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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Brevianamide A
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Accession:CHEBI:200715 term browser browse the term
Synonyms:exact_synonym: 10',10'-dimethylspiro[1H-indole-2,11'-3,13-diazatetracyclo[5.5.2.01,9.03,7]tetradecane]-2',3,14'-trione
 related_synonym: Formula=C21H23N3O3;   InChI=1S/C21H23N3O3/c1-18(2)14-10-19-8-5-9-24(19)17(27)20(14,23-16(19)26)11-21(18)15(25)12-6-3-4-7-13(12)22-21/h3-4,6-7,14,22H,5,8-11H2,1-2H3,(H,23,26);   InChIKey=MWOFPQAPILIIPR-UHFFFAOYSA-N;   SMILES=O=C1N2C3(C(=O)NC14C(C(C)(C)C5(C4)NC=6C=CC=CC6C5=O)C3)CCC2
 xref: Chemspider:90141;   HMDB:HMDB0030380
 xref_mesh: MESH:C006794


show annotations for term's descendants           Sort by:
Brevianamide A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcf1 ATP binding cassette subfamily F member 1 increases expression ISO brevianamide A results in increased expression of ABCF1 mRNA CTD PMID:19818335 NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433 		JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO brevianamide A results in increased expression of AIMP1 mRNA CTD PMID:19818335 NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 increases expression ISO brevianamide A results in increased expression of CCL11 mRNA CTD PMID:19818335 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 decreases expression
increases expression		 ISO brevianamide A results in decreased expression of CCL12 mRNA
brevianamide A results in increased expression of CCL12 mRNA		 CTD PMID:19818335 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO brevianamide A results in increased expression of CCL19 mRNA CTD PMID:19818335 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO brevianamide A results in decreased expression of CCL2 mRNA CTD PMID:19818335 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression
increases expression		 ISO brevianamide A results in decreased expression of CCL20 mRNA
brevianamide A results in increased expression of CCL20 mRNA		 CTD PMID:19818335 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccl24 C-C motif chemokine ligand 24 increases expression ISO brevianamide A results in increased expression of CCL24 mRNA CTD PMID:19818335 NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893 		JBrowse link
G Ccl25 C-C motif chemokine ligand 25 increases expression ISO brevianamide A results in increased expression of CCL25 mRNA CTD PMID:19818335 NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO brevianamide A results in decreased expression of CCL4 mRNA CTD PMID:19818335 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression ISO brevianamide A results in increased expression of CCL5 mRNA CTD PMID:19818335 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO brevianamide A results in decreased expression of CCL7 mRNA CTD PMID:19818335 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303 		JBrowse link
G Ccr10 C-C motif chemokine receptor 10 increases expression ISO brevianamide A results in increased expression of CCR10 mRNA CTD PMID:19818335 NCBI chr10:86,108,551...86,110,988
Ensembl chr10:86,108,551...86,110,988 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO brevianamide A results in increased expression of CCR2 mRNA CTD PMID:19818335 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Ccr3 C-C motif chemokine receptor 3 increases expression ISO brevianamide A results in increased expression of CCR3 mRNA CTD PMID:19818335 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 increases expression ISO brevianamide A results in increased expression of CCR4 mRNA CTD PMID:19818335 NCBI chr 8:114,176,291...114,182,033
Ensembl chr 8:114,176,974...114,178,056 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 increases expression ISO brevianamide A results in increased expression of CCR6 mRNA CTD PMID:19818335 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Ccr7 C-C motif chemokine receptor 7 increases expression ISO brevianamide A results in increased expression of CCR7 mRNA CTD PMID:19818335 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309 		JBrowse link
G Ccr9 C-C motif chemokine receptor 9 increases expression ISO brevianamide A results in increased expression of CCR9 mRNA CTD PMID:19818335 NCBI chr 8:123,396,157...123,410,199
Ensembl chr 8:123,395,813...123,413,969 		JBrowse link
G Cd40lg CD40 ligand increases expression ISO brevianamide A results in increased expression of CD40LG mRNA CTD PMID:19818335 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO brevianamide A results in increased expression of CX3CL1 mRNA CTD PMID:19818335 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression ISO brevianamide A results in increased expression of CXCL12 mRNA CTD PMID:19818335 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression ISO brevianamide A results in increased expression of CXCL13 mRNA CTD PMID:19818335 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO brevianamide A results in increased expression of CXCL2 protein CTD PMID:19818335 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO brevianamide A results in decreased expression of CXCL1 mRNA CTD PMID:19818335 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 increases expression
decreases expression		 ISO brevianamide A results in increased expression of CXCL5 mRNA
brevianamide A results in decreased expression of CXCL5 mRNA		 CTD PMID:19818335 NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO brevianamide A results in increased expression of CXCR2 mRNA CTD PMID:19818335 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 increases expression ISO brevianamide A results in increased expression of CXCR3 mRNA CTD PMID:19818335 NCBI chr  X:66,844,318...66,846,969
Ensembl chr  X:66,844,318...66,846,969 		JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 increases expression ISO brevianamide A results in increased expression of CXCR5 mRNA CTD PMID:19818335 NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893 		JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO brevianamide A results in increased expression of IL10RA mRNA CTD PMID:19818335 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061 		JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression ISO brevianamide A results in increased expression of IL10RB mRNA CTD PMID:19818335 NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074 		JBrowse link
G Il11 interleukin 11 increases expression ISO brevianamide A results in increased expression of IL11 mRNA CTD PMID:19818335 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129 		JBrowse link
G Il13 interleukin 13 increases expression ISO brevianamide A results in increased expression of IL13 mRNA CTD PMID:19818335 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO brevianamide A results in increased expression of IL13RA1 mRNA CTD PMID:19818335 NCBI chr  X:115,348,822...115,408,682
Ensembl chr  X:115,348,860...115,408,681
Ensembl chr11:115,348,860...115,408,681 		JBrowse link
G Il16 interleukin 16 increases expression ISO brevianamide A results in increased expression of IL16 mRNA CTD PMID:19818335 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il18 interleukin 18 increases expression ISO brevianamide A results in increased expression of IL18 mRNA CTD PMID:19818335 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 increases expression ISO brevianamide A results in increased expression of IL1R1 mRNA CTD PMID:19818335 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937 		JBrowse link
G Il2rb interleukin 2 receptor subunit beta increases expression ISO brevianamide A results in increased expression of IL2RB mRNA CTD PMID:19818335 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054 		JBrowse link
G Il2rg interleukin 2 receptor subunit gamma increases expression ISO brevianamide A results in increased expression of IL2RG mRNA CTD PMID:19818335 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823 		JBrowse link
G Il6r interleukin 6 receptor increases expression ISO brevianamide A results in increased expression of IL6RA mRNA CTD PMID:19818335 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression ISO brevianamide A results in increased expression of IL6ST mRNA CTD PMID:19818335 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Ltb lymphotoxin beta increases expression ISO brevianamide A results in increased expression of LTB mRNA CTD PMID:19818335 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381 		JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO brevianamide A results in increased expression of MIF mRNA CTD PMID:19818335 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Pf4 platelet factor 4 increases expression ISO brevianamide A results in increased expression of PF4 mRNA CTD PMID:19818335 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO brevianamide A results in increased expression of TGFB1 mRNA CTD PMID:19818335 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression		 ISO brevianamide A results in decreased expression of TNF mRNA
brevianamide A results in increased expression of TNF mRNA; brevianamide A results in increased expression of TNF protein		 CTD PMID:19818335 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO brevianamide A results in increased expression of TNFRSF1A mRNA CTD PMID:19818335 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO brevianamide A results in increased expression of TNFRSF1B mRNA CTD PMID:19818335 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    chemical entity 19832
      group 19791
        polyatomic entity 19790
          molecule 19695
            cyclic compound 19511
              polycyclic compound 18829
                spiro compound 4996
                  azaspiro compound 878
                    Brevianamide A 48
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            organic molecule 19680
                              organic cyclic compound 19493
                                organic heterocyclic compound 18871
                                  organonitrogen heterocyclic compound 18152
                                    azaspiro compound 878
                                      Brevianamide A 48
paths to the root