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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:styrene oxide
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Accession:CHEBI:17907 term browser browse the term
Definition:An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group.
Synonyms:exact_synonym: 2-phenyloxirane
 related_synonym: (epoxyethyl)benzene;   1,2-epoxy-1-phenylethane;   1,2-epoxyethylbenzene;   1-phenyl-1,2-epoxyethane;   1-phenyloxirane;   Formula=C8H8O;   InChI=1S/C8H8O/c1-2-4-7(5-3-1)8-6-9-8/h1-5,8H,6H2;   InChIKey=AWMVMTVKBNGEAK-UHFFFAOYSA-N;   SMILES=C1OC1c1ccccc1;   alpha,beta-epoxystyrene;   epoxyethylbenzene;   epoxystyrene;   phenethylene oxide;   phenyl oxirane;   phenylethylene oxide;   phenyloxirane;   styrene 7,8-oxide;   styrene epoxide;   styryl oxide
 alt_id: CHEBI:15124;   CHEBI:26798;   CHEBI:9298
 xref: Beilstein:108582;   CAS:96-09-3;   Gmelin:50213;   KEGG:C02083
 xref_mesh: MESH:C013690
 xref: MetaCyc:2-Phenyloxirane;   PMID:11551533;   PMID:19245253;   PMID:24320693;   Reaxys:108582;   UM-BBD_compID:c0037;   Wikipedia:Styrene_oxide


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styrene oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions
affects binding		 ISO styrene oxide promotes the reaction [styrene oxide binds to ALB protein]; Styrene promotes the reaction [styrene oxide binds to ALB protein] CTD PMID:10511253 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects expression
increases expression		 ISO
EXP		 styrene oxide affects the expression of BAX mRNA
styrene oxide results in increased expression of BAX protein		 CTD PMID:11230554 PMID:12663515 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression
decreases expression		 ISO
EXP		 styrene oxide affects the expression of BCL2 mRNA
styrene oxide results in decreased expression of BCL2 protein		 CTD PMID:11230554 PMID:12663515 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO styrene oxide results in increased expression of BCL2L1 protein CTD PMID:16705669 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases activity ISO
EXP		 styrene oxide results in increased activity of CASP3 protein CTD PMID:11929631 PMID:12663515 PMID:17662326 PMID:19666080 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO styrene oxide affects the expression of CDKN1A mRNA CTD PMID:11230554 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO styrene oxide results in increased expression of CHEK1 protein CTD PMID:20025956 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide] CTD PMID:12051674 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases chemical synthesis ISO CYP2E1 results in increased chemical synthesis of styrene oxide; CYP2E1 results in increased chemical synthesis of styrene oxide analog CTD PMID:22366341 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases chemical synthesis ISO CYP2F2 protein results in increased chemical synthesis of styrene oxide CTD PMID:22386858 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions
affects hydrolysis		 EXP
ISO		 CYP1A1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2B1 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP2C11 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]; CYP3A12 protein promotes the reaction [EPHX1 protein affects the hydrolysis of styrene oxide]
EPHX1 protein affects the metabolism of and results in decreased activity of styrene oxide		 CTD PMID:11076696 PMID:12051674 PMID:12694745 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO styrene oxide results in increased expression of FOSL1 protein CTD PMID:20025956 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases response to substance
multiple interactions
affects metabolic processing		 ISO
EXP		 GSTM1 protein results in decreased susceptibility to styrene oxide
GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
GSTM1 protein affects the metabolism of styrene oxide		 CTD PMID:1638515 PMID:2604743 PMID:11424177 PMID:11599931 PMID:14698568 More... NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 affects metabolic processing
multiple interactions		 EXP GSTM2 protein affects the metabolism of styrene oxide
GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]		 CTD PMID:1638515 PMID:2604743 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 exon polymorphism affects the susceptibility to styrene oxide CTD PMID:12694745 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases response to substance
affects response to substance		 ISO GSTT1 gene polymorphism results in increased susceptibility to styrene oxide
GSTT1 protein affects the susceptibility to styrene oxide		 CTD PMID:12016165 PMID:15468052 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Hbb hemoglobin subunit beta affects binding ISO styrene oxide binds to HBB protein CTD PMID:11948819 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hells helicase, lymphoid specific increases expression ISO styrene oxide results in increased expression of HELLS protein CTD PMID:20025956 NCBI chr 1:236,701,704...236,748,239
Ensembl chr 1:236,701,758...236,746,844 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
increases activity		 ISO styrene oxide results in increased expression of HMOX1 protein
styrene oxide results in increased activity of HMOX1 protein		 CTD PMID:15582351 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 increases expression ISO styrene oxide results in increased expression of IL1RL1 protein CTD PMID:20025956 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256 		JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression ISO styrene oxide results in increased expression of MCM3 protein CTD PMID:20025956 NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO styrene oxide results in increased expression of MYC protein CTD PMID:16705669 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Orm1 orosomucoid 1 increases expression ISO styrene oxide results in increased expression of ORM1 protein CTD PMID:20025956 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO styrene oxide results in increased cleavage of PARP1 protein CTD PMID:11929631 PMID:17662326 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Phex phosphate regulating endopeptidase X-linked increases expression ISO styrene oxide results in increased expression of PHEX protein CTD PMID:20025956 NCBI chr  X:37,607,553...37,856,183
Ensembl chr  X:37,610,760...37,854,469 		JBrowse link
G Por cytochrome p450 oxidoreductase increases chemical synthesis ISO POR protein results in increased chemical synthesis of styrene oxide CTD PMID:22386858 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO styrene oxide results in decreased expression of RAC1 protein CTD PMID:17662326 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression ISO styrene oxide results in decreased expression of SCGB1A1 mRNA; styrene oxide results in decreased expression of SCGB1A1 protein CTD PMID:19428955 NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610 		JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 increases cleavage ISO styrene oxide results in increased cleavage of SPTAN1 protein CTD PMID:11929631 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046 		JBrowse link
G Syp synaptophysin decreases expression ISO styrene oxide results in decreased expression of SYP protein CTD PMID:17662326 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression ISO styrene oxide affects the expression of TGFB2 mRNA; styrene oxide affects the expression of TGFB2 protein CTD PMID:16705669 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 affects expression ISO styrene oxide affects the expression of TGFBR3 mRNA; styrene oxide affects the expression of TGFBR3 protein CTD PMID:16705669 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression ISO styrene oxide results in increased expression of TNFRSF9 mRNA CTD PMID:22723965 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000 		JBrowse link
G Tp53 tumor protein p53 affects expression ISO styrene oxide affects the expression of TP53 mRNA CTD PMID:11230554 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 affects response to substance ISO XRCC1 protein polymorphism affects the susceptibility to styrene oxide CTD PMID:15468052 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        aetiopathogenetic role 19194
          genotoxin 17675
            mutagen 17589
              styrene 119
                styrene oxide 37
                  (R)-styrene oxide 0
                  (S)-styrene oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 18002
                                    benzenes 17867
                                      styrenes 244
                                        styrene 119
                                          styrene oxide 37
                                            (R)-styrene oxide 0
                                            (S)-styrene oxide 0
paths to the root