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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Fusaric acid
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Accession:CHEBI:5199 term browser browse the term
Definition:An aromatic carboxylic acid that has formula C10H13NO2.
Synonyms:related_synonym: Formula=C10H13NO2;   InChI=1S/C10H13NO2/c1-2-3-4-8-5-6-9(10(12)13)11-7-8/h5-7H,2-4H2,1H3,(H,12,13);   InChIKey=DGMPVYSXXIOGJY-UHFFFAOYSA-N;   SMILES=CCCCc1ccc(nc1)C(O)=O
 xref: CAS:536-69-6;   KEGG:C10146;   KNApSAcK:C00002040;   LINCS:LSM-3944
 xref_mesh: MESH:D005669


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Fusaric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases expression
multiple interactions		 EXP Fusaric Acid results in decreased expression of ACHE protein
Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of ACHE protein]		 CTD PMID:31150628 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation ISO Fusaric Acid affects the phosphorylation of AKT1 protein CTD PMID:32156565 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Fusaric Acid results in increased expression of ATG5 mRNA CTD PMID:30582969 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Atg7 autophagy related 7 increases expression ISO Fusaric Acid results in increased expression of ATG7 mRNA CTD PMID:30582969 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression		 EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of BDNF protein] CTD PMID:31150628 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp1 caspase 1 decreases expression
affects activity		 ISO Fusaric Acid results in decreased expression of CASP1 mRNA
Fusaric Acid affects the activity of CASP1 protein		 CTD PMID:30582969 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 EXP Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of CASP3 protein] CTD PMID:31150628 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Dbh dopamine beta-hydroxylase decreases activity EXP Fusaric Acid results in decreased activity of DBH protein CTD PMID:2724147 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha decreases phosphorylation
increases phosphorylation		 ISO Fusaric Acid results in decreased phosphorylation of GSK3A protein
Fusaric Acid results in increased phosphorylation of GSK3A protein		 CTD PMID:32156565 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of GSK3B protein CTD PMID:32156565 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression
multiple interactions
affects expression		 ISO Fusaric Acid results in increased expression of HIF1A mRNA
Galactose affects the reaction [Fusaric Acid affects the expression of HIF1A protein]; Glucose affects the reaction [Fusaric Acid affects the expression of HIF1A protein]		 CTD PMID:31654802 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO Fusaric Acid results in increased expression of HSPD1 protein CTD PMID:30582969 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases phosphorylation ISO Fusaric Acid results in decreased phosphorylation of IKBKB protein CTD PMID:30582969 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il1b interleukin 1 beta decreases expression
decreases secretion		 ISO Fusaric Acid results in decreased expression of IL1B mRNA
Fusaric Acid results in decreased secretion of IL1B protein		 CTD PMID:30582969 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 decreases expression ISO Fusaric Acid results in decreased expression of IRAK1 protein CTD PMID:30582969 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 decreases expression ISO Fusaric Acid results in decreased expression of IRAK4 protein CTD PMID:30582969 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions
increases expression		 ISO Glucose affects the reaction [Fusaric Acid results in increased expression of LDHA mRNA] CTD PMID:31654802 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Mtor mechanistic target of rapamycin kinase affects phosphorylation ISO Fusaric Acid affects the phosphorylation of MTOR protein CTD PMID:32156565 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of NFE2L2 protein CTD PMID:30582969 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression ISO Fusaric Acid results in decreased expression of NLRP3 mRNA CTD PMID:30582969 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 increases phosphorylation
decreases phosphorylation		 ISO Fusaric Acid results in increased phosphorylation of PDHA1 protein
Fusaric Acid results in decreased phosphorylation of PDHA1 protein		 CTD PMID:31654802 PMID:32156565 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions
increases expression
affects expression		 ISO Galactose affects the reaction [Fusaric Acid results in increased expression of PDK1 protein]; Glucose affects the reaction [Fusaric Acid results in increased expression of PDK1 mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PDK1 protein]
Fusaric Acid results in increased expression of PDK1 mRNA; Fusaric Acid results in increased expression of PDK1 protein
Fusaric Acid affects the expression of PDK1 protein		 CTD PMID:31654802 PMID:32156565 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pink1 PTEN induced kinase 1 increases expression ISO Fusaric Acid results in increased expression of PINK1 protein CTD PMID:30582969 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression		 ISO Galactose affects the reaction [Fusaric Acid results in increased expression of PKM mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PKM mRNA]; Glucose affects the reaction [Fusaric Acid results in increased expression of PKM protein]
Fusaric Acid results in increased expression of PKM mRNA; Fusaric Acid results in increased expression of PKM protein		 CTD PMID:31654802 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression ISO Fusaric Acid results in increased expression of RELA mRNA CTD PMID:30582969 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO Fusaric Acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:32156565 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects expression ISO Fusaric Acid affects the expression of SLC2A1 mRNA CTD PMID:32156565 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression
affects expression		 ISO Fusaric Acid results in increased expression of SLC2A4 mRNA
Fusaric Acid affects the expression of SLC2A4 protein		 CTD PMID:32156565 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Fusaric Acid results in increased expression of SOD2 mRNA; Fusaric Acid results in increased expression of SOD2 protein CTD PMID:30582969 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO Fusaric Acid results in decreased expression of SQSTM1 protein CTD PMID:30582969 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Fusaric Acid results in increased expression of TFAM protein CTD PMID:30582969 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tp53 tumor protein p53 affects phosphorylation ISO Fusaric Acid affects the phosphorylation of TRP53 protein CTD PMID:32156565 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Traf6 TNF receptor associated factor 6 decreases expression ISO Fusaric Acid results in decreased expression of TRAF6 protein CTD PMID:30582969 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Ucp2 uncoupling protein 2 decreases expression ISO Fusaric Acid results in decreased expression of UCP2 protein CTD PMID:30582969 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          nitrogen atom 18933
            nitrogen molecular entity 18933
              organonitrogen compound 18783
                organonitrogen heterocyclic compound 18126
                  pyridines 11511
                    Fusaric acid 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      aromatic carboxylic acid 12598
                                        Fusaric acid 34
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