Bmpr1a (bone morphogenetic protein receptor type 1A) - Rat Genome Database

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Gene: Bmpr1a (bone morphogenetic protein receptor type 1A) Rattus norvegicus
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Symbol: Bmpr1a
Name: bone morphogenetic protein receptor type 1A
RGD ID: 70989
Description: Predicted to enable several functions, including ATP binding activity; BMP binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including circulatory system development; positive regulation of cell population proliferation; and transforming growth factor beta receptor superfamily signaling pathway. Predicted to act upstream of or within several processes, including limb morphogenesis; regionalization; and regulation of gene expression. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; cytokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 17alpha-ethynylestradiol; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMPR-1A; bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Bmpr1a-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,740,751 - 9,786,861 (-)NCBIGRCr8
mRatBN7.2169,736,390 - 9,829,825 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,736,630 - 9,780,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,756,712 - 9,800,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,901,424 - 10,945,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,751,786 - 9,795,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,758,278 - 10,852,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,084,569 - 9,127,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,061,943 - 10,105,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11610,061,941 - 10,105,852 (-)NCBI
Celera165,436,477 - 5,480,314 (+)NCBICelera
Cytogenetic Map16p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
atrioventricular node cell development  (ISO)
atrioventricular valve development  (ISO)
biological_process  (ND)
BMP signaling pathway  (IBA,ISO,ISS)
cardiac conduction system development  (ISO)
cardiac right ventricle morphogenesis  (ISO)
cartilage development  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to growth factor stimulus  (IBA)
central nervous system neuron differentiation  (ISO)
chondrocyte differentiation  (ISO)
developmental growth  (ISO)
dorsal aorta morphogenesis  (ISO)
dorsal/ventral axis specification  (ISO)
dorsal/ventral pattern formation  (IBA,ISO)
ectoderm development  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic morphogenesis  (ISO)
embryonic organ development  (ISO)
endocardial cushion formation  (ISO)
endocardial cushion morphogenesis  (ISO)
endoderm development  (ISO)
epithelial cell proliferation  (ISO)
fibrous ring of heart morphogenesis  (ISO)
heart development  (ISO)
heart formation  (ISO)
heart morphogenesis  (ISO)
hindlimb morphogenesis  (ISO)
immune response  (ISO)
in utero embryonic development  (ISO)
lateral mesoderm development  (ISO)
lung development  (ISO)
mesendoderm development  (ISO)
mesoderm formation  (ISO)
mitral valve morphogenesis  (ISO)
Mullerian duct regression  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of muscle cell differentiation  (ISO)
negative regulation of neurogenesis  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
nervous system development  (ISO)
neural crest cell development  (ISO)
neural plate mediolateral regionalization  (ISO)
neural plate pattern specification  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
osteoblast differentiation  (ISO)
outflow tract morphogenesis  (ISO)
outflow tract septum morphogenesis  (ISO)
paraxial mesoderm development  (ISO)
paraxial mesoderm structural organization  (ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (ISO)
pituitary gland development  (ISO)
positive regulation of bone mineralization  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of cardiac ventricle development  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of osteoblast differentiation  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transforming growth factor beta2 production  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein phosphorylation  (IEA)
regulation of cardiac muscle cell apoptotic process  (ISO)
regulation of cardiac muscle cell proliferation  (ISO)
regulation of cellular senescence  (ISO)
regulation of endothelial cell differentiation  (ISO)
regulation of endothelial cell proliferation  (ISO)
regulation of lateral mesodermal cell fate specification  (ISO)
regulation of neural crest cell differentiation  (ISO)
regulation of neural crest cell fate specification  (ISO)
roof of mouth development  (ISO)
somatic stem cell population maintenance  (ISO)
somitogenesis  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
tricuspid valve morphogenesis  (ISO)
ventricular compact myocardium morphogenesis  (ISO)
ventricular septum morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high-density single nucleotide polymorphism (SNP) scan and identification of BMPR1A loss of function. Cao X, etal., J Med Genet. 2006 Mar;43(3):e13.
2. Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes. Delnatte C, etal., Am J Hum Genet. 2006 Jun;78(6):1066-74. Epub 2006 Apr 14.
3. Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension. Dewachter L, etal., Eur Respir J. 2009 Nov;34(5):1100-10. Epub 2009 Mar 26.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Howe JR, etal., Nat Genet. 2001 Jun;28(2):184-7.
7. Basal expression of bone morphogenetic protein receptor is reduced in mild asthma. Kariyawasam HH, etal., Am J Respir Crit Care Med. 2008 May 15;177(10):1074-81. Epub 2008 Feb 21.
8. Gene Data Set MGD Curation, June 12, 2002
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Bone morphogenetic protein receptor expressions in the adult rat brain. Miyagi M, etal., Neuroscience. 2011 Mar 10;176:93-109. Epub 2010 Dec 23.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Expression of serine/threonine kinase receptors during ectopic bone formation induced by bone morphogenetic protein (BMP). Takeda K Kokubyo Gakkai Zasshi 1994 Dec;61(4):512-26.
20. Molecular cloning of rat bone morphogenetic protein (BMP) type IA receptor and its expression during ectopic bone formation induced by BMP. Takeda K, etal., Biochem Biophys Res Commun 1994 Oct 14;204(1):203-9.
21. Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Zhou XP, etal., Am J Hum Genet 2001 Oct;69(4):704-11. Epub 2001 Aug 30.
Additional References at PubMed
PMID:9268344   PMID:9389648   PMID:12065756   PMID:12368913   PMID:12923052   PMID:15073157   PMID:15136139   PMID:15136140   PMID:15469980   PMID:15492776   PMID:15657086   PMID:15673568  
PMID:15716346   PMID:16037571   PMID:16049014   PMID:16314491   PMID:16414041   PMID:16556916   PMID:16604073   PMID:16886151   PMID:16943278   PMID:17359964   PMID:17699604   PMID:18326817  
PMID:18436533   PMID:18667463   PMID:19416967   PMID:19669850   PMID:19793887   PMID:20043884   PMID:20406889   PMID:21145505   PMID:21542012   PMID:21764678   PMID:22729085   PMID:22871113  
PMID:23097200   PMID:24098149   PMID:24904118   PMID:26774823   PMID:27477499   PMID:29415997   PMID:30656682  


Genomics

Comparative Map Data
Bmpr1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,740,751 - 9,786,861 (-)NCBIGRCr8
mRatBN7.2169,736,390 - 9,829,825 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,736,630 - 9,780,616 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,756,712 - 9,800,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,901,424 - 10,945,388 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,751,786 - 9,795,752 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,758,278 - 10,852,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0169,084,569 - 9,127,943 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41610,061,943 - 10,105,854 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11610,061,941 - 10,105,852 (-)NCBI
Celera165,436,477 - 5,480,314 (+)NCBICelera
Cytogenetic Map16p15NCBI
BMPR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381086,755,763 - 86,932,844 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1086,755,786 - 86,932,825 (+)EnsemblGRCh38hg38GRCh38
GRCh371088,516,376 - 88,687,726 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361088,506,376 - 88,674,925 (+)NCBINCBI36Build 36hg18NCBI36
Build 341088,506,375 - 88,674,924NCBI
Celera1082,519,484 - 82,687,979 (+)NCBICelera
Cytogenetic Map10q23.2NCBI
HuRef1082,370,811 - 82,538,774 (+)NCBIHuRef
CHM1_11088,798,078 - 88,966,382 (+)NCBICHM1_1
T2T-CHM13v2.01087,639,833 - 87,816,596 (+)NCBIT2T-CHM13v2.0
Bmpr1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391434,133,018 - 34,225,335 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1434,132,691 - 34,225,298 (-)EnsemblGRCm39 Ensembl
GRCm381434,411,061 - 34,503,336 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1434,410,734 - 34,503,341 (-)EnsemblGRCm38mm10GRCm38
MGSCv371435,224,254 - 35,315,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361433,240,160 - 33,331,638 (-)NCBIMGSCv36mm8
Celera1430,676,409 - 30,725,958 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.81NCBI
Bmpr1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555105,905,008 - 5,936,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555105,812,571 - 5,936,312 (+)NCBIChiLan1.0ChiLan1.0
BMPR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2898,749,056 - 98,920,091 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11098,750,184 - 98,925,412 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01083,185,040 - 83,353,239 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11086,742,248 - 86,912,912 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1086,837,469 - 86,912,912 (+)Ensemblpanpan1.1panPan2
BMPR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,499,898 - 34,582,481 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,517,492 - 34,578,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,508,865 - 34,570,053 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0434,801,402 - 34,942,941 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl434,769,955 - 34,941,813 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1434,723,326 - 34,784,614 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0434,892,537 - 34,953,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,397,828 - 35,459,419 (+)NCBIUU_Cfam_GSD_1.0
Bmpr1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721343,941,218 - 44,004,913 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493680448,947 - 115,412 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493680452,435 - 115,289 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMPR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1487,742,459 - 87,891,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11487,743,270 - 87,891,790 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21495,239,745 - 95,280,923 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BMPR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,944,463 - 45,108,832 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl944,941,460 - 45,027,275 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660485,049,884 - 5,217,543 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmpr1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624841219,133 - 265,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624841218,642 - 304,744 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bmpr1a
388 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:668
Count of miRNA genes:286
Interacting mature miRNAs:354
Transcripts:ENSRNOT00000015047
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
RH136590  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29100,601,827 - 100,602,044 (-)MAPPERmRatBN7.2
mRatBN7.2169,737,373 - 9,737,595 (+)MAPPERmRatBN7.2
Rnor_6.01610,759,271 - 10,759,492NCBIRnor6.0
Rnor_6.09108,272,425 - 108,272,641NCBIRnor6.0
Rnor_5.09107,856,586 - 107,856,802UniSTSRnor5.0
Rnor_5.0169,085,314 - 9,085,531UniSTSRnor5.0
RGSC_v3.4999,469,454 - 99,469,670UniSTSRGSC3.4
RGSC_v3.41610,062,688 - 10,062,909UniSTSRGSC3.4
Celera165,479,348 - 5,479,569UniSTS
Celera998,036,243 - 98,036,459UniSTS
Cytogenetic Map9q36UniSTS
Cytogenetic Map16p16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 136 128 63 36 63 36 38 250 115 115 57 24
Low 5 99 84 33 84 7 30
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000079554   ⟹   ENSRNOP00000074885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,736,630 - 9,780,616 (-)Ensembl
Rnor_6.0 Ensembl1610,758,527 - 10,802,512 (-)Ensembl
RefSeq Acc Id: NM_030849   ⟹   NP_110476
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,742,875 - 9,786,861 (-)NCBI
mRatBN7.2169,736,629 - 9,780,616 (-)NCBI
Rnor_6.01610,758,526 - 10,802,512 (-)NCBI
Rnor_5.0169,084,569 - 9,127,943 (-)NCBI
RGSC_v3.41610,061,943 - 10,105,854 (-)RGD
Celera165,436,477 - 5,480,314 (+)RGD
Sequence:
RefSeq Acc Id: XM_063275760   ⟹   XP_063131830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,740,751 - 9,757,409 (-)NCBI
RefSeq Acc Id: NP_110476   ⟸   NM_030849
- Peptide Label: precursor
- UniProtKB: Q64308 (UniProtKB/Swiss-Prot),   Q78EA7 (UniProtKB/Swiss-Prot),   A6KFR5 (UniProtKB/TrEMBL),   A6KFR6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074885   ⟸   ENSRNOT00000079554
RefSeq Acc Id: XP_063131830   ⟸   XM_063275760
- Peptide Label: isoform X1
Protein Domains
GS   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q78EA7-F1-model_v2 AlphaFold Q78EA7 1-532 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70989 AgrOrtholog
BioCyc Gene G2FUF-12060 BioCyc
Ensembl Genes ENSRNOG00000052469 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055009048 UniProtKB/Swiss-Prot
  ENSRNOG00060014195 UniProtKB/Swiss-Prot
  ENSRNOG00065014276 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000079554.2 UniProtKB/Swiss-Prot
  ENSRNOT00055015312 UniProtKB/Swiss-Prot
  ENSRNOT00060024297 UniProtKB/Swiss-Prot
  ENSRNOT00065023550 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.60.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Snake_toxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFB_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81507 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81507 ENTREZGENE
PANTHER BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23255 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Activin_recp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_beta_GS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmpr1a PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS51256 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052469 RatGTEx
  ENSRNOG00055009048 RatGTEx
  ENSRNOG00060014195 RatGTEx
  ENSRNOG00065014276 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00467 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL
  Snake toxin-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
  SSF57302 UniProtKB/Swiss-Prot
UniProt A6KFR5 ENTREZGENE, UniProtKB/TrEMBL
  A6KFR6 ENTREZGENE, UniProtKB/TrEMBL
  BMR1A_RAT UniProtKB/Swiss-Prot
  Q64308 ENTREZGENE
  Q78EA7 ENTREZGENE
UniProt Secondary Q64308 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Bmpr1a  bone morphogenetic protein receptor type 1A  Bmpr1a  bone morphogenetic protein receptor, type IA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Bmpr1a  bone morphogenetic protein receptor, type IA  Bmpr1a  bone morphogenetic protein receptor, type 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Bmpr1a  bone morphogenetic protein receptor, type 1A      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference