Ar (androgen receptor) - Rat Genome Database

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Gene: Ar (androgen receptor) Rattus norvegicus
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Symbol: Ar
Name: androgen receptor
RGD ID: 2147
Description: Enables several functions, including androgen binding activity; nuclear androgen receptor binding activity; and nuclear receptor activity. Involved in several processes, including androgen receptor signaling pathway; cellular response to follicle-stimulating hormone stimulus; and regulation of DNA-templated transcription. Located in several cellular components, including axon; dendrite; and nuclear matrix. Used to study hypertension; osteoporosis; prostate adenocarcinoma; prostate cancer; and prostatic hypertrophy. Biomarker of acute kidney failure; androgen insensitivity syndrome; and metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; disorder of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (androgen receptor); PARTICIPATES IN altered androgen signaling pathway; androgen signaling pathway; forkhead class A signaling pathway; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; (R)-lipoic acid; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Andr; Androgen receptor (Testicular feminization); Androgen receptor (Testicular feminization) same as Tfm; androgen receptor (Testicular feminization), same as Tfm; dihydrotestosterone receptor; nuclear receptor subfamily 3 group C member 4; Tfm
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X67,135,317 - 67,304,476 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX67,135,317 - 67,304,467 (+)EnsemblGRCr8
mRatBN7.2X63,104,771 - 63,273,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX63,104,771 - 63,273,925 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX64,593,944 - 64,763,102 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X68,094,494 - 68,263,645 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X65,655,236 - 65,824,382 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X67,656,253 - 67,828,998 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX67,656,253 - 67,829,026 (+)Ensemblrn6Rnor6.0
Rnor_5.0X68,533,662 - 68,705,929 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X85,949,507 - 86,119,199 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX63,512,152 - 63,679,533 (+)NCBICelera
RGSC_v3.1X86,022,798 - 86,192,491 (+)NCBI
Cytogenetic MapXq22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
46,XY complete gonadal dysgenesis  (ISO)
acute kidney failure  (IEP)
alcohol dependence  (ISO)
alopecia  (ISO)
androgen insensitivity syndrome  (IEP,ISO,ISS)
Androgen Insensitivity Syndrome due to Coactivator Deficiency  (ISO)
aromatase excess syndrome  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
Breast Neoplasms  (ISO)
castration-resistant prostate carcinoma  (ISO)
complete androgen insensitivity syndrome  (ISO)
conduct disorder  (ISO)
coronary artery disease  (ISO)
cryptorchidism  (ISO)
Denys-Drash syndrome  (ISO)
disorder of sexual development  (ISO)
ductal carcinoma in situ  (ISO)
endometrial cancer  (ISO)
endometriosis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Mammary Neoplasms  (IEP)
Fabry disease  (ISO)
Familial Prostate Cancer  (ISO)
Female Infertility  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
hepatocellular carcinoma  (ISO)
hypertension  (IDA,IMP,ISO)
hypospadias  (ISO)
Hypospadias 1, X-Linked  (ISO)
Insulin Resistance  (ISO)
invasive ductal carcinoma  (ISO)
Kennedy's disease  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
leukemia  (ISO)
Lubs Syndrome  (ISO)
Lung Neoplasms  (ISO)
Male Breast Neoplasms  (ISO)
male infertility  (ISO)
male reproductive system disease  (ISO)
malignant astrocytoma  (ISO)
Mayer-Rokitansky-Kuster-Hauser syndrome  (ISO)
metabolic dysfunction and alcohol associated liver disease  (IEP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
multicentric Castleman disease  (ISO)
Neoplasm Recurrence, Local  (ISO)
obesity  (ISO,ISS)
oppositional defiant disorder  (ISO)
osteoporosis  (IDA,ISO)
Osteoporotic Fractures  (ISO)
ovarian cancer  (ISO)
partial androgen insensitivity syndrome  (ISO)
polycystic ovary syndrome  (ISO)
Postmenopausal Osteoporosis  (ISO)
prostate adenocarcinoma  (IDA)
prostate cancer  (IDA,ISO)
Prostate Cancer, Hereditary, X-Linked 3  (ISO)
Prostate Cancer, Somatic  (ISO)
prostate carcinoma in situ  (ISO)
prostatic hypertrophy  (IMP)
Prostatic Neoplasms  (ISO)
Sarcopenia  (IDA,ISO)
spermatogenic failure 3  (ISO)
spermatogenic failure 57  (ISO)
spinal muscular atrophy  (ISO)
type 2 diabetes mellitus  (ISS)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-Arctigenin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1E,4E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (EXP)
(20R)-17,20-dihydroxypregn-4-en-3-one  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(Dimethoxymethyl)benzene  (ISO)
(E)-thiamethoxam  (ISO)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP)
(S)-duloxetine hydrochloride  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,4-dithiothreitol  (EXP)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-Aminopyrene  (ISO)
1-Hydroxypyrene  (ISO)
1-methylphenanthrene  (EXP)
1-naphthaldehyde  (EXP)
1-naphthol  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
10H-phenothiazine  (ISO)
11-deoxycorticosterone  (ISO)
11-deoxycortisol  (ISO)
11beta,21-Dihydroxypregn-4-ene-3,20-dione 21-acetate  (ISO)
15-acetyldeoxynivalenol  (ISO)
16-alpha,17-Epoxypregn-4-ene-3,20-dione  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,4'-tetrachlorobiphenyl  (EXP,ISO)
2,2',4,5'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Bisphenol F  (ISO)
2,2':5',2''-terthiophene  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3',5-trichlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,3',4,4',5-Hexachlorobiphenyl  (ISO)
2,3,4,3',4'-Pentachlorobiphenyl  (ISO)
2,3,4,4'-tetrachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (EXP)
2,3,4,7,8-Pentachlorodibenzofuran  (ISO)
2,3,5,6-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4'-dichlorobiphenyl  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,5-trichlorophenol  (ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (EXP,ISO)
2,5-di-tert-butylbenzene-1,4-diol  (ISO)
2,6-Di-tert-butyl-4-hydroxymethylphenol  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dichlorobiphenyl  (ISO)
2-aminobiphenyl  (ISO)
2-benzyl-4-chlorophenol  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-chlorobiphenyl  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxypropanoic acid  (ISO)
2-naphthol  (EXP)
2-sec-butylphenol  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethoxybenzidine  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,5,6-trichloro-2-pyridinol  (EXP,ISO)
3,5,6-trichloropyridine-2-one  (EXP,ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3,5-dichlorobiphenyl  (ISO)
3,6-diaminoacridine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-Benzylidene camphor  (ISO)
3-chlorophenol  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-iodoprop-2-yn-1-yl butylcarbamate  (ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4'-epidoxorubicin  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-Dichlorobenzophenone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,4'-thiodiphenol  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (ISO)
4-Acetyl-6-tert-butyl-1,1-dimethylindane  (ISO)
4-chloro-2-methylphenol  (EXP)
4-chloro-3,5-dimethylphenol  (ISO)
4-chloro-m-cresol  (ISO)
4-hexylbenzene-1,3-diol  (ISO)
4-hydroxy-17beta-estradiol  (EXP)
4-Hydroxybenzophenone  (EXP,ISO)
4-hydroxychalcone  (EXP)
4-Hydroxytestosterone  (ISO)
4-isopropylphenol  (ISO)
4-nitrophenol  (EXP)
4-nonylphenol  (ISO)
4-octylphenol  (EXP,ISO)
4-tert-butylphenol  (EXP,ISO)
4-tert-Octylphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5alpha-Androstan-17beta-ol  (EXP)
6-propyl-2-thiouracil  (EXP,ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (ISO)
9-phenanthrol  (EXP,ISO)
abiraterone  (ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetochlor  (ISO)
acetophenazine  (ISO)
acridines  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
alachlor  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldrin  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
Allylestrenol  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (ISO)
alsterpaullone  (ISO)
alternariol  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amsacrine  (ISO)
androst-4-ene-3,17-dione  (EXP,ISO)
androst-5-ene-3beta,17beta-diol  (EXP)
androstane-3,17-dione  (ISO)
androsterone  (EXP)
anilines  (ISO)
Anilofos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
anthracen-2-amine  (ISO)
anthracene  (ISO)
anthracenes  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
arecoline  (EXP)
Aroclor 1254  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atrazine  (EXP,ISO)
Aurin  (EXP)
avobenzone  (ISO)
Azelnidipine  (ISO)
azinphos-methyl  (ISO)
azithromycin  (ISO)
Azoxymethane  (ISO)
beauvericin  (ISO)
benidipine  (ISO)
benomyl  (ISO)
Benz[a]acridine  (ISO)
Benz[c]acridine  (ISO)
benzaldehyde  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[j]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzophenone  (EXP)
benzophenones  (ISO)
benzotriazole  (ISO)
Benzyl parahydroxybenzoate  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-Zearalanol  (EXP,ISO)
betamethasone  (ISO)
bexarotene  (EXP,ISO)
bicalutamide  (EXP,ISO)
biphenyl-2,2'-diol  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4,4'-diol  (ISO)
biphenyl-4-ol  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol A dimethacrylate  (ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
bisphenol F diglycidyl ether  (ISO)
Bisphenol Z  (EXP,ISO)
bitertanol  (ISO)
bornane-2,3-dione  (ISO)
bortezomib  (ISO)
Bromadiolone  (ISO)
Bromophos-ethyl  (ISO)
bromuconazole  (ISO)
bucladesine  (EXP)
budesonide  (ISO)
busulfan  (ISO)
butachlor  (ISO)
butamben  (EXP)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
calciol  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbaryl  (EXP)
carbimazole  (EXP)
carfilzomib  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
chalcone  (EXP)
Chlomethoxyfen  (ISO)
chlordecone  (EXP,ISO)
Chlormadinone acetate  (ISO)
chlornitrofen  (ISO)
chlorobenzenes  (ISO)
Chlorobenzilate  (ISO)
chlorogenic acid  (ISO)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chloropropylate  (ISO)
chloroquine  (ISO)
chlorpropham  (ISO)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (ISO)
chlozolinate  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium(6+)  (EXP)
chrysene  (EXP,ISO)
Ciclesonide  (ISO)
ciclopirox  (ISO)
cimetidine  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clomiphene  (EXP,ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
corticosterone  (EXP,ISO)
cortisol  (EXP,ISO)
coumaphos  (ISO)
coumarin 460  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyanophos  (ISO)
Cyclopamine  (ISO)
cyclopentanes  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (EXP,ISO)
cypermethrin  (EXP,ISO)
cyprodinil  (ISO)
cyproterone acetate  (EXP,ISO)
D-aspartic acid  (EXP)
D-glucose  (EXP,ISO)
daidzein  (EXP,ISO)
danazol  (ISO)
dapoxetine  (EXP)
daunorubicin  (ISO)
DDD  (EXP,ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP,ISO)
Dibenz[a,j]acridine  (ISO)
Dibenz[c,h]acridine  (ISO)
Dibutyl adipate  (EXP)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
dichloromethane  (ISO)
dichlorvos  (ISO)
diclofenac  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (ISO)
digitoxin  (ISO)
diisobutyl phthalate  (EXP,ISO)
diisononyl phthalate  (EXP)
dimethomorph  (ISO)
Dimethyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dimethyl terephthalate  (EXP)
dimethylarsinic acid  (EXP)
diniconazole  (ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
Dithiopyr  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
drometrizole  (ISO)
drospirenone  (ISO)
dutasteride  (ISO)
elemental selenium  (ISO)
emetine  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (ISO)
enzacamene  (ISO)
enzalutamide  (ISO)
epitestosterone  (EXP)
EPN  (ISO)
epoxiconazole  (ISO)
equilin  (ISO)
equol  (EXP)
erastin  (ISO)
estra-1,3,5(10)-trien-3-ol  (EXP)
estriol  (EXP,ISO)
estrone  (ISO)
Ethalfluralin  (ISO)
ethanol  (EXP)
ethion  (ISO)
ethoxyquin  (ISO)
ethyl myristate  (ISO)
ethylparaben  (ISO)
ethynodiol diacetate  (ISO)
etofenprox  (ISO)
etoposide  (ISO)
etoposide phosphate  (ISO)
etoxazole  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
exemestane  (ISO)
felodipine  (ISO)
fenamiphos  (ISO)
fenarimol  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenthion  (ISO)
fentin acetate  (ISO)
fentin chloride  (ISO)
fenvalerate  (EXP,ISO)
finasteride  (EXP,ISO)
fipronil  (ISO)
fisetin  (ISO)
flavanone  (EXP)
flavone  (EXP)
flucythrinate  (ISO)
fludioxonil  (ISO)
fludrocortisone  (ISO)
flufenamic acid  (ISO)
flufenoxuron  (ISO)
Flumetralin  (ISO)
fluoranthene  (ISO)
fluoxastrobin  (ISO)
fluphenazine  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
folic acid  (ISO)
formestane  (ISO)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
Fusarenone X  (ISO)
galaxolide  (ISO)
Galiellalactone  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-linolenic acid  (ISO)
gamma-terpinene  (ISO)
gamma-tocopherol  (ISO)
ganoderol B  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gestodene  (ISO)
Gestrinone  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione disulfide  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
Goserelin  (ISO)
heptachlor  (EXP,ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexestrol  (ISO)
hydrazines  (EXP)
hydrogen peroxide  (ISO)
hydroxyflutamide  (EXP,ISO)
idarubicin  (ISO)
imidacloprid  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
inulin  (ISO)
iodoform  (ISO)
iprodione  (ISO)
irilone  (ISO)
Isobavachin  (ISO)
Isobutylparaben  (EXP)
isoeugenol  (EXP)
isofenphos  (ISO)
isoflavones  (EXP)
itraconazole  (ISO)
kaempferol  (ISO)
kenpaullone  (ISO)
ketoconazole  (EXP,ISO)
L-1,4-dithiothreitol  (EXP)
L-methionine  (ISO)
lacidipine  (ISO)
lasofoxifene  (EXP)
Laurolactam  (ISO)
lead diacetate  (ISO)
leptomycin B  (ISO)
leptophos  (ISO)
lercanidipine  (ISO)
letrozole  (ISO)
levonorgestrel  (EXP,ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linuron  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
loratadine  (ISO)
loteprednol etabonate  (ISO)
LY294002  (ISO)
lycopene  (ISO)
M1  (EXP,ISO)
malathion  (EXP,ISO)
mancozeb  (ISO)
manidipine  (ISO)
masoprocol  (EXP)
MC-4379  (ISO)
medroxyprogesterone  (EXP,ISO)
medroxyprogesterone acetate  (EXP,ISO)
mefenacet  (ISO)
megestrol acetate  (ISO)
melatonin  (EXP)
Melengestrol acetate  (ISO)
melphalan  (ISO)
meprednisone  (ISO)
mestranol  (ISO)
metconazole  (ISO)
methamphetamine  (EXP)
Methandrostenolone  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methiocarb  (EXP,ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP,ISO)
metoclopramide  (EXP)
metolachlor  (EXP,ISO)
mibolerone  (EXP,ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mirex  (ISO)
Mitotane  (EXP,ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzone  (EXP)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
morin  (EXP,ISO)
mycophenolic acid  (ISO)
N(6)-butyryl-cAMP  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N,N-dimethylethanolamine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Acetylleucyl-leucyl-methioninal  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
Nafoxidine  (EXP)
Nandrolone decanoate  (EXP)
nandrolone phenpropionate  (ISO)
naphthalene  (EXP,ISO)
naphthols  (EXP)
napropamide  (ISO)
nebivolol  (EXP,ISO)
nevirapine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nilutamide  (ISO)
nimodipine  (ISO)
nirogacestat  (ISO)
nisoldipine  (ISO)
nitrendipine  (ISO)
nitrobenzenes  (ISO)
nitrofen  (ISO)
Nivalenol  (ISO)
nocodazole  (ISO)
Nonylphenol  (EXP,ISO)
Nookatone  (ISO)
norelgestromin  (ISO)
Norethindrone enanthate  (ISO)
norethisterone  (EXP,ISO)
Norethynodrel  (EXP,ISO)
norgestimate  (ISO)
norgestrel  (ISO)
Obacunone  (ISO)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oryzalin  (ISO)
Osajin  (ISO)
oseltamivir  (ISO)
ospemifene  (ISO)
Oxabolone cipionate  (ISO)
oxandrolone  (ISO)
oxybenzone  (EXP,ISO)
Oxyfluorfen  (EXP,ISO)
oxymetholone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP,ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (EXP,ISO)
parathion-methyl  (EXP,ISO)
paroxetine  (ISO)
pazopanib  (ISO)
PCB138  (EXP,ISO)
pencycuron  (ISO)
pendimethalin  (EXP,ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
perfluorobutyric acid  (ISO)
perfluorododecanoic acid  (EXP)
perfluorohexanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
periciazine  (ISO)
permethrin  (ISO)
phenanthrene  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenols  (EXP)
phenytoin  (EXP,ISO)
phosalone  (ISO)
phoxim  (ISO)
phthalic acid  (ISO)
phytoestrogen  (EXP,ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
Piperophos  (EXP,ISO)
pirarubicin  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (ISO)
Pomiferin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (EXP)
potassium iodide  (EXP)
prallethrin  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP,ISO)
procymidone  (EXP,ISO)
progesterone  (EXP,ISO)
promegestone  (EXP)
propanil  (EXP,ISO)
propargite  (ISO)
propiconazole  (ISO)
propylparaben  (EXP,ISO)
propyzamide  (ISO)
prothioconazole  (ISO)
prothiofos  (ISO)
Prulifloxacin  (ISO)
puerarin  (ISO)
pyrene  (ISO)
pyrethrins  (EXP)
pyridaben  (ISO)
Pyridate  (ISO)
pyrimethanil  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetagetin  (EXP)
quercetin  (EXP,ISO)
quercitrin  (ISO)
quinalphos  (ISO)
quinoxyfen  (ISO)
rac-lactic acid  (ISO)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
raspberry ketone  (ISO)
reactive oxygen species  (ISO)
reserpine  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rifapentine  (ISO)
Riluzole  (ISO)
Rosavin  (ISO)
royal jelly  (EXP)
rubitecan  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
Se-methyl-L-selenocysteine  (EXP,ISO)
Se-methylselenocysteine  (EXP,ISO)
selenium atom  (ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium benzoate  (EXP)
spironolactone  (EXP,ISO)
Stanolone benzoate  (EXP)
stanozolol  (ISO)
staurosporine  (ISO)
stilben-4-ol  (EXP)
stilbene-4,4'-diol  (EXP)
sucrose  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (EXP,ISO)
sunitinib  (ISO)
superoxide  (ISO)
Swertiamarin  (EXP)
T-2 toxin  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tea tree oil  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
Temsirolimus  (ISO)
teniposide  (ISO)
terbutylazine  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP,ISO)
Testosterone propionate  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetrachlorohydroquinone  (ISO)
tetrachlorvinphos  (ISO)
tetracycline  (ISO)
tetrahydropalmatine  (EXP)
tetralin  (ISO)
tetramethrin  (ISO)
tetraphene  (EXP,ISO)
thapsigargin  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
Thiobencarb  (ISO)
thymoquinone  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
tolclofos-methyl  (ISO)
topotecan  (ISO)
toremifene  (ISO)
toxaphene  (ISO)
trans-chalcone  (EXP)
trans-isoeugenol  (EXP)
trans-stilbene-4,4'-diol  (EXP)
trenbolone  (EXP,ISO)
Tri-2-ethylhexyl trimellitate  (ISO)
triadimefon  (ISO)
triamcinolone  (ISO)
tributyl phosphate  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclocarban  (ISO)
triclosan  (EXP,ISO)
trifloxystrobin  (ISO)
triflumizole  (ISO)
trifluralin  (ISO)
triphenyl phosphate  (EXP,ISO)
Triphenylethylene  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
tris(4-chlorophenyl)methanol  (EXP,ISO)
triticonazole  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (ISO)
undecan-2-one  (ISO)
uranium atom  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP,ISO)
vorinostat  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP)
zingerone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
androgen receptor signaling pathway  (IBA,IMP,ISO)
animal organ formation  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to steroid hormone stimulus  (IEP,ISO)
cellular response to testosterone stimulus  (ISO)
copulation  (IMP)
DNA-templated transcription  (IEA)
drinking behavior  (IMP)
epithelial cell differentiation involved in prostate gland development  (ISO)
epithelial cell morphogenesis  (ISO)
estrogen receptor signaling pathway  (ISO)
fertilization  (ISO)
gene expression  (ISO)
in utero embryonic development  (ISO)
intracellular receptor signaling pathway  (ISO,ISS)
lateral sprouting involved in mammary gland duct morphogenesis  (ISO)
Leydig cell differentiation  (ISO)
liver regeneration  (IEP)
locomotion  (IMP)
male courtship behavior  (IMP)
male genitalia morphogenesis  (ISO)
male gonad development  (IBA,ISO)
male sex differentiation  (IEA,IMP)
male somatic sex determination  (ISO)
mammary gland alveolus development  (ISO)
membraneless organelle assembly  (ISO)
morphogenesis of an epithelial fold  (ISO)
multicellular organism growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO,ISS)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of epithelial cell proliferation involved in prostate gland development  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hippocampal neuron apoptotic process  (IMP)
positive regulation of insulin-like growth factor receptor signaling pathway  (ISO)
positive regulation of integrin biosynthetic process  (ISO)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of locomotion  (IMP)
positive regulation of MAPK cascade  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of penile erection  (IMP)
positive regulation of reproductive process  (IEA)
positive regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
positive regulation of transcription by RNA polymerase III  (ISO)
prostate gland epithelium morphogenesis  (ISO)
prostate gland growth  (IEA,IEP,ISO)
prostate induction  (ISO)
regulation of developmental growth  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (ISO)
regulation of prostatic bud formation  (ISO)
regulation of protein localization to plasma membrane  (ISO,ISS)
regulation of systemic arterial blood pressure  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
reproductive behavior  (IDA)
reproductive structure development  (ISO)
reproductive system development  (ISO)
response to environmental enrichment  (IMP)
response to estradiol  (IEP)
response to ethanol  (IDA)
response to insulin  (IEP)
response to muscle activity  (IEP)
response to nicotine  (IEP)
response to steroid hormone  (IEP)
response to testosterone  (IEA,IEP)
seminiferous tubule development  (ISO)
single fertilization  (ISO)
skeletal muscle hypertrophy  (IMP)
spermatogenesis  (IBA,IEA,IMP,ISO)
tertiary branching involved in mammary gland duct morphogenesis  (ISO)

Cellular Component
axon  (IDA)
chromatin  (IBA,ISO,ISS)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IDA,ISO)
dendrite  (IDA)
nuclear matrix  (IDA)
nuclear speck  (ISO)
nucleus  (IBA,IDA,IEA,ISO,ISS)
plasma membrane  (ISO)
protein-containing complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
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2. A novel selective androgen receptor modulator, NEP28, is efficacious in muscle and brain without serious side effects on prostate. Akita K, etal., Eur J Pharmacol. 2013 Nov 15;720(1-3):107-14. doi: 10.1016/j.ejphar.2013.10.042. Epub 2013 Oct 29.
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8. Linkage between cryptorchidism, hypospadias, and GGN repeat length in the androgen receptor gene. Aschim EL, etal., J Clin Endocrinol Metab. 2004 Oct;89(10):5105-9.
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10. Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene. Baltatu O, etal., J Am Soc Nephrol. 2002 Nov;13(11):2681-7.
11. Developmental profiles of TSH, sex steroids, and their receptors in the thyroid and their relevance to thyroid growth in immature rats. Banu SK, etal., Steroids 2002 Feb;67(2):137-44.
12. The mutational landscape of prostate cancer. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
13. Immunohistochemistry Study on Androgen and Estrogen Receptors of Rat Seminal Vesicle Submitted to Simultaneous Alcohol-Nicotine Treatment. Basiri M, etal., Cell J. 2016 Fall;18(3):458-63. doi: 10.22074/cellj.2016.4574. Epub 2016 Aug 24.
14. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
15. Blockade of androgen receptor in the medial amygdala inhibits noncontact erections in male rats. Bialy M, etal., Physiol Behav. 2011 Jun 1;103(3-4):295-301. doi: 10.1016/j.physbeh.2011.02.003. Epub 2011 Feb 20.
16. Follicle-stimulating hormone regulates androgen receptor mRNA in Sertoli cells. Blok LJ, etal., Mol Cell Endocrinol. 1989 May;63(1-2):267-71.
17. Androgen modulation of Foxp1 and Foxp2 in the developing rat brain: impact on sex specific vocalization. Bowers JM, etal., Endocrinology. 2014 Dec;155(12):4881-94. doi: 10.1210/en.2014-1486. Epub 2014 Sep 23.
18. Deletion of the steroid-binding domain of the human androgen receptor gene in one family with complete androgen insensitivity syndrome: evidence for further genetic heterogeneity in this syndrome. Brown TR, etal., Proc Natl Acad Sci U S A. 1988 Nov;85(21):8151-5.
19. Steroid receptor proteins and regulation of growth in mammary tumors. Bruchovsky N and Van Doorn E, Recent Results Cancer Res 1976;(57):121-42.
20. Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors. Chang CS, etal., Proc Natl Acad Sci U S A 1988 Oct;85(19):7211-5.
21. Androgen receptor (AR) gene microsatellite polymorphism in postmenopausal women: correlation to bone mineral density and susceptibility to osteoporosis. Chen HY, etal., Eur J Obstet Gynecol Reprod Biol. 2003 Mar 26;107(1):52-6.
22. A selective androgen receptor modulator for hormonal male contraception. Chen J, etal., J Pharmacol Exp Ther. 2005 Feb;312(2):546-53. Epub 2004 Sep 3.
23. Effect of ethanol on androgen receptors in the anterior pituitary, hypothalamus and brain cortex in rats. Chung KW, Life Sci. 1989;44(4):273-80. doi: 10.1016/0024-3205(89)90185-9.
24. Androgen receptor binding to nuclear matrix in vitro and its inhibition by 8S androgen receptor promoting factor. Colvard DS and Wilson EM, Biochemistry. 1984 Jul 17;23(15):3479-86. doi: 10.1021/bi00310a015.
25. Association of the androgen receptor gene (AR) with ADHD and conduct disorder. Comings DE, etal., Neuroreport. 1999 May 14;10(7):1589-92.
26. Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women. Corbould A J Endocrinol. 2007 Mar;192(3):585-94.
27. Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases. Cortes CJ and La Spada AR, Rare Dis. 2014 Oct 30;2(1):e962402. doi: 10.4161/2167549X.2014.962402. eCollection 2014.
28. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial. Dalton JT, etal., J Cachexia Sarcopenia Muscle. 2011 Sep;2(3):153-161. Epub 2011 Aug 2.
29. Androgen receptor immunoreactivity in forebrain axons and dendrites in the rat. DonCarlos LL, etal., Endocrinology. 2003 Aug;144(8):3632-8.
30. Effects of the testicular feminization mutation (tfm) of the androgen receptor gene on BSTMPM volume and morphology in rats. Durazzo A, etal., Neurosci Lett. 2007 May 29;419(2):168-71. Epub 2007 Apr 21.
31. Downregulation of nuclear sex steroid receptor activity correlates with severity of alcoholic liver injury. Eagon PK, etal., Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G342-9. doi: 10.1152/ajpgi.2001.281.2.G342.
32. Androgen-responsive functions of male rat liver. Effect of chronic alcohol ingestion. Eagon PK, etal., Gastroenterology. 1987 Dec;93(6):1162-9. doi: 10.1016/0016-5085(87)90240-x.
33. An examination of how different mutations at arginine 855 of the androgen receptor result in different androgen insensitivity phenotypes. Elhaji YA, etal., Mol Endocrinol. 2004 Aug;18(8):1876-86. Epub 2004 Apr 29.
34. Androgen receptor gene CAG and GGC repeat lengths in cryptorchidism. Ferlin A, etal., Eur J Endocrinol. 2005 Mar;152(3):419-25.
35. Distribution of androgen receptor immunoreactivity in the spinal cord of wild-type, androgen-insensitive and gonadectomized male rats. Freeman LM, etal., J Neurobiol. 1995 May;27(1):51-9.
36. Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis. Fytili P, etal., Clin Genet. 2005 Sep;68(3):268-77.
37. Antihypertensive effects of flutamide in rats that are exposed to a low-protein diet in utero. Gangula PR, etal., Am J Obstet Gynecol. 2005 Mar;192(3):952-60.
38. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
39. Absence of a correlation of androgen receptor gene CAG repeat length and prostate cancer risk in an African-American population. Gilligan T, etal., Clin Prostate Cancer. 2004 Sep;3(2):98-103.
40. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
41. Expression of androgen receptor and two androgen-induced proteins (apolipoprotein D and pepsinogen C) in ductal carcinoma in situ of the breast. Gonzalez LO, etal., Histopathology. 2007 Jun;50(7):866-74.
42. Androgen receptor gene repeats and indices of obesity in older adults. Gustafson DR, etal., Int J Obes Relat Metab Disord. 2003 Jan;27(1):75-81.
43. Androgen insensitive male rats display increased anxiety-like behavior on the elevated plus maze. Hamson DK, etal., Behav Brain Res. 2014 Feb 1;259:158-63. doi: 10.1016/j.bbr.2013.11.021. Epub 2013 Nov 20.
44. Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis. Hanada K, etal., Biol Pharm Bull. 2003 Nov;26(11):1563-9.
45. Androgen receptor blockade in the MPOA or VMN: effects on male sociosexual behaviors. Harding SM and McGinnis MY, Physiol Behav. 2004 Jun;81(4):671-80.
46. Single strand conformation polymorphism analysis of androgen receptor gene mutations in patients with androgen insensitivity syndromes: application for diagnosis, genetic counseling, and therapy. Hiort O, etal., J Clin Endocrinol Metab. 1993 Jul;77(1):262-6.
47. Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor DAX-1. Holter E, etal., Mol Endocrinol. 2002 Mar;16(3):515-28.
48. The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator. Hsiao PW, etal., J Biol Chem. 1999 Jul 16;274(29):20229-34.
49. Androgen receptor trinucleotide polymorphism in leiomyoma. Hsieh YY, etal., J Assist Reprod Genet. 2004 Dec;21(12):453-7.
50. Prenatal androgen receptor activation determines adult alcohol and water drinking in a sex-specific way. Huber SE, etal., Addict Biol. 2018 May;23(3):904-920. doi: 10.1111/adb.12540. Epub 2017 Aug 4.
51. Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle. Inoue K, etal., Eur J Appl Physiol Occup Physiol. 1994;69(1):88-91.
52. Gene Data File Integration of LocusLink data, October 12, 2001
53. Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome. Jaaskelainen J, etal., Fertil Steril. 2005 Jun;83(6):1724-8.
54. Point mutation in the steroid-binding domain of the androgen receptor gene in a family with complete androgen insensitivity syndrome (CAIS). Jakubiczka S, etal., Hum Genet. 1992 Nov;90(3):311-2.
55. Androgen signaling and its interactions with other signaling pathways in prostate cancer. Kaarbo M, etal., Bioessays. 2007 Dec;29(12):1227-38.
56. A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene: expression in prostate cancer cells and enhancement of androgen receptor activity. Kawashima H, etal., Biochem J 2003 Jan 1;369(Pt 1):163-71.
57. A selective androgen receptor modulator enhances male-directed sexual preference, proceptive behavior, and lordosis behavior in sexually experienced, but not sexually naive, female rats. Kudwa AE, etal., Endocrinology. 2010 Jun;151(6):2659-68. doi: 10.1210/en.2009-1289. Epub 2010 Apr 14.
58. BRCA2 mutations and androgen receptor expression as independent predictors of outcome of male breast cancer patients. Kwiatkowska E, etal., Clin Cancer Res. 2003 Oct 1;9(12):4452-9.
59. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. La Spada AR, etal., Nature 1991 Jul 4;352(6330):77-9.
60. A CAG repeat polymorphism in the androgen receptor gene is associated with reduced bone mass and increased risk of osteoporotic fractures. Langdahl BL, etal., Calcif Tissue Int. 2003 Sep;73(3):237-43.
61. Androgen receptor gene cytosine, adenine, and guanine trinucleotide repeats in patients with endometriosis. Lattuada D, etal., J Soc Gynecol Investig. 2004 May;11(4):237-40.
62. Polymorphism of the long polyglutamine tract in the human androgen receptor influences craving of men in alcohol withdrawal. Lenz B, etal., Psychoneuroendocrinology. 2009 Aug;34(7):968-71. doi: 10.1016/j.psyneuen.2009.01.009. Epub 2009 Feb 23.
63. Androgen receptor: a new player associated with apoptosis and proliferation of pancreatic beta-cell in type 1 diabetes mellitus. Li RJ, etal., Apoptosis. 2008 Aug;13(8):959-71.
64. [Study on the expression of androgen receptor in testis, epididymis and prostate of adult rats with diabetes] Liu SH and Wang ZS, Zhonghua Nan Ke Xue. 2005 Dec;11(12):891-4.
65. Dihydrotestosterone and estrogen regulation of rat brain androgen-receptor immunoreactivity. Lynch CS and Story AJ, Physiol Behav. 2000 Jun 1-15;69(4-5):445-53.
66. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
67. Cloning and functional characterization of a rat Daxx that functions as a corepressor for the androgen receptor. Mizuta H and Kuroda Y, Cell Biol Int 2004;28(8-9):609-14.
68. Ontogeny of the androgen receptor in rat ventral prostate during sexual development. Moeller H, etal., Res Exp Med (Berl). 1987;187(4):287-94.
69. The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome. Mohlig M, etal., Eur J Endocrinol. 2006 Jul;155(1):127-30.
70. Identification of a novel RING finger protein as a coregulator in steroid receptor-mediated gene transcription. Moilanen AM, etal., Mol Cell Biol 1998 Sep;18(9):5128-39.
71. DNA and ribonucleotide binding characteristics of two forms of the androgen receptor from rat prostates. Mulder E, etal., Biochem Biophys Res Commun. 1983 Aug 12;114(3):1147-53.
72. CAGn repeat of the androgen receptor is linked to proopiomelanocortin promoter methylation-relevance for craving of male alcohol-dependent patients? Muschler MA, etal., Psychopharmacology (Berl). 2014 May;231(10):2059-66. doi: 10.1007/s00213-013-3349-5. Epub 2013 Nov 24.
73. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
74. Anti-androgenic effects of S-40542, a novel non-steroidal selective androgen receptor modulator (SARM) for the treatment of benign prostatic hyperplasia. Nejishima H, etal., Prostate. 2012 Oct 1;72(14):1580-7. doi: 10.1002/pros.22511. Epub 2012 Mar 16.
75. Androgens predispose males to GABAA-mediated excitotoxicity in the developing hippocampus. Nuñez JL and McCarthy MM, Exp Neurol. 2008 Apr;210(2):699-708. doi: 10.1016/j.expneurol.2008.01.001. Epub 2008 Jan 19.
76. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
77. The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay. Ozers MS, etal., Biochemistry. 2007 Jan 23;46(3):683-95.
78. Gonadal effects of a mouse Denys-Drash syndrome mutation. Patek CE, etal., Transgenic Res. 2005 Oct;14(5):691-702.
79. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
80. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
81. A single low dose of cadmium exposure induces benign prostate hyperplasia like condition in rat: A novel benign prostate hyperplasia rodent model. Prajapati A, etal., Exp Biol Med (Maywood). 2014 May 28;239(7):829-841.
82. Molecular chaperones throughout the life cycle of the androgen receptor. Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
83. GOA pipeline RGD automated data pipeline
84. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
85. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
86. A practical approach to the detection of androgen receptor gene mutations and pedigree analysis in families with x-linked androgen insensitivity. Ris-Stalpers C, etal., Pediatr Res. 1994 Aug;36(2):227-34.
87. Immunohistochemical study of androgen receptors in breast carcinoma. Evidence of their frequent expression in lobular carcinoma. Riva C, etal., Virchows Arch. 2005 Oct;447(4):695-700. Epub 2005 Oct 19.
88. Higher tumor to benign ratio of the androgen receptor mRNA expression associates with prostate cancer progression after radical prostatectomy. Rosner IL, etal., Urology. 2007 Dec;70(6):1225-9.
89. GGC and StuI polymorphism on the androgen receptor gene in endometrial cancer patients. Sasaki M, etal., Biochem Biophys Res Commun. 2005 Apr 1;329(1):100-4.
90. Point mutations detected in the androgen receptor gene of three men with partial androgen insensitivity syndrome. Saunders PT, etal., Clin Endocrinol (Oxf). 1992 Sep;37(3):214-20.
91. Suppression of prostate cancer growth by resveratrol in the transgenic rat for adenocarcinoma of prostate (TRAP) model. Seeni A, etal., Asian Pac J Cancer Prev. 2008 Jan-Mar;9(1):7-14.
92. A novel Arg615Ser mutation of androgen receptor DNA-binding domain in three 46,XY sisters with complete androgen insensitivity syndrome and bilateral inguinal hernia. Sharma V, etal., Fertil Steril. 2011 Feb;95(2):804.e19-21. doi: 10.1016/j.fertnstert.2010.08.015.
93. Blocking hyperactive androgen receptor signaling ameliorates cardiac and renal hypertrophy in Fabry mice. Shen JS, etal., Hum Mol Genet. 2015 Jun 1;24(11):3181-91. doi: 10.1093/hmg/ddv070. Epub 2015 Feb 20.
94. Androgen, estrogen, and progesterone receptor gene regulation during diabetic erectile dysfunction and insulin treatment. Shirai M, etal., Urology. 2004 Dec;64(6):1244-9.
95. Androgen receptor mRNA measured by quantitative real time PCR is decreased in the urethral mucosa of patients with middle idiopathic hypospadias. Silva TS, etal., Horm Metab Res. 2013 Jul;45(7):495-500. doi: 10.1055/s-0033-1333717. Epub 2013 Feb 5.
96. Androgen receptor CAG repeat polymorphism is associated with serum testosterone levels, obesity and serum leptin in men with type 2 diabetes. Stanworth RD, etal., Eur J Endocrinol. 2008 Dec;159(6):739-46. Epub 2008 Sep 19.
97. Effect of antiandrogen flutamide on measures of hepatic regeneration in rats. Svanas GW, etal., Dig Dis Sci. 1989 Dec;34(12):1916-23. doi: 10.1007/BF01536712.
98. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
99. Gene-based anchoring of the rat genetic linkage and cytogenetic maps. Szpirer C, etal., Transplant Proc 1999 May;31(3):1541-3
100. DNA methylation in the androgen receptor gene promoter region in rat prostate cancers. Takahashi S, etal., Prostate 2002 Jun 1;52(1):82-8.
101. Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila. Takeyama K, etal., Neuron. 2002 Aug 29;35(5):855-64.
102. The rat androgen receptor: primary structure, autoregulation of its messenger ribonucleic acid, and immunocytochemical localization of the receptor protein. Tan JA, etal., Mol Endocrinol 1988 Dec;2(12):1276-85.
103. TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains. Tavassoli P, etal., Mol Endocrinol. 2010 Apr;24(4):696-708. doi: 10.1210/me.2009-0229. Epub 2010 Feb 24.
104. Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis. Taylor AH, etal., Br J Dermatol. 2008 Feb;158(2):319-28. Epub 2007 Dec 11.
105. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
106. Suppression of steroid receptor-chromatin interaction by inhibitors present in ammonium sulfate-fractionated rat testicular androgen receptor preparations. Tsai YH J Androl. 1987 Sep-Oct;8(5):299-306.
107. Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats. Vajda EG, etal., J Bone Miner Res. 2009 Feb;24(2):231-40. doi: 10.1359/jbmr.081007.
108. Chronic alcohol intake, resistance training, and muscle androgen receptor content. Vingren JL, etal., Med Sci Sports Exerc. 2005 Nov;37(11):1842-8. doi: 10.1249/01.mss.0000176679.80555.cd.
109. Amelioration of Hepatic Steatosis by the Androgen Receptor Inhibitor EPI-001 in Mice and Human Hepatic Cells Is Associated with the Inhibition of CYP2E1. Wang S, etal., Int J Mol Sci. 2022 Dec 16;23(24):16063. doi: 10.3390/ijms232416063.
110. Androgen-dependent mammary carcinogenesis in rats transgenic for the Neu proto-oncogene. Watson PA, etal., Cancer Cell. 2002 Jul;2(1):67-79.
111. A single base mutation in the androgen receptor gene causes androgen insensitivity in the testicular feminized rat. Yarbrough WG, etal., J Biol Chem 1990 May 25;265(15):8893-900.
112. Nuclear factor-kappaB activates transcription of the androgen receptor gene in Sertoli cells isolated from testes of adult rats. Zhang L, etal., Endocrinology 2004 Feb;145(2):781-9. Epub 2003 Oct 23.
113. Identification of nestin as a urinary biomarker for acute kidney injury. Zhang W, etal., Am J Nephrol. 2014;39(2):110-21. doi: 10.1159/000358260. Epub 2014 Feb 6.
114. Nuclear transcriptional changes in hypothalamus of Pomc enhancer knockout mice after excessive alcohol drinking. Zhou Y, etal., Genes Brain Behav. 2019 Nov;18(8):e12600. doi: 10.1111/gbb.12600. Epub 2019 Aug 8.
Additional References at PubMed
PMID:1298681   PMID:3353726   PMID:5452809   PMID:8119157   PMID:9482849   PMID:9725910   PMID:10319319   PMID:11105903   PMID:11356695   PMID:11477070   PMID:11535819   PMID:11916967  
PMID:11997177   PMID:12058073   PMID:12145204   PMID:12210844   PMID:12441185   PMID:12479044   PMID:12799378   PMID:12801993   PMID:12864730   PMID:12884268   PMID:12902338   PMID:12941620  
PMID:14521927   PMID:14557238   PMID:14567394   PMID:14576152   PMID:14576337   PMID:14671656   PMID:14676301   PMID:15062576   PMID:15067718   PMID:15131013   PMID:15199138   PMID:15312892  
PMID:15561432   PMID:15572661   PMID:15660130   PMID:15795901   PMID:15888569   PMID:15923603   PMID:15924910   PMID:16120611   PMID:16223864   PMID:16228996   PMID:16254014   PMID:16256176  
PMID:16439462   PMID:16728402   PMID:16822503   PMID:17142810   PMID:17257522   PMID:17276355   PMID:17277772   PMID:17317769   PMID:17332066   PMID:17451792   PMID:17482455   PMID:17505061  
PMID:17510388   PMID:17587566   PMID:17652515   PMID:17982270   PMID:18287941   PMID:18403489   PMID:18468998   PMID:18487222   PMID:18546532   PMID:18582470   PMID:18761815   PMID:18771723  
PMID:18827067   PMID:18853427   PMID:18945670   PMID:18992787   PMID:19015999   PMID:19051266   PMID:19143008   PMID:19224431   PMID:19244107   PMID:19282366   PMID:19282382   PMID:19345326  
PMID:19359382   PMID:19420389   PMID:19428441   PMID:19574395   PMID:19698287   PMID:19770590   PMID:19775733   PMID:19886863   PMID:20048160   PMID:20064538   PMID:20137860   PMID:20228055  
PMID:20430028   PMID:20605618   PMID:20670640   PMID:21084446   PMID:21310825   PMID:21427060   PMID:21427128   PMID:21471296   PMID:21730049   PMID:21730289   PMID:21801726   PMID:22152882  
PMID:22541803   PMID:22585832   PMID:22734680   PMID:23104419   PMID:23239638   PMID:23304817   PMID:23414238   PMID:23487765   PMID:23566155   PMID:23570504   PMID:23689136   PMID:23748361  
PMID:23749762   PMID:23782943   PMID:23786676   PMID:23836701   PMID:24055403   PMID:24070737   PMID:24347325   PMID:24642882   PMID:24681825   PMID:25091737   PMID:25215939   PMID:25607844  
PMID:25639671   PMID:25795778   PMID:26187065   PMID:26514922   PMID:27765882   PMID:28505146   PMID:28856243   PMID:28953224   PMID:29896988   PMID:30172646   PMID:30729682   PMID:30894518  
PMID:31804540   PMID:32160160   PMID:32781251   PMID:32800775   PMID:33513940   PMID:33546359   PMID:34215832   PMID:34416391   PMID:35982617   PMID:36379312   PMID:37669164   PMID:38976730  


Genomics

Comparative Map Data
Ar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X67,135,317 - 67,304,476 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX67,135,317 - 67,304,467 (+)EnsemblGRCr8
mRatBN7.2X63,104,771 - 63,273,934 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX63,104,771 - 63,273,925 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX64,593,944 - 64,763,102 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X68,094,494 - 68,263,645 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X65,655,236 - 65,824,382 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X67,656,253 - 67,828,998 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX67,656,253 - 67,829,026 (+)Ensemblrn6Rnor6.0
Rnor_5.0X68,533,662 - 68,705,929 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X85,949,507 - 86,119,199 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX63,512,152 - 63,679,533 (+)NCBICelera
RGSC_v3.1X86,022,798 - 86,192,491 (+)NCBI
Cytogenetic MapXq22NCBI
AR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X67,544,021 - 67,730,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX67,543,353 - 67,730,619 (+)Ensemblhg38GRCh38
GRCh37X66,763,863 - 66,950,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X66,680,599 - 66,860,844 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X66,571,703 - 66,727,140NCBI
CeleraX67,112,960 - 67,293,967 (+)NCBICelera
Cytogenetic MapXq12NCBI
HuRefX60,592,006 - 60,778,929 (+)NCBIHuRef
CHM1_1X66,656,369 - 66,842,989 (+)NCBICHM1_1
T2T-CHM13v2.0X65,973,852 - 66,160,479 (+)NCBIT2T-CHM13v2.0
Ar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X97,192,363 - 97,366,824 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX97,192,375 - 97,366,821 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X98,148,757 - 98,323,218 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX98,148,769 - 98,323,215 (+)Ensemblmm10GRCm38
MGSCv37X95,345,089 - 95,512,486 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X94,352,469 - 94,519,866 (+)NCBIMGSCv36mm8
CeleraX85,096,584 - 85,263,216 (+)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX42.82NCBI
Ar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554757,013,960 - 7,186,069 (+)Ensembl
ChiLan1.0NW_0049554757,013,960 - 7,192,473 (+)NCBIChiLan1.0ChiLan1.0
AR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X67,131,384 - 67,317,580 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X67,134,984 - 67,321,183 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X56,722,828 - 56,909,004 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X66,790,419 - 66,975,921 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX66,791,081 - 66,969,357 (+)EnsemblpanPan2panpan1.1
AR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X51,969,785 - 52,167,450 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.12434,713,390 - 34,731,461 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX51,969,785 - 52,151,912 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX42,802,440 - 42,991,502 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X52,938,974 - 53,121,719 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX52,939,453 - 53,121,588 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X50,910,919 - 51,093,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X52,242,285 - 52,424,949 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X52,163,183 - 52,345,868 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X49,717,252 - 49,882,487 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936635485,903 - 647,932 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936635485,903 - 647,820 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX53,609,176 - 53,800,677 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X53,609,113 - 53,806,778 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X60,313,281 - 60,504,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXq11-q13NCBI
AR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X57,380,587 - 57,553,613 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX57,380,611 - 57,546,776 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660834,772,253 - 4,943,244 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248913,138,848 - 3,329,459 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248913,135,824 - 3,330,487 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ar
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X56,136,390 - 56,301,529 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ar
94 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:294
Count of miRNA genes:181
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000009129
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX45182909117740458Rat
70221Bp56Blood pressure QTL 564.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X6103585667175160Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X4493088389930883Rat

Markers in Region
DXWox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,106,267 - 63,106,373 (+)MAPPERmRatBN7.2
Rnor_6.0X67,657,750 - 67,657,855NCBIRnor6.0
Rnor_5.0X68,535,159 - 68,535,264UniSTSRnor5.0
RGSC_v3.4X85,951,004 - 85,951,109UniSTSRGSC3.4
RGSC_v3.4X85,951,003 - 85,951,109RGDRGSC3.4
CeleraX63,513,449 - 63,513,554UniSTS
Cytogenetic MapXq22-q32UniSTS
DXMgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X67,132,972 - 67,133,179 (+)Marker Load Pipeline
mRatBN7.2X63,102,425 - 63,102,632 (+)MAPPERmRatBN7.2
Rnor_6.0X67,653,909 - 67,654,115NCBIRnor6.0
Rnor_5.0X68,531,318 - 68,531,524UniSTSRnor5.0
RGSC_v3.4X85,947,163 - 85,947,369UniSTSRGSC3.4
RGSC_v3.4X85,947,162 - 85,947,369RGDRGSC3.4
CeleraX63,509,604 - 63,509,812UniSTS
RGSC_v3.1X86,020,454 - 86,020,661RGD
Cytogenetic MapXq22-q32UniSTS
Ar  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X67,136,901 - 67,137,855 (+)Marker Load Pipeline
mRatBN7.2X63,106,354 - 63,107,309 (+)MAPPERmRatBN7.2
Rnor_6.0X67,657,837 - 67,658,791NCBIRnor6.0
Rnor_5.0X68,535,246 - 68,536,200UniSTSRnor5.0
RGSC_v3.4X85,951,091 - 85,952,045UniSTSRGSC3.4
CeleraX63,513,536 - 63,514,490UniSTS
Cytogenetic MapXq22-q32UniSTS
UniSTS:141120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,106,848 - 63,106,912 (+)MAPPERmRatBN7.2
Rnor_6.0X67,658,331 - 67,658,394NCBIRnor6.0
Rnor_5.0X68,535,740 - 68,535,803UniSTSRnor5.0
RGSC_v3.4X85,951,585 - 85,951,648UniSTSRGSC3.4
CeleraX63,514,030 - 63,514,093UniSTS
Cytogenetic MapXq22-q32UniSTS
GDB:176286  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,106,013 - 63,106,480 (+)MAPPERmRatBN7.2
Rnor_6.0X67,657,496 - 67,657,962NCBIRnor6.0
Rnor_5.0X68,534,905 - 68,535,371UniSTSRnor5.0
RGSC_v3.4X85,950,750 - 85,951,216UniSTSRGSC3.4
CeleraX63,513,195 - 63,513,661UniSTS
Cytogenetic MapXq22-q32UniSTS
GDB:194743  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,106,035 - 63,106,480 (+)MAPPERmRatBN7.2
Rnor_6.0X67,657,518 - 67,657,962NCBIRnor6.0
Rnor_5.0X68,534,927 - 68,535,371UniSTSRnor5.0
RGSC_v3.4X85,950,772 - 85,951,216UniSTSRGSC3.4
CeleraX63,513,217 - 63,513,661UniSTS
Cytogenetic MapXq22-q32UniSTS
PMC304104P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,105,814 - 63,106,373 (+)MAPPERmRatBN7.2
Rnor_6.0X67,657,297 - 67,657,855NCBIRnor6.0
Rnor_5.0X68,534,706 - 68,535,264UniSTSRnor5.0
RGSC_v3.4X85,950,551 - 85,951,109UniSTSRGSC3.4
CeleraX63,512,996 - 63,513,554UniSTS
Cytogenetic MapXq22-q32UniSTS
PMC64995P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,105,807 - 63,106,176 (+)MAPPERmRatBN7.2
Rnor_6.0X67,657,290 - 67,657,658NCBIRnor6.0
Rnor_5.0X68,534,699 - 68,535,067UniSTSRnor5.0
RGSC_v3.4X85,950,544 - 85,950,912UniSTSRGSC3.4
CeleraX63,512,989 - 63,513,357UniSTS
Cytogenetic MapXq22-q32UniSTS
Ar  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X63,259,968 - 63,260,156 (+)MAPPERmRatBN7.2
Rnor_6.0X67,815,844 - 67,816,031NCBIRnor6.0
Rnor_5.0X68,692,885 - 68,693,072UniSTSRnor5.0
RGSC_v3.4X86,104,796 - 86,104,983UniSTSRGSC3.4
CeleraX63,666,231 - 63,666,418UniSTS
Cytogenetic MapXq22-q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 55 124 64 63 32 84 32 6 294 170 9 104 74 92 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000009129   ⟹   ENSRNOP00000009129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX67,135,317 - 67,304,467 (+)Ensembl
mRatBN7.2 EnsemblX63,104,771 - 63,273,925 (+)Ensembl
Rnor_6.0 EnsemblX67,656,253 - 67,829,026 (+)Ensembl
RefSeq Acc Id: NM_012502   ⟹   NP_036634
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X67,135,317 - 67,304,476 (+)NCBI
mRatBN7.2X63,104,771 - 63,273,934 (+)NCBI
Rnor_6.0X67,656,253 - 67,828,998 (+)NCBI
Rnor_5.0X68,533,662 - 68,705,929 (+)NCBI
RGSC_v3.4X85,949,507 - 86,119,199 (+)RGD
CeleraX63,512,152 - 63,679,533 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036634 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40733 (Get FASTA)   NCBI Sequence Viewer  
  AAA40734 (Get FASTA)   NCBI Sequence Viewer  
  AAA40759 (Get FASTA)   NCBI Sequence Viewer  
  EDL95956 (Get FASTA)   NCBI Sequence Viewer  
  EDL95957 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009129
GenBank Protein P15207 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036634   ⟸   NM_012502
- UniProtKB: Q63049 (UniProtKB/Swiss-Prot),   P15207 (UniProtKB/Swiss-Prot),   A0A0G2JSI8 (UniProtKB/TrEMBL),   A6IQ56 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009129   ⟸   ENSRNOT00000009129
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P15207-F1-model_v2 AlphaFold P15207 1-902 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701854
Promoter ID:EPDNEW_R12378
Type:multiple initiation site
Name:Ar_1
Description:androgen receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X67,656,252 - 67,656,312EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2147 AgrOrtholog
BioCyc Gene G2FUF-2168 BioCyc
Ensembl Genes ENSRNOG00000005639 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000009129 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro Andrgn_rcpt UniProtKB/Swiss-Prot
  NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR3 UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:24208 UniProtKB/Swiss-Prot
NCBI Gene 24208 ENTREZGENE
PANTHER KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam Androgen_recep UniProtKB/Swiss-Prot
  Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB AR RGD
PhenoGen Ar PhenoGen
PRINTS ANDROGENR UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005639 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
TIGR TC222121
UniProt A0A0G2JSI8 ENTREZGENE, UniProtKB/TrEMBL
  A6IQ56 ENTREZGENE, UniProtKB/TrEMBL
  A6IQ57_RAT UniProtKB/TrEMBL
  ANDR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63049 ENTREZGENE
UniProt Secondary Q63049 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ar  androgen receptor      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Ar  androgen receptor      Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease gene mutation and decreased androgen binding causes androgen insensitivity in the testicular feminized (Tfm) rat 1298681
gene_function binds androgens and acts as a steroid-hormone activated transcription factor 70256
gene_process functions in transcription of androgen responsive genes 70256