XBP1 (X-box binding protein 1) - Rat Genome Database

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Gene: XBP1 (X-box binding protein 1) Homo sapiens
Analyze
Symbol: XBP1
Name: X-box binding protein 1
RGD ID: 1352787
HGNC Page HGNC
Description: Enables several functions, including DNA binding activity; enzyme binding activity; and protein heterodimerization activity. Involved in several processes, including positive regulation of lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Located in cytosol; endoplasmic reticulum; and nucleus. Is integral component of endoplasmic reticulum membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: tax-responsive element-binding protein 5; TREB-5; TREB5; X-box-binding protein 1; XBP-1; XBP2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: XBP1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2228,794,555 - 28,800,597 (-)EnsemblGRCh38hg38GRCh38
GRCh382228,794,560 - 28,800,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,190,548 - 29,196,557 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,520,548 - 27,526,560 (-)NCBINCBI36hg18NCBI36
Build 342227,515,102 - 27,521,114NCBI
Celera2212,990,518 - 12,996,530 (-)NCBI
Cytogenetic Map22q12.1NCBI
HuRef2212,155,463 - 12,161,487 (-)NCBIHuRef
CHM1_12229,149,582 - 29,155,594 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-anisomycin  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-nicotine  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dichlorophenol  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-aminophenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nitrophenol  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-fluorouracil  (EXP)
8-Br-cAMP  (EXP)
acrolein  (EXP)
acrylamide  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
Aloe emodin  (EXP)
alpha-pinene  (EXP)
AM-251  (EXP)
amiloride  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
antimycin A  (EXP,ISO)
antirheumatic drug  (EXP)
aristolochic acid  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
benzalkonium chloride  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
benzoates  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bilirubin IXalpha  (EXP,ISO)
bisphenol A  (ISO)
boric acid  (EXP)
bortezomib  (EXP)
brefeldin A  (EXP)
bromobenzene  (ISO)
bupropion  (EXP)
butan-1-ol  (EXP)
butanal  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP)
cannabidiol  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP)
carbaryl  (EXP)
carbon nanotube  (EXP,ISO)
casticin  (EXP)
cerulenin  (EXP)
ceruletide  (ISO)
chloroacetaldehyde  (EXP)
chloroacetic acid  (ISO)
chloropicrin  (EXP)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chrysene  (ISO)
cidofovir anhydrous  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
D-penicillamine  (EXP)
dantrolene  (ISO)
Deguelin  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
diclofenac  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
ebselen  (ISO)
endosulfan  (ISO)
entinostat  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethylbenzene  (EXP)
fenofibrate  (EXP,ISO)
fenpyroximate  (EXP)
ferric ammonium citrate  (EXP)
flutamide  (ISO)
folic acid  (ISO)
folpet  (ISO)
fructose  (ISO)
furan  (ISO)
gadolinium trichloride  (ISO)
gemcitabine  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP)
glycine  (EXP)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (EXP)
hydrogen peroxide  (EXP)
hydroxychloroquine  (EXP)
ibuprofen  (EXP)
ifosfamide  (EXP)
Indeno[1,2,3-cd]pyrene  (EXP)
indometacin  (EXP)
indoxyl sulfate  (ISO)
L-methionine  (ISO)
lactacystin  (EXP)
lanthanum atom  (EXP)
leflunomide  (EXP)
letrozole  (ISO)
linuron  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
menadione  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
mevastatin  (ISO)
minocycline  (ISO)
MK-2206  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
nilotinib  (EXP)
Nodularin  (EXP)
o-xylene  (EXP)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oleic acid  (EXP)
orlistat  (EXP)
ozone  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
patulin  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenobarbital  (ISO)
picene  (EXP)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
potassium iodide  (EXP)
prallethrin  (EXP)
progesterone  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (EXP,ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
Riluzole  (EXP)
rimonabant  (EXP)
rotenone  (EXP,ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
serpentine asbestos  (EXP,ISO)
sertraline  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sincalide  (ISO)
sirolimus  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sorafenib  (EXP)
SR 144528  (EXP)
streptozocin  (ISO)
sulfasalazine  (EXP)
sulforaphane  (EXP)
sulfur dioxide  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (EXP)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
temozolomide  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
trierixin  (EXP)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
urethane  (EXP)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
withaferin A  (EXP)
zearalenone  (EXP)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (ISS)
angiogenesis  (ISS)
apoptotic process  (IEA)
autophagy  (IEA)
cellular response to amino acid stimulus  (ISS)
cellular response to antibiotic  (ISO)
cellular response to fluid shear stress  (IDA)
cellular response to fructose stimulus  (ISS)
cellular response to glucose starvation  (ISS)
cellular response to glucose stimulus  (ISS)
cellular response to insulin stimulus  (ISS)
cellular response to interleukin-4  (ISS)
cellular response to laminar fluid shear stress  (IDA)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IDA)
cellular response to nutrient  (ISS)
cellular response to oxidative stress  (IDA)
cellular response to peptide hormone stimulus  (ISS)
cellular response to vascular endothelial growth factor stimulus  (IDA)
cellular triglyceride homeostasis  (ISS)
cholesterol homeostasis  (ISS)
endoplasmic reticulum unfolded protein response  (ISO,ISS)
endothelial cell proliferation  (IDA)
epithelial cell maturation  (ISO)
epithelial cell maturation involved in salivary gland development  (ISO)
exocrine pancreas development  (ISO)
fatty acid biosynthetic process  (TAS)
fatty acid homeostasis  (ISS)
glucose homeostasis  (ISO)
immune response  (TAS)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
IRE1-mediated unfolded protein response  (TAS)
liver development  (ISS)
muscle organ development  (IEA)
negative regulation of apoptotic process  (ISS)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IDA)
negative regulation of endoplasmic reticulum unfolded protein response  (IDA)
negative regulation of ERK1 and ERK2 cascade  (IDA)
negative regulation of myotube differentiation  (ISS)
negative regulation of pathway-restricted SMAD protein phosphorylation  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of transforming growth factor beta receptor signaling pathway  (IDA)
neuron development  (ISS)
organelle organization  (TAS)
phosphatidylinositol 3-kinase signaling  (IDA)
positive regulation of angiogenesis  (IMP)
positive regulation of autophagy  (IDA)
positive regulation of B cell differentiation  (IDA)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA,IGI)
positive regulation of endoplasmic reticulum unfolded protein response  (IMP)
positive regulation of endothelial cell apoptotic process  (IDA)
positive regulation of ER-associated ubiquitin-dependent protein catabolic process  (TAS)
positive regulation of fat cell differentiation  (ISS)
positive regulation of hepatocyte proliferation  (ISS)
positive regulation of histone methylation  (IDA)
positive regulation of immunoglobulin production  (IDA,ISS)
positive regulation of interleukin-6 production  (ISS)
positive regulation of lactation  (ISS)
positive regulation of MHC class II biosynthetic process  (IMP)
positive regulation of phospholipid biosynthetic process  (TAS)
positive regulation of plasma cell differentiation  (IDA)
positive regulation of proteasomal protein catabolic process  (ISO)
positive regulation of protein acetylation  (IDA)
positive regulation of protein import into nucleus  (IDA)
positive regulation of protein kinase B signaling  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of T cell differentiation  (IDA)
positive regulation of TOR signaling  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO,ISS,TAS)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (TAS)
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response  (IBA,IDA,ISS)
positive regulation of vascular associated smooth muscle cell migration  (IDA)
positive regulation of vascular associated smooth muscle cell proliferation  (IDA)
positive regulation of vascular wound healing  (IDA)
protein destabilization  (IDA,IMP)
protein transport  (IEA)
regulation of autophagy  (ISO)
regulation of cell growth  (IDA)
regulation of protein stability  (IDA)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IEA)
response to electrical stimulus  (ISO)
response to endoplasmic reticulum stress  (IDA)
response to insulin-like growth factor stimulus  (ISS)
response to xenobiotic stimulus  (ISO)
serotonin secretion, neurotransmission  (ISO)
sterol homeostasis  (ISS)
transcription by RNA polymerase II  (ISO,ISS)
ubiquitin-dependent protein catabolic process  (ISS)
vascular endothelial growth factor receptor signaling pathway  (IDA)

Cellular Component

References

Additional References at PubMed
PMID:1718857   PMID:1903538   PMID:2196176   PMID:2321018   PMID:8349596   PMID:8657566   PMID:9563853   PMID:10591208   PMID:10652269   PMID:11076863   PMID:11256614   PMID:11460154  
PMID:11779464   PMID:11813207   PMID:12067985   PMID:12477932   PMID:12586069   PMID:12713871   PMID:12805554   PMID:12949534   PMID:12954762   PMID:14576841   PMID:14634507   PMID:14702039  
PMID:15063770   PMID:15149721   PMID:15184063   PMID:15298659   PMID:15331160   PMID:15351732   PMID:15380296   PMID:15461802   PMID:15489334   PMID:15489336   PMID:15598891   PMID:15882996  
PMID:15892135   PMID:15927087   PMID:15936534   PMID:16002735   PMID:16009131   PMID:16154272   PMID:16327981   PMID:16342282   PMID:16381901   PMID:16461360   PMID:16645094   PMID:16958950  
PMID:17026957   PMID:17034899   PMID:17092596   PMID:17418411   PMID:17442311   PMID:17660348   PMID:17884689   PMID:17898050   PMID:17906960   PMID:17928342   PMID:17932454   PMID:18082745  
PMID:18191223   PMID:18192112   PMID:18386815   PMID:18417469   PMID:18552212   PMID:18583979   PMID:18635891   PMID:18676680   PMID:18775308   PMID:18840095   PMID:18840627   PMID:19009018  
PMID:19112081   PMID:19122331   PMID:19135031   PMID:19154631   PMID:19170196   PMID:19176362   PMID:19237300   PMID:19265690   PMID:19274049   PMID:19321437   PMID:19380033   PMID:19389935  
PMID:19403667   PMID:19412428   PMID:19416856   PMID:19420237   PMID:19435892   PMID:19470730   PMID:19530237   PMID:19543371   PMID:19564049   PMID:19609461   PMID:19622636   PMID:19625176  
PMID:19669932   PMID:19692168   PMID:19722195   PMID:19735688   PMID:19751410   PMID:19941857   PMID:19958799   PMID:20013084   PMID:20102225   PMID:20170659   PMID:20211142   PMID:20348923  
PMID:20368688   PMID:20421453   PMID:20688044   PMID:20955178   PMID:20980528   PMID:21050047   PMID:21061914   PMID:21085187   PMID:21129256   PMID:21129257   PMID:21138464   PMID:21138840  
PMID:21233347   PMID:21385877   PMID:21423203   PMID:21660045   PMID:21677677   PMID:21858728   PMID:21873635   PMID:21924241   PMID:22002058   PMID:22013210   PMID:22370484   PMID:22422988  
PMID:22427205   PMID:22445760   PMID:22469468   PMID:22644804   PMID:22679299   PMID:22787145   PMID:22925926   PMID:22934019   PMID:22960999   PMID:23184933   PMID:23277279   PMID:23335490  
PMID:23421912   PMID:23447676   PMID:23470653   PMID:23510626   PMID:23529610   PMID:23560553   PMID:23661758   PMID:23737521   PMID:23930139   PMID:24027308   PMID:24029229   PMID:24165480  
PMID:24194940   PMID:24269637   PMID:24356728   PMID:24387801   PMID:24497562   PMID:24670641   PMID:24762547   PMID:24821775   PMID:24909686   PMID:25086665   PMID:25129146   PMID:25170079  
PMID:25190803   PMID:25216212   PMID:25231123   PMID:25239945   PMID:25280941   PMID:25378478   PMID:25426559   PMID:25437541   PMID:25448679   PMID:25450523   PMID:25633195   PMID:25633224  
PMID:25656649   PMID:25692573   PMID:25754093   PMID:25870107   PMID:25901709   PMID:25963833   PMID:25986851   PMID:25993558   PMID:26073941   PMID:26112372   PMID:26134873   PMID:26299655  
PMID:26331676   PMID:26403762   PMID:26469762   PMID:26483401   PMID:26491160   PMID:26514267   PMID:26517687   PMID:26633383   PMID:26680227   PMID:26740125   PMID:26742428   PMID:26803729  
PMID:26979393   PMID:27109102   PMID:27133203   PMID:27226027   PMID:27334111   PMID:27338006   PMID:27356931   PMID:27472396   PMID:27570073   PMID:27573888   PMID:27646263   PMID:27647225  
PMID:27651490   PMID:27853315   PMID:27996033   PMID:28082079   PMID:28099966   PMID:28111258   PMID:28167662   PMID:28222747   PMID:28333149   PMID:28408069   PMID:28473536   PMID:28514442  
PMID:28717189   PMID:28986522   PMID:29057323   PMID:29276149   PMID:29352987   PMID:29480818   PMID:29534223   PMID:29627568   PMID:29649564   PMID:29650257   PMID:29768047   PMID:29843019  
PMID:29916547   PMID:30032821   PMID:30282030   PMID:30305426   PMID:30305738   PMID:30355738   PMID:30473215   PMID:30509487   PMID:30538328   PMID:30594400   PMID:30783083   PMID:30865896  
PMID:30973754   PMID:31128106   PMID:31177839   PMID:31187548   PMID:31227689   PMID:31246176   PMID:31260448   PMID:31314593   PMID:31320508   PMID:31387940   PMID:31424945   PMID:31495285  
PMID:31541078   PMID:31554371   PMID:31837300   PMID:31907348   PMID:31953562   PMID:31954175   PMID:32039055   PMID:32294597   PMID:32296183   PMID:32305055   PMID:32335916   PMID:32418990  
PMID:32513696   PMID:32576923   PMID:32613835   PMID:32896245   PMID:33137310   PMID:33227812   PMID:33256835   PMID:33275235   PMID:33341031   PMID:33352294   PMID:34124911  


Genomics

Candidate Gene Status
XBP1 is a candidate Gene for QTL GLUCO141_H
Comparative Map Data
XBP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2228,794,555 - 28,800,597 (-)EnsemblGRCh38hg38GRCh38
GRCh382228,794,560 - 28,800,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372229,190,548 - 29,196,557 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,520,548 - 27,526,560 (-)NCBINCBI36hg18NCBI36
Build 342227,515,102 - 27,521,114NCBI
Celera2212,990,518 - 12,996,530 (-)NCBI
Cytogenetic Map22q12.1NCBI
HuRef2212,155,463 - 12,161,487 (-)NCBIHuRef
CHM1_12229,149,582 - 29,155,594 (-)NCBICHM1_1
Xbp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39115,470,641 - 5,475,993 (+)NCBIGRCm39mm39
GRCm39 Ensembl115,470,659 - 5,475,893 (+)Ensembl
GRCm38115,520,641 - 5,525,993 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl115,520,659 - 5,525,893 (+)EnsemblGRCm38mm10GRCm38
MGSCv37115,420,970 - 5,425,875 (+)NCBIGRCm37mm9NCBIm37
MGSCv36115,420,970 - 5,425,875 (+)NCBImm8
Celera116,013,954 - 6,018,865 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.61NCBI
Xbp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21480,390,629 - 80,395,713 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1480,390,643 - 80,395,693 (+)Ensembl
Rnor_6.01485,753,736 - 85,758,820 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1485,753,760 - 85,758,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01486,423,839 - 86,428,923 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41486,151,910 - 86,156,975 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11486,171,054 - 86,176,119 (+)NCBI
Celera1479,276,264 - 79,281,348 (+)NCBICelera
Cytogenetic Map14q21NCBI
Xbp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554553,037,885 - 3,041,827 (-)NCBIChiLan1.0ChiLan1.0
XBP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12227,566,423 - 27,572,627 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2227,567,041 - 27,571,943 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0229,863,479 - 9,869,491 (-)NCBIMhudiblu_PPA_v0panPan3
XBP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12622,162,675 - 22,168,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2622,163,222 - 22,168,105 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2622,034,265 - 22,039,738 (-)NCBI
ROS_Cfam_1.02622,536,044 - 22,541,803 (-)NCBI
UMICH_Zoey_3.12622,246,365 - 22,251,835 (-)NCBI
UNSW_CanFamBas_1.02622,509,837 - 22,515,563 (-)NCBI
UU_Cfam_GSD_1.02622,572,658 - 22,578,379 (-)NCBI
Xbp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118112,975,309 - 112,979,534 (+)NCBI
SpeTri2.0NW_0049366572,891,171 - 2,895,409 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
XBP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1446,008,377 - 46,017,036 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11446,011,239 - 46,016,526 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21449,015,849 - 49,016,650 (-)NCBISscrofa10.2Sscrofa10.2susScr3
XBP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11911,670,605 - 11,677,168 (-)NCBI
Vero_WHO_p1.0NW_023666045114,476,586 - 114,483,163 (+)NCBI
Xbp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247475,123,085 - 5,128,465 (-)NCBI

Position Markers
DXS9738  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372229,191,432 - 29,191,527UniSTSGRCh37
Build 362227,521,432 - 27,521,527RGDNCBI36
Celera2212,991,402 - 12,991,497RGD
Cytogenetic Map22q12UniSTS
Cytogenetic Map22q12.1UniSTS
HuRef2212,156,347 - 12,156,442UniSTS
RH27882  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372229,190,591 - 29,190,777UniSTSGRCh37
Build 362227,520,591 - 27,520,777RGDNCBI36
Celera2212,990,561 - 12,990,747RGD
Cytogenetic Map22q12UniSTS
Cytogenetic Map22q12.1UniSTS
HuRef2212,155,506 - 12,155,692UniSTS
RH103903  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372229,197,084 - 29,197,210UniSTSGRCh37
Build 362227,527,084 - 27,527,210RGDNCBI36
Celera2212,997,054 - 12,997,180RGD
Cytogenetic Map22q12UniSTS
Cytogenetic Map22q12.1UniSTS
HuRef2212,162,011 - 12,162,137UniSTS
GeneMap99-GB4 RH Map2279.3UniSTS
D22S1031  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372229,190,621 - 29,190,776UniSTSGRCh37
Build 362227,520,621 - 27,520,776RGDNCBI36
Celera2212,990,591 - 12,990,746RGD
Cytogenetic Map22q12UniSTS
Cytogenetic Map22q12.1UniSTS
HuRef2212,155,536 - 12,155,691UniSTS
Whitehead-YAC Contig Map22 UniSTS
STS-M31627  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372229,190,747 - 29,190,983UniSTSGRCh37
Build 362227,520,747 - 27,520,983RGDNCBI36
Celera2212,990,717 - 12,990,953RGD
Cytogenetic Map22q12UniSTS
Cytogenetic Map22q12.1UniSTS
HuRef2212,155,662 - 12,155,898UniSTS
GeneMap99-GB4 RH Map2277.44UniSTS
XBP1_3218  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372229,190,366 - 29,191,048UniSTSGRCh37
Build 362227,520,366 - 27,521,048RGDNCBI36
Celera2212,990,336 - 12,991,018RGD
HuRef2212,155,281 - 12,155,963UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR625hsa-miR-625-3pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
MIR127hsa-miR-127-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19530237
MIR214hsa-miR-214-3pMirtarbaseexternal_infoELISA//Flow//Luciferase reporter assay//qRT-PCR//WFunctional MTI22359598
MIR214hsa-miR-214-3pOncomiRDBexternal_infoNANA22359598

Predicted Target Of
Summary Value
Count of predictions:1632
Count of miRNA genes:578
Interacting mature miRNAs:623
Transcripts:ENST00000216037, ENST00000344347, ENST00000403532, ENST00000405219, ENST00000482720, ENST00000484256
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3 1 52 7 1 32 2 51
Medium 2343 2925 1695 551 1809 442 4113 2129 3169 386 1342 1449 111 1204 2782 2 2
Low 4 57 3 1 18 2 5 45 500 2 6 3 2 1 4
Below cutoff 1 1 1 1 3 1 5 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001079539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB076383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB076384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK093842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC015709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI545390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M31627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z93930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000216037   ⟹   ENSP00000216037
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2228,794,555 - 28,800,597 (-)Ensembl
RefSeq Acc Id: ENST00000344347   ⟹   ENSP00000343155
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2228,795,175 - 28,800,524 (-)Ensembl
RefSeq Acc Id: ENST00000403532   ⟹   ENSP00000385162
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2228,794,557 - 28,800,558 (-)Ensembl
RefSeq Acc Id: ENST00000405219   ⟹   ENSP00000384295
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2228,794,589 - 28,800,133 (-)Ensembl
RefSeq Acc Id: ENST00000482720
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2228,798,906 - 28,800,569 (-)Ensembl
RefSeq Acc Id: ENST00000484256
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2228,794,559 - 28,797,045 (-)Ensembl
RefSeq Acc Id: ENST00000611155   ⟹   ENSP00000481170
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2228,794,560 - 28,800,572 (-)Ensembl
RefSeq Acc Id: NM_001079539   ⟹   NP_001073007
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382228,794,560 - 28,800,569 (-)NCBI
GRCh372229,190,548 - 29,196,560 (-)ENTREZGENE
Build 362227,520,548 - 27,526,560 (-)NCBI Archive
HuRef2212,155,463 - 12,161,487 (-)ENTREZGENE
CHM1_12229,149,582 - 29,155,594 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001393999   ⟹   NP_001380928
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382228,794,560 - 28,800,077 (-)NCBI
RefSeq Acc Id: NM_001394000   ⟹   NP_001380929
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382228,794,560 - 28,800,077 (-)NCBI
RefSeq Acc Id: NM_005080   ⟹   NP_005071
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382228,794,560 - 28,800,569 (-)NCBI
GRCh372229,190,548 - 29,196,560 (-)ENTREZGENE
Build 362227,520,548 - 27,526,560 (-)NCBI Archive
HuRef2212,155,463 - 12,161,487 (-)ENTREZGENE
CHM1_12229,149,582 - 29,155,594 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001073007   ⟸   NM_001079539
- Peptide Label: isoform XBP1(S)
- UniProtKB: P17861 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_005071   ⟸   NM_005080
- Peptide Label: isoform XBP1(U)
- UniProtKB: P17861 (UniProtKB/Swiss-Prot),   A0A024R1F0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000216037   ⟸   ENST00000216037
RefSeq Acc Id: ENSP00000481170   ⟸   ENST00000611155
RefSeq Acc Id: ENSP00000385162   ⟸   ENST00000403532
RefSeq Acc Id: ENSP00000384295   ⟸   ENST00000405219
RefSeq Acc Id: ENSP00000343155   ⟸   ENST00000344347
RefSeq Acc Id: NP_001380928   ⟸   NM_001393999
- Peptide Label: isoform 3 precursor
RefSeq Acc Id: NP_001380929   ⟸   NM_001394000
- Peptide Label: isoform 4 precursor
Protein Domains
bZIP

Promoters
RGD ID:6800486
Promoter ID:HG_KWN:42198
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000321277
Position:
Human AssemblyChrPosition (strand)Source
Build 362227,522,041 - 27,523,442 (-)MPROMDB
RGD ID:6799795
Promoter ID:HG_KWN:42199
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000403532,   NM_001079539,   OTTHUMT00000321270,   OTTHUMT00000321271,   OTTHUMT00000321274,   OTTHUMT00000321278,   UC003AED.1,   UC003AEF.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362227,525,066 - 27,526,647 (+)MPROMDB
RGD ID:6852338
Promoter ID:EP73976
Type:initiation region
Name:HS_XBP1
Description:X-box binding protein 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 362227,526,514 - 27,526,574EPD
RGD ID:13603600
Promoter ID:EPDNEW_H27984
Type:initiation region
Name:XBP1_1
Description:X-box binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382228,800,537 - 28,800,597EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
XBP1, -116C-G single nucleotide variant Major affective disorder 7, susceptibility to [RCV000012978] Chr22:22q12 risk factor
GRCh38/hg38 22q11.21-12.3(chr22:18178957-31821193)x3 copy number gain See cases [RCV000050768] Chr22:18178957..31821193 [GRCh38]
Chr22:18661724..32217179 [GRCh37]
Chr22:17041724..30547179 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1-12.3(chr22:26979579-33992220)x3 copy number gain See cases [RCV000050553] Chr22:26979579..33992220 [GRCh38]
Chr22:27375542..34388209 [GRCh37]
Chr22:25705542..32718209 [NCBI36]
Chr22:22q12.1-12.3
pathogenic
GRCh38/hg38 22q12.1(chr22:27557778-28988149)x3 copy number gain See cases [RCV000052852] Chr22:27557778..28988149 [GRCh38]
Chr22:27953739..29384137 [GRCh37]
Chr22:26283739..27714137 [NCBI36]
Chr22:22q12.1
uncertain significance
GRCh38/hg38 22q12.1-12.2(chr22:26221273-29477543)x1 copy number loss See cases [RCV000052869] Chr22:26221273..29477543 [GRCh38]
Chr22:26617239..29873532 [GRCh37]
Chr22:24947239..28203532 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:28278805-31742328)x1 copy number loss See cases [RCV000052870] Chr22:28278805..31742328 [GRCh38]
Chr22:28674793..32138314 [GRCh37]
Chr22:27004793..30468314 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:28441035-30276511)x1 copy number loss See cases [RCV000052871] Chr22:28441035..30276511 [GRCh38]
Chr22:28837023..30672500 [GRCh37]
Chr22:27167023..29002500 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.23-12.3(chr22:23279231-36247369)x3 copy number gain See cases [RCV000138172] Chr22:23279231..36247369 [GRCh38]
Chr22:23621418..36643415 [GRCh37]
Chr22:21951418..34973361 [NCBI36]
Chr22:22q11.23-12.3
pathogenic
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3 copy number gain See cases [RCV000137926] Chr22:20907226..37187347 [GRCh38]
Chr22:21261514..37583387 [GRCh37]
Chr22:19591514..35913333 [NCBI36]
Chr22:22q11.21-12.3
pathogenic
GRCh38/hg38 22q12.1(chr22:28441053-28819615)x3 copy number gain See cases [RCV000139107] Chr22:28441053..28819615 [GRCh38]
Chr22:28837041..29215603 [GRCh37]
Chr22:27167041..27545603 [NCBI36]
Chr22:22q12.1
likely benign
GRCh38/hg38 22q12.1-12.2(chr22:26451042-31451926)x1 copy number loss See cases [RCV000143415] Chr22:26451042..31451926 [GRCh38]
Chr22:26847008..31847912 [GRCh37]
Chr22:25177008..30177912 [NCBI36]
Chr22:22q12.1-12.2
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.1-12.3(chr22:28349854-33013062)x3 copy number gain See cases [RCV000510523] Chr22:28349854..33013062 [GRCh37]
Chr22:22q12.1-12.3
likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.23-12.3(chr22:23637907-36614412)x3 copy number gain See cases [RCV000511098] Chr22:23637907..36614412 [GRCh37]
Chr22:22q11.23-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.22-12.3(chr22:22460754-35198232)x3 copy number gain not provided [RCV000684530] Chr22:22460754..35198232 [GRCh37]
Chr22:22q11.22-12.3
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_005080.3(XBP1):c.453+7C>A single nucleotide variant not provided [RCV000920663] Chr22:28797070 [GRCh38]
Chr22:29193058 [GRCh37]
Chr22:22q12.1
likely benign
GRCh37/hg19 22q12.1(chr22:29167380-29205638)x1 copy number loss not provided [RCV000845831] Chr22:29167380..29205638 [GRCh37]
Chr22:22q12.1
uncertain significance
GRCh37/hg19 22q12.1(chr22:29167380-29205638)x1 copy number loss not provided [RCV000845865] Chr22:29167380..29205638 [GRCh37]
Chr22:22q12.1
uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_005080.3(XBP1):c.599+1G>T single nucleotide variant Major affective disorder 7 [RCV001001988] Chr22:28796046 [GRCh38]
Chr22:29192034 [GRCh37]
Chr22:22q12.1
uncertain significance
NC_000022.10:g.(?_29083875)_(30090801_?)del deletion Familial cancer of breast [RCV001033149] Chr22:29083875..30090801 [GRCh37]
Chr22:22q12.1-12.2
pathogenic
NC_000022.10:g.(?_29083885)_(29621477_?)del deletion Familial cancer of breast [RCV001033041] Chr22:29083885..29621477 [GRCh37]
Chr22:22q12.1-12.2
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.1-12.2(chr22:28291202-30450920)x1 copy number loss not provided [RCV001258778] Chr22:28291202..30450920 [GRCh37]
Chr22:22q12.1-12.2
pathogenic
NC_000022.10:g.(?_29083885)_(30337586_?)del deletion Neurofibromatosis, type 2 [RCV001390044] Chr22:29083885..30337586 [GRCh37]
Chr22:22q12.1-12.2
pathogenic
NC_000022.10:g.(?_29105984)_(30337586_?)del deletion Familial cancer of breast [RCV001390747] Chr22:29105984..30337586 [GRCh37]
Chr22:22q12.1-12.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12801 AgrOrtholog
COSMIC XBP1 COSMIC
Ensembl Genes ENSG00000100219 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000216037 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000343155 UniProtKB/Swiss-Prot
  ENSP00000384295 UniProtKB/TrEMBL
  ENSP00000385162 UniProtKB/TrEMBL
  ENSP00000481170 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000216037 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000344347 UniProtKB/Swiss-Prot
  ENST00000403532 UniProtKB/TrEMBL
  ENST00000405219 UniProtKB/TrEMBL
  ENST00000611155 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000100219 GTEx
HGNC ID HGNC:12801 ENTREZGENE
Human Proteome Map XBP1 Human Proteome Map
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 7494 ENTREZGENE
OMIM 194355 OMIM
  612371 OMIM
Pfam bZIP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37400 PharmGKB
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R1F0 ENTREZGENE, UniProtKB/TrEMBL
  B1AHH1_HUMAN UniProtKB/TrEMBL
  B1AHH2_HUMAN UniProtKB/TrEMBL
  P17861 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q8WYK6 UniProtKB/Swiss-Prot
  Q969P1 UniProtKB/Swiss-Prot
  Q96BD7 UniProtKB/Swiss-Prot