Bmpr1a (bone morphogenetic protein receptor type 1A) - Rat Genome Database
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Gene: Bmpr1a (bone morphogenetic protein receptor type 1A) Rattus norvegicus
Analyze
Symbol: Bmpr1a
Name: bone morphogenetic protein receptor type 1A
RGD ID: 70989
Description: Predicted to have several functions, including ATP binding activity; protein homodimerization activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including animal organ development; chordate embryonic development; and positive regulation of cell population proliferation. Localizes to dendrite and neuronal cell body. Predicted to colocalize with caveola. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 17alpha-ethynylestradiol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMPR-1A; bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA
Orthologs:
Homo sapiens (human) : BMPR1A (bone morphogenetic protein receptor type 1A)  HGNC  Alliance
Mus musculus (house mouse) : Bmpr1a (bone morphogenetic protein receptor, type 1A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bmpr1a (bone morphogenetic protein receptor type 1A)
Pan paniscus (bonobo/pygmy chimpanzee) : BMPR1A (bone morphogenetic protein receptor type 1A)
Canis lupus familiaris (dog) : BMPR1A (bone morphogenetic protein receptor type 1A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bmpr1a (bone morphogenetic protein receptor type 1A)
Sus scrofa (pig) : BMPR1A (bone morphogenetic protein receptor type 1A)
Chlorocebus sabaeus (African green monkey) : BMPR1A (bone morphogenetic protein receptor type 1A)
Heterocephalus glaber (naked mole-rat) : Bmpr1a (bone morphogenetic protein receptor type 1A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01610,758,278 - 10,852,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,084,569 - 9,127,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,061,943 - 10,105,854 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11610,061,941 - 10,105,852 (-)NCBI
Celera165,436,477 - 5,480,314 (+)NCBICelera
Cytogenetic Map16p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
biological_process  (ND)
BMP signaling pathway  (IBA,ISO,ISS)
cardiac conduction system development  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cartilage development  (ISO)
cell differentiation  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
chondrocyte differentiation  (ISO)
developmental growth  (ISO)
dorsal aorta morphogenesis  (ISO)
dorsal/ventral axis specification  (ISO)
dorsal/ventral pattern formation  (IBA,ISO)
ectoderm development  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic morphogenesis  (ISO)
embryonic organ development  (ISO)
endocardial cushion formation  (ISO)
endocardial cushion morphogenesis  (ISO)
endoderm development  (ISO)
fibrous ring of heart morphogenesis  (ISO)
heart development  (ISO)
heart formation  (ISO)
heart morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
immune response  (ISO)
in utero embryonic development  (ISO)
lateral mesoderm development  (ISO)
lung development  (ISO)
mesendoderm development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (ISO)
Mullerian duct regression  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
nervous system development  (ISO)
neural crest cell development  (ISO)
neural plate mediolateral regionalization  (ISO)
neural plate pattern specification  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
paraxial mesoderm development  (ISO)
paraxial mesoderm structural organization  (ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
pituitary gland development  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cardiac ventricle development  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein phosphorylation  (IBA,ISO)
regulation of cardiac muscle cell apoptotic process  (ISO)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of cellular senescence  (ISO)
regulation of endothelial cell differentiation  (ISO)
regulation of endothelial cell proliferation  (ISO)
regulation of lateral mesodermal cell fate specification  (ISO)
regulation of neural crest cell differentiation  (ISO)
regulation of neural crest cell fate specification  (ISO)
roof of mouth development  (ISO)
somitogenesis  (ISO)
stem cell population maintenance  (ISO)
tricuspid valve morphogenesis  (ISO)
ventricular compact myocardium morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

References

Additional References at PubMed
PMID:9268344   PMID:9389648   PMID:12065756   PMID:12368913   PMID:12923052   PMID:15073157   PMID:15136139   PMID:15136140   PMID:15469980   PMID:15492776   PMID:15657086   PMID:15673568  
PMID:15716346   PMID:16037571   PMID:16049014   PMID:16314491   PMID:16414041   PMID:16556916   PMID:16604073   PMID:16886151   PMID:16943278   PMID:17359964   PMID:17699604   PMID:18326817  
PMID:18436533   PMID:18667463   PMID:19416967   PMID:19669850   PMID:19793887   PMID:20043884   PMID:20406889   PMID:21145505   PMID:21542012   PMID:21764678   PMID:22729085   PMID:22871113  
PMID:23097200   PMID:24098149   PMID:24904118   PMID:26774823   PMID:27477499   PMID:29415997   PMID:30656682  


Genomics

Comparative Map Data
Bmpr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01610,758,278 - 10,852,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,084,569 - 9,127,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,061,943 - 10,105,854 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11610,061,941 - 10,105,852 (-)NCBI
Celera165,436,477 - 5,480,314 (+)NCBICelera
Cytogenetic Map16p15NCBI
BMPR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1086,756,601 - 86,932,838 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1086,756,601 - 86,932,825 (+)EnsemblGRCh38hg38GRCh38
GRCh381086,755,786 - 86,927,969 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371088,516,396 - 88,684,945 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,506,376 - 88,674,925 (+)NCBINCBI36hg18NCBI36
Build 341088,506,375 - 88,674,924NCBI
Celera1082,519,484 - 82,687,979 (+)NCBI
Cytogenetic Map10q23.2NCBI
HuRef1082,370,811 - 82,538,774 (+)NCBIHuRef
CHM1_11088,798,078 - 88,966,382 (+)NCBICHM1_1
Bmpr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,133,018 - 34,225,335 (-)NCBI
GRCm381434,411,061 - 34,503,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,410,734 - 34,503,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv371435,224,254 - 35,315,732 (-)NCBIGRCm37mm9NCBIm37
MGSCv361433,240,160 - 33,331,638 (-)NCBImm8
Celera1430,676,409 - 30,725,958 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.81NCBI
Bmpr1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,905,008 - 5,936,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555105,812,571 - 5,936,312 (+)NCBIChiLan1.0ChiLan1.0
BMPR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11086,742,248 - 86,912,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1086,837,469 - 86,912,912 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01083,185,040 - 83,353,239 (+)NCBI
BMPR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl434,517,492 - 34,578,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1434,499,898 - 34,582,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Bmpr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493680452,435 - 115,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,742,459 - 87,891,793 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,743,270 - 87,891,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,239,745 - 95,280,923 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR1A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl944,941,460 - 45,027,275 (-)Ensembl
ChlSab1.1944,944,463 - 45,108,832 (-)NCBI
Bmpr1a
(Heterocephalus glaber - naked mole-rat)
No map positions available.

Position Markers
RH136590  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.09108,272,425 - 108,272,641NCBIRnor6.0
Rnor_6.01610,759,271 - 10,759,492NCBIRnor6.0
Rnor_5.0169,085,314 - 9,085,531UniSTSRnor5.0
Rnor_5.09107,856,586 - 107,856,802UniSTSRnor5.0
RGSC_v3.41610,062,688 - 10,062,909UniSTSRGSC3.4
RGSC_v3.4999,469,454 - 99,469,670UniSTSRGSC3.4
Celera165,479,348 - 5,479,569UniSTS
Celera998,036,243 - 98,036,459UniSTS
Cytogenetic Map16p16UniSTS
Cytogenetic Map9q36UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16124228366Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16127556253Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16127556253Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16127556253Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16131816439Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16133160624Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16134465490Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16141240937Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16141240937Rat
631561Hcuc2Hepatic copper content QTL 22.8hepatic copper amount (VT:0003065)liver total copper weight (CMO:0001507)16141240957Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)1624459345244593Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16134074146340741Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)16155018749247447Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)16155018763210301Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16155018763210301Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)16155018763210301Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)16155018763210301Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16172829746728297Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16329668817464293Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16413635523105837Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16413635545905331Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380218360147Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380245905331Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16501380245905331Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16501380250013802Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16501380250169318Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16501380252144919Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16501380264012784Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16509870419398181Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:668
Count of miRNA genes:286
Interacting mature miRNAs:354
Transcripts:ENSRNOT00000015047
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 31 20 12 20 8 10 74 35 37 11 8
Low 1 26 21 7 21 1 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000079554   ⟹   ENSRNOP00000074885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)Ensembl
RefSeq Acc Id: NM_030849   ⟹   NP_110476
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01610,758,526 - 10,802,512 (-)NCBI
Rnor_5.0169,084,569 - 9,127,943 (-)NCBI
RGSC_v3.41610,061,943 - 10,105,854 (-)RGD
Celera165,436,477 - 5,480,314 (+)RGD
Sequence:
RefSeq Acc Id: XM_017600256   ⟹   XP_017455745
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01610,758,278 - 10,852,170 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_110476   ⟸   NM_030849
- Peptide Label: precursor
- UniProtKB: Q78EA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455745   ⟸   XM_017600256
- Peptide Label: isoform X1
- UniProtKB: Q78EA7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074885   ⟸   ENSRNOT00000079554
Protein Domains
GS   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70989 AgrOrtholog
Ensembl Genes ENSRNOG00000052469 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000074885 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079554 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Activin_recp UniProtKB/Swiss-Prot
  GS_dom UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  TGFB_receptor UniProtKB/Swiss-Prot
KEGG Report rno:81507 UniProtKB/Swiss-Prot
NCBI Gene 81507 ENTREZGENE
PANTHER PTHR23255 UniProtKB/Swiss-Prot
Pfam Activin_recp UniProtKB/Swiss-Prot
  PK_Tyr_Ser-Thr UniProtKB/Swiss-Prot
  TGF_beta_GS UniProtKB/Swiss-Prot
PhenoGen Bmpr1a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS51256 UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
  SM00467 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniGene Rn.88925 ENTREZGENE
UniProt BMR1A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q64308 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Bmpr1a  bone morphogenetic protein receptor type 1A  Bmpr1a  bone morphogenetic protein receptor, type IA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bmpr1a  bone morphogenetic protein receptor, type IA  Bmpr1a  bone morphogenetic protein receptor, type 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Bmpr1a  bone morphogenetic protein receptor, type 1A      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.