Mal (mal, T cell differentiation protein)

Gene: Mal (mal, T cell differentiation protein) Chinchilla lanigera

Analyze

Symbol:

Mal

Name:

mal, T cell differentiation protein

RGD ID:

9055628

Description:

ENCODES a protein that exhibits structural constituent of myelin sheath (ortholog); INVOLVED IN central nervous system myelination (ortholog); myelination (ortholog); positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); genetic disease (ortholog); Head and Neck Neoplasms (ortholog); FOUND IN apical plasma membrane (ortholog); endoplasmic reticulum (ortholog); hinge region between urothelial plaques of apical plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	3,372,577 - 3,398,836 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	3,372,577 - 3,396,868 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

genetic disease (ISO)

Head and Neck Neoplasms (ISO)

metachromatic leukodystrophy (ISO)

squamous cell carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

central nervous system myelination (ISO)

myelination (ISO)

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (ISO)

protein insertion into plasma membrane (ISO)

protein localization to paranode region of axon (ISO)

Cellular Component

apical plasma membrane (ISO)

endoplasmic reticulum (ISO)

hinge region between urothelial plaques of apical plasma membrane (ISO)

membrane raft (ISO)

plasma membrane raft (ISO)

Schmidt-Lanterman incisure (ISO)

Molecular Function

protein binding (ISO)

structural constituent of myelin sheath (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Mal
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955470	3,372,577 - 3,398,836 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955470	3,372,577 - 3,396,868 (+)	NCBI	ChiLan1.0	ChiLan1.0

MAL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	95,025,708 - 95,053,992 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	95,025,677 - 95,053,992 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	95,691,453 - 95,719,737 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	95,055,206 - 95,083,462 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	95,113,352 - 95,141,609	NCBI
Celera	2	90,041,551 - 90,070,642 (+)	NCBI		Celera
Cytogenetic Map	2	q11.1	ENTREZGENE
HuRef	2	89,720,233 - 89,748,565 (+)	NCBI		HuRef
CHM1_1	2	95,695,693 - 95,724,010 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	95,532,209 - 95,560,493 (+)	NCBI		T2T-CHM13v2.0

Mal
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	127,475,146 - 127,498,615 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	127,475,146 - 127,498,615 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	127,633,226 - 127,656,695 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	127,633,226 - 127,656,695 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	127,458,962 - 127,482,431 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	127,324,671 - 127,347,724 (-)	NCBI		MGSCv36	mm8
Celera	2	128,878,634 - 128,902,174 (-)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	62.06	NCBI

Mal
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	135,317,664 - 135,341,423 (-)	NCBI		GRCr8
mRatBN7.2	3	114,864,378 - 114,888,136 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	114,864,378 - 114,888,136 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	118,753,666 - 118,777,409 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	127,349,206 - 127,372,951 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	125,009,582 - 125,033,317 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	120,209,647 - 120,233,655 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	120,209,647 - 120,233,655 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	127,099,278 - 127,123,286 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	115,166,671 - 115,190,432 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	115,072,243 - 115,096,005 (-)	NCBI
Celera	3	113,699,325 - 113,723,029 (-)	NCBI		Celera
RH 3.4 Map	3	998.6	RGD
Cytogenetic Map	3	q36	NCBI

MAL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	33,243,632 - 33,271,455 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	33,246,391 - 33,274,217 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	104,355,020 - 104,382,849 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	95,930,298 - 95,956,573 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	95,930,315 - 95,956,573 (+)	Ensembl	panpan1.1		panPan2

MAL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	34,977,298 - 35,000,690 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	34,977,298 - 35,001,349 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	34,746,124 - 34,769,084 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	35,748,374 - 35,771,352 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	35,748,374 - 35,772,227 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	34,876,424 - 34,899,422 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	34,945,386 - 34,968,323 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	35,154,731 - 35,177,728 (-)	NCBI		UU_Cfam_GSD_1.0

Mal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405073	83,398 - 89,966 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937185	63,274 - 68,187 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004937185	62,807 - 68,205 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MAL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	46,181,555 - 46,242,047 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	46,223,610 - 46,242,306 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	48,182,689 - 48,200,460 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MAL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	66,521 - 92,476 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	66,610 - 93,588 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	167,449,824 - 167,476,696 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mal
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624749	1,853,838 - 1,879,590 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624749	1,854,177 - 1,877,054 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005400636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005400637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01052700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01007567	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000008088 ⟹ ENSCLAP00000007968

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955470	3,372,577 - 3,398,836 (+)	Ensembl

RefSeq Acc Id:

ENSCLAT00000008089 ⟹ ENSCLAP00000007969

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955470	3,372,702 - 3,396,359 (+)	Ensembl

RefSeq Acc Id:

XM_005400636 ⟹ XP_005400693

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955470	3,372,577 - 3,396,868 (+)	NCBI

Sequence:

show sequence

GGCTCTCCAGCTCTTAACCCTCGCACAAGGGCGCCCGGGCCACTGGGTCCCGCGGAGCGAGCGA
GTGGTCATCGCGGAGCCGCAGCGCGCGCGTCCCGTCCCGAGGCCGTCGCCAGCTCGTCGGCATG
GCCCCCGCAGCGGCTTCGGGTGGCAGCACCCTGCCCAGTGGCTTTTCGGTCTTCACCACCTTCC
CCGACTTGCTCTTCATCTTTGAGTTTGTCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTC
GCTGGTGCCCATCCCCCTGATCCAAGGCTGGGTGATGTTCGTGTCTGTGTTCTGCTTCGTGACC
ACCACTACCCTGCTCGTCCTGTATATAATTAATGCCCACGGTGGGGAGACATCCTGGGTCACGC
TGGACGCAGCCTACAACTGTGTGGCTGCCCTGTTTTACCTCAGCGCGTCAGTCCTGGAAGCCCT
GGCCACCATTCTCACACGTGACGGTTACACCTACAAGCAGTACCACGAAAACATCTCGGCCGTG
GTGTTTTCCTACGTAGCCACTTTGCTGTACGTGACCCATGCTGTGTTCTCTTTAATCAGATGGA
AGTCTTCATAAAGAGGCAGATTTGAGCTAGAAACCCAGAATGGTGTTAACTCCTCAGCCTGTCT
TCCAGCCTAACTTTCTAGAATGCAGACACGCTCTCCATGATGGAAAAAAAGGAAACAAACCAAA
AGGAAAAAAGAAAAGGCCACACTGTTTCTGCAGTAGCGTGTTTATCCTCCTATGCCTTTGCCTC
AGGGCTTGGGGGCTTGCTGTGTTTAACCTCCAACTGCTGAGCTGTCTTTCTAGAGTCACTTCCT
GTCTGTGAAAGGGGCCAATGGGTGTGGGACATAACCTGTGACAGAAGCAACAGTCCCCTGCTGA
CCCCCGGACCACAGCTTGAGAAGCACCTTCTGGAATATTCCACAGGCTCTTTTGAGCACACCAC
TGAGGGCATGTTTCTGTCTCCATGGATGTTCTGCATGTCACAGGGACTGATACTCACCCAACTG
AGGTTTCCAAATGTCCATGGTGGAAGATGATAACCCTTGGGAATACTTTATAAAGTGCTTTTAT
GTTCAATA

hide sequence

RefSeq Acc Id:

XM_005400637 ⟹ XP_005400694

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955470	3,372,718 - 3,396,868 (+)	NCBI

Sequence:

show sequence

CTTCGGGTGGCAGCACCCTGCCCAGTGGCTTTTCGGTCTTCACCACCTTCCCCGACTTGCTCTT
CATCTTTGAGTTTGGTATTTTTGATCTGAAGTTGGTTGAATCTGTAGATGTGGATGGAACCTGT
GGCTATGAAGGAGTGGCTGGAATGGGCTGCTGATGCACCTGTTTCTTCTGGGCTATCAGCCTCC
AGGGTCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCGCTGGTGCCCATCCCCCTGATCC
AAGGCTGGGTGATGTTCGTGTCTGTGTTCTGCTTCGTGACCACCACTACCCTGCTCGTCCTGTA
TATAATTAATGCCCACGGTGGGGAGACATCCTGGGTCACGCTGGACGCAGCCTACAACTGTGTG
GCTGCCCTGTTTTACCTCAGCGCGTCAGTCCTGGAAGCCCTGGCCACCATTCTCACACGTGACG
GTTACACCTACAAGCAGTACCACGAAAACATCTCGGCCGTGGTGTTTTCCTACGTAGCCACTTT
GCTGTACGTGACCCATGCTGTGTTCTCTTTAATCAGATGGAAGTCTTCATAAAGAGGCAGATTT
GAGCTAGAAACCCAGAATGGTGTTAACTCCTCAGCCTGTCTTCCAGCCTAACTTTCTAGAATGC
AGACACGCTCTCCATGATGGAAAAAAAGGAAACAAACCAAAAGGAAAAAAGAAAAGGCCACACT
GTTTCTGCAGTAGCGTGTTTATCCTCCTATGCCTTTGCCTCAGGGCTTGGGGGCTTGCTGTGTT
TAACCTCCAACTGCTGAGCTGTCTTTCTAGAGTCACTTCCTGTCTGTGAAAGGGGCCAATGGGT
GTGGGACATAACCTGTGACAGAAGCAACAGTCCCCTGCTGACCCCCGGACCACAGCTTGAGAAG
CACCTTCTGGAATATTCCACAGGCTCTTTTGAGCACACCACTGAGGGCATGTTTCTGTCTCCAT
GGATGTTCTGCATGTCACAGGGACTGATACTCACCCAACTGAGGTTTCCAAATGTCCATGGTGG
AAGATGATAACCCTTGGGAATACTTTATAAAGTGCTTTTATGTTCAATA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005400693	(Get FASTA)	NCBI Sequence Viewer
	XP_005400694	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000007968
	ENSCLAP00000007968.1
	ENSCLAP00000007969.1

RefSeq Acc Id:	XP_005400693 ⟸ XM_005400636
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2YLR5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPAAASGGSTLPSGFSVFTTFPDLLFIFEFVFGGLVWILVASSLVPIPLIQGWVMFVSVFCFV TTTTLLVLYIINAHGGETSWVTLDAAYNCVAALFYLSASVLEALATILTRDGYTYKQYHENISA VVFSYVATLLYVTHAVFSLIRWKSS hide sequence

RefSeq Acc Id:	XP_005400694 ⟸ XM_005400637
- Peptide Label:	isoform X2
- Sequence:	show sequence MWMEPVAMKEWLEWAADAPVSSGLSASRVFGGLVWILVASSLVPIPLIQGWVMFVSVFCFVTTT TLLVLYIINAHGGETSWVTLDAAYNCVAALFYLSASVLEALATILTRDGYTYKQYHENISAVVF SYVATLLYVTHAVFSLIRWKSS hide sequence

RefSeq Acc Id:

ENSCLAP00000007968 ⟸ ENSCLAT00000008088

RefSeq Acc Id:

ENSCLAP00000007969 ⟸ ENSCLAT00000008089

Protein Domains

MARVEL

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000005590	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000008088	ENTREZGENE
	ENSCLAT00000008088.1	UniProtKB/TrEMBL
	ENSCLAT00000008089.1	UniProtKB/TrEMBL
InterPro	MAL	UniProtKB/TrEMBL
	Marvel	UniProtKB/TrEMBL
NCBI Gene	Mal	ENTREZGENE
PANTHER	MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN	UniProtKB/TrEMBL
	MYELIN AND LYMPHOCYTE PROTEIN	UniProtKB/TrEMBL
Pfam	MARVEL	UniProtKB/TrEMBL
PRINTS	MALPROTEIN	UniProtKB/TrEMBL
PROSITE	MARVEL	UniProtKB/TrEMBL
UniProt	A0A8C2V057_CHILA	UniProtKB/TrEMBL
	A0A8C2YLR5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-12-19	Mal	mal, T cell differentiation protein		mal, T-cell differentiation protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD