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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Aloe emodin
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Accession:CHEBI:2607 term browser browse the term
Definition:A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.
Synonyms:exact_synonym: 1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione
 related_synonym: 1,8-Dihydroxy-3-hydroxymethylanthraquinone;   3-(Hydroxymethyl)chrysazin;   Aloeemodin;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2;   InChIKey=YDQWDHRMZQUTBA-UHFFFAOYSA-N;   Rhabarberone;   SMILES=OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
 alt_id: MESH:C518327
 xref: CAS:481-72-1;   HMDB:HMDB0030829;   KEGG:C10294;   KNApSAcK:C00002789;   LIPID_MAPS_instance:LMPK13040002
 xref_mesh: MESH:C518327
 xref: PMID:22931417;   PMID:24685589;   PMID:24707862;   Patent:US4670265;   Reaxys:2059062;   Wikipedia:Aloe_emodin


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Aloe emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA] CTD PMID:22645054 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AKR1B10 aldo-keto reductase family 1 member B10 decreases activity EXP aloe emodin results in decreased activity of AKR1B10 protein CTD PMID:35065925 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 decreases activity EXP aloe emodin results in decreased activity of AKR1C3 protein CTD PMID:35065925 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP aloe emodin results in increased expression of ATF3 mRNA CTD PMID:22210228 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP aloe emodin results in increased expression of BAX protein CTD PMID:19928967 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein CTD PMID:19928967 PMID:22210228 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression		 EXP aloe emodin results in increased activity of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]
aloe emodin results in increased cleavage of CASP3 protein		 CTD PMID:19928967 PMID:22210228 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions
increases expression		 EXP aloe emodin results in increased activity of CASP8 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]		 CTD PMID:19928967 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity
increases expression
multiple interactions		 EXP aloe emodin results in increased activity of CASP9 protein
aloe emodin results in increased expression of CASP9 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]		 CTD PMID:19928967 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CBR1 carbonyl reductase 1 decreases activity EXP aloe emodin results in decreased activity of CBR1 protein CTD PMID:35065925 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166 		JBrowse link
G CYCS cytochrome c, somatic increases expression EXP aloe emodin results in increased expression of CYCS protein CTD PMID:19928967 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity EXP aloe emodin results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases activity EXP aloe emodin results in decreased activity of CYP1A2 protein CTD PMID:27633141 PMID:33438235 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP aloe emodin results in decreased activity of CYP1B1 protein CTD PMID:27633141 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions
increases chemical synthesis		 EXP [CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin		 CTD PMID:29698620 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity EXP aloe emodin results in decreased activity of CYP2C19 protein CTD PMID:33438235 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity EXP aloe emodin results in decreased activity of CYP2C9 protein CTD PMID:33438235 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases chemical synthesis		 EXP [CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP3A4 protein results in increased chemical synthesis of aloe emodin		 CTD PMID:29698620 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein CTD PMID:22210228 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP aloe emodin results in increased phosphorylation of EIF2S1 protein CTD PMID:22210228 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516 		JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions EXP aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA] CTD PMID:22645054 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FADD Fas associated via death domain multiple interactions EXP aloe emodin results in increased expression of and affects the localization of FADD protein CTD PMID:19928967 NCBI chr11:70,203,296...70,207,390
Ensembl chr11:70,203,296...70,207,390 		JBrowse link
G FAS Fas cell surface death receptor increases expression EXP aloe emodin results in increased expression of FAS protein CTD PMID:19928967 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand increases expression EXP aloe emodin results in increased expression of FASLG protein CTD PMID:19928967 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein CTD PMID:22210228 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G LPL lipoprotein lipase multiple interactions EXP aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA] CTD PMID:22645054 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G NAT1 N-acetyltransferase 1 multiple interactions
decreases expression		 EXP aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA		 CTD PMID:16314733 NCBI chr 8:18,170,467...18,223,689
Ensembl chr 8:18,170,477...18,223,689 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:19352036 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA] CTD PMID:22645054 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA] CTD PMID:19352036 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RETN resistin multiple interactions EXP aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA] CTD PMID:22645054 NCBI chr19:7,669,049...7,670,455
Ensembl chr19:7,669,049...7,670,455 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 decreases activity EXP aloe emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G SULT1E1 sulfotransferase family 1E member 1 decreases activity EXP aloe emodin results in decreased activity of SULT1E1 protein CTD PMID:27633141 NCBI chr 4:69,821,122...69,860,145
Ensembl chr 4:69,841,212...69,860,145 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 EXP aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein		 CTD PMID:19928967 PMID:22645054 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A increases expression EXP aloe emodin results in increased expression of TNFRSF1A protein CTD PMID:19928967 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B increases expression EXP aloe emodin results in increased expression of TNFRSF1B protein CTD PMID:19928967 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228 		JBrowse link
G TP53 tumor protein p53 increases expression EXP aloe emodin results in increased expression of TP53 protein CTD PMID:19928967 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions EXP aloe emodin results in increased expression of and affects the localization of TRADD protein CTD PMID:19928967 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909 		JBrowse link
G UGT1A9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation EXP UGT1A9 protein results in increased glucuronidation of aloe emodin CTD PMID:24854283 NCBI chr 2:233,671,898...233,773,300
Ensembl chr 2:233,671,898...233,773,300 		JBrowse link
G XBP1 X-box binding protein 1 increases splicing EXP aloe emodin results in increased splicing of XBP1 mRNA CTD PMID:22210228 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      application 25177
        pharmaceutical 24551
          drug 24548
            antineoplastic agent 20855
              Aloe emodin 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            heteroorganic entity 24770
                              organochalcogen compound 24383
                                organooxygen compound 24060
                                  carbonyl compound 23571
                                    ketone 19350
                                      cyclic ketone 16838
                                        quinone 9216
                                          acenoquinone 8214
                                            anthraquinone 533
                                              hydroxyanthraquinones 522
                                                dihydroxyanthraquinone 370
                                                  chrysazin 74
                                                    Aloe emodin 40
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