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ONTOLOGY REPORT - ANNOTATIONS

Term:endocardial cushion morphogenesis
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Accession:GO:0003203 term browser browse the term
Definition:The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.


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endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (PMID:12941632) RGD PMID:12941632 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591 		JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 involved_in ISO UniProtKB:Q62432 (PMID:23531444) RGD PMID:23531444 NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205 		JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within
involved_in		 ISO MGI:3583785 (PMID:16314491)
(PMID:20890042)		 RGD PMID:16314491 PMID:20890042 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A involved_in ISO (PMID:11854453), (PMID:15073157) RGD PMID:11854453 PMID:15073157 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Eng endoglin involved_in ISO (PMID:12941632), (PMID:19703439) RGD PMID:12941632 PMID:19703439 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 involved_in ISO UniProtKB:Q9DBX7 (PMID:17303760) RGD PMID:17303760 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like involved_in ISO UniProtKB:Q9WV93 (PMID:17303760) RGD PMID:17303760 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152 		JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q02248 (PMID:17519333)		 Ensembl
RGD		 PMID:17519333 GO_REF:0000107 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Mdm2 MDM2 proto-oncogene acts_upstream_of_or_within ISO MGI:107934|MGI:2385439 (PMID:22821713) RGD PMID:22821713 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mdm4 MDM4 regulator of p53 acts_upstream_of_or_within ISO MGI:96952 (PMID:22821713) RGD PMID:22821713 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q01705 (PMID:27107132)		 Ensembl
RGD		 PMID:27107132 GO_REF:0000107 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO UniProtKB:P70313 (PMID:14701881), (PMID:27107132) RGD PMID:14701881 PMID:27107132 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Smad2 SMAD family member 2 involved_in ISO UniProtKB:Q9R001 (PMID:23531444) RGD PMID:23531444 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Sox9 SRY-box transcription factor 9 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:2385468|MGI:2450311 (PMID:11951052)		 UniProt
RGD		 PMID:11951052 GO_REF:0000024 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO (PMID:15459098) RGD PMID:15459098 NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529 		JBrowse link
G Tbx20 T-box transcription factor 20 involved_in ISO (PMID:15901664) RGD PMID:15901664 NCBI chr 8:23,200,104...23,258,218
Ensembl chr 8:23,204,507...23,258,175 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (PMID:11390347), (PMID:19161227) RGD PMID:11390347 PMID:19161227 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 acts_upstream_of_or_within ISO MGI:1857265 (PMID:18539270) RGD PMID:18539270 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
apoptotic process involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 NOT|involved_in ISO (PMID:18924235) RGD PMID:18924235 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
cell migration involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dchs1 dachsous cadherin-related 1 involved_in ISO (PMID:26258302) RGD PMID:26258302 NCBI chr 1:160,104,931...160,138,958
Ensembl chr 1:160,104,931...160,124,808 		JBrowse link
G Eng endoglin acts_upstream_of_or_within ISO MGI:2177824 (PMID:19703439) RGD PMID:19703439 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:20890042) RGD PMID:20890042 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Snai2 snail family transcriptional repressor 2 involved_in ISO (PMID:18663143) RGD PMID:18663143 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
cell proliferation involved in endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor 2 NOT|involved_in ISO (PMID:20652948) RGD PMID:20652948 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (PMID:16140292) RGD PMID:16140292 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Aplnr apelin receptor involved_in ISO (PMID:23603510) RGD PMID:23603510 NCBI chr 3:70,217,407...70,221,052
Ensembl chr 3:70,217,385...70,221,050 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:16730346)		 Ensembl
RGD		 PMID:16730346 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO UniProtKB:P23359 (PMID:10079236) RGD PMID:10079236 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO UniProtKB:P49003 (PMID:10079236) RGD PMID:10079236 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO (PMID:16314491) RGD PMID:16314491 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Nog noggin involved_in IEA
ISO		 GO_REF:0000107
(PMID:17218603)		 Ensembl
RGD		 PMID:17218603 GO_REF:0000107 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
G Robo1 roundabout guidance receptor 1 involved_in ISO UniProtKB:Q7TPD3 (PMID:25691540) RGD PMID:25691540 NCBI chr11:10,580,863...11,621,675
Ensembl chr11:10,580,908...11,620,203 		JBrowse link
G Robo2 roundabout guidance receptor 2 involved_in ISO UniProtKB:O89026 (PMID:25691540) RGD PMID:25691540 NCBI chr11:12,528,949...14,096,726
Ensembl chr11:12,528,951...13,041,536 		JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO (PMID:22130515) RGD PMID:22130515 NCBI chr10:70,679,670...70,688,868
Ensembl chr10:70,679,518...70,688,529 		JBrowse link
G Tbx20 T-box transcription factor 20 involved_in ISO (PMID:15843409), (PMID:21983003) RGD PMID:15843409 PMID:21983003 NCBI chr 8:23,200,104...23,258,218
Ensembl chr 8:23,204,507...23,258,175 		JBrowse link
G Tbx3 T-box transcription factor 3 involved_in ISO (PMID:22130515) RGD PMID:22130515 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
endocardial cushion fusion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (PMID:16140292) RGD PMID:16140292 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Cplane2 ciliogenesis and planar polarity effector complex subunit 2 acts_upstream_of_or_within ISO MGI:6887373 (PMID:29038301) RGD PMID:29038301 NCBI chr 5:153,515,507...153,516,455
Ensembl chr 5:153,515,376...153,522,508 		JBrowse link
G Gata5 GATA binding protein 5 involved_in ISO (PMID:21633169) RGD PMID:21633169 NCBI chr 3:167,418,563...167,426,751
Ensembl chr 3:167,418,565...167,426,751 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (PMID:11390347) RGD PMID:11390347 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20652948)		 Ensembl
RGD		 PMID:20652948 GO_REF:0000107 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 NOT|involved_in ISO (PMID:18924235) RGD PMID:18924235 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Eng endoglin involved_in ISO (PMID:19703439) RGD PMID:19703439 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within
involved_in		 ISO (PMID:21364285)
(PMID:19509466)		 RGD PMID:19509466 PMID:21364285 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO MGI:1860511 (PMID:17303760) RGD PMID:17303760 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like acts_upstream_of_or_within ISO MGI:1341800 (PMID:17303760) RGD PMID:17303760 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152 		JBrowse link
G Msx1 msh homeobox 1 acts_upstream_of_or_within ISO MGI:97169 (PMID:18667074) RGD PMID:18667074 NCBI chr14:72,961,036...72,964,970
Ensembl chr14:72,961,148...72,964,966 		JBrowse link
G Msx2 msh homeobox 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:97168 (PMID:18667074)		 Ensembl
RGD		 PMID:18667074 GO_REF:0000107 NCBI chr17:11,097,214...11,102,879
Ensembl chr17:11,097,103...11,102,879 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:14701881) RGD PMID:14701881 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:14701881) RGD PMID:14701881 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21330551)		 Ensembl
RGD		 PMID:21330551 GO_REF:0000107 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO UniProtKB:Q3UZ96 (PMID:18663143) RGD PMID:18663143 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 acts_upstream_of_or_within
involved_in		 ISO MGI:2447175 (PMID:18663143) RGD PMID:18663143 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within ISO MGI:5432904 (PMID:25318679) RGD PMID:25318679 NCBI chr10:74,854,779...74,861,147
Ensembl chr10:74,854,468...74,862,941 		JBrowse link
inferior endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17050629)		 Ensembl
RGD		 PMID:17050629 GO_REF:0000107 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (PMID:19161227) RGD PMID:19161227 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eng endoglin involved_in ISO (PMID:19703439) RGD PMID:19703439 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (PMID:19161227) RGD PMID:19161227 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18718461)		 Ensembl
RGD		 PMID:18718461 GO_REF:0000107 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17050629)		 Ensembl
RGD		 PMID:17050629 GO_REF:0000107 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 NOT|involved_in ISO (PMID:19161227) RGD PMID:19161227 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 NOT|involved_in ISO (PMID:19161227) RGD PMID:19161227 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
superior endocardial cushion morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfbr2 transforming growth factor, beta receptor 2 NOT|involved_in ISO (PMID:17050629) RGD PMID:17050629 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    developmental process 7067
      anatomical structure morphogenesis 2985
        tissue morphogenesis 715
          mesenchyme morphogenesis 62
            endocardial cushion morphogenesis 42
              apoptotic process involved in endocardial cushion morphogenesis 1
              cell proliferation involved in endocardial cushion morphogenesis 1
              endocardial cushion formation + 31
              endocardial cushion fusion 5
              inferior endocardial cushion morphogenesis 1
              superior endocardial cushion morphogenesis 1
Path 2
Term Annotations click to browse term
  biological_process 20069
    developmental process 7067
      anatomical structure development 6570
        multicellular organism development 5298
          system development 4583
            circulatory system development 1374
              heart development 745
                endocardial cushion development 54
                  endocardial cushion morphogenesis 42
                    apoptotic process involved in endocardial cushion morphogenesis 1
                    cell proliferation involved in endocardial cushion morphogenesis 1
                    endocardial cushion formation + 31
                    endocardial cushion fusion 5
                    inferior endocardial cushion morphogenesis 1
                    superior endocardial cushion morphogenesis 1
paths to the root