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Gene: XBP1 (X-box binding protein 1) Homo sapiens
Symbol: XBP1
Name: X-box binding protein 1
Description: Exhibits several functions, including DNA binding activity; enzyme binding activity; and protein heterodimerization activity. Involved in several processes, including positive regulation of lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Localizes to several cellular components, including cytosol; endoplasmic reticulum; and integral component of endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: tax-responsive element-binding protein 5; TREB-5; TREB5; X-box-binding protein 1; XBP-1; XBP2
Mus musculus (house mouse) : Xbp1 (X-box binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Xbp1 (X-box binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Xbp1 (X-box binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : XBP1 (X-box binding protein 1)
Canis lupus familiaris (dog) : XBP1 (X-box binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Xbp1 (X-box binding protein 1)
Sus scrofa (pig) : XBP1 (X-box binding protein 1)
Chlorocebus sabaeus (African green monkey) : XBP1 (X-box binding protein 1)
Heterocephalus glaber (naked mole-rat) : Xbp1 (X-box binding protein 1)
more info ...
Related Pseudogenes: XBP1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2228,794,555 - 28,800,597 (-)EnsemblGRCh38hg38GRCh38
GRCh382228,794,560 - 28,800,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,190,548 - 29,196,560 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,520,548 - 27,526,560 (-)NCBINCBI36hg18NCBI36
Build 342227,515,102 - 27,521,114NCBI
Celera2212,990,518 - 12,996,530 (-)NCBI
Cytogenetic Map22q12.1NCBI
HuRef2212,155,463 - 12,161,487 (-)NCBIHuRef
CHM1_12229,149,582 - 29,155,594 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on XBP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1352787
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.