Nfatc4 (nuclear factor of activated T cells 4) - Rat Genome Database

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Gene: Nfatc4 (nuclear factor of activated T cells 4) Chinchilla lanigera
Analyze
Symbol: Nfatc4
Name: nuclear factor of activated T cells 4
RGD ID: 8725080
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN brain-derived neurotrophic factor receptor signaling pathway (ortholog); branching involved in blood vessel morphogenesis (ortholog); calcineurin-NFAT signaling cascade (ortholog); PARTICIPATES IN calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); Chemical and Drug Induced Liver Injury (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear speck (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear factor of activated T-cells 4; nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,931,173 - 35,940,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,931,208 - 35,941,555 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nfatc4Chinchilladilated cardiomyopathy  ISONFATC4 (Homo sapiens)9068941DNA:missense mutation:cds:p.G160A (human)RGDPMID:12939651 and REF_RGD_ID:1580248
Nfatc4ChinchillaLeft Ventricular Hypertrophy  ISONFATC4 (Homo sapiens)9068941human gene in a mouse modelRGDPMID:9568714 and REF_RGD_ID:1579956
Nfatc4ChinchillaNeuralgia treatmentISONfatc4 (Rattus norvegicus)9068941 RGDPMID:23386250 and REF_RGD_ID:329337338
Nfatc4ChinchillaRight Ventricular Hypertrophy  ISONFATC4 (Homo sapiens)9068941human gene in a mouse modelRGDPMID:9568714 and REF_RGD_ID:1579956
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nfatc4ChinchillaBrain-Lung-Thyroid Syndrome  ISONFATC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Brain-lung-thyroid syndromeClinVarPMID:25741868
Nfatc4Chinchillalysinuric protein intolerance  ISONFATC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Lysinuric protein intoleranceClinVarPMID:28492532
Nfatc4ChinchillaSpecific Granule Deficiency  ISONFATC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Specific granule deficiencyClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nfatc4ChinchillaChemical and Drug Induced Liver Injury  ISONFATC4 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:34192554


Biological Process
1 to 20 of 35 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nfatc4Chinchillabrain-derived neurotrophic factor receptor signaling pathway involved_inISONfatc4 (Mus musculus)9068941 PMID:22586092UniProtPMID:22586092
Nfatc4Chinchillabranching involved in blood vessel morphogenesis acts_upstream_of_or_withinISOMGI:1032969068941 PMID:11439183MGIPMID:11439183
Nfatc4Chinchillacalcineurin-NFAT signaling cascade acts_upstream_of_or_withinISOMGI:1071729068941 PMID:19179536MGIPMID:19179536
Nfatc4Chinchillacellular respiration acts_upstream_of_or_withinISONfatc4 (Mus musculus)9068941 PMID:12750314MGIPMID:12750314
Nfatc4Chinchillacellular response to ionomycin  ISONfatc4 (Rattus norvegicus)9068941 RGDPMID:21606195 and REF_RGD_ID:11561924
Nfatc4Chinchillacellular response to lithium ion acts_upstream_of_or_withinISONfatc4 (Mus musculus)9068941 PMID:20530871MGIPMID:20530871
Nfatc4Chinchillacellular response to UV acts_upstream_of_or_withinISOMGI:975839068941 PMID:17242187MGIPMID:17242187
Nfatc4Chinchilladendrite morphogenesis acts_upstream_ofISONfatc4 (Mus musculus)9068941 PMID:23407945MGIPMID:23407945
Nfatc4Chinchillaheart development acts_upstream_of_or_withinISOMGI:1032969068941 PMID:12750314 and PMID:17229811MGIPMID:12750314 and PMID:17229811
Nfatc4Chinchillaintrinsic apoptotic signaling pathway in response to DNA damage acts_upstream_of_or_withinISONfatc4 (Mus musculus)9068941 PMID:17242187MGIPMID:17242187
Nfatc4Chinchillaintrinsic apoptotic signaling pathway in response to DNA damage acts_upstream_of_or_withinISOMGI:975839068941 PMID:17242187MGIPMID:17242187
Nfatc4Chinchillalong-term memory involved_inISONfatc4 (Mus musculus)9068941 PMID:22586092UniProtPMID:22586092
Nfatc4Chinchillalong-term synaptic potentiation involved_inISONfatc4 (Mus musculus)9068941 PMID:22586092UniProtPMID:22586092
Nfatc4Chinchillanegative regulation of dendrite morphogenesis acts_upstream_of_or_withinISONfatc4 (Mus musculus)9068941 PMID:23407945MGIPMID:23407945
Nfatc4Chinchillanegative regulation of miRNA transcription involved_inISOUniProtKB:Q129689068941 PMID:23543060BHF-UCLPMID:23543060
Nfatc4Chinchillanegative regulation of neuron apoptotic process involved_inISONfatc4 (Mus musculus)9068941 PMID:22586092UniProtPMID:22586092
Nfatc4Chinchillanegative regulation of synapse maturation acts_upstream_of_or_withinISONfatc4 (Mus musculus)9068941 PMID:23407945MGIPMID:23407945
Nfatc4Chinchillanegative regulation of transcription by RNA polymerase II involved_inISONfatc4 (Mus musculus)9068941 PMID:16644691 and PMID:21880741NTNU_SBPMID:16644691 and PMID:21880741
Nfatc4Chinchillanegative regulation of Wnt signaling pathway involved_inISONfatc4 (Mus musculus)9068941 PMID:21880741ParkinsonsUK-UCLPMID:21880741
Nfatc4Chinchillaneuron apoptotic process acts_upstream_ofISONfatc4 (Mus musculus)9068941 PMID:18354019MGIPMID:18354019
1 to 20 of 35 rows

Cellular Component
1 to 9 of 9 rows

  
1 to 9 of 9 rows

Molecular Function
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nfatc4ChinchillaDNA-binding transcription factor activity  ISONfatc4 (Rattus norvegicus)9068941 RGDPMID:12954875 and REF_RGD_ID:1580247
Nfatc4ChinchillaDNA-binding transcription factor activity enablesISONfatc4 (Mus musculus)9068941 PMID:12796475 and PMID:21880741ParkinsonsUK-UCLPMID:12796475 and PMID:21880741
Nfatc4ChinchillaDNA-binding transcription factor activity, RNA polymerase II-specific enablesISONfatc4 (Mus musculus)9068941 PMID:17242187MGIPMID:17242187
Nfatc4ChinchillaDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOUniProtKB:Q129689068941 PMID:23543060BHF-UCLPMID:23543060
Nfatc4ChinchillaDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISONfatc4 (Mus musculus)9068941 PMID:16644691NTNU_SBPMID:16644691
Nfatc4Chinchillaperoxisome proliferator activated receptor binding  ISOPparg (Rattus norvegicus)9068941 RGDPMID:18600431 and REF_RGD_ID:2301872
Nfatc4Chinchillaperoxisome proliferator activated receptor binding  ISOPpara (Rattus norvegicus)9068941 RGDPMID:22198280 and REF_RGD_ID:5687133
Nfatc4Chinchillaprotein binding enablesISOUniProtKB:P42227 and UniProtKB:P973059068941 PMID:19538478UniProtPMID:19538478
Nfatc4Chinchillaprotein binding enablesISOUniProtKB:P51141 more ...9068941 PMID:21880741ParkinsonsUK-UCLPMID:21880741
Nfatc4Chinchillaprotein binding enablesISOUniProtKB:Q86YM7 more ...9068941 PMID:18218901UniProtPMID:18218901
Nfatc4Chinchillaprotein binding enablesISOPR:Q91ZP39068941 PMID:20385772MGIPMID:20385772
Nfatc4Chinchillaprotein binding enablesISOUniProtKB:P0CG489068941 PMID:19026640IntActPMID:19026640
Nfatc4ChinchillaRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISONfatc4 (Mus musculus)9068941 PMID:12796475 more ...NTNU_SBPMID:12796475 more ...
Nfatc4Chinchillasequence-specific double-stranded DNA binding enablesISONFATC4 (Homo sapiens)9068941 PMID:28473536ARUK-UCLPMID:28473536
Nfatc4Chinchillatranscription cis-regulatory region binding enablesISONfatc4 (Mus musculus)9068941 PMID:19538478UniProtPMID:19538478
Nfatc4Chinchillatranscription factor binding  ISOGata4 (Rattus norvegicus)9068941 RGDPMID:22198280 and REF_RGD_ID:5687133
Nfatc4Chinchillatranscription factor binding  ISOFoxp1 (Rattus norvegicus)9068941 RGDPMID:21606195 and REF_RGD_ID:11561924
1 to 17 of 17 rows

RGD Manual Annotations


  

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:30032202  



Nfatc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,931,173 - 35,940,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,931,208 - 35,941,555 (-)NCBIChiLan1.0ChiLan1.0
NFATC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,366,911 - 24,379,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1424,365,673 - 24,379,604 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,836,117 - 24,848,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,907,094 - 23,918,650 (+)NCBINCBI36Build 36hg18NCBI36
Build 341423,907,093 - 23,918,648NCBI
Celera144,700,788 - 4,713,452 (+)NCBICelera
Cytogenetic Map14q12NCBI
HuRef144,950,950 - 4,963,469 (+)NCBIHuRef
CHM1_11424,834,722 - 24,847,385 (+)NCBICHM1_1
T2T-CHM13v2.01418,565,666 - 18,578,358 (+)NCBIT2T-CHM13v2.0
Nfatc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,062,252 - 56,071,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1456,060,601 - 56,071,400 (+)EnsemblGRCm39 Ensembl
GRCm381455,824,795 - 55,833,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,823,144 - 55,833,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,443,632 - 56,452,780 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361454,779,079 - 54,788,014 (+)NCBIMGSCv36mm8
Celera1453,626,552 - 53,635,649 (+)NCBICelera
Cytogenetic Map14C3NCBI
cM Map1428.19NCBI
Nfatc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81533,256,912 - 33,284,522 (+)NCBIGRCr8
mRatBN7.21529,286,998 - 29,314,610 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1529,305,535 - 29,314,610 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1531,151,202 - 31,160,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01532,298,412 - 32,307,487 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01530,540,765 - 30,549,840 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01534,493,163 - 34,502,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,493,138 - 34,504,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,381,669 - 38,390,744 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,969,774 - 33,978,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11533,985,319 - 33,994,626 (+)NCBI
Celera1528,880,299 - 28,889,401 (+)NCBICelera
Cytogenetic Map15p13NCBI
NFATC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21525,722,011 - 25,733,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11424,936,780 - 24,949,576 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,141,699 - 5,156,021 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11423,267,667 - 23,279,249 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,266,702 - 23,279,249 (+)Ensemblpanpan1.1panPan2
NFATC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,337,098 - 4,346,409 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,336,450 - 4,346,100 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,259,072 - 4,268,379 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.084,448,860 - 4,458,168 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl84,448,341 - 4,458,173 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.184,138,640 - 4,147,945 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.084,201,033 - 4,210,339 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.084,463,303 - 4,472,610 (+)NCBIUU_Cfam_GSD_1.0
Nfatc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,201,144 - 36,210,126 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936722179,200 - 187,800 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936722178,866 - 187,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,918,984 - 74,929,600 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,918,982 - 74,929,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,189,893 - 80,200,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,352,173 - 1,362,150 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl241,352,291 - 1,362,680 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603613,036,667 - 13,046,650 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfatc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,136,156 - 8,146,312 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248208,136,231 - 8,145,395 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000017225   ⟹   ENSCLAP00000017058
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540935,931,173 - 35,940,696 (-)Ensembl
RefSeq Acc Id: XM_005377004   ⟹   XP_005377061
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540935,931,208 - 35,940,696 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005377005   ⟹   XP_005377062
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540935,931,208 - 35,941,555 (-)NCBI
Sequence:
Protein RefSeqs XP_005377061 (Get FASTA)   NCBI Sequence Viewer  
  XP_005377062 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017058
  ENSCLAP00000017058.1
RefSeq Acc Id: XP_005377062   ⟸   XM_005377005
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005377061   ⟸   XM_005377004
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VKW8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000017058   ⟸   ENSCLAT00000017225
RHD



1 to 24 of 24 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000011705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017225 ENTREZGENE
  ENSCLAT00000017225.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
NCBI Gene Nfatc4 ENTREZGENE
PANTHER NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 4 UniProtKB/TrEMBL
  PTHR12533 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A8C2VKW8 ENTREZGENE, UniProtKB/TrEMBL
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 Nfatc4  nuclear factor of activated T cells 4    nuclear factor of activated T-cells 4  Symbol and/or name change 5135510 APPROVED
2016-08-03 Nfatc4  nuclear factor of activated T-cells 4    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4  Symbol and/or name change 5135510 APPROVED