Mtch2 (mitochondrial carrier 2) - Rat Genome Database

Name: Mtch2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Mtch2 (mitochondrial carrier 2) Chinchilla lanigera

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Symbol:

Mtch2

Name:

mitochondrial carrier 2

RGD ID:

8931886

Description:

ENCODES a protein that exhibits membrane insertase activity (ortholog); INVOLVED IN cellular response to radiation (ortholog); establishment of protein localization to mitochondrial membrane involved in mitochondrial fission (ortholog); hematopoietic stem cell homeostasis (ortholog); ASSOCIATED WITH congenital disorder of glycosylation type IIc (ortholog); COVID-19 (ortholog); intellectual disability (ortholog); FOUND IN mitochondrial outer membrane (ortholog); mitochondrion (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

mitochondrial carrier homolog 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MTCH2 (mitochondrial carrier 2)	NCBI	Ortholog
Mus musculus (house mouse):	Mtch2 (mitochondrial carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Mtch2 (mitochondrial carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MTCH2 (mitochondrial carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MTCH2 (mitochondrial carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mtch2 (mitochondrial carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MTCH2 (mitochondrial carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mtch2 (mitochondrial carrier 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	672,301 - 690,989 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	672,301 - 690,989 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital disorder of glycosylation type IIc (ISO)

COVID-19 (ISO)

intellectual disability (ISO)

obesity (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to radiation (ISO)

establishment of protein localization to mitochondrial membrane involved in mitochondrial fission (ISO)

hematopoietic stem cell homeostasis (ISO)

hematopoietic stem cell migration (ISO)

hepatocyte apoptotic process (ISO)

lactate metabolic process (ISO)

lipid homeostasis (ISO)

mitochondrial ATP synthesis coupled electron transport (ISO)

negative regulation of glycolytic process (ISO)

negative regulation of mitochondrial membrane potential (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (ISO)

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage (ISO)

positive regulation of stem cell differentiation (ISO)

protein insertion into mitochondrial outer membrane (ISO)

protein localization to mitochondrion (ISO)

regulation of mitochondrial fusion (ISO)

regulation of mitochondrial membrane permeability involved in apoptotic process (ISO)

Cellular Component

mitochondrial outer membrane (ISO)

mitochondrion (ISO)

Molecular Function

membrane insertase activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Mtch2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	672,301 - 690,989 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955422	672,301 - 690,989 (+)	NCBI	ChiLan1.0	ChiLan1.0

MTCH2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	47,604,317 - 47,642,559 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	47,617,315 - 47,642,607 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	47,638,869 - 47,664,111 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	47,595,446 - 47,620,640 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	47,595,443 - 47,620,640	NCBI
Celera	11	47,781,598 - 47,811,486 (-)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	47,340,003 - 47,369,889 (-)	NCBI		HuRef
CHM1_1	11	47,638,107 - 47,663,488 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	47,764,706 - 47,807,519 (-)	NCBI		T2T-CHM13v2.0

Mtch2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	90,677,434 - 90,697,154 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	90,677,499 - 90,697,154 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	90,847,090 - 90,866,810 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	90,847,155 - 90,866,810 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	90,687,312 - 90,706,791 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	90,647,994 - 90,667,473 (+)	NCBI		MGSCv36	mm8
Celera	2	92,232,045 - 92,251,524 (+)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	50.41	NCBI

Mtch2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	97,286,388 - 97,306,028 (+)	NCBI		GRCr8
mRatBN7.2	3	76,830,549 - 76,850,189 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	76,830,413 - 76,850,189 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	80,308,286 - 80,327,915 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	88,906,770 - 88,926,399 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	86,758,047 - 86,777,679 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	79,678,141 - 79,695,356 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	79,678,201 - 79,694,006 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	86,385,047 - 86,404,836 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	75,210,002 - 75,230,282 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	75,092,877 - 75,126,646 (+)	NCBI
Celera	3	76,039,634 - 76,059,248 (+)	NCBI		Celera
Cytogenetic Map	3	q24	NCBI

MTCH2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	49,823,023 - 49,851,518 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	49,841,378 - 49,871,243 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	47,566,884 - 47,596,711 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	48,115,773 - 48,146,312 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	48,115,774 - 48,146,312 (-)	Ensembl	panpan1.1		panPan2

MTCH2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	42,023,484 - 42,045,331 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	42,023,511 - 42,044,060 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	40,754,913 - 40,776,950 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	42,679,386 - 42,701,445 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	42,166,589 - 42,188,438 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	41,720,899 - 41,742,751 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	42,451,062 - 42,472,832 (+)	NCBI		UU_Cfam_GSD_1.0

Mtch2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	19,510,698 - 19,532,549 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936562	1,622,341 - 1,644,191 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MTCH2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	14,983,154 - 15,005,213 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	14,982,991 - 15,005,214 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	16,159,926 - 16,181,752 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Mtch2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	1,199,291 - 1,221,123 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624767	1,199,367 - 1,218,425 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013514048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01022427	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01022428	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01054763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01066292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000017687 ⟹ ENSCLAP00000017515

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955422	672,301 - 690,989 (+)	Ensembl

Ensembl Acc Id:

ENSCLAT00000017688 ⟹ ENSCLAP00000017516

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955422	672,301 - 690,119 (+)	Ensembl

RefSeq Acc Id:

XM_013514048 ⟹ XP_013369502

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955422	672,301 - 690,989 (+)	NCBI

Sequence:

show sequence

GCCTGTCGGGGCGGAGCGTGCGTGCGTGTGCGTGCGTGCGCGCGCGCCGCGGGCGGGCGGGCCA
GTGAAGCCGGCGGCCCCGGCACGTGATCTTGGGGCTGGAGGTGTCGCTTGGTGGCTCGGTCTGT
CTGTCTGTCCGTCCGCCCGCGGGTGCCATCATGGCGGACGCGGCCAGTCAGGTGCTCCTGGGCT
CCGGTCTCACCATCCTGTCCCAGCCGCTCATGTACGTGAAAGTGCTCATCCAGGTGGGATACGA
GCCTCTTCCTCCAAAAGTAGGACGGAATATTTTTGGGCGGCAAGTGTGTCAGCTTCCAGGTCTC
TTCAGTTACGCTCATCACATTGCGAGCATCGATGGGAAGCGCGGGCTGTTCACCGGCTTAACGC
CCAGACTGTGCTCGGGCGTCCTTGGAACTGTGGTCCACGGTAGAGTCTTACAGCATTACCAGGA
TGGTGACAAGCCCGAGGAGTCTGGACCTGGAAGTGTACAAAAAGAAGGCTCGCCTTCCTTTGAC
CAAGTTATCAAAGAGACAACTCGAGAGATGATTGCTCGCTCCGCTGCTACCCTCATCACGCACC
CCTTCCACGTCATCACTCTGAGATCGATGGTGCAGTTCATAGGAAGAGAATCCAAGTACTGCGG
GCTCTGTGACTCTGTAGTGACCATCTACCGAGAAGAGGGCATCCTGGGATTCTTCGCAGGTCTG
ATTCCTCGCCTGCTGGGGGACATCATTTCTCTGTGGCTCTGTAACTCGCTGGCCTACCTCGTCA
ATACCTACGCCCTGGACAGTGGGGTTTCCACCATGAATGAAATGAAGAGTTATTCCCAAGCTGT
CACAGGATTCTTCGCCAGCATGCTCACCTACCCCTTCGTGCTTGTGTCCAACCTCATGGCCGTC
AACAACTGCGGGCTTGCTGGTGGGTGCCCCCCCTACTCCCCAGTCTACACGTCCTGGATCCACT
GCTGGTGCTCGCTGCAGAAGGAGGGAAACATGAGCCGGGGAAACAGCTTGTTTTTCCGGAAGGT
CCCCTTCGGGAAGACGTACTGCTGCGACCTGAGGATGCTGATCTGAAGATGCGGGGCAGGGACA
GTGACATTTCTGCGGTCCCAGACGCACAGAATGATGGGAGAGAATGTTGATTTCTATATGGTGT
GGCGCGCTTTTTTAATAATCACTTGATCTTGGGAAACGGAGGCGGCGGGTGTCTACTTTTCTGT
TGTCTGTCCTGCACGGCCCGGCCGCCGGCACCCGTAGTGACCCTGAGCTCACCAGGGTCGCACT
CTCCCATTTGCTCCAGGTTCGCACTCTACCTAAGCAGAGAAGACGCCATGTTCCCCTGCAGGCC
AGGCAGGCTGTGGTGGCTTGAGACTGGCTGTCACCGCTCCTGCCCTCTCCCTGGGGGCCTGACC
GCCTCGTGCCCAGCCCAGACCTCCTGGCTCACAGGGACGCGCTGCTGAGGGACATGTGTGCCCT
GAGCGTGTCACCCACCGTAAAGGGAGGGACTTCCCTGCGGCGAGGGGCGGGTGAGCGCTGGAGC
GGACACGCGGTGCGCGCCATGTGCTGTCGCTCTGGCCTTCGGTCCCAAAGCTTTCGGTTTTGCT
CCCTTTGTGTTATCCCAAGAGGCAAGAGGTGCCTCCTGAGGGTGCCTCGGAAGGCGTTGGTCAC
CGCCTTGCTGGCGCGGCTGTGGCTGAAGTCCCCAGGGCCCAGGACAGCCCCGTCACACCCTCGG
TCGGGTTAGCGGCTGGGGAGGTGGGGCCCGCGGCCGCAGCCAGGCCTGGAGAAGCCGCTCGGCA
GTTCTGAGCGGCAGGAGTGCCCACAGCGCCACCACCGCAGGGTCATTTCATATTCTAGGTGCAA
GCTGTGCTGCTTTTATTTTAATATAAAAATGTTTTCATTTCCTACTTTTTTCTCCCCAAAAATC
TTCCAGTAAAGCTGATCTAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_013369502	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000017515
	ENSCLAP00000017515.1
	ENSCLAP00000017516.1

RefSeq Acc Id:

XP_013369502 ⟸ XM_013514048

- UniProtKB:

A0A8C2VU23 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLPPKVGRNIFGRQVCQLPGLFSYAHHIASI
DGKRGLFTGLTPRLCSGVLGTVVHGRVLQHYQDGDKPEESGPGSVQKEGSPSFDQVIKETTREM
IARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSVVTIYREEGILGFFAGLIPRLLGDIIS
LWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGCP
PYSPVYTSWIHCWCSLQKEGNMSRGNSLFFRKVPFGKTYCCDLRMLI

hide sequence

Ensembl Acc Id:

ENSCLAP00000017516 ⟸ ENSCLAT00000017688

Ensembl Acc Id:

ENSCLAP00000017515 ⟸ ENSCLAT00000017687

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000012026	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000017687	ENTREZGENE
	ENSCLAT00000017687.1	UniProtKB/TrEMBL
	ENSCLAT00000017688.1	UniProtKB/TrEMBL
Gene3D-CATH	1.50.40.10	UniProtKB/TrEMBL
InterPro	Mitochondrial_sb/sol_carrier	UniProtKB/TrEMBL
	Mt_carrier_dom_sf	UniProtKB/TrEMBL
NCBI Gene	LOC102006473	ENTREZGENE
PANTHER	MITOCHONDRIAL CARRIER HOMOLOG	UniProtKB/TrEMBL
	MITOCHONDRIAL CARRIER HOMOLOG 2	UniProtKB/TrEMBL
Pfam	Mito_carr	UniProtKB/TrEMBL
PROSITE	SOLCAR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103506	UniProtKB/TrEMBL
UniProt	A0A8C2VNW5_CHILA	UniProtKB/TrEMBL
	A0A8C2VU23	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	Mtch2	mitochondrial carrier 2	LOC102006473	mitochondrial carrier homolog 1-like	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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