Traf2 (TNF receptor associated factor 2)

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Gene: Traf2 (TNF receptor associated factor 2) Chinchilla lanigera

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Symbol:

Traf2

Name:

TNF receptor associated factor 2

RGD ID:

8827655

Description:

ENCODES a protein that exhibits CD40 receptor binding (ortholog); enzyme binding (ortholog); identical protein binding (ortholog); INVOLVED IN CD27 signaling pathway (ortholog); CD40 signaling pathway (ortholog); cellular response to nitric oxide (ortholog); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; ceramide signaling pathway; p38 MAPK signaling pathway; ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN CD40 receptor complex (ortholog); cell cortex (ortholog); cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

TNF receptor-associated factor 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	4,967,984 - 4,983,987 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	4,964,692 - 4,984,359 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adams-Oliver Syndrome 5 (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

autosomal dominant nocturnal frontal lobe epilepsy 5 (ISO)

developmental and epileptic encephalopathy 14 (ISO)

epilepsy (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

Leigh disease (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

Transplant Rejection (ISO)

tuberous sclerosis 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

CD27 signaling pathway (ISO)

CD40 signaling pathway (ISO)

cellular response to nitric oxide (ISO)

innate immune response (ISO)

interleukin-17-mediated signaling pathway (ISO)

mRNA stabilization (ISO)

negative regulation of glial cell apoptotic process (ISO)

non-canonical NF-kappaB signal transduction (ISO)

positive regulation of canonical NF-kappaB signal transduction (ISO)

positive regulation of DNA-binding transcription factor activity (ISO)

positive regulation of extrinsic apoptotic signaling pathway (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of JUN kinase activity (ISO)

positive regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of T cell cytokine production (ISO)

positive regulation of tumor necrosis factor-mediated signaling pathway (ISO)

programmed necrotic cell death (ISO)

protein autoubiquitination (ISO)

protein catabolic process (ISO)

protein K63-linked ubiquitination (ISO)

protein-containing complex assembly (ISO)

regulation of apoptotic process (ISO)

regulation of immunoglobulin production (ISO)

regulation of JNK cascade (ISO)

regulation of protein-containing complex assembly (ISO)

signal transduction (ISO)

signal transduction involved in regulation of gene expression (ISO)

T cell activation (ISO)

TORC1 complex assembly (ISO)

TORC2 complex disassembly (ISO)

tumor necrosis factor-mediated signaling pathway (ISO)

Cellular Component

CD40 receptor complex (ISO)

cell cortex (ISO)

cytoplasm (ISO)

cytoplasmic side of plasma membrane (ISO)

cytosol (ISO)

IRE1-TRAF2-ASK1 complex (ISO)

membrane raft (ISO)

protein-containing complex (ISO)

TRAF2-GSTP1 complex (ISO)

tumor necrosis factor receptor superfamily complex (ISO)

ubiquitin ligase complex (ISO)

vesicle membrane (ISO)

Molecular Function

CD40 receptor binding (ISO)

enzyme binding (ISO)

identical protein binding (ISO)

mitogen-activated protein kinase kinase kinase binding (ISO)

protein binding (ISO)

protein kinase binding (ISO)

protein phosphatase binding (ISO)

protein-containing complex binding (ISO)

protein-macromolecule adaptor activity (ISO)

signaling adaptor activity (ISO)

sphingolipid binding (ISO)

thioesterase binding (ISO)

tumor necrosis factor binding (ISO)

tumor necrosis factor receptor binding (ISO)

ubiquitin protein ligase activity (ISO)

ubiquitin protein ligase binding (ISO)

ubiquitin-protein transferase activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

c-Jun N-terminal kinases MAPK signaling pathway (ISO)

ceramide signaling pathway (ISO)

p38 MAPK signaling pathway (ISO)

Trail mediated signaling pathway (ISO)

tumor necrosis factor mediated signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Traf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	4,967,984 - 4,983,987 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	4,964,692 - 4,984,359 (+)	NCBI	ChiLan1.0	ChiLan1.0

TRAF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	136,881,958 - 136,926,607 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	136,881,912 - 136,926,607 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	139,780,968 - 139,821,059 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	138,900,786 - 138,940,888 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	137,056,801 - 137,096,903	NCBI
Celera	9	110,295,018 - 110,335,296 (+)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,252,590 - 109,280,516 (+)	NCBI		HuRef
CHM1_1	9	139,929,666 - 139,969,783 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,116,134 - 149,160,997 (+)	NCBI		T2T-CHM13v2.0

Traf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,407,994 - 25,436,952 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,407,994 - 25,436,952 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,517,982 - 25,546,940 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,517,982 - 25,546,940 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,373,502 - 25,402,414 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,339,991 - 25,368,903 (-)	NCBI		MGSCv36	mm8
Celera	2	25,245,480 - 25,274,398 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.32	NCBI

Traf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,740,098 - 28,764,752 (-)	NCBI		GRCr8
mRatBN7.2	3	8,341,950 - 8,366,609 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,341,951 - 8,366,538 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,447,015 - 11,471,676 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,033,239 - 20,057,902 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	18,223,083 - 18,247,745 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,746,061 - 2,770,690 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,746,075 - 2,770,620 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,727,474 - 2,752,102 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,692,740 - 3,717,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,693,271 - 3,717,346 (-)	NCBI
Celera	3	3,167,057 - 3,191,598 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

TRAF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,474,741 - 2,516,037 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,477,075 - 2,518,371 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	107,938,935 - 107,984,797 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	136,912,671 - 136,955,331 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	136,917,358 - 136,955,331 (+)	Ensembl	panpan1.1		panPan2

TRAF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,688,071 - 48,713,936 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,689,331 - 48,703,633 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,901,455 - 47,927,699 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,565,899 - 49,592,130 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,562,621 - 49,590,227 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,342,106 - 48,368,330 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,640,817 - 48,667,045 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,687,986 - 48,714,231 (-)	NCBI		UU_Cfam_GSD_1.0

Traf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,339,938 - 202,370,164 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	1,003,528 - 1,029,249 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	1,004,891 - 1,034,913 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRAF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa10.2	1	313,771,819 - 313,789,938 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRAF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,263,688 - 1,309,626 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,263,274 - 1,290,907 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	3,989,592 - 4,034,330 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Traf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	952,574 - 965,661 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	952,574 - 973,511 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013506639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013506640	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01066949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01188361	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000015098 ⟹ ENSCLAP00000014939

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955513	4,967,984 - 4,983,987 (+)	Ensembl

RefSeq Acc Id:

XM_013506639 ⟹ XP_013362093

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955513	4,967,984 - 4,984,359 (+)	NCBI

Sequence:

show sequence

GGCCACAAGGCGTGTGGGGTTCCAGGTCTCATGGCTGCAGCCAGTGTGACCCCCCTGGGCTCCC
TGGACCTGCTGCAGCCGGGCTTTTCCAAGACCCTCCTGGGGACCAAGCTCGAGGCCAAGTACCT
GTGCTCTGCCTGTAGAAACGTCCTGCGGAGGCCCTTCCAGGCCCAGTGTGGCCACCGCTACTGC
TCCTTCTGCCTAAGCAGCATCCTCAGCTCTGGGCCTCAGAACTGCGCTGCCTGTGTTCAGGAGG
GGATCTACGAGGAAGGCATTTCTATCTTAGAAACCAGCTCAGCCTTTCCAGACAATGCTGCCCG
CAGGGAGGTGGAGAGCCTGCCAGCCGTCTGTCCCAACGAGGGGTGCACCTGGAAGGGGACCTTG
AAGGAATATGAGAGCTGCCACGAAGGACTCTGCCCGTTCCTGCTGACGGAGTGCCCTGCGTGTA
AAGGCCAAGTCCGCCTTGGGGAGAAGGAGCGCCATGCTGAGCAGGAGTGCCCAGAGAGGAGCCT
GGCCTGCCGCCACTGCCGGGCGCCCTGTTGCCGATCGGACCTAGAGGCGCACTATGTGGTCTGC
CCCAAGTTCCCCTTGATCTGCGATGGCTGCGGCAAGAAGAAGATCCCTCGGGAGAAGGTGGAAG
TTGAGGAGCTGGAGGGGCATGAGGGGCAGCAGTTGCGGGAACACCTGGCCCTGCTGCTCAGTGC
CCTCCTGGATGCCCAGACCCTCCCGGGGGGCCAGAGCCAGTCAGAGTCCGAACTGTTGCAGCGG
TGCCAGGCCCTGGAGCGGAAGACAGCCACCTTCGAGAACATTGTCTGTGTTCTGAACCGGGAGG
TGGAGAGGGTGGCTGTGACTGCAGAGGCCTGTAGCCGGCAGCACCGGCTGGACCAGGACAAGAT
TGAGGCCCTGAGCAACAAGGTGCAGCAGCTGGAGAGGAGCATTGGGCTAAAGGACCTGGCCATG
GCTGACCTGGAGCAGAAGGTCCTGGAGTTGGAGGCTGCCACCTACGATGGGGTCTTCATCTGGA
AGATCTCCGACTTCAGCAGGAAGCGCCAGGAGGCTGTGGCTGGCCGAACGCCGGCCATCTTCTC
CCCAGCCTTCTACACGAGCAGGTACGGCTACAAGATGTGTCTGCGCATCTACCTGAATGGCGAT
GGCACCGGGCGGGGGACGCACCTGTCCCTCTTCTTTGTGGTGATGAAAGGCCCTAACGATGCTC
TCCTGCGTTGGCCATTCAACCAGAAGGTGACGCTGATGCTGCTCGACCCGAACAACAGGGAGCA
CGTGATCGACGCCTTCAGGCCTGATGTGACCTCCTCATCCTTCCAGAGGCCGGTCAGCGACATG
AACATTGCCAGCGGCTGCCCCCTCTTCTGCCCCGTGTCCAAGATGGAGGCCAAGAACTCCTATG
TGCGGGATGATGCCATCTTCATCAAGGCCATTGTGGACTTGACGGGGCTTTAGCCACAGCTGGG
GGACACAGTGCTTAGGGAGAAGTCACACTGGGCCAGGGCCCTGCACACTGGCAGGCAGGCAGCA
GCTGCCGCCCTCTCTGCGCCAGAGACCGTGAGGAGCTGGCCTGGAAAGCCCCGGCCTTCATGGA
AGGGCCCTGCACCCGTGTGGGCACTCGGGAGCCATTTCTGCCCAGGCTCCCGGCCTGCTGCAGT
GGCAGGAGTGTCGGCCGCCACCAGGAGAAGGGCTGCTGCCTGCAGAGGGGCCCTGGAGCACGGG
GCTCAGACCCCACACGTACTGCACAGGAGAGTGGCTCAAGGGAGCCCATGGGGCGACACTTGGG
CTGTGGAGCCATCGGTATTAAACCCTTGAGATCCCGTGGTG

hide sequence

RefSeq Acc Id:

XM_013506640 ⟹ XP_013362094

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955513	4,964,692 - 4,984,359 (+)	NCBI

Sequence:

show sequence

CCTGCCTCAGCCTCTTGAGTGCTGGGATTATAGGCATGAGCCACCCCTCCTGGCAAGAATGTGG
GTTTTTAAACTAGTGATATTTGAAATGGGAAAATCCCTCCACCTGAAGTGATTCAGAGCAATGT
CTTTTGCCATTAGTGGTTCATGAGGTCAATTTATCAGCTTTTAACCAGAGAAAAAGAAATACCC
TGGGAAACTCAGATGCCACGCATGGAGGGCAGCGAGGTCTGATGTGCTTTGGCTGCTGTTTCGA
GCACATGTGCAGCAGGTCACATGGACACCAGGTTGGGGGTGTGGTGCTGCCAGGTGTGGATGTG
AGCAGGTGACTGAGCCTGGCCTTGGTGTGGCATAGGCTTTTCGGGGACAGGGTCTCACTGCTTT
GCCTGGGCTGGCATCAGACTCCTGGACTCAGGCAATCATGCCTCAGCCTCCCGAGTAGCTGGAA
TACAGGCGTGGTGGCCCTGTGCTTGGCTTACATGTGGCAATCCAGAACATCTGTATAGATTGCT
GCCAGGGGGAGCAGGCCCATCCATGGTGCAAGGAGATTATGACCCCCTCTGAGAGATGCATAGT
GATGGGGGTGCTGTCCTGTTTGCAGAGCCTAGCTCCCCCTCTTGTAGGTGCTTGGGGAGTACAT
GTAGGCTCCACATATGTTCGGGAGTGCCACACAGATGGCATTGTCATACATTATATGCTTATTA
GCGTTGGCTGGTCCTGGACAGTGTCCCCTGTGTGCCCAAGAGGAAGGGTGACCCGTGTGGTCCT
GAGCTGATCATCCAGGGCCAGACCTGGCCAGGACAGCAAGAGGGCTCCCGGCCACGGCCCTGTG
AGGGCCTCCTGTGGGGTCTCCCTCGAGAACCGGGGCTGGAAAGCCTGTGCTCCTCCACAGAGGG
TGCTGTTCCATAGACTTGGTGTCAGGTGCTCAGTGGGGAGACTGTGGGATGGGTTGTCACCGGG
GCACGGGTTGTATAGCGGCTGAGCTGCTTATCCTAGGGGCTCGAGTTTTCTGAGTCGGAAGTAC
GCCGTTCAGGGCCATTTGGGAGTCACTCCTTTTCCAGGGTTACAGGTAGCATCTCTTGCATCTT
TGAGCTCTGGACATCACACAAATGTGAGGTCCCTGAAGGCTGCTGGGTTCCGTCTCTCACCCCC
AGACTTGCCATCCTCAGAGTCACCACACAGTGGCCCATAGGGTCAGCTCTGCCGGCACCTGGGG
TCTGAAAGCATTTGTGGAATGAGGGGACAGTGGCATGTGGCAGCTGTCGGGCGGGGGGGTGTCT
TACCACGTGAAACTGAAATGGAGATGGCGTGTGGGAATGGGACTGTGACTGCCGTCAGCCAAAT
GCTGCCTCGTGGGAGCTGCTCTGCCTCAGGGCCCGCGGTGGTGTGGCCAGGCCTAACCTGGGCC
ACAAGGCGTGTGGGGTTCCAGGTCTCATGGCTGCAGCCAGTGTGACCCCCCTGGGCTCCCTGGA
CCTGCTGCAGCCGGGCTTTTCCAAGACCCTCCTGGGGACCAAGCTCGAGGCCAAGTACCTGTGC
TCTGCCTGTAGAAACGTCCTGCGGAGGCCCTTCCAGGCCCAGTGTGGCCACCGCTACTGCTCCT
TCTGCCTAAGCAGCATCCTCAGCTCTGGGCCTCAGAACTGCGCTGCCTGTGTTCAGGAGGGGAT
CTACGAGGAAGGCATTTCTATCTTAGAAACCAGCTCAGCCTTTCCAGACAATGCTGCCCGCAGG
GAGGTGGAGAGCCTGCCAGCCGTCTGTCCCAACGAGGGGTGCACCTGGAAGGGGACCTTGAAGG
AATATGAGAGCTGCCACGAAGGACTCTGCCCGTTCCTGCTGACGGAGTGCCCTGCGTGTAAAGG
CCAAGTCCGCCTTGGGGAGAAGGAGCGCCATGCTGAGCAGGAGTGCCCAGAGAGGAGCCTGGCC
TGCCGCCACTGCCGGGCGCCCTGTTGCCGATCGGACCTAGAGGCGCACTATGTGGTCTGCCCCA
AGTTCCCCTTGATCTGCGATGGCTGCGGCAAGAAGAAGATCCCTCGGGAGAAGTTTCAGGACCA
TGTCAGGACCTGTGGCAAGTGCCGGGTCCCCTGCAGATTCCACGCCGTGGGCTGCCCTGAGCTG
GTGGAAGTTGAGGAGCTGGAGGGGCATGAGGGGCAGCAGTTGCGGGAACACCTGGCCCTGCTGC
TCAGTGCCCTCCTGGATGCCCAGACCCTCCCGGGGGGCCAGAGCCAGTCAGAGTCCGAACTGTT
GCAGCGGTGCCAGGCCCTGGAGCGGAAGACAGCCACCTTCGAGAACATTGTCTGTGTTCTGAAC
CGGGAGGTGGAGAGGGTGGCTGTGACTGCAGAGGCCTGTAGCCGGCAGCACCGGCTGGACCAGG
ACAAGATTGAGGCCCTGAGCAACAAGGTGCAGCAGCTGGAGAGGAGCATTGGGCTAAAGGACCT
GGCCATGGCTGACCTGGAGCAGAAGGTCCTGGAGTTGGAGGCTGCCACCTACGATGGGGTCTTC
ATCTGGAAGATCTCCGACTTCAGCAGGAAGCGCCAGGAGGCTGTGGCTGGCCGAACGCCGGCCA
TCTTCTCCCCAGCCTTCTACACGAGCAGGTACGGCTACAAGATGTGTCTGCGCATCTACCTGAA
TGGCGATGGCACCGGGCGGGGGACGCACCTGTCCCTCTTCTTTGTGGTGATGAAAGGCCCTAAC
GATGCTCTCCTGCGTTGGCCATTCAACCAGAAGGTGACGCTGATGCTGCTCGACCCGAACAACA
GGGAGCACGTGATCGACGCCTTCAGGCCTGATGTGACCTCCTCATCCTTCCAGAGGCCGGTCAG
CGACATGAACATTGCCAGCGGCTGCCCCCTCTTCTGCCCCGTGTCCAAGATGGAGGCCAAGAAC
TCCTATGTGCGGGATGATGCCATCTTCATCAAGGCCATTGTGGACTTGACGGGGCTTTAGCCAC
AGCTGGGGGACACAGTGCTTAGGGAGAAGTCACACTGGGCCAGGGCCCTGCACACTGGCAGGCA
GGCAGCAGCTGCCGCCCTCTCTGCGCCAGAGACCGTGAGGAGCTGGCCTGGAAAGCCCCGGCCT
TCATGGAAGGGCCCTGCACCCGTGTGGGCACTCGGGAGCCATTTCTGCCCAGGCTCCCGGCCTG
CTGCAGTGGCAGGAGTGTCGGCCGCCACCAGGAGAAGGGCTGCTGCCTGCAGAGGGGCCCTGGA
GCACGGGGCTCAGACCCCACACGTACTGCACAGGAGAGTGGCTCAAGGGAGCCCATGGGGCGAC
ACTTGGGCTGTGGAGCCATCGGTATTAAACCCTTGAGATCCCGTGGTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_013362093	(Get FASTA)	NCBI Sequence Viewer
	XP_013362094	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000014939
	ENSCLAP00000014939.1

RefSeq Acc Id:	XP_013362094 ⟸ XM_013506640
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2VFR9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAASVTPLGSLDLLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLSSILSS GPQNCAACVQEGIYEEGISILETSSAFPDNAARREVESLPAVCPNEGCTWKGTLKEYESCHEGL CPFLLTECPACKGQVRLGEKERHAEQECPERSLACRHCRAPCCRSDLEAHYVVCPKFPLICDGC GKKKIPREKFQDHVRTCGKCRVPCRFHAVGCPELVEVEELEGHEGQQLREHLALLLSALLDAQT LPGGQSQSESELLQRCQALERKTATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNK VQQLERSIGLKDLAMADLEQKVLELEAATYDGVFIWKISDFSRKRQEAVAGRTPAIFSPAFYTS RYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDPNNREHVIDAFR PDVTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL hide sequence

RefSeq Acc Id:

XP_013362093 ⟸ XM_013506639

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAAASVTPLGSLDLLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLSSILSS
GPQNCAACVQEGIYEEGISILETSSAFPDNAARREVESLPAVCPNEGCTWKGTLKEYESCHEGL
CPFLLTECPACKGQVRLGEKERHAEQECPERSLACRHCRAPCCRSDLEAHYVVCPKFPLICDGC
GKKKIPREKVEVEELEGHEGQQLREHLALLLSALLDAQTLPGGQSQSESELLQRCQALERKTAT
FENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVLEL
EAATYDGVFIWKISDFSRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSL
FFVVMKGPNDALLRWPFNQKVTLMLLDPNNREHVIDAFRPDVTSSSFQRPVSDMNIASGCPLFC
PVSKMEAKNSYVRDDAIFIKAIVDLTGL

hide sequence

Ensembl Acc Id:

ENSCLAP00000014939 ⟸ ENSCLAT00000015098

Protein Domains

MATH RING-type TRAF-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000010303	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000015098	ENTREZGENE
	ENSCLAT00000015098.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
InterPro	MATH/TRAF_dom	UniProtKB/TrEMBL
	TNF_rcpt-assoc_TRAF_met	UniProtKB/TrEMBL
	TRAF-like	UniProtKB/TrEMBL
	TRAF2	UniProtKB/TrEMBL
	TRAF2_MATH	UniProtKB/TrEMBL
	TRAF2_Znf	UniProtKB/TrEMBL
	TRAF_BIRC3-bd	UniProtKB/TrEMBL
	TRAF_MEP1_MATH_dom	UniProtKB/TrEMBL
	Znf_C3HC4_RING-type	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
	Znf_TRAF	UniProtKB/TrEMBL
NCBI Gene	Traf2	ENTREZGENE
PANTHER	PTHR10131	UniProtKB/TrEMBL
	PTHR10131:SF21	UniProtKB/TrEMBL
Pfam	TRAF-mep_MATH	UniProtKB/TrEMBL
	TRAF2_zf	UniProtKB/TrEMBL
	TRAF_BIRC3_bd	UniProtKB/TrEMBL
	zf-C3HC4	UniProtKB/TrEMBL
	zf-TRAF	UniProtKB/TrEMBL
PIRSF	TRAF	UniProtKB/TrEMBL
PROSITE	MATH	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
	ZF_TRAF	UniProtKB/TrEMBL
SMART	MATH	UniProtKB/TrEMBL
	RING	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	TRAF domain-like	UniProtKB/TrEMBL
	Trimerization domain of TRAF	UniProtKB/TrEMBL
UniProt	A0A8C2VFR9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Traf2	TNF receptor associated factor 2		TNF receptor-associated factor 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - PID (archival)