Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:heart formation
go back to main search page
Accession:GO:0060914 term browser browse the term
Definition:The developmental process pertaining to the initial formation of the heart from unspecified parts. This process begins with the specific processes that contribute to the appearance of the heart field and the arrival of cardiac neural crest to the heart region. The process ends when the structural rudiment is recognizable.
Synonyms:related_synonym: cardiogenesis


show annotations for term's descendants           Sort by:
heart formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:2158343 (PMID:16943278) RGD PMID:16943278 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Emp2 epithelial membrane protein 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6443292|PMID:30773261)		 UniProt
RGD		 PMID:30773261 GO_REF:0000024 MGI:6443292 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733 		JBrowse link
G Ift88 intraflagellar transport 88 acts_upstream_of_or_within ISO MGI:1859153 (PMID:19654211) RGD PMID:19654211 NCBI chr15:31,573,325...31,666,068
Ensembl chr15:31,573,376...31,672,147 		JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 involved_in ISO (MGI:5640886|PMID:25790465) RGD PMID:25790465 MGI:5640886 NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626 		JBrowse link
G Rbm20 RNA binding motif protein 20 involved_in IDA
ISO
IMP		 PMID:23307558
(PMID:33188278)
(PMID:22466703), (PMID:26604136), (PMID:27496873), (PMID:30948719), (PMID:32840935), (PMID:34732726)
(MGI:5571640|PMID:24584570), (MGI:5817050|PMID:27630136), (MGI:6162809|PMID:29895960), (MGI:6472247|PMID:33110103), (MGI:6885606|PMID:35041844), (MGI:7266785|PMID:35394688)		 RGD PMID:22466703 PMID:24584570 PMID:26604136 PMID:27496873 PMID:27630136 More... MGI:5571640 MGI:5817050 MGI:6162809 MGI:6472247 MGI:6885606 MGI:7266785, RGD:152025504, RGD:7241566 NCBI chr 1:252,683,760...252,907,465
Ensembl chr 1:252,683,771...252,886,060 		JBrowse link
cardioblast anterior-lateral migration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:1339460|PMID:10393122) RGD PMID:10393122 MGI:1339460 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
cardioblast migration term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:2182080 (PMID:10393122) RGD PMID:10393122 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
cardioblast migration to the midline involved in heart field formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:1339460|PMID:10393122) RGD PMID:10393122 MGI:1339460 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
heart field specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (PMID:26295701) RGD PMID:26295701 NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357 		JBrowse link
heart induction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO
ISS		 (PMID:19736317)
GO_REF:0000024		 RGD
UniProt		 PMID:19736317 GO_REF:0000024 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in ISO
ISS
IEA		 (PMID:20702560)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:20702560 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Gata5 GATA binding protein 5 involved_in ISO (MGI:5286818|PMID:21633169) RGD PMID:21633169 MGI:5286818 NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:3835736|PMID:18297060), (MGI:4441249|PMID:18593560) RGD PMID:18297060 PMID:18593560 MGI:3835736 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 involved_in ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO (MGI:5913048|PMID:25691540) RGD PMID:25691540 MGI:5913048 NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in ISO (MGI:5913048|PMID:25691540) RGD PMID:25691540 MGI:5913048 NCBI chr11:12,528,949...14,096,726
Ensembl chr11:12,528,951...13,041,536 		JBrowse link
neural crest cell migration involved in heart formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Folr1 folate receptor alpha involved_in ISO (MGI:3721767|PMID:17286298) RGD PMID:17286298 MGI:3721767 NCBI chr 1:156,219,460...156,238,436
Ensembl chr 1:156,219,460...156,230,667 		JBrowse link
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 acts_upstream_of_or_within ISO (PMID:19620969) RGD PMID:19620969 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
positive regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase involved_in ISO (PMID:21474815) RGD PMID:21474815 NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174 		JBrowse link
positive regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 acts_upstream_of_or_within ISO MGI:102780 (PMID:21364285) RGD PMID:21364285 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Gng5 G protein subunit gamma 5 acts_upstream_of_or_within ISO (PMID:24599258) RGD PMID:24599258 NCBI chr 2:235,394,680...235,403,177
Ensembl chr 1:77,292,043...77,292,513 		JBrowse link
G Six1 SIX homeobox 1 acts_upstream_of_or_within ISO MGI:109344 (PMID:21364285) RGD PMID:21364285 NCBI chr 6:91,746,739...91,751,975
Ensembl chr 6:91,746,739...91,751,975 		JBrowse link
G Tbx1 T-box transcription factor 1 acts_upstream_of_or_within ISO (PMID:19745164) RGD PMID:19745164 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380 		JBrowse link
G Tbx5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2387851 (PMID:22898775)		 Ensembl
RGD		 PMID:22898775 GO_REF:0000107 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885 		JBrowse link
primary heart field specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(MGI:3830899|PMID:16680724)		 UniProt
RGD		 PMID:16680724 GO_REF:0000024 MGI:3830899 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Wnt11 Wnt family member 11 involved_in ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA		 UniProtKB:P48615 (MGI:5424267|PMID:22569553)
GO_REF:0000107		 RGD
Ensembl		 PMID:22569553 GO_REF:0000107 MGI:5424267 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
regulation of cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 IMP RGD PMID:18824567 RGD:2325311 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:19620969)		 Ensembl
RGD		 PMID:19620969 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Hand2 heart and neural crest derivatives expressed 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:4413411|PMID:19008477)		 Ensembl
RGD		 PMID:19008477 GO_REF:0000107 MGI:4413411 NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:19609448)		 Ensembl
RGD		 PMID:19609448 GO_REF:0000107 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2447758 (PMID:19620969)		 Ensembl
RGD		 PMID:19620969 GO_REF:0000107 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
secondary heart field specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:96522 (PMID:22711842)		 Ensembl
RGD		 PMID:22711842 GO_REF:0000107 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:20702560)		 Ensembl
UniProt
RGD		 PMID:20702560 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Foxh1 forkhead box H1 involved_in ISO (MGI:3055632|PMID:15363409) RGD PMID:15363409 MGI:3055632 NCBI chr 7:108,387,969...108,391,566
Ensembl chr 7:108,387,969...108,390,049 		JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in ISO
IEA		 (PMID:20520780)
GO_REF:0000107		 RGD
Ensembl		 PMID:20520780 GO_REF:0000107 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Lrp2 LDL receptor related protein 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5770180|PMID:26822476)		 UniProt
Ensembl
RGD		 PMID:26822476 GO_REF:0000024 GO_REF:0000107 MGI:5770180 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708 		JBrowse link
G Mef2c myocyte enhancer factor 2C involved_in ISS
ISO		 GO_REF:0000024
(MGI:3578591|PMID:15890826)		 UniProt
RGD		 PMID:15890826 GO_REF:0000024 MGI:3578591 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region acts_upstream_of_or_within ISO MGI:1270862|MGI:3583755 (PMID:22711842) RGD PMID:22711842 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 acts_upstream_of_or_within ISO MGI:2148567 (PMID:17519332) RGD PMID:17519332 NCBI chr 4:10,548,693...10,580,334
Ensembl chr 4:10,548,751...10,580,326 		JBrowse link
G Wnt11 Wnt family member 11 involved_in ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA		 UniProtKB:P48615 (MGI:5424267|PMID:22569553)
GO_REF:0000107		 RGD
Ensembl		 PMID:22569553 GO_REF:0000107 MGI:5424267 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mks1 MKS transition zone complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4821832 (PMID:27340223)		 Ensembl
RGD		 PMID:27340223 GO_REF:0000107 NCBI chr10:72,655,921...72,667,007
Ensembl chr10:72,655,921...72,666,655 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19694
    developmental process 6963
      anatomical structure formation involved in morphogenesis 1366
        animal organ formation 77
          heart formation 35
            cardioblast proliferation + 12
            cell migration involved in heart formation + 2
            heart field specification + 18
Path 2
Term Annotations click to browse term
  biological_process 19694
    developmental process 6963
      anatomical structure development 6486
        multicellular organism development 5239
          system development 4526
            circulatory system development 1367
              heart development 740
                heart morphogenesis 294
                  heart formation 35
                    cardioblast proliferation + 12
                    cell migration involved in heart formation + 2
                    heart field specification + 18
paths to the root