GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ar | affects binding | EXP | | 6480464 | CTD | Flutamide binds to AR protein | PMID:14565775 PMID:19833195 | Ar | decreases expression | EXP | | 6480464 | CTD | Flutamide results in decreased expression of AR mRNA; Flutamide results in decreased expression of AR protein | PMID:14967917 PMID:23135684 PMID:23146716 PMID:23541399 | Ar | increases expression | EXP | | 6480464 | CTD | Flutamide results in increased expression of AR mRNA | PMID:23146716 | Ar | multiple interactions | EXP | | 6480464 | CTD | [Diethylstilbestrol co-treated with Flutamide] results in decreased expression of AR protein; daidzein inhibits the reaction [Flutamide results in decreased expression of AR mRNA]; daidzein inhibits the reaction [Flutamide results in decreased expression of AR protein]; Flutamide binds to and results in decreased activity of AR protein; Flutamide inhibits the reaction [estradiol 3-benzoate results in increased expression of AR mRNA]; Flutamide inhibits the reaction [Testosterone results in increased activity of AR protein]; Flutamide inhibits the reaction [Testosterone results in increased expression of AR mRNA] | PMID:10523385 PMID:12446607 PMID:15925091 PMID:23135684 PMID:24902786 PMID:27684650 | Ar | decreases activity | ISO | AR (Homo sapiens) | 6480464 | CTD | Flutamide results in decreased activity of AR protein | PMID:11981028 PMID:16169144 PMID:16893599 PMID:21543282 PMID:26867867 PMID:28757136 PMID:29777833 PMID:30247711 PMID:9846162 | Ar | decreases expression | ISO | AR (Homo sapiens) | 6480464 | CTD | Flutamide results in decreased expression of AR protein | PMID:28176351 | Ar | increases activity | ISO | AR (Homo sapiens) | 6480464 | CTD | Flutamide results in increased activity of AR protein; Flutamide results in increased activity of AR protein mutant form | PMID:11118046 PMID:11956172 | Ar | multiple interactions | ISO | Ar (Mus musculus) | 6480464 | CTD | Flutamide binds to and results in decreased activity of AR protein; Flutamide inhibits the reaction [CD38 gene mutant form results in decreased expression of AR mRNA] | PMID:14630719 PMID:21840325 | Ar | multiple interactions | ISO | AR (Homo sapiens) | 6480464 | CTD | [Flutamide binds to and results in decreased activity of AR protein] which results in decreased expression of NKX3-1 protein; bicalutamide inhibits the reaction [Flutamide results in increased activity of AR protein mutant form]; Flutamide binds to and results in decreased activity of AR protein; Flutamide binds to and results in increased activity of AR protein; Flutamide inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Flutamide inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of AR protein]; Flutamide inhibits the reaction [Dibutyl Phthalate results in increased activity of AR protein]; Flutamide inhibits the reaction [Diethylhexyl Phthalate results in increased activity of AR protein]; Flutamide inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; Flutamide inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; Flutamide inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Flutamide inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; Flutamide inhibits the reaction [Metribolone binds to AR protein]; Flutamide inhibits the reaction [monobutyl phthalate results in increased activity of AR protein]; Flutamide inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; Flutamide inhibits the reaction [Testosterone results in increased activity of AR protein]; Flutamide inhibits the reaction [Testosterone results in increased expression of AR mRNA]; Flutamide metabolite inhibits the reaction [Stanozolol binds to and results in increased activity of AR protein]; Mifepristone inhibits the reaction [Flutamide results in increased activity of AR protein mutant form] | PMID:10696776 PMID:11118046 PMID:11956172 PMID:12730620 PMID:15033008 PMID:15483189 PMID:15589981 PMID:16111029 PMID:16601080 PMID:16857237 PMID:17303007 PMID:19643168 PMID:20438827 PMID:20943248 PMID:21357386 PMID:25752796 PMID:26022396 PMID:26602169 PMID:27436773 PMID:27684650 PMID:28009930 PMID:28176351 PMID:28377212 PMID:28571686 PMID:28728110 PMID:28803809 PMID:29162470 PMID:29421333 PMID:30408883 PMID:31393563 PMID:31586605 PMID:33049310 PMID:9705896 | | ||||||||||||||||||||||
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