RGD Reference Report - Molecular chaperones throughout the life cycle of the androgen receptor. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Molecular chaperones throughout the life cycle of the androgen receptor.

Authors: Prescott, J  Coetzee, GA 
Citation: Prescott J and Coetzee GA, Cancer Lett. 2006 Jan 8;231(1):12-9.
RGD ID: 2326084
Pubmed: PMID:16356826   (View Abstract at PubMed)
DOI: DOI:10.1016/j.canlet.2004.12.037   (Journal Full-text)

Aberrant signaling by the androgen receptor contributes to the initiation and progression of prostate cancer. The involvement of molecular chaperones in the processes of folding, activation, trafficking, and transcriptional activity of the androgen receptor provide different points along the signaling axis where regulation of androgen receptor activity can be hijacked to provide growth signals for clonal selection in cancer progression. Evidence exists of abnormal chaperone expression that could contribute to the upregulation of AR activity in prostate tumors. Regardless of whether chaperones are involved in the causation of prostate carcinogenesis, molecular chaperones provide therapeutic targets for the treatment of prostate cancer.

Objects Annotated

Genes (Rattus norvegicus)
Ar  (androgen receptor)
Dnaja2  (DnaJ heat shock protein family (Hsp40) member A2)
Hsp90aa1  (heat shock protein 90 alpha family class A member 1)
Hsp90ab1  (heat shock protein 90 alpha family class B member 1)
Hspa8  (heat shock protein family A (Hsp70) member 8)
St13  (ST13, Hsp70 interacting protein)
Stip1  (stress-induced phosphoprotein 1)

Genes (Mus musculus)
Ar  (androgen receptor)
Dnaja2  (DnaJ heat shock protein family (Hsp40) member A2)
Hsp90aa1  (heat shock protein 90, alpha (cytosolic), class A member 1)
Hsp90ab1  (heat shock protein 90 alpha (cytosolic), class B member 1)
Hspa8  (heat shock protein 8)
St13  (suppression of tumorigenicity 13)
Stip1  (stress-induced phosphoprotein 1)

Genes (Homo sapiens)
AR  (androgen receptor)
DNAJA2  (DnaJ heat shock protein family (Hsp40) member A2)
HSP90AA1  (heat shock protein 90 alpha family class A member 1)
HSP90AB1  (heat shock protein 90 alpha family class B member 1)
HSPA8  (heat shock protein family A (Hsp70) member 8)
ST13  (ST13 Hsp70 interacting protein)
STIP1  (stress induced phosphoprotein 1)


Additional Information