Nfatc4 (nuclear factor of activated T cells 4) - Rat Genome Database

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Gene: Nfatc4 (nuclear factor of activated T cells 4) Chinchilla lanigera
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Symbol: Nfatc4
Name: nuclear factor of activated T cells 4
RGD ID: 8725080
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); DNA-binding transcription repressor activity, RNA polymerase II-specific (ortholog); INVOLVED IN brain-derived neurotrophic factor receptor signaling pathway (ortholog); branching involved in blood vessel morphogenesis (ortholog); calcineurin-NFAT signaling cascade (ortholog); PARTICIPATES IN calcineurin signaling pathway; nuclear factor of activated T-cells signaling pathway; ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); Chemical and Drug Induced Liver Injury (ortholog); dilated cardiomyopathy (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nuclear speck (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear factor of activated T-cells 4; nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,931,173 - 35,940,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,931,208 - 35,941,555 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data
Nfatc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540935,931,173 - 35,940,696 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540935,931,208 - 35,941,555 (-)NCBIChiLan1.0ChiLan1.0
NFATC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381424,366,911 - 24,379,604 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1424,365,673 - 24,379,604 (+)EnsemblGRCh38hg38GRCh38
GRCh371424,836,117 - 24,848,810 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361423,907,094 - 23,918,650 (+)NCBINCBI36hg18NCBI36
Build 341423,907,093 - 23,918,648NCBI
Celera144,700,788 - 4,713,452 (+)NCBI
Cytogenetic Map14q12NCBI
HuRef144,950,950 - 4,963,469 (+)NCBIHuRef
CHM1_11424,834,722 - 24,847,385 (+)NCBICHM1_1
T2T-CHM13v2.01418,565,666 - 18,578,358 (+)NCBI
Nfatc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391456,062,252 - 56,071,400 (+)NCBIGRCm39mm39
GRCm39 Ensembl1456,060,601 - 56,071,400 (+)Ensembl
GRCm381455,824,795 - 55,833,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1455,823,144 - 55,833,943 (+)EnsemblGRCm38mm10GRCm38
MGSCv371456,443,632 - 56,452,780 (+)NCBIGRCm37mm9NCBIm37
MGSCv361454,779,079 - 54,788,014 (+)NCBImm8
Celera1453,626,552 - 53,635,649 (+)NCBICelera
Cytogenetic Map14C3NCBI
Nfatc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21529,286,998 - 29,314,610 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1529,305,535 - 29,314,610 (+)Ensembl
Rnor_6.01534,493,163 - 34,502,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1534,493,138 - 34,504,326 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01538,381,669 - 38,390,744 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41533,969,774 - 33,978,848 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11533,985,319 - 33,994,626 (+)NCBI
Celera1528,880,299 - 28,889,401 (+)NCBICelera
Cytogenetic Map15p13NCBI
NFATC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11423,267,667 - 23,279,249 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1423,266,702 - 23,279,249 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0145,141,699 - 5,156,021 (+)NCBIMhudiblu_PPA_v0panPan3
NFATC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.184,337,098 - 4,346,409 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl84,336,450 - 4,346,100 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha84,259,072 - 4,268,379 (+)NCBI
ROS_Cfam_1.084,448,860 - 4,458,168 (+)NCBI
ROS_Cfam_1.0 Ensembl84,448,341 - 4,458,173 (+)Ensembl
UMICH_Zoey_3.184,138,640 - 4,147,945 (+)NCBI
UNSW_CanFamBas_1.084,201,033 - 4,210,339 (+)NCBI
UU_Cfam_GSD_1.084,463,303 - 4,472,610 (+)NCBI
Nfatc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864036,201,144 - 36,210,126 (+)NCBI
SpeTri2.0NW_004936722178,866 - 187,847 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl774,918,984 - 74,929,600 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1774,918,982 - 74,929,688 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2780,189,893 - 80,200,589 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1241,352,173 - 1,362,150 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl241,352,291 - 1,362,680 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603613,036,667 - 13,046,650 (+)NCBIVero_WHO_p1.0
Nfatc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248208,136,156 - 8,146,312 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248208,136,231 - 8,145,395 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017225   ⟹   ENSCLAP00000017058
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540935,931,173 - 35,940,696 (-)Ensembl
RefSeq Acc Id: XM_005377004   ⟹   XP_005377061
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540935,931,208 - 35,940,696 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005377005   ⟹   XP_005377062
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540935,931,208 - 35,941,555 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005377061 (Get FASTA)   NCBI Sequence Viewer  
  XP_005377062 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005377062   ⟸   XM_005377005
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005377061   ⟸   XM_005377004
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000017058   ⟸   ENSCLAT00000017225
Protein Domains
RHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000017058 ENTREZGENE
  ENSCLAP00000017058.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017225 ENTREZGENE
  ENSCLAT00000017225.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  NFAT UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
NCBI Gene Nfatc4 ENTREZGENE
PANTHER PTHR12533 UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS NUCFACTORATC UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/TrEMBL
SMART IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A8C2VKW8_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 Nfatc4  nuclear factor of activated T cells 4    nuclear factor of activated T-cells 4  Symbol and/or name change 5135510 APPROVED
2016-08-03 Nfatc4  nuclear factor of activated T-cells 4    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4  Symbol and/or name change 5135510 APPROVED