GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ar | decreases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of AR mRNA | PMID:11222880 PMID:11896295 PMID:16254025 PMID:32109520 | Ar | increases activity | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased activity of AR protein | PMID:10771140 | Ar | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of AR protein | PMID:11099645 | Ar | affects expression | ISO | Ar (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of AR mRNA; Tetrachlorodibenzodioxin affects the expression of AR protein | PMID:18972606 PMID:21570461 PMID:24058054 PMID:26377647 | Ar | decreases expression | ISO | Ar (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of AR mRNA | PMID:19465110 | Ar | decreases expression | ISO | AR (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of AR mRNA | PMID:20106945 | Ar | multiple interactions | ISO | Ar (Mus musculus) | 6480464 | CTD | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of AR mRNA; [Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of AR mRNA; [Dietary Fats co-treated with Dietary Sucrose] affects the reaction [[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of AR mRNA] | PMID:28774668 PMID:30722647 | Ar | multiple interactions | ISO | AR (Homo sapiens) | 6480464 | CTD | [FHL2 protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; AHR protein inhibits the reaction [[FHL2 protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]; FHL2 protein affects the reaction [[Dihydrotestosterone co-treated with Tetrachlorodibenzodioxin] results in increased activity of AR protein]; SRC protein promotes the reaction [[Dihydrotestosterone co-treated with Tetrachlorodibenzodioxin] results in increased activity of AR protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Tetrachlorodibenzodioxin inhibits the reaction [Dihydrotestosterone results in increased expression of AR protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased activity of AR protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of AR protein] | PMID:10696776 PMID:15026081 PMID:19815066 | | ||||||||||||||||||||||
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