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Gene: Msx2 (msh homeobox 2) Rattus norvegicus
Symbol: Msx2
Name: msh homeobox 2
RGD ID: 3116
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cartilage development; osteoblast development; and transcription by RNA polymerase II. Predicted to localize to cytosol; nuclear speck; and transcription regulator complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human MSX2 (msh homeobox 2); INTERACTS WITH 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 2,6-dinitrotoluene; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein Hox-8-1; homeobox protein MSX-2; hox-8.1; Msh (Drosophila) homeo box homolog; msh homeo box homolog 2; msh homeo box homolog 2 (Drosophila)
Homo sapiens (human) : MSX2 (msh homeobox 2)  HGNC  Alliance
Mus musculus (house mouse) : Msx2 (msh homeobox 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msx2 (msh homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MSX2 (msh homeobox 2)
Canis lupus familiaris (dog) : MSX2 (msh homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msx2 (msh homeobox 2)
Sus scrofa (pig) : MSX2 (msh homeobox 2)
Chlorocebus sabaeus (African green monkey) : MSX2 (msh homeobox 2)
Heterocephalus glaber (naked mole-rat) : Msx2 (msh homeobox 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01711,683,862 - 11,689,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1711,683,862 - 11,689,527 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01713,785,024 - 13,790,689 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41717,243,262 - 17,248,927 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11717,247,335 - 17,247,755 (+)NCBI
Celera1711,158,359 - 11,164,024 (+)NCBICelera
Cytogenetic Map17p14NCBI
RH 3.4 Map17109.2RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Msx2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3116
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.