004955420:18,178,639...18,384,786
Ensembl chrNW_004955420:18,176,155...18,384,786 		JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within ISO (PMID:16044147) MGI PMID:16044147 NCBI chrNW_004955486:7,914,608...7,961,992
Ensembl chrNW_004955486:7,914,440...7,952,982 		JBrowse link
G Tpd52l1 TPD52 like 1 involved_in ISO (PMID:14761963) UniProt PMID:14761963 NCBI chrNW_004955436:6,648,140...6,672,474
Ensembl chrNW_004955436:6,602,051...6,671,978 		JBrowse link
G Traf7 TNF receptor associated factor 7 involved_in ISO (PMID:15001576) UniProt PMID:15001576 NCBI chrNW_004955442:15,092,955...15,112,842
Ensembl chrNW_004955442:15,092,955...15,112,840 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO (MGI:5291547|PMID:21857966) ARUK-UCL PMID:21857966 MGI:5291547 NCBI chrNW_004955430:5,304,817...5,325,684
Ensembl chrNW_004955430:5,304,745...5,325,684 		JBrowse link
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5648772|PMID:26015568)
(MGI:5796067|PMID:26949185)		 UniProt PMID:26015568 PMID:26949185 MGI:5648772 MGI:5796067 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:22240901) MGI PMID:22240901 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593 		JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:14676213)
(MGI:5613475|PMID:16835242)		 ParkinsonsUK-UCL PMID:14676213 PMID:16835242 MGI:5613475 NCBI chrNW_004955501:1,867,956...1,963,091 JBrowse link
G Nck2 NCK adaptor protein 2 involved_in ISO (MGI:5613475|PMID:16835242) ParkinsonsUK-UCL PMID:16835242 MGI:5613475 NCBI chrNW_004955470:10,487,962...10,593,046
Ensembl chrNW_004955470:10,487,481...10,593,046 		JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 involved_in ISO (MGI:5619464|PMID:21216966) ParkinsonsUK-UCL PMID:21216966 MGI:5619464 NCBI chrNW_004955402:771,410...846,671 JBrowse link
G Rnf183 ring finger protein 183 involved_in ISO (PMID:29507230) UniProt PMID:29507230 NCBI chrNW_004955419:14,181,073...14,189,230
Ensembl chrNW_004955419:14,181,073...14,189,230 		JBrowse link
G Serinc3 serine incorporator 3 acts_upstream_of_or_within ISO (PMID:12486168) MGI PMID:12486168 NCBI chrNW_004955445:12,837,616...12,868,631
Ensembl chrNW_004955445:12,837,586...12,865,758 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:5607229|PMID:20955178) UniProt PMID:20955178 MGI:5607229 NCBI chrNW_004955425:20,280,725...20,307,663
Ensembl chrNW_004955425:20,279,963...20,307,663 		JBrowse link
G Spop speckle type BTB/POZ protein acts_upstream_of_or_within ISO (PMID:20811152) MGI PMID:20811152 NCBI chrNW_004955451:11,897,642...11,970,269
Ensembl chrNW_004955451:11,897,592...11,970,269 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO (PMID:10406457) BHF-UCL PMID:10406457 NCBI chrNW_004955492:7,863,662...7,874,863
Ensembl chrNW_004955492:7,866,833...7,873,357 		JBrowse link
G Agtr2 angiotensin II receptor type 2 involved_in ISO (PMID:10406457) BHF-UCL PMID:10406457 NCBI chrNW_004955534:3,653,112...3,654,248
Ensembl chrNW_004955534:3,653,157...3,654,248 		JBrowse link
G App amyloid beta precursor protein involved_in ISO (PMID:20037584) ARUK-UCL PMID:20037584 NCBI chrNW_004955407:25,725,259...25,973,582
Ensembl chrNW_004955407:25,722,849...25,974,268 		JBrowse link
G Bcl10 BCL10 immune signaling adaptor involved_in
acts_upstream_of_or_within		 ISO (PMID:11466612)
(PMID:10753917)		 UniProt
MGI		 PMID:10753917 PMID:11466612 NCBI chrNW_004955423:8,710,231...8,720,530
Ensembl chrNW_004955423:8,709,890...8,722,050 		JBrowse link
G Bcl2l14 BCL2 like 14 involved_in ISO (PMID:11054413) UniProt PMID:11054413 NCBI chrNW_004955413:9,040,272...9,069,266
Ensembl chrNW_004955413:9,055,126...9,069,007 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in ISO (PMID:21459798) UniProt PMID:21459798 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118 		JBrowse link
G Casp8 caspase 8 acts_upstream_of_or_within ISO (PMID:16183742) MGI PMID:16183742 NCBI chrNW_004955403:322,082...348,591
Ensembl chrNW_004955403:322,555...347,053 		JBrowse link
G Cav1 caveolin 1 involved_in ISO (PMID:21382479) UniProt PMID:21382479 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403 		JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO (PMID:21525013) UniProt PMID:21525013 NCBI chrNW_004955433:8,788,867...8,845,925
Ensembl chrNW_004955433:8,788,655...8,845,925 		JBrowse link
G Dedd2 death effector domain containing 2 involved_in ISO (PMID:11741985) UniProt PMID:11741985 NCBI chrNW_004955555:684,523...701,915
Ensembl chrNW_004955555:684,523...701,915 		JBrowse link
G Fadd Fas associated via death domain involved_in
acts_upstream_of_or_within		 ISO (PMID:21525013)
(PMID:22675671)		 UniProt
MGI		 PMID:21525013 PMID:22675671 NCBI chrNW_004955422:16,026,323...16,035,808
Ensembl chrNW_004955422:16,031,280...16,036,281 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chrNW_004955460:8,790,798...8,794,902
Ensembl chrNW_004955460:8,790,798...8,794,902 		JBrowse link
G Hyal2 hyaluronidase 2 involved_in
acts_upstream_of_or_within		 ISO (MGI:3851310|PMID:19366691)
(PMID:19366691)		 BHF-UCL
MGI		 PMID:19366691 MGI:3851310 NCBI chrNW_004955532:2,120,781...2,125,083
Ensembl chrNW_004955532:2,120,781...2,123,726 		JBrowse link
G Itm2c integral membrane protein 2C involved_in ISO (MGI:4821078|PMID:14592447) UniProt PMID:14592447 MGI:4821078 NCBI chrNW_004955453:4,546,736...4,557,649
Ensembl chrNW_004955453:4,543,476...4,557,757 		JBrowse link
G Ltbr lymphotoxin beta receptor involved_in ISO (PMID:20732415) UniProt PMID:20732415 NCBI chrNW_004955413:4,031,659...4,038,396
Ensembl chrNW_004955413:4,031,754...4,038,992 		JBrowse link
G Pak2 p21 (RAC1) activated kinase 2 involved_in ISO (PMID:19240112) UniProt PMID:19240112 NCBI chrNW_004955420:12,893,760...12,930,955
Ensembl chrNW_004955420:12,892,845...12,930,955 		JBrowse link
G Pdia3 protein disulfide isomerase family A member 3 acts_upstream_of_or_within ISO (PMID:15858817) MGI PMID:15858817 NCBI chrNW_004955416:10,197,957...10,221,104
Ensembl chrNW_004955416:10,198,099...10,220,792 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:21803845) UniProt PMID:21803845 NCBI chrNW_004955450:3,654,854...3,692,057
Ensembl chrNW_004955450:3,656,498...3,692,406 		JBrowse link
G Ptprc protein tyrosine phosphatase receptor type C acts_upstream_of_or_within ISO (PMID:8666928) MGI PMID:8666928 NCBI chrNW_004955406:35,005,577...35,127,395
Ensembl chrNW_004955406:35,005,214...35,129,552 		JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 acts_upstream_of_or_within ISO (PMID:19136968) MGI PMID:19136968 NCBI chrNW_004955597:272,352...289,348
Ensembl chrNW_004955597:271,897...289,348 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:21525013), (PMID:22274400)
(PMID:19498109)		 UniProt
MGI		 PMID:19498109 PMID:21525013 PMID:22274400 NCBI chrNW_004955465:10,127,907...10,167,895
Ensembl chrNW_004955465:10,128,931...10,168,399 		JBrowse link
G Runx3 RUNX family transcription factor 3 acts_upstream_of_or_within ISO (PMID:11955451) MGI PMID:11955451 NCBI chrNW_004955452:4,580,444...4,606,820
Ensembl chrNW_004955452:4,579,331...4,636,884 		JBrowse link
G Sfrp1 secreted frizzled related protein 1 acts_upstream_of_or_within ISO (PMID:14976225) MGI PMID:14976225 NCBI chrNW_004955536:1,663,721...1,702,678
Ensembl chrNW_004955536:1,663,344...1,703,514 		JBrowse link
G Siglec1 sialic acid binding Ig like lectin 1 acts_upstream_of_or_within ISO (PMID:23408841) MGI PMID:23408841 NCBI chrNW_004955415:14,539,284...14,560,614
Ensembl chrNW_004955415:14,536,266...14,560,632 		JBrowse link
G Tlr4 toll like receptor 4 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955419:10,190,937...10,201,896
Ensembl chrNW_004955419:10,191,120...10,202,135 		JBrowse link
G Tlr6 toll like receptor 6 involved_in ISO (MGI:4438693|PMID:20037584) ARUK-UCL PMID:20037584 MGI:4438693 NCBI chrNW_004955443:8,401,461...8,427,175
Ensembl chrNW_004955443:8,422,534...8,424,942 		JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A involved_in ISO (PMID:21525013) UniProt PMID:21525013 NCBI chrNW_004955442:14,320,159...14,322,146
Ensembl chrNW_004955442:14,320,159...14,322,146 		JBrowse link
G Tnfsf10 TNF superfamily member 10 involved_in
acts_upstream_of_or_within		 ISO (PMID:20097879), (PMID:21525171), (PMID:22266862)
(PMID:15632112)		 UniProt
MGI		 PMID:15632112 PMID:20097879 PMID:21525171 PMID:22266862 NCBI chrNW_004955420:2,550,392...2,566,448
Ensembl chrNW_004955420:2,549,142...2,566,564 		JBrowse link
G Traf2 TNF receptor associated factor 2 involved_in ISO (PMID:21525013) UniProt PMID:21525013 NCBI chrNW_004955513:4,964,692...4,984,359
Ensembl chrNW_004955513:4,967,984...4,983,987 		JBrowse link
G Wwox WW domain containing oxidoreductase involved_in ISO (MGI:3851310|PMID:19366691) BHF-UCL PMID:19366691 MGI:3851310 NCBI chrNW_004955522:1,265,732...2,185,372
Ensembl chrNW_004955522:1,265,404...2,184,562 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnna1 catenin alpha 1 acts_upstream_of_or_within ISO (PMID:22411810) MGI PMID:22411810 NCBI chrNW_004955418:1,592,555...1,754,423
Ensembl chrNW_004955418:1,592,229...1,754,689 		JBrowse link
G Dapk3 death associated protein kinase 3 involved_in ISO PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chrNW_004955495:4,809,475...4,822,210
Ensembl chrNW_004955495:4,810,474...4,823,259 		JBrowse link
G Htra2 HtrA serine peptidase 2 involved_in ISO (PMID:20125124) UniProt PMID:20125124 NCBI chrNW_004955424:11,255,756...11,259,170
Ensembl chrNW_004955424:11,255,756...11,259,170 		JBrowse link
G Inhba inhibin subunit beta A involved_in ISO (PMID:8267637) UniProt PMID:8267637 NCBI chrNW_004955460:2,054,879...2,066,628
Ensembl chrNW_004955460:2,046,588...2,066,609 		JBrowse link
G Jak3 Janus kinase 3 involved_in ISO (MGI:3719947|PMID:16020505) BHF-UCL PMID:16020505 MGI:3719947 NCBI chrNW_004955524:3,399,895...3,412,018
Ensembl chrNW_004955524:3,401,642...3,411,643 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within ISO (PMID:15039234) MGI PMID:15039234 NCBI chrNW_004955481:6,145,855...6,404,179
Ensembl chrNW_004955481:6,145,855...6,404,179 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha acts_upstream_of_or_within ISO (PMID:12115603) MGI PMID:12115603 NCBI chrNW_004955422:18,076,670...18,079,859
Ensembl chrNW_004955422:18,076,670...18,079,859 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit Aalpha acts_upstream_of_or_within ISO (PMID:12944463) MGI PMID:12944463 NCBI chrNW_004955558:381,794...410,485
Ensembl chrNW_004955558:381,794...410,485 		JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit Abeta involved_in ISO (PMID:21172653) UniProt PMID:21172653 NCBI chrNW_004955412:13,458,078...13,494,583
Ensembl chrNW_004955412:13,458,136...13,494,585 		JBrowse link
G Ret ret proto-oncogene involved_in ISO (PMID:10921886) UniProt PMID:10921886 NCBI chrNW_004955546:1,221,995...1,252,147
Ensembl chrNW_004955546:1,221,995...1,253,946 		JBrowse link
G Srpx sushi repeat containing protein X-linked acts_upstream_of_or_within ISO (PMID:17088259) MGI PMID:17088259 NCBI chrNW_004955601:286,092...364,235
Ensembl chrNW_004955601:286,069...364,235 		JBrowse link
G Tgfb2 transforming growth factor beta 2 acts_upstream_of_or_within ISO (PMID:8206089) MGI PMID:8206089 NCBI chrNW_004955406:174,949...249,248
Ensembl chrNW_004955406:172,814...249,248 		JBrowse link
G Unc5b unc-5 netrin receptor B involved_in ISO PMID:21172653 UniProt PMID:21172653 RGD:8554227 NCBI chrNW_004955437:20,120,996...20,199,877
Ensembl chrNW_004955437:20,120,946...20,199,877 		JBrowse link
G Wwox WW domain containing oxidoreductase acts_upstream_of_or_within ISO (PMID:19366691) MGI PMID:19366691 NCBI chrNW_004955522:1,265,732...2,185,372
Ensembl chrNW_004955522:1,265,404...2,184,562 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1b bone morphogenetic protein receptor type 1B acts_upstream_of_or_within ISO (PMID:18363966) MGI PMID:18363966 NCBI chrNW_004955405:5,408,171...5,784,930
Ensembl chrNW_004955405:5,700,162...5,787,957 		JBrowse link
G Faf1 Fas associated factor 1 acts_upstream_of_or_within ISO (PMID:8524870) MGI PMID:8524870 NCBI chrNW_004955464:8,037,344...8,477,798
Ensembl chrNW_004955464:8,036,955...8,479,249 		JBrowse link
G Mal mal, T cell differentiation protein acts_upstream_of_or_within ISO (PMID:12776198) MGI PMID:12776198 NCBI chrNW_004955470:3,372,577...3,396,868
Ensembl chrNW_004955470:3,372,577...3,398,836 		JBrowse link
G Pea15 proliferation and apoptosis adaptor protein 15 acts_upstream_of_or_within ISO (PMID:10588860) MGI PMID:10588860 NCBI chrNW_004955468:11,981,956...11,991,427
Ensembl chrNW_004955468:11,981,960...11,991,427 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15705586) BHF-UCL PMID:15705586 NCBI chrNW_004955402:44,005,517...44,010,722 JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO (PMID:8940094) MGI PMID:8940094 NCBI chrNW_004955406:5,727,367...5,748,798
Ensembl chrNW_004955406:5,727,367...5,752,234 		JBrowse link
G Sfrp1 secreted frizzled related protein 1 involved_in ISO (PMID:9391078) BHF-UCL PMID:9391078 NCBI chrNW_004955536:1,663,721...1,702,678
Ensembl chrNW_004955536:1,663,344...1,703,514 		JBrowse link
G Skil SKI like proto-oncogene acts_upstream_of_or_within ISO (PMID:10811619) MGI PMID:10811619 NCBI chrNW_004955420:530,531...554,308
Ensembl chrNW_004955420:530,528...554,551 		JBrowse link
G Stk3 serine/threonine kinase 3 acts_upstream_of_or_within ISO (PMID:20080598) MGI PMID:20080598 NCBI chrNW_004955417:14,098,851...14,381,553
Ensembl chrNW_004955417:14,095,694...14,381,607 		JBrowse link
G Stk4 serine/threonine kinase 4 acts_upstream_of_or_within ISO (PMID:20080598) MGI PMID:20080598 NCBI chrNW_004955445:12,308,285...12,399,012
Ensembl chrNW_004955445:12,308,285...12,399,012 		JBrowse link
G Thbs1 thrombospondin 1 involved_in ISO (PMID:18726995) BHF-UCL PMID:18726995 NCBI chrNW_004955416:6,490,034...6,506,419
Ensembl chrNW_004955416:6,489,451...6,506,419 		JBrowse link
G Trps1 transcriptional repressor GATA binding 1 acts_upstream_of_or_within ISO (PMID:18363966) MGI PMID:18363966 NCBI chrNW_004955417:21,674,545...21,913,137
Ensembl chrNW_004955417:21,680,116...21,913,173 		JBrowse link
G Zswim2 zinc finger SWIM-type containing 2 acts_upstream_of_or_within ISO (PMID:16522193) MGI PMID:16522193 NCBI chrNW_004955403:11,478,682...11,494,725
Ensembl chrNW_004955403:11,479,808...11,495,577 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 ISO MMO:0000679 RGD PMID:23729662 RGD:329403056 NCBI chrNW_004955462:9,196,984...9,278,850
Ensembl chrNW_004955462:9,207,314...9,278,621 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 ISO (PMID:14963330), (PMID:21199865), (PMID:21262771)
(PMID:14502238)		 UniProt
MGI		 PMID:14502238 PMID:14963330 PMID:21199865 PMID:21262771 NCBI chrNW_004955559:1,695,960...1,700,246
Ensembl chrNW_004955559:1,695,960...1,700,244 		JBrowse link
G Bbc3 BCL2 binding component 3 involved_in ISO PMID:27031958
(PMID:17289999), (PMID:27031958)		 UniProt PMID:17289999 PMID:27031958 RGD:14390051 NCBI chrNW_004955574:1,167,790...1,174,966
Ensembl chrNW_004955574:1,167,242...1,174,966 		JBrowse link
G Bcap31 B cell receptor associated protein 31 involved_in ISO (PMID:21183955) UniProt PMID:21183955 NCBI chrNW_004955580:429,223...459,168
Ensembl chrNW_004955580:428,644...459,168 		JBrowse link
G Bcl2l11 BCL2 like 11 involved_in ISO (PMID:21671007) UniProt PMID:21671007 NCBI chrNW_004955470:2,740,682...2,780,225 JBrowse link
G Bclaf1 BCL2 associated transcription factor 1 involved_in ISO (PMID:17938203) UniProt PMID:17938203 NCBI chrNW_004955439:608,849...641,005
Ensembl chrNW_004955439:608,861...641,005 		JBrowse link
G Becn1 beclin 1 involved_in ISO (PMID:27031958) UniProt PMID:27031958 RGD:14390051 NCBI chrNW_004955451:16,616,595...16,625,731
Ensembl chrNW_004955451:16,616,595...16,625,730 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in ISO (PMID:21262771) UniProt PMID:21262771 NCBI chrNW_004955454:5,776,656...5,785,500
Ensembl chrNW_004955454:5,777,667...5,783,118 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5705719|PMID:23429263) UniProt PMID:23429263 MGI:5705719 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428 		JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase acts_upstream_of_or_within ISO (PMID:17938250) MGI PMID:17938250 NCBI chrNW_004955470:3,152,798...3,190,185
Ensembl chrNW_004955470:3,152,758...3,191,888 		JBrowse link
G Cav1 caveolin 1 involved_in ISO (PMID:21382479) UniProt PMID:21382479 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403 		JBrowse link
G Clu clusterin involved_in ISO (PMID:21567405) UniProt PMID:21567405 NCBI chrNW_004955403:50,160,598...50,175,876
Ensembl chrNW_004955403:50,160,598...50,175,876 		JBrowse link
G Ddit3 DNA damage inducible transcript 3 involved_in ISO (PMID:27031958) UniProt PMID:27031958 NCBI chrNW_004955458:5,232,979...5,238,513
Ensembl chrNW_004955458:5,232,979...5,238,513 		JBrowse link
G Dnm1l dynamin 1 like involved_in ISO (PMID:20850011) UniProt PMID:20850011 NCBI chrNW_004955505:3,025,742...3,081,491
Ensembl chrNW_004955505:3,023,018...3,081,680 		JBrowse link
G Ei24 EI24 autophagy associated transmembrane protein acts_upstream_of_or_within ISO (PMID:17981155) MGI PMID:17981155 NCBI chrNW_004955412:26,574,814...26,586,154
Ensembl chrNW_004955412:26,574,866...26,585,161 		JBrowse link
G Fis1 fission, mitochondrial 1 involved_in ISO (PMID:21183955) UniProt PMID:21183955 NCBI chrNW_004955456:16,057,158...16,060,623
Ensembl chrNW_004955456:16,038,221...16,060,623 		JBrowse link
G Flcn folliculin acts_upstream_of_or_within ISO (PMID:21258407) MGI PMID:21258407 NCBI chrNW_004955577:672,774...694,140
Ensembl chrNW_004955577:672,410...694,140 		JBrowse link
G Gsdme gasdermin E involved_in ISO (PMID:21522185) UniProt PMID:21522185 NCBI chrNW_004955410:26,700,977...26,761,683
Ensembl chrNW_004955410:26,701,893...26,769,989 		JBrowse link
G Il19 interleukin 19 acts_upstream_of_or_within ISO (PMID:23468852) MGI PMID:23468852 NCBI chrNW_004955406:42,376,102...42,384,902
Ensembl chrNW_004955406:42,376,104...42,384,902 		JBrowse link
G Il20ra interleukin 20 receptor subunit alpha acts_upstream_of_or_within ISO (PMID:23468852) MGI PMID:23468852 NCBI chrNW_004955436:22,281,422...22,323,242
Ensembl chrNW_004955436:22,281,713...22,326,229 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase involved_in ISO (PMID:16116473) UniProt PMID:16116473 NCBI chrNW_004955452:10,608,317...10,632,310
Ensembl chrNW_004955452:10,608,318...10,632,310 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 involved_in ISO (PMID:20012548) UniProt PMID:20012548 NCBI chrNW_004955553:1,639,267...1,656,850
Ensembl chrNW_004955553:1,639,267...1,656,850 		JBrowse link
G Nkx3-1 NK3 homeobox 1 involved_in ISO (PMID:17486276) UniProt PMID:17486276 NCBI chrNW_004955403:46,807,846...46,809,924
Ensembl chrNW_004955403:46,806,178...46,836,310 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISO (PMID:27031958) UniProt PMID:27031958 RGD:14390051 NCBI chrNW_004955493:6,746,380...6,747,763
Ensembl chrNW_004955493:6,746,380...6,747,763 		JBrowse link
G Plagl2 PLAG1 like zinc finger 2 acts_upstream_of_or_within ISO (PMID:11832486) MGI PMID:11832486 NCBI chrNW_004955422:28,839,021...28,847,255
Ensembl chrNW_004955422:28,839,020...28,847,255 		JBrowse link
G Plekhf1 pleckstrin homology and FYVE domain containing 1 acts_upstream_of_or_within ISO (PMID:16188880) MGI PMID:16188880 NCBI chrNW_004955468:7,934,024...7,943,499
Ensembl chrNW_004955468:7,934,024...7,943,499 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:21454712) UniProt PMID:21454712 NCBI chrNW_004955402:44,005,517...44,010,722 JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 acts_upstream_of_or_within ISO (PMID:12181197) MGI PMID:12181197 NCBI chrNW_004955403:18,394,609...18,410,381
Ensembl chrNW_004955403:18,373,375...18,410,627 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:19767770) UniProt PMID:19767770 NCBI chrNW_004955530:78,488...83,297
Ensembl chrNW_004955530:78,426...83,297 		JBrowse link
G Ripk3 receptor interacting serine/threonine kinase 3 acts_upstream_of_or_within ISO (PMID:10490590) MGI PMID:10490590 NCBI chrNW_004955409:35,961,604...35,965,477
Ensembl chrNW_004955409:35,937,880...35,965,712 		JBrowse link
G S100a9 S100 calcium binding protein A9 involved_in ISO (PMID:19935772) UniProt PMID:19935772 NCBI chrNW_004955592:90,647...93,842 JBrowse link
G Septin4 septin 4 involved_in ISO (PMID:21185211) UniProt PMID:21185211 NCBI chrNW_004955451:4,505,318...4,530,387 JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 involved_in ISO (PMID:21185211) UniProt PMID:21185211 NCBI chrNW_004955474:6,970,383...6,982,231
Ensembl chrNW_004955474:6,978,130...6,981,189 		JBrowse link
G Styxl1 serine/threonine/tyrosine interacting like 1 involved_in ISO (PMID:21262771), (PMID:24709986) UniProt PMID:21262771 PMID:24709986 NCBI chrNW_004955456:14,755,516...14,819,326
Ensembl chrNW_004955456:14,755,637...14,819,125 		JBrowse link
G Taf6 TATA-box binding protein associated factor 6 involved_in ISO (PMID:20096117) UniProt PMID:20096117 NCBI chrNW_004955573:752,646...759,292
Ensembl chrNW_004955573:752,601...759,292 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO (PMID:14963330), (PMID:27031958) UniProt PMID:14963330 PMID:27031958 RGD:14390051 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif5a eukaryotic translation initiation factor 5A involved_in ISO (PMID:15371445) UniProt PMID:15371445 NCBI chrNW_004955467:9,603,800...9,608,490 JBrowse link
G Msx1 msh homeobox 1 involved_in ISO (PMID:15705871) BHF-UCL PMID:15705871 NCBI chrNW_004955514:4,923,552...4,927,471
Ensembl chrNW_004955514:4,923,552...4,927,471 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO (PMID:10962037) UniProt PMID:10962037 NCBI chrNW_004955461:2,714,022...2,718,872
Ensembl chrNW_004955461:2,714,022...2,718,982 		JBrowse link
G Rps7 ribosomal protein S7 involved_in ISO (PMID:17310983) CAFA PMID:17310983 NCBI chrNW_004955487:3,793,168...3,798,007
Ensembl chrNW_004955487:3,792,870...3,798,153 		JBrowse link
G Sh3glb1 SH3 domain containing GRB2 like, endophilin B1 involved_in ISO (MGI:5553386|PMID:24523556) UniProt PMID:24523556 MGI:5553386 NCBI chrNW_004955423:7,393,186...7,414,199
Ensembl chrNW_004955423:7,393,186...7,423,903 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbh1 F-box DNA helicase 1 acts_upstream_of_or_within ISO (PMID:23361013) MGI PMID:23361013 NCBI chrNW_004955421:22,535,777...22,579,965
Ensembl chrNW_004955421:22,535,777...22,579,965 		JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO (PMID:26219591) MGI PMID:26219591 NCBI chrNW_004955422:672,301...690,989
Ensembl chrNW_004955422:672,301...690,989 		JBrowse link
G Nacc2 NACC family member 2 involved_in ISO (PMID:22926524) BHF-UCL PMID:22926524 NCBI chrNW_004955513:4,560,903...4,595,081
Ensembl chrNW_004955513:4,561,643...4,595,364 		JBrowse link
G Pias4 protein inhibitor of activated STAT 4 acts_upstream_of_or_within ISO (PMID:16816390) MGI PMID:16816390 NCBI chrNW_004955495:4,760,576...4,791,422
Ensembl chrNW_004955495:4,761,862...4,791,490 		JBrowse link
G Plscr1 phospholipid scramblase 1 acts_upstream_of_or_within ISO (PMID:12509439) MGI PMID:12509439 NCBI chrNW_004955474:10,953,381...10,989,100 JBrowse link
G Rad9a RAD9 checkpoint clamp component A acts_upstream_of_or_within ISO (PMID:15983387) MGI PMID:15983387 NCBI chrNW_004955422:18,079,634...18,146,122
Ensembl chrNW_004955422:18,079,652...18,085,548 		JBrowse link
G Rps3 ribosomal protein S3 involved_in ISO (PMID:22510408) UniProt PMID:22510408 NCBI chrNW_004955414:16,436,899...16,442,325
Ensembl chrNW_004955414:16,436,899...16,443,073 		JBrowse link
G Skil SKI like proto-oncogene acts_upstream_of_or_within ISO (PMID:10811619) MGI PMID:10811619 NCBI chrNW_004955420:530,531...554,308
Ensembl chrNW_004955420:530,528...554,551 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 involved_in ISO (PMID:16213212)
(MGI:5882892|PMID:16213212)		 CAFA PMID:16213212 MGI:5882892 NCBI chrNW_004955467:8,519,760...8,525,514
Ensembl chrNW_004955467:8,519,760...8,527,182 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:18617898) MGI PMID:18617898 NCBI chrNW_004955459:10,441,906...10,485,235
Ensembl chrNW_004955459:10,441,752...10,485,269 		JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within ISO (PMID:15983387) MGI PMID:15983387 NCBI chrNW_004955486:7,914,608...7,961,992
Ensembl chrNW_004955486:7,914,440...7,952,982 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2 associated agonist of cell death involved_in ISO (PMID:21716255)
(MGI:5474549|PMID:21716255)		 CAFA PMID:21716255 MGI:5474549 NCBI chrNW_004955422:20,795,585...20,809,039
Ensembl chrNW_004955422:20,795,676...20,809,245 		JBrowse link
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nox1 NADPH oxidase 1 acts_upstream_of_or_within ISO (PMID:19661248) MGI PMID:19661248 NCBI chrNW_004955503:6,973,965...7,020,182
Ensembl chrNW_004955503:6,974,239...6,997,618 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (PMID:22555455) MGI PMID:22555455 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885 		JBrowse link
G Sfpq splicing factor proline and glutamine rich involved_in ISO (PMID:15790595) ParkinsonsUK-UCL PMID:15790595 NCBI chrNW_004955452:13,267,968...13,283,823 JBrowse link
G Sod1 superoxide dismutase 1 involved_in ISO (PMID:12551919) BHF-UCL PMID:12551919 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727 		JBrowse link
G Vnn1 vanin 1 involved_in ISO (MGI:3052282|PMID:15282320) BHF-UCL PMID:15282320 MGI:3052282 NCBI chrNW_004955436:13,238,307...13,266,800
Ensembl chrNW_004955436:13,238,603...13,259,577 		JBrowse link
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 ISO RGD PMID:28386847 RGD:329337357 NCBI chrNW_004955462:9,196,984...9,278,850
Ensembl chrNW_004955462:9,207,314...9,278,621 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 involved_in ISO (PMID:23858059)
(MGI:5543313|PMID:23858059)		 ParkinsonsUK-UCL PMID:23858059 MGI:5543313 NCBI chrNW_004955471:6,852,459...7,026,590
Ensembl chrNW_004955471:6,848,101...6,955,881 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in ISO (PMID:23858059)
(MGI:5543313|PMID:23858059)		 ParkinsonsUK-UCL PMID:23858059 MGI:5543313 NCBI chrNW_004955413:238,043...243,317 JBrowse link
G Mmp2 matrix metallopeptidase 2 ISO RGD PMID:27614125 RGD:329961568 NCBI chrNW_004955433:13,024,844...13,050,041
Ensembl chrNW_004955433:13,024,418...13,052,775 		JBrowse link
G Ralbp1 ralA binding protein 1 ISO RGD PMID:23788031 RGD:12904719 NCBI chrNW_004955402:2,571,672...2,616,040
Ensembl chrNW_004955402:2,569,637...2,616,040 		JBrowse link
positive regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 involved_in ISO (PMID:24939851) ParkinsonsUK-UCL PMID:24939851 NCBI chrNW_004955406:4,875,672...4,889,173
Ensembl chrNW_004955406:4,875,613...4,889,242 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12352
    cellular process 11484
      signal transduction 3954
        positive regulation of signal transduction 1500
          positive regulation of apoptotic signaling pathway 152
            positive regulation of extrinsic apoptotic signaling pathway + 56
            positive regulation of intrinsic apoptotic signaling pathway + 70
Path 2
Term Annotations click to browse term
  biological_process 12352
    biological regulation 8890
      regulation of biological process 8624
        signaling 4451
          signal transduction 3954
            regulation of signal transduction 2641
              positive regulation of signal transduction 1500
                positive regulation of apoptotic signaling pathway 152
                  positive regulation of extrinsic apoptotic signaling pathway + 56
                  positive regulation of intrinsic apoptotic signaling pathway + 70
paths to the root