Park7 (Parkinsonism associated deglycase) - Rat Genome Database

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Gene: Park7 (Parkinsonism associated deglycase) Chinchilla lanigera
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Symbol: Park7
Name: Parkinsonism associated deglycase
RGD ID: 8892808
Description: ENCODES a protein that exhibits androgen receptor binding (ortholog); copper ion binding (ortholog); cupric ion binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); aging (ortholog); cellular detoxification of aldehyde (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ortholog); cerebral infarction (ortholog); FOUND IN axon (ortholog); cell body (ortholog); chromatin (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: parkinson protein 7
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
aging  (ISO)
cellular detoxification of aldehyde  (ISO)
cellular detoxification of methylglyoxal  (ISO)
cellular response to glyoxal  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to oxidative stress  (ISO)
cellular response to reactive oxygen species  (ISO)
detection of oxidative stress  (ISO)
detoxification of copper ion  (ISO)
detoxification of mercury ion  (ISO)
DNA repair  (ISO)
dopamine uptake involved in synaptic transmission  (ISO)
glucose homeostasis  (ISO)
glutathione deglycation  (ISO)
glycolate biosynthetic process  (ISO)
glyoxal metabolic process  (ISO)
guanine deglycation  (ISO)
guanine deglycation, glyoxal removal  (ISO)
guanine deglycation, methylglyoxal removal  (ISO)
histone modification  (ISO)
hydrogen peroxide metabolic process  (ISO)
insulin secretion  (ISO)
lactate biosynthetic process  (ISO)
maternal process involved in female pregnancy  (ISO)
membrane depolarization  (ISO)
membrane hyperpolarization  (ISO)
methylglyoxal catabolic process to lactate  (ISO)
methylglyoxal metabolic process  (ISO)
mitochondrion organization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of hydrogen peroxide-induced cell death  (ISO)
negative regulation of hydrogen peroxide-induced neuron death  (ISO)
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of NMDA glutamate receptor activity  (ISO)
negative regulation of oxidative stress-induced cell death  (ISO)
negative regulation of oxidative stress-induced neuron death  (ISO)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of protein export from nucleus  (ISO)
negative regulation of protein K48-linked deubiquitination  (ISO)
negative regulation of protein kinase activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein sumoylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of TRAIL-activated apoptotic signaling pathway  (ISO)
negative regulation of ubiquitin-protein transferase activity  (ISO)
negative regulation of ubiquitin-specific protease activity  (ISO)
peptidyl-arginine deglycation  (ISO)
peptidyl-cysteine deglycation  (ISO)
peptidyl-lysine deglycation  (ISO)
positive regulation of acute inflammatory response to antigenic stimulus  (ISO)
positive regulation of androgen receptor activity  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of dopamine biosynthetic process  (ISO)
positive regulation of fertilization  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of L-dopa biosynthetic process  (ISO)
positive regulation of L-dopa decarboxylase activity  (ISO)
positive regulation of mitochondrial electron transport, NADH to ubiquinone  (ISO)
positive regulation of NAD(P)H oxidase activity  (ISO)
positive regulation of oxidative phosphorylation uncoupler activity  (ISO)
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of pyrroline-5-carboxylate reductase activity  (ISO)
positive regulation of reactive oxygen species biosynthetic process  (ISO)
positive regulation of superoxide dismutase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription regulatory region DNA binding  (ISO)
positive regulation of tyrosine 3-monooxygenase activity  (ISO)
protein deglycation, glyoxal removal  (ISO)
protein deglycation, methylglyoxal removal  (ISO)
protein deglycosylation  (ISO)
protein stabilization  (ISO)
regulation of androgen receptor signaling pathway  (ISO)
regulation of histone acetylation  (ISO)
regulation of histone ubiquitination  (ISO)
regulation of inflammatory response  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of TRAIL production  (ISO)
response to hydrogen peroxide  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
spermatogenesis  (ISO)
synaptic transmission, dopaminergic  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Park7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBIChiLan1.0ChiLan1.0
PARK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl17,954,291 - 7,985,505 (+)EnsemblGRCh38hg38GRCh38
GRCh3817,961,711 - 7,985,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3718,021,771 - 8,045,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3617,944,380 - 7,967,926 (+)NCBINCBI36hg18NCBI36
Build 3417,956,058 - 7,979,602NCBI
Celera17,128,771 - 7,152,398 (+)NCBI
Cytogenetic Map1p36.23NCBI
HuRef17,169,316 - 7,193,163 (+)NCBIHuRef
CHM1_118,009,469 - 8,033,097 (+)NCBICHM1_1
Park7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394150,981,590 - 150,994,378 (-)NCBIGRCm39mm39
GRCm39 Ensembl4150,981,590 - 150,998,894 (-)Ensembl
GRCm384150,897,133 - 150,909,921 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4150,897,133 - 150,914,437 (-)EnsemblGRCm38mm10GRCm38
MGSCv374150,271,242 - 150,284,030 (-)NCBIGRCm37mm9NCBIm37
MGSCv364149,740,942 - 149,753,650 (-)NCBImm8
Celera4153,174,297 - 153,187,100 (-)NCBICelera
Cytogenetic Map4E2NCBI
Park7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25161,353,718 - 161,376,993 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl5161,353,719 - 161,376,970 (-)Ensembl
Rnor_6.05167,982,438 - 168,004,724 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5167,982,439 - 168,004,724 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05171,559,202 - 171,582,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45168,050,149 - 168,061,616 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15168,060,336 - 168,071,804 (-)NCBI
Celera5159,607,648 - 159,630,713 (-)NCBICelera
Cytogenetic Map5q36NCBI
PARK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.117,969,265 - 7,993,271 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17,969,280 - 7,993,271 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v016,722,260 - 6,745,915 (+)NCBIMhudiblu_PPA_v0panPan3
PARK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1561,576,219 - 61,592,325 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl561,576,069 - 61,592,303 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha561,584,413 - 61,601,125 (+)NCBI
ROS_Cfam_1.0561,791,984 - 61,808,701 (+)NCBI
UMICH_Zoey_3.1561,791,244 - 61,807,961 (+)NCBI
UNSW_CanFamBas_1.0561,656,017 - 61,672,730 (+)NCBI
UU_Cfam_GSD_1.0562,059,399 - 62,076,120 (+)NCBI
Park7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505831,937,508 - 31,951,577 (+)NCBI
SpeTri2.0NW_0049366232,422,780 - 2,436,817 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl668,629,214 - 68,645,520 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1668,629,327 - 68,645,147 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2663,023,779 - 63,033,855 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120123,776,084 - 123,808,031 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl20123,776,297 - 123,798,434 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605427,810,002 - 27,834,129 (-)NCBIVero_WHO_p1.0
Park7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248183,900,917 - 3,915,457 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000009223   ⟹   ENSCLAP00000009094
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554864,969,497 - 4,985,885 (-)Ensembl
RefSeq Acc Id: XM_005404061   ⟹   XP_005404118
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,974,130 - 4,985,107 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404062   ⟹   XP_005404119
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,974,130 - 4,985,885 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404063   ⟹   XP_005404120
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,974,130 - 4,985,927 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005404064   ⟹   XP_005404121
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554864,974,130 - 4,985,591 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005404118 (Get FASTA)   NCBI Sequence Viewer  
  XP_005404119 (Get FASTA)   NCBI Sequence Viewer  
  XP_005404120 (Get FASTA)   NCBI Sequence Viewer  
  XP_005404121 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005404120   ⟸   XM_005404063
- Sequence:
RefSeq Acc Id: XP_005404119   ⟸   XM_005404062
- Sequence:
RefSeq Acc Id: XP_005404121   ⟸   XM_005404064
- Sequence:
RefSeq Acc Id: XP_005404118   ⟸   XM_005404061
- Sequence:
RefSeq Acc Id: ENSCLAP00000009094   ⟸   ENSCLAT00000009223


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000006345 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000009094 ENTREZGENE
Ensembl Transcript ENSCLAT00000009223 ENTREZGENE
NCBI Gene Park7 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Park7  Parkinsonism associated deglycase    parkinson protein 7  Symbol and/or name change 5135510 APPROVED