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Gene: Six1 (SIX homeobox 1) Rattus norvegicus
Symbol: Six1
Name: SIX homeobox 1
RGD ID: 620906
Description: Exhibits transcription coactivator binding activity. Involved in cellular response to 3,3',5-triiodo-L-thyronine. Localizes to nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 23; branchiootorenal syndrome; and nephroblastoma. Orthologous to human SIX1 (SIX homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein SIX1; sine oculis homeobox (Drosophila) homolog 1; sine oculis homeobox homolog 1; sine oculis homeobox homolog 1 (Drosophila); sine oculis-related homeobox 1 homolog; sine oculis-related homeobox 1 homolog (Drosophila)
Homo sapiens (human) : SIX1 (SIX homeobox 1)  HGNC  Alliance
Mus musculus (house mouse) : Six1 (sine oculis-related homeobox 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Six1 (SIX homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SIX1 (SIX homeobox 1)
Canis lupus familiaris (dog) : SIX1 (SIX homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Six1 (SIX homeobox 1)
Sus scrofa (pig) : SIX1 (SIX homeobox 1)
Chlorocebus sabaeus (African green monkey) : SIX1 (SIX homeobox 1)
Heterocephalus glaber (naked mole-rat) : Six1 (SIX homeobox 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0695,929,060 - 95,934,296 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl695,929,060 - 95,934,296 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06105,364,372 - 105,369,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4695,470,153 - 95,475,389 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1695,475,346 - 95,478,212 (-)NCBI
Celera690,209,553 - 90,214,789 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Six1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620906
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.