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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2147
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:38746
Term: parathion-methyl
Definition: A C-nitro compound that is 4-nitrophenol substituted by a (dimethoxyphosphorothioyl)oxy group at position 4.
Chemical ID: MESH:D008743
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Araffects bindingEXP 6480464CTDMethyl Parathion binds to AR proteinPMID:14565775
Armultiple interactionsISOAR (Homo sapiens)6480464CTDDihydrotestosterone inhibits the reaction [Methyl Parathion results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Methyl Parathion inhibits the reaction [Metribolone results in increased activity of AR protein]PMID:15064155 PMID:18324785 PMID:33049310
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